Amino acid dipepetide frequency for Tenacibaculum sp. M341

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.261AlaAla: 3.261 ± 0.062
0.509AlaCys: 0.509 ± 0.021
2.947AlaAsp: 2.947 ± 0.062
3.302AlaGlu: 3.302 ± 0.058
2.953AlaPhe: 2.953 ± 0.05
3.453AlaGly: 3.453 ± 0.052
0.902AlaHis: 0.902 ± 0.027
4.995AlaIle: 4.995 ± 0.071
4.502AlaLys: 4.502 ± 0.069
5.161AlaLeu: 5.161 ± 0.076
1.145AlaMet: 1.145 ± 0.03
3.496AlaAsn: 3.496 ± 0.056
1.728AlaPro: 1.728 ± 0.053
1.929AlaGln: 1.929 ± 0.039
1.684AlaArg: 1.684 ± 0.036
4.13AlaSer: 4.13 ± 0.058
3.597AlaThr: 3.597 ± 0.072
3.488AlaVal: 3.488 ± 0.059
0.515AlaTrp: 0.515 ± 0.017
2.255AlaTyr: 2.255 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.416CysAla: 0.416 ± 0.017
0.105CysCys: 0.105 ± 0.008
0.472CysAsp: 0.472 ± 0.026
0.478CysGlu: 0.478 ± 0.02
0.444CysPhe: 0.444 ± 0.02
0.609CysGly: 0.609 ± 0.036
0.16CysHis: 0.16 ± 0.013
0.587CysIle: 0.587 ± 0.027
0.538CysLys: 0.538 ± 0.019
0.583CysLeu: 0.583 ± 0.022
0.121CysMet: 0.121 ± 0.01
0.513CysAsn: 0.513 ± 0.029
0.26CysPro: 0.26 ± 0.018
0.183CysGln: 0.183 ± 0.011
0.191CysArg: 0.191 ± 0.011
0.62CysSer: 0.62 ± 0.024
0.416CysThr: 0.416 ± 0.019
0.433CysVal: 0.433 ± 0.019
0.085CysTrp: 0.085 ± 0.009
0.322CysTyr: 0.322 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.356AspAla: 3.356 ± 0.06
0.461AspCys: 0.461 ± 0.028
3.009AspAsp: 3.009 ± 0.06
3.709AspGlu: 3.709 ± 0.056
3.864AspPhe: 3.864 ± 0.063
3.638AspGly: 3.638 ± 0.096
0.805AspHis: 0.805 ± 0.024
4.558AspIle: 4.558 ± 0.07
4.25AspLys: 4.25 ± 0.056
5.104AspLeu: 5.104 ± 0.057
0.884AspMet: 0.884 ± 0.025
3.557AspAsn: 3.557 ± 0.072
1.622AspPro: 1.622 ± 0.058
1.406AspGln: 1.406 ± 0.037
1.754AspArg: 1.754 ± 0.033
3.189AspSer: 3.189 ± 0.058
3.036AspThr: 3.036 ± 0.066
3.723AspVal: 3.723 ± 0.056
0.742AspTrp: 0.742 ± 0.023
2.711AspTyr: 2.711 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
3.911GluAla: 3.911 ± 0.059
0.36GluCys: 0.36 ± 0.015
3.54GluAsp: 3.54 ± 0.056
5.387GluGlu: 5.387 ± 0.089
3.139GluPhe: 3.139 ± 0.044
3.692GluGly: 3.692 ± 0.061
1.042GluHis: 1.042 ± 0.031
5.998GluIle: 5.998 ± 0.08
6.57GluLys: 6.57 ± 0.095
6.432GluLeu: 6.432 ± 0.076
1.371GluMet: 1.371 ± 0.033
5.148GluAsn: 5.148 ± 0.065
1.318GluPro: 1.318 ± 0.031
2.125GluGln: 2.125 ± 0.048
2.313GluArg: 2.313 ± 0.047
3.43GluSer: 3.43 ± 0.055
3.745GluThr: 3.745 ± 0.056
4.552GluVal: 4.552 ± 0.055
0.613GluTrp: 0.613 ± 0.022
2.582GluTyr: 2.582 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
2.529PheAla: 2.529 ± 0.042
0.408PheCys: 0.408 ± 0.018
3.407PheAsp: 3.407 ± 0.059
3.465PheGlu: 3.465 ± 0.057
2.981PhePhe: 2.981 ± 0.059
3.271PheGly: 3.271 ± 0.06
0.843PheHis: 0.843 ± 0.025
4.27PheIle: 4.27 ± 0.064
4.352PheLys: 4.352 ± 0.07
4.897PheLeu: 4.897 ± 0.08
1.039PheMet: 1.039 ± 0.029
3.879PheAsn: 3.879 ± 0.059
1.597PhePro: 1.597 ± 0.036
1.474PheGln: 1.474 ± 0.031
1.561PheArg: 1.561 ± 0.034
4.473PheSer: 4.473 ± 0.053
3.282PheThr: 3.282 ± 0.057
2.98PheVal: 2.98 ± 0.052
0.574PheTrp: 0.574 ± 0.022
2.437PheTyr: 2.437 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
3.714GlyAla: 3.714 ± 0.064
0.6GlyCys: 0.6 ± 0.034
3.404GlyAsp: 3.404 ± 0.077
3.578GlyGlu: 3.578 ± 0.055
3.538GlyPhe: 3.538 ± 0.056
4.443GlyGly: 4.443 ± 0.109
0.929GlyHis: 0.929 ± 0.024
5.104GlyIle: 5.104 ± 0.066
4.886GlyLys: 4.886 ± 0.076
4.892GlyLeu: 4.892 ± 0.074
1.3GlyMet: 1.3 ± 0.03
4.087GlyAsn: 4.087 ± 0.08
1.108GlyPro: 1.108 ± 0.034
1.591GlyGln: 1.591 ± 0.036
1.894GlyArg: 1.894 ± 0.043
3.831GlySer: 3.831 ± 0.063
3.957GlyThr: 3.957 ± 0.084
4.385GlyVal: 4.385 ± 0.069
0.749GlyTrp: 0.749 ± 0.026
2.683GlyTyr: 2.683 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
0.804HisAla: 0.804 ± 0.025
0.158HisCys: 0.158 ± 0.01
0.771HisAsp: 0.771 ± 0.024
0.924HisGlu: 0.924 ± 0.025
1.043HisPhe: 1.043 ± 0.028
0.913HisGly: 0.913 ± 0.027
0.466HisHis: 0.466 ± 0.019
1.333HisIle: 1.333 ± 0.031
1.361HisLys: 1.361 ± 0.031
1.661HisLeu: 1.661 ± 0.039
0.253HisMet: 0.253 ± 0.013
1.05HisAsn: 1.05 ± 0.031
0.745HisPro: 0.745 ± 0.026
0.667HisGln: 0.667 ± 0.022
0.622HisArg: 0.622 ± 0.021
1.056HisSer: 1.056 ± 0.033
0.951HisThr: 0.951 ± 0.028
0.871HisVal: 0.871 ± 0.026
0.192HisTrp: 0.192 ± 0.012
0.76HisTyr: 0.76 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.191IleAla: 5.191 ± 0.063
0.6IleCys: 0.6 ± 0.021
5.251IleAsp: 5.251 ± 0.062
5.909IleGlu: 5.909 ± 0.082
3.671IlePhe: 3.671 ± 0.059
4.81IleGly: 4.81 ± 0.072
1.456IleHis: 1.456 ± 0.037
6.366IleIle: 6.366 ± 0.082
6.554IleLys: 6.554 ± 0.08
6.861IleLeu: 6.861 ± 0.091
1.186IleMet: 1.186 ± 0.027
5.518IleAsn: 5.518 ± 0.064
3.166IlePro: 3.166 ± 0.045
2.813IleGln: 2.813 ± 0.047
2.481IleArg: 2.481 ± 0.041
6.046IleSer: 6.046 ± 0.067
5.392IleThr: 5.392 ± 0.093
4.931IleVal: 4.931 ± 0.063
0.65IleTrp: 0.65 ± 0.022
2.856IleTyr: 2.856 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
4.712LysAla: 4.712 ± 0.075
0.36LysCys: 0.36 ± 0.018
4.599LysAsp: 4.599 ± 0.065
7.557LysGlu: 7.557 ± 0.105
3.138LysPhe: 3.138 ± 0.054
4.775LysGly: 4.775 ± 0.065
1.441LysHis: 1.441 ± 0.03
6.933LysIle: 6.933 ± 0.094
8.589LysLys: 8.589 ± 0.113
7.295LysLeu: 7.295 ± 0.102
1.931LysMet: 1.931 ± 0.04
6.235LysAsn: 6.235 ± 0.094
2.245LysPro: 2.245 ± 0.05
2.895LysGln: 2.895 ± 0.053
3.019LysArg: 3.019 ± 0.054
5.055LysSer: 5.055 ± 0.061
4.997LysThr: 4.997 ± 0.073
5.088LysVal: 5.088 ± 0.068
0.827LysTrp: 0.827 ± 0.026
3.355LysTyr: 3.355 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
4.933LeuAla: 4.933 ± 0.072
0.633LeuCys: 0.633 ± 0.02
4.838LeuAsp: 4.838 ± 0.06
6.025LeuGlu: 6.025 ± 0.073
4.855LeuPhe: 4.855 ± 0.084
5.354LeuGly: 5.354 ± 0.07
1.535LeuHis: 1.535 ± 0.035
7.089LeuIle: 7.089 ± 0.097
8.166LeuLys: 8.166 ± 0.102
8.618LeuLeu: 8.618 ± 0.112
1.637LeuMet: 1.637 ± 0.035
6.114LeuAsn: 6.114 ± 0.086
3.281LeuPro: 3.281 ± 0.051
3.251LeuGln: 3.251 ± 0.055
2.914LeuArg: 2.914 ± 0.048
6.799LeuSer: 6.799 ± 0.075
5.292LeuThr: 5.292 ± 0.077
5.03LeuVal: 5.03 ± 0.059
0.741LeuTrp: 0.741 ± 0.024
3.148LeuTyr: 3.148 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
1.06MetAla: 1.06 ± 0.03
0.133MetCys: 0.133 ± 0.01
0.885MetAsp: 0.885 ± 0.028
1.033MetGlu: 1.033 ± 0.03
0.878MetPhe: 0.878 ± 0.043
1.079MetGly: 1.079 ± 0.031
0.341MetHis: 0.341 ± 0.015
1.419MetIle: 1.419 ± 0.035
2.125MetLys: 2.125 ± 0.036
1.628MetLeu: 1.628 ± 0.033
0.481MetMet: 0.481 ± 0.019
1.32MetAsn: 1.32 ± 0.03
0.651MetPro: 0.651 ± 0.02
0.62MetGln: 0.62 ± 0.019
0.74MetArg: 0.74 ± 0.023
1.274MetSer: 1.274 ± 0.032
0.94MetThr: 0.94 ± 0.027
1.106MetVal: 1.106 ± 0.027
0.15MetTrp: 0.15 ± 0.011
0.761MetTyr: 0.761 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.765AsnAla: 3.765 ± 0.056
0.535AsnCys: 0.535 ± 0.028
3.874AsnAsp: 3.874 ± 0.056
4.411AsnGlu: 4.411 ± 0.061
3.573AsnPhe: 3.573 ± 0.06
4.454AsnGly: 4.454 ± 0.085
1.164AsnHis: 1.164 ± 0.028
5.564AsnIle: 5.564 ± 0.069
5.393AsnLys: 5.393 ± 0.078
5.897AsnLeu: 5.897 ± 0.085
1.16AsnMet: 1.16 ± 0.029
5.383AsnAsn: 5.383 ± 0.107
2.697AsnPro: 2.697 ± 0.048
2.35AsnGln: 2.35 ± 0.041
2.26AsnArg: 2.26 ± 0.047
4.796AsnSer: 4.796 ± 0.068
4.463AsnThr: 4.463 ± 0.072
4.025AsnVal: 4.025 ± 0.069
0.859AsnTrp: 0.859 ± 0.028
3.263AsnTyr: 3.263 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
1.597ProAla: 1.597 ± 0.043
0.213ProCys: 0.213 ± 0.014
1.774ProAsp: 1.774 ± 0.043
2.382ProGlu: 2.382 ± 0.043
1.723ProPhe: 1.723 ± 0.031
1.575ProGly: 1.575 ± 0.038
0.542ProHis: 0.542 ± 0.022
2.511ProIle: 2.511 ± 0.04
2.524ProLys: 2.524 ± 0.05
2.674ProLeu: 2.674 ± 0.05
0.585ProMet: 0.585 ± 0.019
2.375ProAsn: 2.375 ± 0.05
0.722ProPro: 0.722 ± 0.026
0.889ProGln: 0.889 ± 0.025
0.843ProArg: 0.843 ± 0.025
2.254ProSer: 2.254 ± 0.049
2.0ProThr: 2.0 ± 0.051
2.161ProVal: 2.161 ± 0.051
0.317ProTrp: 0.317 ± 0.015
1.303ProTyr: 1.303 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
1.603GlnAla: 1.603 ± 0.035
0.189GlnCys: 0.189 ± 0.018
1.39GlnAsp: 1.39 ± 0.027
2.318GlnGlu: 2.318 ± 0.048
1.665GlnPhe: 1.665 ± 0.029
1.594GlnGly: 1.594 ± 0.031
0.57GlnHis: 0.57 ± 0.02
2.685GlnIle: 2.685 ± 0.044
3.184GlnLys: 3.184 ± 0.057
3.238GlnLeu: 3.238 ± 0.057
0.679GlnMet: 0.679 ± 0.017
2.222GlnAsn: 2.222 ± 0.036
0.967GlnPro: 0.967 ± 0.033
1.517GlnGln: 1.517 ± 0.038
1.062GlnArg: 1.062 ± 0.029
1.892GlnSer: 1.892 ± 0.043
1.777GlnThr: 1.777 ± 0.035
1.774GlnVal: 1.774 ± 0.04
0.334GlnTrp: 0.334 ± 0.014
1.257GlnTyr: 1.257 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
1.795ArgAla: 1.795 ± 0.032
0.191ArgCys: 0.191 ± 0.014
1.614ArgAsp: 1.614 ± 0.037
1.994ArgGlu: 1.994 ± 0.039
1.96ArgPhe: 1.96 ± 0.042
1.881ArgGly: 1.881 ± 0.042
0.491ArgHis: 0.491 ± 0.019
2.796ArgIle: 2.796 ± 0.041
2.937ArgLys: 2.937 ± 0.05
2.926ArgLeu: 2.926 ± 0.047
0.744ArgMet: 0.744 ± 0.019
2.191ArgAsn: 2.191 ± 0.038
0.892ArgPro: 0.892 ± 0.026
0.857ArgGln: 0.857 ± 0.024
1.244ArgArg: 1.244 ± 0.031
1.854ArgSer: 1.854 ± 0.042
1.756ArgThr: 1.756 ± 0.041
2.102ArgVal: 2.102 ± 0.037
0.342ArgTrp: 0.342 ± 0.017
1.411ArgTyr: 1.411 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
3.351SerAla: 3.351 ± 0.06
0.707SerCys: 0.707 ± 0.026
3.68SerAsp: 3.68 ± 0.07
4.335SerGlu: 4.335 ± 0.063
4.486SerPhe: 4.486 ± 0.057
4.557SerGly: 4.557 ± 0.084
1.021SerHis: 1.021 ± 0.029
5.711SerIle: 5.711 ± 0.07
5.449SerLys: 5.449 ± 0.068
6.423SerLeu: 6.423 ± 0.079
1.209SerMet: 1.209 ± 0.03
4.696SerAsn: 4.696 ± 0.085
1.947SerPro: 1.947 ± 0.046
1.971SerGln: 1.971 ± 0.037
1.937SerArg: 1.937 ± 0.041
4.898SerSer: 4.898 ± 0.082
3.789SerThr: 3.789 ± 0.056
4.192SerVal: 4.192 ± 0.069
0.8SerTrp: 0.8 ± 0.026
3.073SerTyr: 3.073 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
3.296ThrAla: 3.296 ± 0.059
0.414ThrCys: 0.414 ± 0.024
3.492ThrAsp: 3.492 ± 0.078
3.554ThrGlu: 3.554 ± 0.058
3.195ThrPhe: 3.195 ± 0.049
3.849ThrGly: 3.849 ± 0.08
0.957ThrHis: 0.957 ± 0.026
5.428ThrIle: 5.428 ± 0.07
4.409ThrLys: 4.409 ± 0.062
5.294ThrLeu: 5.294 ± 0.069
0.85ThrMet: 0.85 ± 0.024
4.259ThrAsn: 4.259 ± 0.077
2.496ThrPro: 2.496 ± 0.049
1.808ThrGln: 1.808 ± 0.038
1.6ThrArg: 1.6 ± 0.037
4.437ThrSer: 4.437 ± 0.069
3.94ThrThr: 3.94 ± 0.078
3.994ThrVal: 3.994 ± 0.078
0.641ThrTrp: 0.641 ± 0.022
2.583ThrTyr: 2.583 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
3.852ValAla: 3.852 ± 0.063
0.518ValCys: 0.518 ± 0.021
3.534ValAsp: 3.534 ± 0.062
3.775ValGlu: 3.775 ± 0.05
3.506ValPhe: 3.506 ± 0.051
3.655ValGly: 3.655 ± 0.061
0.959ValHis: 0.959 ± 0.028
4.706ValIle: 4.706 ± 0.066
4.782ValLys: 4.782 ± 0.054
5.922ValLeu: 5.922 ± 0.067
1.125ValMet: 1.125 ± 0.024
4.043ValAsn: 4.043 ± 0.053
1.952ValPro: 1.952 ± 0.049
1.672ValGln: 1.672 ± 0.035
1.95ValArg: 1.95 ± 0.039
4.716ValSer: 4.716 ± 0.061
3.994ValThr: 3.994 ± 0.098
4.061ValVal: 4.061 ± 0.068
0.605ValTrp: 0.605 ± 0.022
2.462ValTyr: 2.462 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.521TrpAla: 0.521 ± 0.019
0.098TrpCys: 0.098 ± 0.009
0.585TrpAsp: 0.585 ± 0.025
0.622TrpGlu: 0.622 ± 0.021
0.591TrpPhe: 0.591 ± 0.021
0.615TrpGly: 0.615 ± 0.021
0.187TrpHis: 0.187 ± 0.011
0.767TrpIle: 0.767 ± 0.023
0.944TrpLys: 0.944 ± 0.026
0.943TrpLeu: 0.943 ± 0.03
0.261TrpMet: 0.261 ± 0.011
0.868TrpAsn: 0.868 ± 0.035
0.173TrpPro: 0.173 ± 0.012
0.375TrpGln: 0.375 ± 0.015
0.399TrpArg: 0.399 ± 0.017
0.711TrpSer: 0.711 ± 0.022
0.57TrpThr: 0.57 ± 0.019
0.526TrpVal: 0.526 ± 0.021
0.136TrpTrp: 0.136 ± 0.01
0.455TrpTyr: 0.455 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.286TyrAla: 2.286 ± 0.045
0.347TyrCys: 0.347 ± 0.017
2.309TyrAsp: 2.309 ± 0.053
2.511TyrGlu: 2.511 ± 0.041
2.513TyrPhe: 2.513 ± 0.051
2.454TyrGly: 2.454 ± 0.042
0.791TyrHis: 0.791 ± 0.026
2.887TyrIle: 2.887 ± 0.044
3.529TyrLys: 3.529 ± 0.061
3.804TyrLeu: 3.804 ± 0.063
0.663TyrMet: 0.663 ± 0.023
2.933TyrAsn: 2.933 ± 0.047
1.396TyrPro: 1.396 ± 0.035
1.524TyrGln: 1.524 ± 0.027
1.512TyrArg: 1.512 ± 0.032
2.771TyrSer: 2.771 ± 0.048
2.6TyrThr: 2.6 ± 0.046
2.369TyrVal: 2.369 ± 0.038
0.478TyrTrp: 0.478 ± 0.02
1.959TyrTyr: 1.959 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4253 proteins (1484396 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski