Amino acid dipepetide frequency for Corynebacterium ureicelerivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.114AlaAla: 17.114 ± 0.268	0.979AlaCys: 0.979 ± 0.047	7.798AlaAsp: 7.798 ± 0.117	8.678AlaGlu: 8.678 ± 0.151	3.805AlaPhe: 3.805 ± 0.081	11.13AlaGly: 11.13 ± 0.161	2.533AlaHis: 2.533 ± 0.062	5.073AlaIle: 5.073 ± 0.103	3.973AlaLys: 3.973 ± 0.11	11.849AlaLeu: 11.849 ± 0.18	2.873AlaMet: 2.873 ± 0.069	2.955AlaAsn: 2.955 ± 0.074	5.525AlaPro: 5.525 ± 0.124	4.383AlaGln: 4.383 ± 0.097	7.515AlaArg: 7.515 ± 0.143	6.298AlaSer: 6.298 ± 0.107	7.122AlaThr: 7.122 ± 0.116	10.587AlaVal: 10.587 ± 0.135	1.662AlaTrp: 1.662 ± 0.057	2.505AlaTyr: 2.505 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.854CysAla: 0.854 ± 0.04	0.082CysCys: 0.082 ± 0.011	0.391CysAsp: 0.391 ± 0.027	0.412CysGlu: 0.412 ± 0.028	0.246CysPhe: 0.246 ± 0.02	0.737CysGly: 0.737 ± 0.035	0.164CysHis: 0.164 ± 0.018	0.292CysIle: 0.292 ± 0.02	0.133CysLys: 0.133 ± 0.014	0.45CysLeu: 0.45 ± 0.029	0.098CysMet: 0.098 ± 0.012	0.147CysAsn: 0.147 ± 0.016	0.388CysPro: 0.388 ± 0.026	0.19CysGln: 0.19 ± 0.018	0.401CysArg: 0.401 ± 0.03	0.407CysSer: 0.407 ± 0.024	0.382CysThr: 0.382 ± 0.025	0.585CysVal: 0.585 ± 0.031	0.087CysTrp: 0.087 ± 0.013	0.138CysTyr: 0.138 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	8.576AspAla: 8.576 ± 0.137	0.347AspCys: 0.347 ± 0.027	4.121AspAsp: 4.121 ± 0.106	4.942AspGlu: 4.942 ± 0.107	2.103AspPhe: 2.103 ± 0.069	5.921AspGly: 5.921 ± 0.107	1.157AspHis: 1.157 ± 0.046	2.938AspIle: 2.938 ± 0.078	1.786AspLys: 1.786 ± 0.062	5.715AspLeu: 5.715 ± 0.098	1.318AspMet: 1.318 ± 0.051	1.767AspAsn: 1.767 ± 0.051	3.753AspPro: 3.753 ± 0.083	1.868AspGln: 1.868 ± 0.049	3.638AspArg: 3.638 ± 0.08	2.884AspSer: 2.884 ± 0.068	3.573AspThr: 3.573 ± 0.081	5.406AspVal: 5.406 ± 0.112	0.831AspTrp: 0.831 ± 0.035	1.555AspTyr: 1.555 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	7.859GluAla: 7.859 ± 0.143	0.363GluCys: 0.363 ± 0.025	3.751GluAsp: 3.751 ± 0.086	4.214GluGlu: 4.214 ± 0.11	2.165GluPhe: 2.165 ± 0.079	4.799GluGly: 4.799 ± 0.106	1.704GluHis: 1.704 ± 0.058	3.17GluIle: 3.17 ± 0.093	2.264GluLys: 2.264 ± 0.064	7.094GluLeu: 7.094 ± 0.126	1.498GluMet: 1.498 ± 0.055	1.714GluAsn: 1.714 ± 0.057	3.102GluPro: 3.102 ± 0.091	2.854GluGln: 2.854 ± 0.068	5.109GluArg: 5.109 ± 0.11	2.753GluSer: 2.753 ± 0.071	3.535GluThr: 3.535 ± 0.072	5.487GluVal: 5.487 ± 0.103	0.883GluTrp: 0.883 ± 0.05	1.472GluTyr: 1.472 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	4.003PheAla: 4.003 ± 0.088	0.251PheCys: 0.251 ± 0.02	2.543PheAsp: 2.543 ± 0.065	1.88PheGlu: 1.88 ± 0.056	1.049PhePhe: 1.049 ± 0.053	3.208PheGly: 3.208 ± 0.079	0.683PheHis: 0.683 ± 0.037	1.498PheIle: 1.498 ± 0.051	0.779PheLys: 0.779 ± 0.035	2.68PheLeu: 2.68 ± 0.08	0.698PheMet: 0.698 ± 0.031	1.025PheAsn: 1.025 ± 0.042	1.379PhePro: 1.379 ± 0.054	0.841PheGln: 0.841 ± 0.038	1.613PheArg: 1.613 ± 0.057	1.742PheSer: 1.742 ± 0.053	2.182PheThr: 2.182 ± 0.069	2.477PheVal: 2.477 ± 0.061	0.405PheTrp: 0.405 ± 0.027	0.812PheTyr: 0.812 ± 0.04	0.002PheXaa: 0.002 ± 0.002
Gly	9.592GlyAla: 9.592 ± 0.156	0.656GlyCys: 0.656 ± 0.035	5.123GlyAsp: 5.123 ± 0.092	5.782GlyGlu: 5.782 ± 0.115	3.051GlyPhe: 3.051 ± 0.078	7.264GlyGly: 7.264 ± 0.167	1.747GlyHis: 1.747 ± 0.059	4.163GlyIle: 4.163 ± 0.094	3.133GlyLys: 3.133 ± 0.085	7.906GlyLeu: 7.906 ± 0.135	2.275GlyMet: 2.275 ± 0.065	2.241GlyAsn: 2.241 ± 0.072	3.493GlyPro: 3.493 ± 0.084	2.884GlyGln: 2.884 ± 0.082	5.247GlyArg: 5.247 ± 0.1	4.663GlySer: 4.663 ± 0.084	5.329GlyThr: 5.329 ± 0.104	7.723GlyVal: 7.723 ± 0.099	1.299GlyTrp: 1.299 ± 0.049	2.29GlyTyr: 2.29 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	2.343HisAla: 2.343 ± 0.068	0.147HisCys: 0.147 ± 0.017	1.417HisAsp: 1.417 ± 0.05	1.232HisGlu: 1.232 ± 0.048	0.639HisPhe: 0.639 ± 0.033	1.861HisGly: 1.861 ± 0.06	0.504HisHis: 0.504 ± 0.031	0.929HisIle: 0.929 ± 0.043	0.461HisLys: 0.461 ± 0.029	1.967HisLeu: 1.967 ± 0.061	0.484HisMet: 0.484 ± 0.028	0.595HisAsn: 0.595 ± 0.034	1.494HisPro: 1.494 ± 0.059	0.6HisGln: 0.6 ± 0.03	1.273HisArg: 1.273 ± 0.049	1.0HisSer: 1.0 ± 0.043	1.241HisThr: 1.241 ± 0.048	1.662HisVal: 1.662 ± 0.055	0.281HisTrp: 0.281 ± 0.023	0.555HisTyr: 0.555 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.345IleAla: 6.345 ± 0.118	0.332IleCys: 0.332 ± 0.024	3.685IleAsp: 3.685 ± 0.078	3.125IleGlu: 3.125 ± 0.075	1.269IlePhe: 1.269 ± 0.054	4.111IleGly: 4.111 ± 0.097	0.875IleHis: 0.875 ± 0.042	2.025IleIle: 2.025 ± 0.063	1.164IleLys: 1.164 ± 0.048	3.414IleLeu: 3.414 ± 0.073	0.92IleMet: 0.92 ± 0.045	1.314IleAsn: 1.314 ± 0.052	2.348IlePro: 2.348 ± 0.067	1.309IleGln: 1.309 ± 0.05	2.587IleArg: 2.587 ± 0.075	2.323IleSer: 2.323 ± 0.068	2.856IleThr: 2.856 ± 0.077	3.947IleVal: 3.947 ± 0.077	0.45IleTrp: 0.45 ± 0.029	0.908IleTyr: 0.908 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.54LysAla: 3.54 ± 0.097	0.12LysCys: 0.12 ± 0.016	1.854LysAsp: 1.854 ± 0.064	1.805LysGlu: 1.805 ± 0.055	0.815LysPhe: 0.815 ± 0.037	2.123LysGly: 2.123 ± 0.072	0.69LysHis: 0.69 ± 0.035	1.384LysIle: 1.384 ± 0.057	1.423LysLys: 1.423 ± 0.075	3.02LysLeu: 3.02 ± 0.081	0.709LysMet: 0.709 ± 0.031	0.925LysAsn: 0.925 ± 0.048	1.665LysPro: 1.665 ± 0.065	1.184LysGln: 1.184 ± 0.043	2.33LysArg: 2.33 ± 0.071	1.405LysSer: 1.405 ± 0.052	1.854LysThr: 1.854 ± 0.06	2.664LysVal: 2.664 ± 0.078	0.346LysTrp: 0.346 ± 0.023	0.669LysTyr: 0.669 ± 0.036	0.002LysXaa: 0.002 ± 0.002
Leu	12.359LeuAla: 12.359 ± 0.175	0.588LeuCys: 0.588 ± 0.03	6.235LeuAsp: 6.235 ± 0.101	5.464LeuGlu: 5.464 ± 0.114	2.641LeuPhe: 2.641 ± 0.082	8.211LeuGly: 8.211 ± 0.13	1.88LeuHis: 1.88 ± 0.059	4.457LeuIle: 4.457 ± 0.093	2.613LeuLys: 2.613 ± 0.068	8.416LeuLeu: 8.416 ± 0.162	1.966LeuMet: 1.966 ± 0.059	2.467LeuAsn: 2.467 ± 0.068	4.98LeuPro: 4.98 ± 0.096	2.674LeuGln: 2.674 ± 0.071	6.426LeuArg: 6.426 ± 0.128	5.034LeuSer: 5.034 ± 0.099	5.944LeuThr: 5.944 ± 0.111	7.88LeuVal: 7.88 ± 0.136	1.035LeuTrp: 1.035 ± 0.041	1.753LeuTyr: 1.753 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.819MetAla: 2.819 ± 0.074	0.168MetCys: 0.168 ± 0.018	1.248MetAsp: 1.248 ± 0.047	1.208MetGlu: 1.208 ± 0.042	0.674MetPhe: 0.674 ± 0.034	1.76MetGly: 1.76 ± 0.063	0.471MetHis: 0.471 ± 0.028	1.081MetIle: 1.081 ± 0.051	0.663MetLys: 0.663 ± 0.035	2.233MetLeu: 2.233 ± 0.07	0.506MetMet: 0.506 ± 0.027	0.69MetAsn: 0.69 ± 0.036	1.232MetPro: 1.232 ± 0.054	0.803MetGln: 0.803 ± 0.034	1.699MetArg: 1.699 ± 0.055	1.534MetSer: 1.534 ± 0.05	1.623MetThr: 1.623 ± 0.052	1.735MetVal: 1.735 ± 0.061	0.293MetTrp: 0.293 ± 0.022	0.384MetTyr: 0.384 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.186AsnAla: 3.186 ± 0.079	0.162AsnCys: 0.162 ± 0.017	1.517AsnAsp: 1.517 ± 0.057	1.597AsnGlu: 1.597 ± 0.058	0.854AsnPhe: 0.854 ± 0.045	2.302AsnGly: 2.302 ± 0.064	0.55AsnHis: 0.55 ± 0.034	1.273AsnIle: 1.273 ± 0.051	0.827AsnLys: 0.827 ± 0.044	2.505AsnLeu: 2.505 ± 0.066	0.627AsnMet: 0.627 ± 0.033	0.82AsnAsn: 0.82 ± 0.037	2.103AsnPro: 2.103 ± 0.062	0.943AsnGln: 0.943 ± 0.041	1.676AsnArg: 1.676 ± 0.056	1.32AsnSer: 1.32 ± 0.05	1.552AsnThr: 1.552 ± 0.05	2.163AsnVal: 2.163 ± 0.062	0.395AsnTrp: 0.395 ± 0.029	0.67AsnTyr: 0.67 ± 0.034	0.002AsnXaa: 0.002 ± 0.002
Pro	6.038ProAla: 6.038 ± 0.138	0.223ProCys: 0.223 ± 0.018	3.598ProAsp: 3.598 ± 0.075	4.396ProGlu: 4.396 ± 0.098	1.648ProPhe: 1.648 ± 0.057	4.701ProGly: 4.701 ± 0.083	1.089ProHis: 1.089 ± 0.044	1.765ProIle: 1.765 ± 0.062	1.683ProLys: 1.683 ± 0.058	4.183ProLeu: 4.183 ± 0.102	0.992ProMet: 0.992 ± 0.038	1.397ProAsn: 1.397 ± 0.053	1.664ProPro: 1.664 ± 0.067	1.632ProGln: 1.632 ± 0.055	2.803ProArg: 2.803 ± 0.07	2.76ProSer: 2.76 ± 0.081	2.919ProThr: 2.919 ± 0.08	4.631ProVal: 4.631 ± 0.092	0.723ProTrp: 0.723 ± 0.038	1.187ProTyr: 1.187 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.978GlnAla: 3.978 ± 0.1	0.14GlnCys: 0.14 ± 0.019	1.674GlnAsp: 1.674 ± 0.053	1.892GlnGlu: 1.892 ± 0.057	1.088GlnPhe: 1.088 ± 0.044	2.325GlnGly: 2.325 ± 0.079	0.665GlnHis: 0.665 ± 0.034	1.632GlnIle: 1.632 ± 0.054	0.957GlnLys: 0.957 ± 0.046	3.788GlnLeu: 3.788 ± 0.078	0.869GlnMet: 0.869 ± 0.035	0.793GlnAsn: 0.793 ± 0.036	1.763GlnPro: 1.763 ± 0.059	1.409GlnGln: 1.409 ± 0.059	2.772GlnArg: 2.772 ± 0.073	1.473GlnSer: 1.473 ± 0.056	1.573GlnThr: 1.573 ± 0.054	2.777GlnVal: 2.777 ± 0.073	0.518GlnTrp: 0.518 ± 0.031	0.749GlnTyr: 0.749 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	7.412ArgAla: 7.412 ± 0.153	0.333ArgCys: 0.333 ± 0.022	4.286ArgAsp: 4.286 ± 0.097	4.954ArgGlu: 4.954 ± 0.096	2.119ArgPhe: 2.119 ± 0.059	4.942ArgGly: 4.942 ± 0.111	1.36ArgHis: 1.36 ± 0.046	3.184ArgIle: 3.184 ± 0.079	2.11ArgLys: 2.11 ± 0.067	5.619ArgLeu: 5.619 ± 0.12	1.845ArgMet: 1.845 ± 0.06	1.772ArgAsn: 1.772 ± 0.063	2.868ArgPro: 2.868 ± 0.084	2.252ArgGln: 2.252 ± 0.062	4.999ArgArg: 4.999 ± 0.106	3.373ArgSer: 3.373 ± 0.081	3.64ArgThr: 3.64 ± 0.077	5.303ArgVal: 5.303 ± 0.111	0.965ArgTrp: 0.965 ± 0.041	1.744ArgTyr: 1.744 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.143SerAla: 6.143 ± 0.11	0.302SerCys: 0.302 ± 0.023	2.842SerAsp: 2.842 ± 0.072	2.908SerGlu: 2.908 ± 0.076	1.618SerPhe: 1.618 ± 0.056	5.178SerGly: 5.178 ± 0.093	1.091SerHis: 1.091 ± 0.048	2.163SerIle: 2.163 ± 0.068	1.613SerLys: 1.613 ± 0.059	4.752SerLeu: 4.752 ± 0.093	1.328SerMet: 1.328 ± 0.042	1.513SerAsn: 1.513 ± 0.048	2.601SerPro: 2.601 ± 0.071	1.634SerGln: 1.634 ± 0.049	3.402SerArg: 3.402 ± 0.087	2.913SerSer: 2.913 ± 0.073	3.298SerThr: 3.298 ± 0.078	4.361SerVal: 4.361 ± 0.087	0.796SerTrp: 0.796 ± 0.036	1.239SerTyr: 1.239 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	6.948ThrAla: 6.948 ± 0.12	0.419ThrCys: 0.419 ± 0.035	3.647ThrAsp: 3.647 ± 0.071	3.278ThrGlu: 3.278 ± 0.087	1.941ThrPhe: 1.941 ± 0.063	5.567ThrGly: 5.567 ± 0.105	1.248ThrHis: 1.248 ± 0.045	2.8ThrIle: 2.8 ± 0.067	1.616ThrLys: 1.616 ± 0.064	5.665ThrLeu: 5.665 ± 0.103	1.278ThrMet: 1.278 ± 0.051	1.51ThrAsn: 1.51 ± 0.049	3.606ThrPro: 3.606 ± 0.086	1.751ThrGln: 1.751 ± 0.052	3.533ThrArg: 3.533 ± 0.08	3.175ThrSer: 3.175 ± 0.063	3.734ThrThr: 3.734 ± 0.091	5.876ThrVal: 5.876 ± 0.104	0.826ThrTrp: 0.826 ± 0.039	1.41ThrTyr: 1.41 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	11.059ValAla: 11.059 ± 0.142	0.681ValCys: 0.681 ± 0.036	6.176ValAsp: 6.176 ± 0.115	5.947ValGlu: 5.947 ± 0.107	2.646ValPhe: 2.646 ± 0.07	6.717ValGly: 6.717 ± 0.121	1.611ValHis: 1.611 ± 0.053	3.964ValIle: 3.964 ± 0.093	2.357ValLys: 2.357 ± 0.066	8.074ValLeu: 8.074 ± 0.142	1.767ValMet: 1.767 ± 0.05	2.282ValAsn: 2.282 ± 0.062	4.219ValPro: 4.219 ± 0.077	2.292ValGln: 2.292 ± 0.059	5.562ValArg: 5.562 ± 0.102	4.645ValSer: 4.645 ± 0.086	5.396ValThr: 5.396 ± 0.099	8.281ValVal: 8.281 ± 0.14	1.096ValTrp: 1.096 ± 0.046	1.692ValTyr: 1.692 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	1.52TrpAla: 1.52 ± 0.05	0.113TrpCys: 0.113 ± 0.016	0.752TrpAsp: 0.752 ± 0.034	0.738TrpGlu: 0.738 ± 0.039	0.567TrpPhe: 0.567 ± 0.036	0.937TrpGly: 0.937 ± 0.046	0.278TrpHis: 0.278 ± 0.021	0.646TrpIle: 0.646 ± 0.035	0.375TrpLys: 0.375 ± 0.029	1.468TrpLeu: 1.468 ± 0.056	0.351TrpMet: 0.351 ± 0.029	0.401TrpAsn: 0.401 ± 0.023	0.651TrpPro: 0.651 ± 0.034	0.545TrpGln: 0.545 ± 0.037	0.993TrpArg: 0.993 ± 0.041	0.702TrpSer: 0.702 ± 0.037	0.676TrpThr: 0.676 ± 0.033	1.213TrpVal: 1.213 ± 0.05	0.311TrpTrp: 0.311 ± 0.025	0.285TrpTyr: 0.285 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.671TyrAla: 2.671 ± 0.074	0.175TyrCys: 0.175 ± 0.018	1.541TyrAsp: 1.541 ± 0.054	1.337TyrGlu: 1.337 ± 0.053	0.81TyrPhe: 0.81 ± 0.041	2.069TyrGly: 2.069 ± 0.062	0.384TyrHis: 0.384 ± 0.029	0.871TyrIle: 0.871 ± 0.039	0.597TyrLys: 0.597 ± 0.036	2.224TyrLeu: 2.224 ± 0.061	0.422TyrMet: 0.422 ± 0.027	0.716TyrAsn: 0.716 ± 0.038	1.194TyrPro: 1.194 ± 0.051	0.787TyrGln: 0.787 ± 0.038	1.501TyrArg: 1.501 ± 0.058	1.29TyrSer: 1.29 ± 0.053	1.4TyrThr: 1.4 ± 0.047	1.705TyrVal: 1.705 ± 0.059	0.321TyrTrp: 0.321 ± 0.025	0.569TyrTyr: 0.569 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.002XaaHis: 0.002 ± 0.002	0.002XaaIle: 0.002 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1837 proteins (572859 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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