Amino acid dipepetide frequency for Micromonospora yangpuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.088AlaAla: 22.088 ± 0.149
0.92AlaCys: 0.92 ± 0.026
9.103AlaAsp: 9.103 ± 0.084
8.488AlaGlu: 8.488 ± 0.085
3.082AlaPhe: 3.082 ± 0.041
14.965AlaGly: 14.965 ± 0.108
2.534AlaHis: 2.534 ± 0.035
3.568AlaIle: 3.568 ± 0.052
2.106AlaLys: 2.106 ± 0.043
13.85AlaLeu: 13.85 ± 0.122
2.258AlaMet: 2.258 ± 0.035
2.148AlaAsn: 2.148 ± 0.038
7.115AlaPro: 7.115 ± 0.082
3.749AlaGln: 3.749 ± 0.047
10.407AlaArg: 10.407 ± 0.082
5.41AlaSer: 5.41 ± 0.06
8.43AlaThr: 8.43 ± 0.081
12.723AlaVal: 12.723 ± 0.098
1.78AlaTrp: 1.78 ± 0.029
2.715AlaTyr: 2.715 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.981CysAla: 0.981 ± 0.025
0.095CysCys: 0.095 ± 0.008
0.48CysAsp: 0.48 ± 0.013
0.307CysGlu: 0.307 ± 0.012
0.211CysPhe: 0.211 ± 0.012
0.859CysGly: 0.859 ± 0.023
0.208CysHis: 0.208 ± 0.011
0.12CysIle: 0.12 ± 0.008
0.076CysLys: 0.076 ± 0.007
0.704CysLeu: 0.704 ± 0.02
0.095CysMet: 0.095 ± 0.007
0.119CysAsn: 0.119 ± 0.008
0.5CysPro: 0.5 ± 0.016
0.199CysGln: 0.199 ± 0.011
0.672CysArg: 0.672 ± 0.021
0.371CysSer: 0.371 ± 0.014
0.425CysThr: 0.425 ± 0.014
0.656CysVal: 0.656 ± 0.019
0.134CysTrp: 0.134 ± 0.009
0.168CysTyr: 0.168 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.32AspAla: 7.32 ± 0.075
0.398AspCys: 0.398 ± 0.015
3.828AspAsp: 3.828 ± 0.053
3.699AspGlu: 3.699 ± 0.05
1.461AspPhe: 1.461 ± 0.028
6.266AspGly: 6.266 ± 0.071
1.341AspHis: 1.341 ± 0.03
1.615AspIle: 1.615 ± 0.033
0.825AspLys: 0.825 ± 0.023
6.86AspLeu: 6.86 ± 0.067
0.661AspMet: 0.661 ± 0.021
0.963AspAsn: 0.963 ± 0.026
5.185AspPro: 5.185 ± 0.053
1.886AspGln: 1.886 ± 0.032
6.038AspArg: 6.038 ± 0.071
2.361AspSer: 2.361 ± 0.037
3.152AspThr: 3.152 ± 0.043
4.728AspVal: 4.728 ± 0.049
0.99AspTrp: 0.99 ± 0.024
1.068AspTyr: 1.068 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
6.172GluAla: 6.172 ± 0.068
0.344GluCys: 0.344 ± 0.014
1.854GluAsp: 1.854 ± 0.032
2.33GluGlu: 2.33 ± 0.043
1.42GluPhe: 1.42 ± 0.028
3.012GluGly: 3.012 ± 0.043
1.352GluHis: 1.352 ± 0.032
2.156GluIle: 2.156 ± 0.037
0.978GluLys: 0.978 ± 0.029
6.564GluLeu: 6.564 ± 0.069
0.751GluMet: 0.751 ± 0.021
0.843GluAsn: 0.843 ± 0.022
3.492GluPro: 3.492 ± 0.055
2.385GluGln: 2.385 ± 0.039
4.866GluArg: 4.866 ± 0.063
2.247GluSer: 2.247 ± 0.036
2.513GluThr: 2.513 ± 0.035
4.753GluVal: 4.753 ± 0.058
0.674GluTrp: 0.674 ± 0.02
1.111GluTyr: 1.111 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.521PheAla: 3.521 ± 0.041
0.244PheCys: 0.244 ± 0.013
1.988PheAsp: 1.988 ± 0.033
1.175PheGlu: 1.175 ± 0.028
0.836PhePhe: 0.836 ± 0.023
2.982PheGly: 2.982 ± 0.044
0.557PheHis: 0.557 ± 0.016
0.608PheIle: 0.608 ± 0.017
0.367PheLys: 0.367 ± 0.016
2.438PheLeu: 2.438 ± 0.035
0.298PheMet: 0.298 ± 0.011
0.532PheAsn: 0.532 ± 0.017
1.302PhePro: 1.302 ± 0.027
0.628PheGln: 0.628 ± 0.02
1.78PheArg: 1.78 ± 0.03
1.267PheSer: 1.267 ± 0.031
1.94PheThr: 1.94 ± 0.03
2.427PheVal: 2.427 ± 0.039
0.421PheTrp: 0.421 ± 0.015
0.565PheTyr: 0.565 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
10.839GlyAla: 10.839 ± 0.097
0.812GlyCys: 0.812 ± 0.023
5.274GlyAsp: 5.274 ± 0.055
4.557GlyGlu: 4.557 ± 0.049
2.692GlyPhe: 2.692 ± 0.039
9.087GlyGly: 9.087 ± 0.095
2.163GlyHis: 2.163 ± 0.037
3.04GlyIle: 3.04 ± 0.044
1.752GlyLys: 1.752 ± 0.034
9.542GlyLeu: 9.542 ± 0.086
1.783GlyMet: 1.783 ± 0.033
1.824GlyAsn: 1.824 ± 0.046
5.88GlyPro: 5.88 ± 0.078
3.218GlyGln: 3.218 ± 0.047
8.442GlyArg: 8.442 ± 0.075
5.054GlySer: 5.054 ± 0.061
6.354GlyThr: 6.354 ± 0.069
7.971GlyVal: 7.971 ± 0.073
1.955GlyTrp: 1.955 ± 0.032
2.396GlyTyr: 2.396 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
2.409HisAla: 2.409 ± 0.035
0.179HisCys: 0.179 ± 0.009
1.346HisAsp: 1.346 ± 0.029
1.037HisGlu: 1.037 ± 0.027
0.563HisPhe: 0.563 ± 0.023
2.086HisGly: 2.086 ± 0.033
0.703HisHis: 0.703 ± 0.022
0.475HisIle: 0.475 ± 0.015
0.249HisLys: 0.249 ± 0.012
2.573HisLeu: 2.573 ± 0.042
0.242HisMet: 0.242 ± 0.011
0.356HisAsn: 0.356 ± 0.015
1.791HisPro: 1.791 ± 0.031
0.726HisGln: 0.726 ± 0.022
2.391HisArg: 2.391 ± 0.046
0.888HisSer: 0.888 ± 0.02
1.184HisThr: 1.184 ± 0.027
1.597HisVal: 1.597 ± 0.03
0.331HisTrp: 0.331 ± 0.014
0.428HisTyr: 0.428 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.348IleAla: 4.348 ± 0.057
0.301IleCys: 0.301 ± 0.012
2.316IleAsp: 2.316 ± 0.038
1.822IleGlu: 1.822 ± 0.035
0.827IlePhe: 0.827 ± 0.023
3.321IleGly: 3.321 ± 0.043
0.543IleHis: 0.543 ± 0.018
0.854IleIle: 0.854 ± 0.025
0.566IleLys: 0.566 ± 0.02
2.375IleLeu: 2.375 ± 0.037
0.411IleMet: 0.411 ± 0.015
0.71IleAsn: 0.71 ± 0.018
1.568IlePro: 1.568 ± 0.03
0.664IleGln: 0.664 ± 0.02
2.476IleArg: 2.476 ± 0.035
1.609IleSer: 1.609 ± 0.03
2.056IleThr: 2.056 ± 0.038
2.743IleVal: 2.743 ± 0.044
0.381IleTrp: 0.381 ± 0.016
0.553IleTyr: 0.553 ± 0.019
0.0IleXaa: 0.0 ± 0.0
Lys
1.952LysAla: 1.952 ± 0.039
0.09LysCys: 0.09 ± 0.007
0.736LysAsp: 0.736 ± 0.022
0.734LysGlu: 0.734 ± 0.022
0.353LysPhe: 0.353 ± 0.016
1.171LysGly: 1.171 ± 0.029
0.297LysHis: 0.297 ± 0.013
0.761LysIle: 0.761 ± 0.026
0.462LysLys: 0.462 ± 0.022
1.678LysLeu: 1.678 ± 0.033
0.272LysMet: 0.272 ± 0.012
0.331LysAsn: 0.331 ± 0.015
1.017LysPro: 1.017 ± 0.024
0.56LysGln: 0.56 ± 0.019
1.137LysArg: 1.137 ± 0.03
0.855LysSer: 0.855 ± 0.026
0.937LysThr: 0.937 ± 0.028
1.42LysVal: 1.42 ± 0.035
0.191LysTrp: 0.191 ± 0.01
0.307LysTyr: 0.307 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
16.495LeuAla: 16.495 ± 0.122
0.747LeuCys: 0.747 ± 0.019
7.038LeuAsp: 7.038 ± 0.072
3.617LeuGlu: 3.617 ± 0.052
2.504LeuPhe: 2.504 ± 0.041
9.183LeuGly: 9.183 ± 0.079
2.259LeuHis: 2.259 ± 0.039
3.128LeuIle: 3.128 ± 0.048
1.328LeuLys: 1.328 ± 0.032
11.852LeuLeu: 11.852 ± 0.105
1.264LeuMet: 1.264 ± 0.023
1.631LeuAsn: 1.631 ± 0.029
6.798LeuPro: 6.798 ± 0.069
1.971LeuGln: 1.971 ± 0.032
9.589LeuArg: 9.589 ± 0.078
4.809LeuSer: 4.809 ± 0.056
7.443LeuThr: 7.443 ± 0.074
10.129LeuVal: 10.129 ± 0.094
1.24LeuTrp: 1.24 ± 0.029
1.66LeuTyr: 1.66 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
1.932MetAla: 1.932 ± 0.035
0.097MetCys: 0.097 ± 0.007
0.672MetAsp: 0.672 ± 0.018
0.537MetGlu: 0.537 ± 0.018
0.405MetPhe: 0.405 ± 0.017
1.098MetGly: 1.098 ± 0.029
0.267MetHis: 0.267 ± 0.011
0.622MetIle: 0.622 ± 0.016
0.301MetLys: 0.301 ± 0.012
1.61MetLeu: 1.61 ± 0.031
0.252MetMet: 0.252 ± 0.014
0.33MetAsn: 0.33 ± 0.013
1.029MetPro: 1.029 ± 0.021
0.411MetGln: 0.411 ± 0.013
1.308MetArg: 1.308 ± 0.028
1.183MetSer: 1.183 ± 0.026
1.461MetThr: 1.461 ± 0.027
1.289MetVal: 1.289 ± 0.026
0.177MetTrp: 0.177 ± 0.01
0.274MetTyr: 0.274 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.081AsnAla: 2.081 ± 0.037
0.159AsnCys: 0.159 ± 0.01
0.931AsnAsp: 0.931 ± 0.023
0.769AsnGlu: 0.769 ± 0.02
0.496AsnPhe: 0.496 ± 0.019
1.835AsnGly: 1.835 ± 0.036
0.388AsnHis: 0.388 ± 0.015
0.575AsnIle: 0.575 ± 0.021
0.316AsnLys: 0.316 ± 0.015
1.897AsnLeu: 1.897 ± 0.035
0.27AsnMet: 0.27 ± 0.012
0.473AsnAsn: 0.473 ± 0.019
1.495AsnPro: 1.495 ± 0.03
0.597AsnGln: 0.597 ± 0.021
1.445AsnArg: 1.445 ± 0.032
0.911AsnSer: 0.911 ± 0.024
0.984AsnThr: 0.984 ± 0.026
1.391AsnVal: 1.391 ± 0.031
0.318AsnTrp: 0.318 ± 0.013
0.386AsnTyr: 0.386 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
10.323ProAla: 10.323 ± 0.105
0.294ProCys: 0.294 ± 0.013
4.768ProAsp: 4.768 ± 0.061
3.819ProGlu: 3.819 ± 0.057
1.395ProPhe: 1.395 ± 0.024
6.965ProGly: 6.965 ± 0.071
1.265ProHis: 1.265 ± 0.028
1.548ProIle: 1.548 ± 0.03
0.914ProLys: 0.914 ± 0.027
5.17ProLeu: 5.17 ± 0.059
0.959ProMet: 0.959 ± 0.023
0.993ProAsn: 0.993 ± 0.027
4.766ProPro: 4.766 ± 0.086
1.818ProGln: 1.818 ± 0.037
4.175ProArg: 4.175 ± 0.053
3.053ProSer: 3.053 ± 0.047
4.743ProThr: 4.743 ± 0.06
6.372ProVal: 6.372 ± 0.068
0.894ProTrp: 0.894 ± 0.025
1.318ProTyr: 1.318 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.929GlnAla: 3.929 ± 0.053
0.151GlnCys: 0.151 ± 0.009
1.125GlnAsp: 1.125 ± 0.026
1.24GlnGlu: 1.24 ± 0.026
0.736GlnPhe: 0.736 ± 0.02
1.989GlnGly: 1.989 ± 0.042
0.66GlnHis: 0.66 ± 0.019
1.103GlnIle: 1.103 ± 0.027
0.407GlnLys: 0.407 ± 0.017
3.54GlnLeu: 3.54 ± 0.046
0.429GlnMet: 0.429 ± 0.015
0.504GlnAsn: 0.504 ± 0.019
2.205GlnPro: 2.205 ± 0.034
1.338GlnGln: 1.338 ± 0.038
2.993GlnArg: 2.993 ± 0.048
1.257GlnSer: 1.257 ± 0.027
1.43GlnThr: 1.43 ± 0.029
3.106GlnVal: 3.106 ± 0.041
0.536GlnTrp: 0.536 ± 0.017
0.55GlnTyr: 0.55 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
10.321ArgAla: 10.321 ± 0.087
0.682ArgCys: 0.682 ± 0.022
4.669ArgAsp: 4.669 ± 0.056
4.175ArgGlu: 4.175 ± 0.054
2.465ArgPhe: 2.465 ± 0.035
5.804ArgGly: 5.804 ± 0.06
2.329ArgHis: 2.329 ± 0.037
3.277ArgIle: 3.277 ± 0.044
1.249ArgLys: 1.249 ± 0.029
9.664ArgLeu: 9.664 ± 0.08
1.901ArgMet: 1.901 ± 0.034
1.487ArgAsn: 1.487 ± 0.032
5.929ArgPro: 5.929 ± 0.088
3.032ArgGln: 3.032 ± 0.038
9.184ArgArg: 9.184 ± 0.09
4.393ArgSer: 4.393 ± 0.055
5.209ArgThr: 5.209 ± 0.055
6.66ArgVal: 6.66 ± 0.064
1.741ArgTrp: 1.741 ± 0.031
2.159ArgTyr: 2.159 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.401SerAla: 6.401 ± 0.064
0.393SerCys: 0.393 ± 0.015
2.353SerAsp: 2.353 ± 0.037
1.895SerGlu: 1.895 ± 0.033
1.453SerPhe: 1.453 ± 0.031
5.55SerGly: 5.55 ± 0.057
0.899SerHis: 0.899 ± 0.023
1.489SerIle: 1.489 ± 0.031
0.746SerLys: 0.746 ± 0.019
4.127SerLeu: 4.127 ± 0.048
0.934SerMet: 0.934 ± 0.025
0.861SerAsn: 0.861 ± 0.021
3.102SerPro: 3.102 ± 0.046
1.22SerGln: 1.22 ± 0.027
3.851SerArg: 3.851 ± 0.055
2.443SerSer: 2.443 ± 0.04
3.378SerThr: 3.378 ± 0.046
4.095SerVal: 4.095 ± 0.046
0.915SerTrp: 0.915 ± 0.022
1.235SerTyr: 1.235 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
9.135ThrAla: 9.135 ± 0.095
0.439ThrCys: 0.439 ± 0.016
3.996ThrAsp: 3.996 ± 0.049
3.281ThrGlu: 3.281 ± 0.05
1.631ThrPhe: 1.631 ± 0.035
7.552ThrGly: 7.552 ± 0.072
1.099ThrHis: 1.099 ± 0.026
1.955ThrIle: 1.955 ± 0.036
0.867ThrLys: 0.867 ± 0.026
5.892ThrLeu: 5.892 ± 0.051
0.996ThrMet: 0.996 ± 0.024
1.16ThrAsn: 1.16 ± 0.028
4.483ThrPro: 4.483 ± 0.053
1.286ThrGln: 1.286 ± 0.032
4.478ThrArg: 4.478 ± 0.049
3.081ThrSer: 3.081 ± 0.046
4.171ThrThr: 4.171 ± 0.067
6.632ThrVal: 6.632 ± 0.064
0.928ThrTrp: 0.928 ± 0.024
1.272ThrTyr: 1.272 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
12.781ValAla: 12.781 ± 0.103
0.702ValCys: 0.702 ± 0.018
6.063ValAsp: 6.063 ± 0.054
4.803ValGlu: 4.803 ± 0.061
2.256ValPhe: 2.256 ± 0.039
7.95ValGly: 7.95 ± 0.066
1.775ValHis: 1.775 ± 0.033
2.657ValIle: 2.657 ± 0.04
1.274ValLys: 1.274 ± 0.028
9.987ValLeu: 9.987 ± 0.093
1.091ValMet: 1.091 ± 0.023
1.714ValAsn: 1.714 ± 0.033
5.74ValPro: 5.74 ± 0.062
2.063ValGln: 2.063 ± 0.035
7.449ValArg: 7.449 ± 0.073
4.258ValSer: 4.258 ± 0.048
6.375ValThr: 6.375 ± 0.065
9.207ValVal: 9.207 ± 0.092
1.08ValTrp: 1.08 ± 0.024
1.445ValTyr: 1.445 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.67TrpAla: 1.67 ± 0.029
0.159TrpCys: 0.159 ± 0.009
0.689TrpAsp: 0.689 ± 0.021
0.589TrpGlu: 0.589 ± 0.019
0.5TrpPhe: 0.5 ± 0.016
0.928TrpGly: 0.928 ± 0.026
0.425TrpHis: 0.425 ± 0.015
0.528TrpIle: 0.528 ± 0.016
0.233TrpLys: 0.233 ± 0.012
1.956TrpLeu: 1.956 ± 0.037
0.229TrpMet: 0.229 ± 0.011
0.368TrpAsn: 0.368 ± 0.015
0.908TrpPro: 0.908 ± 0.023
0.723TrpGln: 0.723 ± 0.021
1.604TrpArg: 1.604 ± 0.036
1.065TrpSer: 1.065 ± 0.028
1.027TrpThr: 1.027 ± 0.026
1.074TrpVal: 1.074 ± 0.023
0.413TrpTrp: 0.413 ± 0.014
0.363TrpTyr: 0.363 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.738TyrAla: 2.738 ± 0.035
0.173TyrCys: 0.173 ± 0.01
1.416TyrAsp: 1.416 ± 0.036
0.943TyrGlu: 0.943 ± 0.025
0.589TyrPhe: 0.589 ± 0.019
2.032TyrGly: 2.032 ± 0.034
0.487TyrHis: 0.487 ± 0.017
0.369TyrIle: 0.369 ± 0.014
0.244TyrLys: 0.244 ± 0.013
2.409TyrLeu: 2.409 ± 0.036
0.16TyrMet: 0.16 ± 0.009
0.369TyrAsn: 0.369 ± 0.015
1.248TyrPro: 1.248 ± 0.029
0.756TyrGln: 0.756 ± 0.023
2.049TyrArg: 2.049 ± 0.039
0.821TyrSer: 0.821 ± 0.023
1.122TyrThr: 1.122 ± 0.028
1.699TyrVal: 1.699 ± 0.032
0.349TyrTrp: 0.349 ± 0.014
0.406TyrTyr: 0.406 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5740 proteins (1903892 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski