Amino acid dipepetide frequency for Moraxellaceae bacterium HYN0046

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.02AlaAla: 10.02 ± 0.157
0.875AlaCys: 0.875 ± 0.03
4.964AlaAsp: 4.964 ± 0.077
5.29AlaGlu: 5.29 ± 0.083
3.554AlaPhe: 3.554 ± 0.055
7.287AlaGly: 7.287 ± 0.105
2.214AlaHis: 2.214 ± 0.045
6.216AlaIle: 6.216 ± 0.086
4.566AlaLys: 4.566 ± 0.077
10.91AlaLeu: 10.91 ± 0.137
2.508AlaMet: 2.508 ± 0.045
3.534AlaAsn: 3.534 ± 0.067
3.932AlaPro: 3.932 ± 0.072
4.578AlaGln: 4.578 ± 0.076
4.685AlaArg: 4.685 ± 0.072
5.863AlaSer: 5.863 ± 0.089
5.465AlaThr: 5.465 ± 0.097
6.676AlaVal: 6.676 ± 0.101
1.213AlaTrp: 1.213 ± 0.037
2.547AlaTyr: 2.547 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.792CysAla: 0.792 ± 0.028
0.093CysCys: 0.093 ± 0.009
0.428CysAsp: 0.428 ± 0.021
0.402CysGlu: 0.402 ± 0.02
0.368CysPhe: 0.368 ± 0.02
0.773CysGly: 0.773 ± 0.027
0.277CysHis: 0.277 ± 0.016
0.49CysIle: 0.49 ± 0.024
0.285CysLys: 0.285 ± 0.018
0.825CysLeu: 0.825 ± 0.03
0.184CysMet: 0.184 ± 0.013
0.264CysAsn: 0.264 ± 0.016
0.4CysPro: 0.4 ± 0.02
0.334CysGln: 0.334 ± 0.017
0.44CysArg: 0.44 ± 0.02
0.57CysSer: 0.57 ± 0.026
0.433CysThr: 0.433 ± 0.022
0.569CysVal: 0.569 ± 0.023
0.094CysTrp: 0.094 ± 0.009
0.212CysTyr: 0.212 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.239AspAla: 5.239 ± 0.074
0.412AspCys: 0.412 ± 0.019
2.735AspAsp: 2.735 ± 0.061
3.028AspGlu: 3.028 ± 0.055
2.329AspPhe: 2.329 ± 0.038
3.768AspGly: 3.768 ± 0.069
1.47AspHis: 1.47 ± 0.037
3.402AspIle: 3.402 ± 0.059
2.133AspLys: 2.133 ± 0.047
5.521AspLeu: 5.521 ± 0.08
1.19AspMet: 1.19 ± 0.04
1.69AspAsn: 1.69 ± 0.041
2.639AspPro: 2.639 ± 0.053
2.627AspGln: 2.627 ± 0.054
2.738AspArg: 2.738 ± 0.055
3.076AspSer: 3.076 ± 0.059
2.671AspThr: 2.671 ± 0.074
3.94AspVal: 3.94 ± 0.064
0.857AspTrp: 0.857 ± 0.028
1.841AspTyr: 1.841 ± 0.049
0.0AspXaa: 0.0 ± 0.0
Glu
4.758GluAla: 4.758 ± 0.078
0.343GluCys: 0.343 ± 0.018
2.156GluAsp: 2.156 ± 0.047
2.519GluGlu: 2.519 ± 0.064
1.815GluPhe: 1.815 ± 0.048
3.212GluGly: 3.212 ± 0.059
1.455GluHis: 1.455 ± 0.041
3.388GluIle: 3.388 ± 0.065
2.684GluLys: 2.684 ± 0.061
5.561GluLeu: 5.561 ± 0.098
1.262GluMet: 1.262 ± 0.034
1.973GluAsn: 1.973 ± 0.046
1.981GluPro: 1.981 ± 0.044
2.905GluGln: 2.905 ± 0.052
3.292GluArg: 3.292 ± 0.064
3.177GluSer: 3.177 ± 0.059
2.829GluThr: 2.829 ± 0.051
3.516GluVal: 3.516 ± 0.076
0.731GluTrp: 0.731 ± 0.026
1.394GluTyr: 1.394 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.826PheAla: 3.826 ± 0.067
0.4PheCys: 0.4 ± 0.021
2.583PheAsp: 2.583 ± 0.046
2.257PheGlu: 2.257 ± 0.052
1.7PhePhe: 1.7 ± 0.049
3.323PheGly: 3.323 ± 0.059
0.829PheHis: 0.829 ± 0.027
2.409PheIle: 2.409 ± 0.056
1.851PheLys: 1.851 ± 0.044
3.501PheLeu: 3.501 ± 0.068
0.919PheMet: 0.919 ± 0.033
1.818PheAsn: 1.818 ± 0.045
1.622PhePro: 1.622 ± 0.041
1.279PheGln: 1.279 ± 0.035
1.618PheArg: 1.618 ± 0.035
2.832PheSer: 2.832 ± 0.06
2.176PheThr: 2.176 ± 0.046
2.588PheVal: 2.588 ± 0.058
0.591PheTrp: 0.591 ± 0.025
1.259PheTyr: 1.259 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
6.105GlyAla: 6.105 ± 0.095
0.754GlyCys: 0.754 ± 0.028
3.363GlyAsp: 3.363 ± 0.058
3.433GlyGlu: 3.433 ± 0.055
3.418GlyPhe: 3.418 ± 0.061
5.373GlyGly: 5.373 ± 0.113
1.765GlyHis: 1.765 ± 0.038
4.782GlyIle: 4.782 ± 0.079
3.576GlyLys: 3.576 ± 0.059
8.124GlyLeu: 8.124 ± 0.139
1.892GlyMet: 1.892 ± 0.039
2.575GlyAsn: 2.575 ± 0.066
1.681GlyPro: 1.681 ± 0.038
3.42GlyGln: 3.42 ± 0.061
3.558GlyArg: 3.558 ± 0.068
4.542GlySer: 4.542 ± 0.087
3.995GlyThr: 3.995 ± 0.09
5.486GlyVal: 5.486 ± 0.084
1.144GlyTrp: 1.144 ± 0.035
2.536GlyTyr: 2.536 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
2.328HisAla: 2.328 ± 0.051
0.243HisCys: 0.243 ± 0.016
1.348HisAsp: 1.348 ± 0.039
1.269HisGlu: 1.269 ± 0.037
1.121HisPhe: 1.121 ± 0.036
1.864HisGly: 1.864 ± 0.046
0.829HisHis: 0.829 ± 0.033
1.436HisIle: 1.436 ± 0.036
0.764HisLys: 0.764 ± 0.03
2.526HisLeu: 2.526 ± 0.054
0.564HisMet: 0.564 ± 0.023
0.73HisAsn: 0.73 ± 0.03
1.385HisPro: 1.385 ± 0.038
1.165HisGln: 1.165 ± 0.037
1.197HisArg: 1.197 ± 0.035
1.373HisSer: 1.373 ± 0.037
1.271HisThr: 1.271 ± 0.035
1.689HisVal: 1.689 ± 0.043
0.397HisTrp: 0.397 ± 0.021
0.886HisTyr: 0.886 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.745IleAla: 6.745 ± 0.082
0.574IleCys: 0.574 ± 0.022
4.014IleAsp: 4.014 ± 0.071
3.806IleGlu: 3.806 ± 0.067
2.201IlePhe: 2.201 ± 0.048
4.83IleGly: 4.83 ± 0.077
1.504IleHis: 1.504 ± 0.041
3.383IleIle: 3.383 ± 0.062
2.824IleLys: 2.824 ± 0.059
5.763IleLeu: 5.763 ± 0.083
1.22IleMet: 1.22 ± 0.035
2.641IleAsn: 2.641 ± 0.056
3.08IlePro: 3.08 ± 0.061
2.625IleGln: 2.625 ± 0.049
3.067IleArg: 3.067 ± 0.061
4.167IleSer: 4.167 ± 0.085
3.68IleThr: 3.68 ± 0.078
4.19IleVal: 4.19 ± 0.068
0.677IleTrp: 0.677 ± 0.027
1.631IleTyr: 1.631 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.348LysAla: 4.348 ± 0.082
0.2LysCys: 0.2 ± 0.013
2.424LysAsp: 2.424 ± 0.048
2.03LysGlu: 2.03 ± 0.047
1.401LysPhe: 1.401 ± 0.039
2.754LysGly: 2.754 ± 0.054
1.055LysHis: 1.055 ± 0.038
2.868LysIle: 2.868 ± 0.059
2.401LysLys: 2.401 ± 0.052
4.38LysLeu: 4.38 ± 0.073
1.185LysMet: 1.185 ± 0.033
2.007LysAsn: 2.007 ± 0.048
2.323LysPro: 2.323 ± 0.046
2.176LysGln: 2.176 ± 0.048
2.478LysArg: 2.478 ± 0.058
2.89LysSer: 2.89 ± 0.052
3.042LysThr: 3.042 ± 0.058
3.186LysVal: 3.186 ± 0.06
0.438LysTrp: 0.438 ± 0.02
1.127LysTyr: 1.127 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
10.738LeuAla: 10.738 ± 0.144
0.89LeuCys: 0.89 ± 0.03
5.731LeuAsp: 5.731 ± 0.085
5.145LeuGlu: 5.145 ± 0.09
3.827LeuPhe: 3.827 ± 0.081
7.562LeuGly: 7.562 ± 0.106
2.322LeuHis: 2.322 ± 0.052
6.795LeuIle: 6.795 ± 0.096
5.1LeuLys: 5.1 ± 0.076
10.714LeuLeu: 10.714 ± 0.149
2.507LeuMet: 2.507 ± 0.047
4.445LeuAsn: 4.445 ± 0.071
5.466LeuPro: 5.466 ± 0.072
4.147LeuGln: 4.147 ± 0.073
5.097LeuArg: 5.097 ± 0.091
7.837LeuSer: 7.837 ± 0.141
6.731LeuThr: 6.731 ± 0.078
6.852LeuVal: 6.852 ± 0.079
1.265LeuTrp: 1.265 ± 0.04
2.564LeuTyr: 2.564 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.18MetAla: 2.18 ± 0.049
0.151MetCys: 0.151 ± 0.012
1.125MetAsp: 1.125 ± 0.033
0.862MetGlu: 0.862 ± 0.029
0.723MetPhe: 0.723 ± 0.029
1.661MetGly: 1.661 ± 0.041
0.553MetHis: 0.553 ± 0.023
1.431MetIle: 1.431 ± 0.036
1.128MetLys: 1.128 ± 0.036
2.416MetLeu: 2.416 ± 0.058
0.736MetMet: 0.736 ± 0.028
1.072MetAsn: 1.072 ± 0.033
1.245MetPro: 1.245 ± 0.035
1.199MetGln: 1.199 ± 0.035
1.291MetArg: 1.291 ± 0.035
1.93MetSer: 1.93 ± 0.037
1.789MetThr: 1.789 ± 0.041
1.515MetVal: 1.515 ± 0.042
0.182MetTrp: 0.182 ± 0.013
0.461MetTyr: 0.461 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.698AsnAla: 3.698 ± 0.073
0.339AsnCys: 0.339 ± 0.019
2.02AsnAsp: 2.02 ± 0.046
1.65AsnGlu: 1.65 ± 0.039
1.542AsnPhe: 1.542 ± 0.035
2.949AsnGly: 2.949 ± 0.076
0.936AsnHis: 0.936 ± 0.033
2.425AsnIle: 2.425 ± 0.056
1.587AsnLys: 1.587 ± 0.041
3.917AsnLeu: 3.917 ± 0.068
0.772AsnMet: 0.772 ± 0.028
1.683AsnAsn: 1.683 ± 0.057
2.409AsnPro: 2.409 ± 0.047
1.963AsnGln: 1.963 ± 0.037
1.915AsnArg: 1.915 ± 0.045
2.423AsnSer: 2.423 ± 0.081
2.482AsnThr: 2.482 ± 0.084
2.593AsnVal: 2.593 ± 0.048
0.586AsnTrp: 0.586 ± 0.022
1.186AsnTyr: 1.186 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.466ProAla: 4.466 ± 0.082
0.279ProCys: 0.279 ± 0.018
2.788ProAsp: 2.788 ± 0.052
3.204ProGlu: 3.204 ± 0.062
1.804ProPhe: 1.804 ± 0.045
1.956ProGly: 1.956 ± 0.048
1.056ProHis: 1.056 ± 0.033
2.966ProIle: 2.966 ± 0.053
2.185ProLys: 2.185 ± 0.043
4.772ProLeu: 4.772 ± 0.063
1.066ProMet: 1.066 ± 0.035
2.008ProAsn: 2.008 ± 0.053
1.735ProPro: 1.735 ± 0.054
2.005ProGln: 2.005 ± 0.045
1.832ProArg: 1.832 ± 0.041
3.077ProSer: 3.077 ± 0.048
2.949ProThr: 2.949 ± 0.062
3.559ProVal: 3.559 ± 0.067
0.578ProTrp: 0.578 ± 0.028
1.409ProTyr: 1.409 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
4.801GlnAla: 4.801 ± 0.082
0.266GlnCys: 0.266 ± 0.017
2.038GlnAsp: 2.038 ± 0.04
1.947GlnGlu: 1.947 ± 0.047
1.703GlnPhe: 1.703 ± 0.037
3.136GlnGly: 3.136 ± 0.061
1.348GlnHis: 1.348 ± 0.039
2.947GlnIle: 2.947 ± 0.049
2.009GlnLys: 2.009 ± 0.051
4.819GlnLeu: 4.819 ± 0.08
1.063GlnMet: 1.063 ± 0.037
1.745GlnAsn: 1.745 ± 0.044
2.144GlnPro: 2.144 ± 0.045
2.713GlnGln: 2.713 ± 0.074
2.483GlnArg: 2.483 ± 0.059
3.072GlnSer: 3.072 ± 0.068
2.707GlnThr: 2.707 ± 0.055
3.341GlnVal: 3.341 ± 0.056
0.594GlnTrp: 0.594 ± 0.028
1.383GlnTyr: 1.383 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
4.423ArgAla: 4.423 ± 0.067
0.384ArgCys: 0.384 ± 0.019
2.708ArgAsp: 2.708 ± 0.057
2.826ArgGlu: 2.826 ± 0.052
2.411ArgPhe: 2.411 ± 0.053
2.947ArgGly: 2.947 ± 0.054
1.264ArgHis: 1.264 ± 0.041
3.431ArgIle: 3.431 ± 0.057
2.141ArgLys: 2.141 ± 0.05
5.887ArgLeu: 5.887 ± 0.082
1.265ArgMet: 1.265 ± 0.037
1.676ArgAsn: 1.676 ± 0.042
2.116ArgPro: 2.116 ± 0.044
2.481ArgGln: 2.481 ± 0.056
2.71ArgArg: 2.71 ± 0.061
2.675ArgSer: 2.675 ± 0.046
2.592ArgThr: 2.592 ± 0.05
3.663ArgVal: 3.663 ± 0.068
0.742ArgTrp: 0.742 ± 0.026
1.818ArgTyr: 1.818 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
6.199SerAla: 6.199 ± 0.121
0.512SerCys: 0.512 ± 0.024
3.541SerAsp: 3.541 ± 0.08
3.149SerGlu: 3.149 ± 0.057
2.692SerPhe: 2.692 ± 0.057
5.349SerGly: 5.349 ± 0.14
1.563SerHis: 1.563 ± 0.04
4.021SerIle: 4.021 ± 0.067
2.75SerLys: 2.75 ± 0.06
6.765SerLeu: 6.765 ± 0.089
1.525SerMet: 1.525 ± 0.038
2.726SerAsn: 2.726 ± 0.085
3.075SerPro: 3.075 ± 0.062
2.709SerGln: 2.709 ± 0.055
3.091SerArg: 3.091 ± 0.055
4.867SerSer: 4.867 ± 0.279
4.027SerThr: 4.027 ± 0.078
4.475SerVal: 4.475 ± 0.136
0.828SerTrp: 0.828 ± 0.029
1.91SerTyr: 1.91 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
5.812ThrAla: 5.812 ± 0.091
0.449ThrCys: 0.449 ± 0.021
3.106ThrAsp: 3.106 ± 0.059
2.709ThrGlu: 2.709 ± 0.051
2.183ThrPhe: 2.183 ± 0.048
4.712ThrGly: 4.712 ± 0.09
1.416ThrHis: 1.416 ± 0.038
3.371ThrIle: 3.371 ± 0.063
2.116ThrLys: 2.116 ± 0.043
7.054ThrLeu: 7.054 ± 0.086
1.084ThrMet: 1.084 ± 0.034
2.15ThrAsn: 2.15 ± 0.075
3.616ThrPro: 3.616 ± 0.077
2.637ThrGln: 2.637 ± 0.061
2.721ThrArg: 2.721 ± 0.052
3.869ThrSer: 3.869 ± 0.086
3.993ThrThr: 3.993 ± 0.084
4.135ThrVal: 4.135 ± 0.065
0.733ThrTrp: 0.733 ± 0.025
1.57ThrTyr: 1.57 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
6.657ValAla: 6.657 ± 0.082
0.674ValCys: 0.674 ± 0.025
4.0ValAsp: 4.0 ± 0.064
3.667ValGlu: 3.667 ± 0.07
2.704ValPhe: 2.704 ± 0.06
5.022ValGly: 5.022 ± 0.076
1.416ValHis: 1.416 ± 0.039
4.596ValIle: 4.596 ± 0.079
3.017ValLys: 3.017 ± 0.061
7.336ValLeu: 7.336 ± 0.099
1.813ValMet: 1.813 ± 0.044
2.831ValAsn: 2.831 ± 0.064
2.962ValPro: 2.962 ± 0.055
2.774ValGln: 2.774 ± 0.053
3.405ValArg: 3.405 ± 0.053
4.89ValSer: 4.89 ± 0.192
4.285ValThr: 4.285 ± 0.077
5.345ValVal: 5.345 ± 0.086
0.922ValTrp: 0.922 ± 0.031
1.823ValTyr: 1.823 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.997TrpAla: 0.997 ± 0.032
0.13TrpCys: 0.13 ± 0.009
0.576TrpAsp: 0.576 ± 0.025
0.464TrpGlu: 0.464 ± 0.022
0.559TrpPhe: 0.559 ± 0.026
0.822TrpGly: 0.822 ± 0.028
0.37TrpHis: 0.37 ± 0.018
0.808TrpIle: 0.808 ± 0.031
0.502TrpLys: 0.502 ± 0.023
1.871TrpLeu: 1.871 ± 0.052
0.37TrpMet: 0.37 ± 0.022
0.454TrpAsn: 0.454 ± 0.019
0.474TrpPro: 0.474 ± 0.023
0.91TrpGln: 0.91 ± 0.032
0.818TrpArg: 0.818 ± 0.026
0.861TrpSer: 0.861 ± 0.032
0.656TrpThr: 0.656 ± 0.024
0.968TrpVal: 0.968 ± 0.027
0.196TrpTrp: 0.196 ± 0.012
0.392TrpTyr: 0.392 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.766TyrAla: 2.766 ± 0.058
0.267TyrCys: 0.267 ± 0.015
1.658TyrAsp: 1.658 ± 0.058
1.297TyrGlu: 1.297 ± 0.036
1.329TyrPhe: 1.329 ± 0.036
2.222TyrGly: 2.222 ± 0.052
0.745TyrHis: 0.745 ± 0.026
1.452TyrIle: 1.452 ± 0.038
1.093TyrLys: 1.093 ± 0.034
3.073TyrLeu: 3.073 ± 0.06
0.524TyrMet: 0.524 ± 0.024
1.055TyrAsn: 1.055 ± 0.041
1.41TyrPro: 1.41 ± 0.036
1.612TyrGln: 1.612 ± 0.044
1.725TyrArg: 1.725 ± 0.041
1.781TyrSer: 1.781 ± 0.045
1.661TyrThr: 1.661 ± 0.049
1.849TyrVal: 1.849 ± 0.048
0.431TyrTrp: 0.431 ± 0.021
0.916TyrTyr: 0.916 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3297 proteins (1068716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski