Amino acid dipepetide frequency for Rickettsiales bacterium Ac37b

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.597AlaAla: 4.597 ± 0.155
0.718AlaCys: 0.718 ± 0.037
2.714AlaAsp: 2.714 ± 0.076
4.261AlaGlu: 4.261 ± 0.099
2.424AlaPhe: 2.424 ± 0.073
3.882AlaGly: 3.882 ± 0.108
1.385AlaHis: 1.385 ± 0.053
6.141AlaIle: 6.141 ± 0.114
4.908AlaLys: 4.908 ± 0.109
6.499AlaLeu: 6.499 ± 0.115
1.523AlaMet: 1.523 ± 0.074
3.423AlaAsn: 3.423 ± 0.09
1.909AlaPro: 1.909 ± 0.082
2.259AlaGln: 2.259 ± 0.079
2.461AlaArg: 2.461 ± 0.073
4.22AlaSer: 4.22 ± 0.099
3.12AlaThr: 3.12 ± 0.081
3.711AlaVal: 3.711 ± 0.094
0.517AlaTrp: 0.517 ± 0.028
2.213AlaTyr: 2.213 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.559CysAla: 0.559 ± 0.035
0.161CysCys: 0.161 ± 0.02
0.473CysAsp: 0.473 ± 0.029
0.519CysGlu: 0.519 ± 0.037
0.505CysPhe: 0.505 ± 0.031
0.64CysGly: 0.64 ± 0.037
0.234CysHis: 0.234 ± 0.021
1.039CysIle: 1.039 ± 0.047
0.782CysLys: 0.782 ± 0.039
0.978CysLeu: 0.978 ± 0.045
0.242CysMet: 0.242 ± 0.022
0.743CysAsn: 0.743 ± 0.045
0.39CysPro: 0.39 ± 0.029
0.265CysGln: 0.265 ± 0.023
0.321CysArg: 0.321 ± 0.025
0.82CysSer: 0.82 ± 0.042
0.586CysThr: 0.586 ± 0.033
0.49CysVal: 0.49 ± 0.033
0.071CysTrp: 0.071 ± 0.011
0.473CysTyr: 0.473 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
2.532AspAla: 2.532 ± 0.064
0.465AspCys: 0.465 ± 0.029
2.136AspAsp: 2.136 ± 0.076
2.778AspGlu: 2.778 ± 0.07
2.177AspPhe: 2.177 ± 0.08
2.296AspGly: 2.296 ± 0.075
1.074AspHis: 1.074 ± 0.047
5.692AspIle: 5.692 ± 0.1
4.244AspLys: 4.244 ± 0.107
5.043AspLeu: 5.043 ± 0.114
1.105AspMet: 1.105 ± 0.038
3.723AspAsn: 3.723 ± 0.082
1.573AspPro: 1.573 ± 0.064
1.923AspGln: 1.923 ± 0.075
1.658AspArg: 1.658 ± 0.062
2.989AspSer: 2.989 ± 0.085
2.434AspThr: 2.434 ± 0.072
2.34AspVal: 2.34 ± 0.077
0.43AspTrp: 0.43 ± 0.029
2.169AspTyr: 2.169 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
4.117GluAla: 4.117 ± 0.088
0.547GluCys: 0.547 ± 0.034
2.83GluAsp: 2.83 ± 0.083
4.995GluGlu: 4.995 ± 0.135
2.682GluPhe: 2.682 ± 0.07
3.037GluGly: 3.037 ± 0.096
1.508GluHis: 1.508 ± 0.057
6.303GluIle: 6.303 ± 0.128
5.41GluLys: 5.41 ± 0.126
7.021GluLeu: 7.021 ± 0.142
1.454GluMet: 1.454 ± 0.054
4.172GluAsn: 4.172 ± 0.099
1.333GluPro: 1.333 ± 0.045
2.953GluGln: 2.953 ± 0.103
2.432GluArg: 2.432 ± 0.082
3.183GluSer: 3.183 ± 0.091
2.541GluThr: 2.541 ± 0.076
3.706GluVal: 3.706 ± 0.107
0.553GluTrp: 0.553 ± 0.036
2.57GluTyr: 2.57 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
2.755PheAla: 2.755 ± 0.078
0.496PheCys: 0.496 ± 0.03
2.211PheAsp: 2.211 ± 0.065
2.057PheGlu: 2.057 ± 0.062
2.0PhePhe: 2.0 ± 0.081
2.438PheGly: 2.438 ± 0.077
0.772PheHis: 0.772 ± 0.04
4.426PheIle: 4.426 ± 0.115
2.816PheLys: 2.816 ± 0.076
4.245PheLeu: 4.245 ± 0.09
0.985PheMet: 0.985 ± 0.044
2.764PheAsn: 2.764 ± 0.071
1.318PhePro: 1.318 ± 0.052
1.139PheGln: 1.139 ± 0.045
1.172PheArg: 1.172 ± 0.047
3.542PheSer: 3.542 ± 0.098
2.526PheThr: 2.526 ± 0.064
2.338PheVal: 2.338 ± 0.075
0.378PheTrp: 0.378 ± 0.029
1.606PheTyr: 1.606 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
3.698GlyAla: 3.698 ± 0.105
0.707GlyCys: 0.707 ± 0.043
2.503GlyAsp: 2.503 ± 0.073
3.158GlyGlu: 3.158 ± 0.091
2.534GlyPhe: 2.534 ± 0.068
3.709GlyGly: 3.709 ± 0.15
1.168GlyHis: 1.168 ± 0.048
5.732GlyIle: 5.732 ± 0.119
4.418GlyLys: 4.418 ± 0.097
4.751GlyLeu: 4.751 ± 0.091
1.377GlyMet: 1.377 ± 0.062
3.177GlyAsn: 3.177 ± 0.117
1.324GlyPro: 1.324 ± 0.068
1.796GlyGln: 1.796 ± 0.061
2.069GlyArg: 2.069 ± 0.081
3.494GlySer: 3.494 ± 0.125
2.86GlyThr: 2.86 ± 0.089
3.321GlyVal: 3.321 ± 0.088
0.546GlyTrp: 0.546 ± 0.035
2.401GlyTyr: 2.401 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.203HisAla: 1.203 ± 0.052
0.244HisCys: 0.244 ± 0.022
1.072HisAsp: 1.072 ± 0.05
1.053HisGlu: 1.053 ± 0.044
0.997HisPhe: 0.997 ± 0.044
1.214HisGly: 1.214 ± 0.057
0.642HisHis: 0.642 ± 0.039
2.088HisIle: 2.088 ± 0.063
1.627HisLys: 1.627 ± 0.061
2.175HisLeu: 2.175 ± 0.071
0.455HisMet: 0.455 ± 0.031
1.867HisAsn: 1.867 ± 0.069
0.838HisPro: 0.838 ± 0.036
0.619HisGln: 0.619 ± 0.035
0.732HisArg: 0.732 ± 0.043
1.402HisSer: 1.402 ± 0.053
1.224HisThr: 1.224 ± 0.053
0.951HisVal: 0.951 ± 0.044
0.152HisTrp: 0.152 ± 0.016
1.13HisTyr: 1.13 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
6.896IleAla: 6.896 ± 0.116
1.099IleCys: 1.099 ± 0.048
5.483IleAsp: 5.483 ± 0.135
6.305IleGlu: 6.305 ± 0.113
4.0IlePhe: 4.0 ± 0.119
5.417IleGly: 5.417 ± 0.104
1.746IleHis: 1.746 ± 0.054
10.247IleIle: 10.247 ± 0.197
7.911IleLys: 7.911 ± 0.139
9.886IleLeu: 9.886 ± 0.15
2.142IleMet: 2.142 ± 0.072
6.685IleAsn: 6.685 ± 0.152
3.496IlePro: 3.496 ± 0.097
2.839IleGln: 2.839 ± 0.084
3.079IleArg: 3.079 ± 0.094
7.331IleSer: 7.331 ± 0.126
5.871IleThr: 5.871 ± 0.114
5.287IleVal: 5.287 ± 0.117
0.695IleTrp: 0.695 ± 0.041
3.456IleTyr: 3.456 ± 0.094
0.0IleXaa: 0.0 ± 0.0
Lys
4.714LysAla: 4.714 ± 0.101
0.636LysCys: 0.636 ± 0.039
3.992LysAsp: 3.992 ± 0.108
6.111LysGlu: 6.111 ± 0.131
3.001LysPhe: 3.001 ± 0.08
3.665LysGly: 3.665 ± 0.096
1.698LysHis: 1.698 ± 0.057
7.628LysIle: 7.628 ± 0.123
5.49LysLys: 5.49 ± 0.118
8.412LysLeu: 8.412 ± 0.134
1.679LysMet: 1.679 ± 0.054
5.492LysAsn: 5.492 ± 0.116
2.39LysPro: 2.39 ± 0.087
3.162LysGln: 3.162 ± 0.084
2.54LysArg: 2.54 ± 0.071
4.847LysSer: 4.847 ± 0.104
3.955LysThr: 3.955 ± 0.091
4.176LysVal: 4.176 ± 0.098
0.626LysTrp: 0.626 ± 0.034
3.11LysTyr: 3.11 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
6.8LeuAla: 6.8 ± 0.128
1.118LeuCys: 1.118 ± 0.047
5.096LeuAsp: 5.096 ± 0.102
6.762LeuGlu: 6.762 ± 0.124
4.128LeuPhe: 4.128 ± 0.097
5.623LeuGly: 5.623 ± 0.105
2.403LeuHis: 2.403 ± 0.082
8.802LeuIle: 8.802 ± 0.156
7.503LeuLys: 7.503 ± 0.145
10.808LeuLeu: 10.808 ± 0.209
2.198LeuMet: 2.198 ± 0.073
6.105LeuAsn: 6.105 ± 0.127
4.146LeuPro: 4.146 ± 0.102
3.571LeuGln: 3.571 ± 0.078
3.588LeuArg: 3.588 ± 0.081
8.485LeuSer: 8.485 ± 0.145
5.191LeuThr: 5.191 ± 0.111
5.283LeuVal: 5.283 ± 0.095
0.732LeuTrp: 0.732 ± 0.045
3.948LeuTyr: 3.948 ± 0.11
0.0LeuXaa: 0.0 ± 0.0
Met
1.556MetAla: 1.556 ± 0.049
0.223MetCys: 0.223 ± 0.021
1.01MetAsp: 1.01 ± 0.043
1.22MetGlu: 1.22 ± 0.049
0.851MetPhe: 0.851 ± 0.046
1.256MetGly: 1.256 ± 0.055
0.655MetHis: 0.655 ± 0.036
1.94MetIle: 1.94 ± 0.074
1.518MetLys: 1.518 ± 0.054
2.413MetLeu: 2.413 ± 0.068
0.565MetMet: 0.565 ± 0.033
1.31MetAsn: 1.31 ± 0.048
1.018MetPro: 1.018 ± 0.042
1.032MetGln: 1.032 ± 0.05
0.888MetArg: 0.888 ± 0.04
1.677MetSer: 1.677 ± 0.059
1.12MetThr: 1.12 ± 0.059
1.569MetVal: 1.569 ± 0.059
0.154MetTrp: 0.154 ± 0.016
0.64MetTyr: 0.64 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
3.437AsnAla: 3.437 ± 0.092
0.63AsnCys: 0.63 ± 0.042
2.956AsnAsp: 2.956 ± 0.087
3.237AsnGlu: 3.237 ± 0.088
3.072AsnPhe: 3.072 ± 0.082
2.724AsnGly: 2.724 ± 0.085
1.573AsnHis: 1.573 ± 0.074
8.358AsnIle: 8.358 ± 0.157
5.823AsnLys: 5.823 ± 0.105
6.668AsnLeu: 6.668 ± 0.142
1.487AsnMet: 1.487 ± 0.05
6.113AsnAsn: 6.113 ± 0.148
2.244AsnPro: 2.244 ± 0.063
2.442AsnGln: 2.442 ± 0.074
1.958AsnArg: 1.958 ± 0.072
4.735AsnSer: 4.735 ± 0.113
3.55AsnThr: 3.55 ± 0.098
3.333AsnVal: 3.333 ± 0.08
0.523AsnTrp: 0.523 ± 0.035
2.93AsnTyr: 2.93 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
1.95ProAla: 1.95 ± 0.089
0.315ProCys: 0.315 ± 0.028
1.677ProAsp: 1.677 ± 0.069
2.568ProGlu: 2.568 ± 0.088
1.485ProPhe: 1.485 ± 0.048
1.798ProGly: 1.798 ± 0.065
0.661ProHis: 0.661 ± 0.037
3.252ProIle: 3.252 ± 0.085
2.44ProLys: 2.44 ± 0.073
3.308ProLeu: 3.308 ± 0.084
0.692ProMet: 0.692 ± 0.038
2.075ProAsn: 2.075 ± 0.066
1.08ProPro: 1.08 ± 0.063
0.93ProGln: 0.93 ± 0.042
0.934ProArg: 0.934 ± 0.049
2.392ProSer: 2.392 ± 0.069
1.836ProThr: 1.836 ± 0.069
2.021ProVal: 2.021 ± 0.067
0.344ProTrp: 0.344 ± 0.027
1.414ProTyr: 1.414 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
2.568GlnAla: 2.568 ± 0.061
0.238GlnCys: 0.238 ± 0.02
2.109GlnAsp: 2.109 ± 0.071
3.077GlnGlu: 3.077 ± 0.105
1.264GlnPhe: 1.264 ± 0.049
1.89GlnGly: 1.89 ± 0.066
0.736GlnHis: 0.736 ± 0.04
3.15GlnIle: 3.15 ± 0.085
2.795GlnLys: 2.795 ± 0.063
3.565GlnLeu: 3.565 ± 0.076
0.717GlnMet: 0.717 ± 0.04
2.703GlnAsn: 2.703 ± 0.083
0.863GlnPro: 0.863 ± 0.044
1.324GlnGln: 1.324 ± 0.052
1.116GlnArg: 1.116 ± 0.042
1.961GlnSer: 1.961 ± 0.057
1.583GlnThr: 1.583 ± 0.052
1.833GlnVal: 1.833 ± 0.059
0.231GlnTrp: 0.231 ± 0.022
1.366GlnTyr: 1.366 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
2.28ArgAla: 2.28 ± 0.07
0.363ArgCys: 0.363 ± 0.025
1.827ArgAsp: 1.827 ± 0.07
2.407ArgGlu: 2.407 ± 0.075
1.356ArgPhe: 1.356 ± 0.052
1.988ArgGly: 1.988 ± 0.083
0.661ArgHis: 0.661 ± 0.039
3.177ArgIle: 3.177 ± 0.088
2.641ArgLys: 2.641 ± 0.08
3.358ArgLeu: 3.358 ± 0.09
0.893ArgMet: 0.893 ± 0.043
2.088ArgAsn: 2.088 ± 0.069
1.078ArgPro: 1.078 ± 0.049
1.156ArgGln: 1.156 ± 0.044
1.391ArgArg: 1.391 ± 0.062
2.127ArgSer: 2.127 ± 0.065
1.679ArgThr: 1.679 ± 0.058
2.029ArgVal: 2.029 ± 0.07
0.267ArgTrp: 0.267 ± 0.021
1.327ArgTyr: 1.327 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
3.838SerAla: 3.838 ± 0.088
0.788SerCys: 0.788 ± 0.042
3.197SerAsp: 3.197 ± 0.074
3.928SerGlu: 3.928 ± 0.098
3.271SerPhe: 3.271 ± 0.072
4.092SerGly: 4.092 ± 0.107
1.502SerHis: 1.502 ± 0.052
6.503SerIle: 6.503 ± 0.123
5.427SerLys: 5.427 ± 0.12
7.546SerLeu: 7.546 ± 0.143
1.637SerMet: 1.637 ± 0.059
4.837SerAsn: 4.837 ± 0.113
2.223SerPro: 2.223 ± 0.072
2.034SerGln: 2.034 ± 0.06
2.332SerArg: 2.332 ± 0.106
5.721SerSer: 5.721 ± 0.142
3.646SerThr: 3.646 ± 0.093
3.675SerVal: 3.675 ± 0.091
0.615SerTrp: 0.615 ± 0.038
3.022SerTyr: 3.022 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
3.197ThrAla: 3.197 ± 0.098
0.473ThrCys: 0.473 ± 0.03
2.244ThrAsp: 2.244 ± 0.069
2.964ThrGlu: 2.964 ± 0.069
2.069ThrPhe: 2.069 ± 0.065
3.066ThrGly: 3.066 ± 0.098
1.085ThrHis: 1.085 ± 0.046
5.254ThrIle: 5.254 ± 0.129
3.928ThrLys: 3.928 ± 0.102
5.29ThrLeu: 5.29 ± 0.106
1.07ThrMet: 1.07 ± 0.044
3.32ThrAsn: 3.32 ± 0.089
2.534ThrPro: 2.534 ± 0.078
1.815ThrGln: 1.815 ± 0.056
1.769ThrArg: 1.769 ± 0.055
3.713ThrSer: 3.713 ± 0.087
3.079ThrThr: 3.079 ± 0.091
2.964ThrVal: 2.964 ± 0.081
0.328ThrTrp: 0.328 ± 0.024
1.739ThrTyr: 1.739 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
3.5ValAla: 3.5 ± 0.092
0.605ValCys: 0.605 ± 0.032
2.855ValAsp: 2.855 ± 0.081
3.617ValGlu: 3.617 ± 0.083
2.073ValPhe: 2.073 ± 0.065
3.385ValGly: 3.385 ± 0.112
1.003ValHis: 1.003 ± 0.045
5.49ValIle: 5.49 ± 0.125
4.034ValLys: 4.034 ± 0.091
5.348ValLeu: 5.348 ± 0.103
1.391ValMet: 1.391 ± 0.057
3.431ValAsn: 3.431 ± 0.087
1.873ValPro: 1.873 ± 0.062
1.804ValGln: 1.804 ± 0.064
2.038ValArg: 2.038 ± 0.06
3.94ValSer: 3.94 ± 0.093
2.732ValThr: 2.732 ± 0.077
3.54ValVal: 3.54 ± 0.095
0.425ValTrp: 0.425 ± 0.032
1.735ValTyr: 1.735 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.467TrpAla: 0.467 ± 0.03
0.104TrpCys: 0.104 ± 0.015
0.344TrpAsp: 0.344 ± 0.028
0.355TrpGlu: 0.355 ± 0.026
0.392TrpPhe: 0.392 ± 0.029
0.407TrpGly: 0.407 ± 0.027
0.286TrpHis: 0.286 ± 0.023
0.655TrpIle: 0.655 ± 0.033
0.576TrpLys: 0.576 ± 0.038
0.991TrpLeu: 0.991 ± 0.048
0.159TrpMet: 0.159 ± 0.017
0.465TrpAsn: 0.465 ± 0.034
0.28TrpPro: 0.28 ± 0.024
0.499TrpGln: 0.499 ± 0.032
0.33TrpArg: 0.33 ± 0.026
0.521TrpSer: 0.521 ± 0.032
0.273TrpThr: 0.273 ± 0.023
0.478TrpVal: 0.478 ± 0.031
0.125TrpTrp: 0.125 ± 0.017
0.344TrpTyr: 0.344 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.225TyrAla: 2.225 ± 0.059
0.361TyrCys: 0.361 ± 0.025
2.05TyrAsp: 2.05 ± 0.064
1.975TyrGlu: 1.975 ± 0.06
1.706TyrPhe: 1.706 ± 0.056
2.217TyrGly: 2.217 ± 0.071
0.889TyrHis: 0.889 ± 0.041
3.99TyrIle: 3.99 ± 0.093
3.033TyrLys: 3.033 ± 0.088
3.986TyrLeu: 3.986 ± 0.094
0.841TyrMet: 0.841 ± 0.037
3.296TyrAsn: 3.296 ± 0.093
1.262TyrPro: 1.262 ± 0.053
1.527TyrGln: 1.527 ± 0.061
1.287TyrArg: 1.287 ± 0.051
2.734TyrSer: 2.734 ± 0.074
2.096TyrThr: 2.096 ± 0.067
1.773TyrVal: 1.773 ± 0.057
0.342TyrTrp: 0.342 ± 0.026
1.844TyrTyr: 1.844 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1659 proteins (520560 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski