Amino acid dipepetide frequency for Streptomyces sp. 3214.6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.871AlaAla: 20.871 ± 0.136	1.117AlaCys: 1.117 ± 0.021	8.217AlaAsp: 8.217 ± 0.06	8.522AlaGlu: 8.522 ± 0.081	3.504AlaPhe: 3.504 ± 0.04	12.75AlaGly: 12.75 ± 0.086	2.963AlaHis: 2.963 ± 0.036	3.452AlaIle: 3.452 ± 0.039	3.082AlaLys: 3.082 ± 0.047	14.119AlaLeu: 14.119 ± 0.114	2.414AlaMet: 2.414 ± 0.033	2.104AlaAsn: 2.104 ± 0.03	7.108AlaPro: 7.108 ± 0.073	4.022AlaGln: 4.022 ± 0.042	9.95AlaArg: 9.95 ± 0.092	6.197AlaSer: 6.197 ± 0.058	7.305AlaThr: 7.305 ± 0.06	12.108AlaVal: 12.108 ± 0.091	1.887AlaTrp: 1.887 ± 0.026	2.822AlaTyr: 2.822 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.022	0.095CysCys: 0.095 ± 0.007	0.469CysAsp: 0.469 ± 0.013	0.406CysGlu: 0.406 ± 0.013	0.228CysPhe: 0.228 ± 0.009	0.96CysGly: 0.96 ± 0.02	0.195CysHis: 0.195 ± 0.01	0.164CysIle: 0.164 ± 0.008	0.122CysLys: 0.122 ± 0.007	0.728CysLeu: 0.728 ± 0.019	0.121CysMet: 0.121 ± 0.006	0.147CysAsn: 0.147 ± 0.007	0.485CysPro: 0.485 ± 0.014	0.187CysGln: 0.187 ± 0.009	0.593CysArg: 0.593 ± 0.015	0.468CysSer: 0.468 ± 0.013	0.541CysThr: 0.541 ± 0.017	0.694CysVal: 0.694 ± 0.018	0.14CysTrp: 0.14 ± 0.008	0.144CysTyr: 0.144 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.645AspAla: 7.645 ± 0.056	0.441AspCys: 0.441 ± 0.013	3.741AspAsp: 3.741 ± 0.045	3.768AspGlu: 3.768 ± 0.044	1.667AspPhe: 1.667 ± 0.029	6.418AspGly: 6.418 ± 0.063	1.425AspHis: 1.425 ± 0.025	1.84AspIle: 1.84 ± 0.035	1.267AspLys: 1.267 ± 0.027	6.046AspLeu: 6.046 ± 0.052	0.83AspMet: 0.83 ± 0.021	1.04AspAsn: 1.04 ± 0.019	4.462AspPro: 4.462 ± 0.046	1.565AspGln: 1.565 ± 0.023	4.717AspArg: 4.717 ± 0.048	2.655AspSer: 2.655 ± 0.036	3.399AspThr: 3.399 ± 0.033	4.801AspVal: 4.801 ± 0.042	1.046AspTrp: 1.046 ± 0.022	1.161AspTyr: 1.161 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	7.231GluAla: 7.231 ± 0.075	0.337GluCys: 0.337 ± 0.012	2.763GluAsp: 2.763 ± 0.041	3.385GluGlu: 3.385 ± 0.048	1.453GluPhe: 1.453 ± 0.024	4.166GluGly: 4.166 ± 0.041	1.459GluHis: 1.459 ± 0.024	2.193GluIle: 2.193 ± 0.031	1.423GluLys: 1.423 ± 0.029	6.643GluLeu: 6.643 ± 0.067	0.87GluMet: 0.87 ± 0.021	1.085GluAsn: 1.085 ± 0.024	3.326GluPro: 3.326 ± 0.042	2.313GluGln: 2.313 ± 0.032	5.194GluArg: 5.194 ± 0.054	2.586GluSer: 2.586 ± 0.035	2.994GluThr: 2.994 ± 0.034	4.321GluVal: 4.321 ± 0.047	0.786GluTrp: 0.786 ± 0.017	1.14GluTyr: 1.14 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.562PheAla: 3.562 ± 0.036	0.263PheCys: 0.263 ± 0.009	1.947PheAsp: 1.947 ± 0.03	1.434PheGlu: 1.434 ± 0.025	0.867PhePhe: 0.867 ± 0.02	2.978PheGly: 2.978 ± 0.039	0.608PheHis: 0.608 ± 0.015	0.702PheIle: 0.702 ± 0.016	0.567PheLys: 0.567 ± 0.016	2.558PheLeu: 2.558 ± 0.034	0.411PheMet: 0.411 ± 0.014	0.575PheAsn: 0.575 ± 0.016	1.392PhePro: 1.392 ± 0.022	0.691PheGln: 0.691 ± 0.018	1.836PheArg: 1.836 ± 0.028	1.478PheSer: 1.478 ± 0.025	2.053PheThr: 2.053 ± 0.029	2.268PheVal: 2.268 ± 0.034	0.429PheTrp: 0.429 ± 0.012	0.589PheTyr: 0.589 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.002GlyAla: 11.002 ± 0.073	0.837GlyCys: 0.837 ± 0.018	5.143GlyAsp: 5.143 ± 0.05	5.049GlyGlu: 5.049 ± 0.047	2.87GlyPhe: 2.87 ± 0.039	8.789GlyGly: 8.789 ± 0.085	2.309GlyHis: 2.309 ± 0.029	3.363GlyIle: 3.363 ± 0.041	2.526GlyLys: 2.526 ± 0.038	9.242GlyLeu: 9.242 ± 0.069	1.945GlyMet: 1.945 ± 0.024	1.896GlyAsn: 1.896 ± 0.032	4.963GlyPro: 4.963 ± 0.051	2.747GlyGln: 2.747 ± 0.041	7.596GlyArg: 7.596 ± 0.065	5.523GlySer: 5.523 ± 0.058	6.355GlyThr: 6.355 ± 0.059	7.501GlyVal: 7.501 ± 0.061	1.715GlyTrp: 1.715 ± 0.027	2.295GlyTyr: 2.295 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.693HisAla: 2.693 ± 0.031	0.196HisCys: 0.196 ± 0.01	1.371HisAsp: 1.371 ± 0.024	1.22HisGlu: 1.22 ± 0.024	0.633HisPhe: 0.633 ± 0.018	2.397HisGly: 2.397 ± 0.032	0.689HisHis: 0.689 ± 0.019	0.689HisIle: 0.689 ± 0.018	0.375HisLys: 0.375 ± 0.011	2.412HisLeu: 2.412 ± 0.035	0.337HisMet: 0.337 ± 0.01	0.416HisAsn: 0.416 ± 0.013	1.826HisPro: 1.826 ± 0.031	0.679HisGln: 0.679 ± 0.017	2.046HisArg: 2.046 ± 0.032	1.045HisSer: 1.045 ± 0.021	1.437HisThr: 1.437 ± 0.024	1.655HisVal: 1.655 ± 0.027	0.404HisTrp: 0.404 ± 0.013	0.506HisTyr: 0.506 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.667IleAla: 4.667 ± 0.045	0.277IleCys: 0.277 ± 0.01	2.223IleAsp: 2.223 ± 0.03	1.918IleGlu: 1.918 ± 0.03	0.698IlePhe: 0.698 ± 0.016	3.438IleGly: 3.438 ± 0.037	0.614IleHis: 0.614 ± 0.014	0.864IleIle: 0.864 ± 0.018	0.786IleLys: 0.786 ± 0.018	2.431IleLeu: 2.431 ± 0.032	0.425IleMet: 0.425 ± 0.013	0.721IleAsn: 0.721 ± 0.018	1.805IlePro: 1.805 ± 0.027	0.752IleGln: 0.752 ± 0.019	2.285IleArg: 2.285 ± 0.036	1.648IleSer: 1.648 ± 0.026	2.268IleThr: 2.268 ± 0.03	2.713IleVal: 2.713 ± 0.034	0.372IleTrp: 0.372 ± 0.011	0.534IleTyr: 0.534 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.16LysAla: 3.16 ± 0.056	0.124LysCys: 0.124 ± 0.008	1.403LysAsp: 1.403 ± 0.027	1.238LysGlu: 1.238 ± 0.026	0.477LysPhe: 0.477 ± 0.015	1.949LysGly: 1.949 ± 0.034	0.437LysHis: 0.437 ± 0.015	0.912LysIle: 0.912 ± 0.02	0.917LysLys: 0.917 ± 0.029	2.114LysLeu: 2.114 ± 0.037	0.372LysMet: 0.372 ± 0.012	0.587LysAsn: 0.587 ± 0.016	1.43LysPro: 1.43 ± 0.026	0.767LysGln: 0.767 ± 0.018	1.451LysArg: 1.451 ± 0.027	1.268LysSer: 1.268 ± 0.029	1.43LysThr: 1.43 ± 0.025	1.994LysVal: 1.994 ± 0.027	0.312LysTrp: 0.312 ± 0.01	0.494LysTyr: 0.494 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.7LeuAla: 14.7 ± 0.104	0.849LeuCys: 0.849 ± 0.018	6.533LeuAsp: 6.533 ± 0.059	4.548LeuGlu: 4.548 ± 0.048	2.535LeuPhe: 2.535 ± 0.031	8.983LeuGly: 8.983 ± 0.067	2.25LeuHis: 2.25 ± 0.032	3.238LeuIle: 3.238 ± 0.039	2.18LeuLys: 2.18 ± 0.037	11.031LeuLeu: 11.031 ± 0.085	1.571LeuMet: 1.571 ± 0.029	1.759LeuAsn: 1.759 ± 0.025	6.459LeuPro: 6.459 ± 0.059	2.318LeuGln: 2.318 ± 0.034	8.435LeuArg: 8.435 ± 0.069	5.367LeuSer: 5.367 ± 0.046	7.118LeuThr: 7.118 ± 0.052	8.638LeuVal: 8.638 ± 0.076	1.33LeuTrp: 1.33 ± 0.022	1.903LeuTyr: 1.903 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.167MetAla: 2.167 ± 0.033	0.142MetCys: 0.142 ± 0.007	0.866MetAsp: 0.866 ± 0.018	0.714MetGlu: 0.714 ± 0.02	0.449MetPhe: 0.449 ± 0.012	1.321MetGly: 1.321 ± 0.023	0.345MetHis: 0.345 ± 0.01	0.654MetIle: 0.654 ± 0.018	0.429MetLys: 0.429 ± 0.014	1.597MetLeu: 1.597 ± 0.026	0.27MetMet: 0.27 ± 0.011	0.452MetAsn: 0.452 ± 0.014	1.125MetPro: 1.125 ± 0.018	0.447MetGln: 0.447 ± 0.014	1.36MetArg: 1.36 ± 0.023	1.354MetSer: 1.354 ± 0.021	1.555MetThr: 1.555 ± 0.024	1.222MetVal: 1.222 ± 0.023	0.21MetTrp: 0.21 ± 0.008	0.323MetTyr: 0.323 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.324AsnAla: 2.324 ± 0.034	0.182AsnCys: 0.182 ± 0.009	1.052AsnAsp: 1.052 ± 0.021	0.831AsnGlu: 0.831 ± 0.017	0.504AsnPhe: 0.504 ± 0.014	2.093AsnGly: 2.093 ± 0.038	0.422AsnHis: 0.422 ± 0.013	0.647AsnIle: 0.647 ± 0.017	0.463AsnLys: 0.463 ± 0.014	1.698AsnLeu: 1.698 ± 0.03	0.325AsnMet: 0.325 ± 0.011	0.512AsnAsn: 0.512 ± 0.019	1.432AsnPro: 1.432 ± 0.027	0.567AsnGln: 0.567 ± 0.018	1.335AsnArg: 1.335 ± 0.021	1.068AsnSer: 1.068 ± 0.027	1.224AsnThr: 1.224 ± 0.025	1.491AsnVal: 1.491 ± 0.027	0.331AsnTrp: 0.331 ± 0.011	0.432AsnTyr: 0.432 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.48ProAla: 8.48 ± 0.085	0.345ProCys: 0.345 ± 0.012	4.439ProAsp: 4.439 ± 0.048	4.184ProGlu: 4.184 ± 0.043	1.523ProPhe: 1.523 ± 0.025	6.43ProGly: 6.43 ± 0.061	1.432ProHis: 1.432 ± 0.025	1.329ProIle: 1.329 ± 0.024	1.28ProLys: 1.28 ± 0.023	5.361ProLeu: 5.361 ± 0.053	0.968ProMet: 0.968 ± 0.02	0.984ProAsn: 0.984 ± 0.02	3.608ProPro: 3.608 ± 0.063	1.908ProGln: 1.908 ± 0.036	3.894ProArg: 3.894 ± 0.046	3.316ProSer: 3.316 ± 0.047	3.549ProThr: 3.549 ± 0.047	5.44ProVal: 5.44 ± 0.056	0.896ProTrp: 0.896 ± 0.018	1.445ProTyr: 1.445 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.914GlnAla: 3.914 ± 0.043	0.196GlnCys: 0.196 ± 0.008	1.492GlnAsp: 1.492 ± 0.026	1.518GlnGlu: 1.518 ± 0.025	0.719GlnPhe: 0.719 ± 0.016	2.435GlnGly: 2.435 ± 0.031	0.705GlnHis: 0.705 ± 0.017	1.116GlnIle: 1.116 ± 0.02	0.663GlnLys: 0.663 ± 0.018	3.126GlnLeu: 3.126 ± 0.036	0.493GlnMet: 0.493 ± 0.014	0.571GlnAsn: 0.571 ± 0.018	1.793GlnPro: 1.793 ± 0.033	1.37GlnGln: 1.37 ± 0.026	2.386GlnArg: 2.386 ± 0.029	1.389GlnSer: 1.389 ± 0.022	1.501GlnThr: 1.501 ± 0.025	2.497GlnVal: 2.497 ± 0.03	0.532GlnTrp: 0.532 ± 0.015	0.648GlnTyr: 0.648 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.609ArgAla: 9.609 ± 0.091	0.592ArgCys: 0.592 ± 0.016	4.081ArgAsp: 4.081 ± 0.049	4.663ArgGlu: 4.663 ± 0.052	2.306ArgPhe: 2.306 ± 0.031	5.598ArgGly: 5.598 ± 0.053	2.06ArgHis: 2.06 ± 0.032	3.104ArgIle: 3.104 ± 0.035	1.614ArgLys: 1.614 ± 0.029	8.776ArgLeu: 8.776 ± 0.069	1.666ArgMet: 1.666 ± 0.027	1.297ArgAsn: 1.297 ± 0.025	4.906ArgPro: 4.906 ± 0.054	2.357ArgGln: 2.357 ± 0.034	7.473ArgArg: 7.473 ± 0.081	3.931ArgSer: 3.931 ± 0.039	5.365ArgThr: 5.365 ± 0.043	5.738ArgVal: 5.738 ± 0.057	1.379ArgTrp: 1.379 ± 0.027	1.846ArgTyr: 1.846 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	7.013SerAla: 7.013 ± 0.059	0.439SerCys: 0.439 ± 0.013	2.864SerAsp: 2.864 ± 0.033	2.381SerGlu: 2.381 ± 0.034	1.551SerPhe: 1.551 ± 0.026	6.083SerGly: 6.083 ± 0.059	1.039SerHis: 1.039 ± 0.02	1.458SerIle: 1.458 ± 0.025	1.125SerLys: 1.125 ± 0.023	4.871SerLeu: 4.871 ± 0.047	1.067SerMet: 1.067 ± 0.021	0.968SerAsn: 0.968 ± 0.018	3.294SerPro: 3.294 ± 0.043	1.327SerGln: 1.327 ± 0.024	3.676SerArg: 3.676 ± 0.037	3.214SerSer: 3.214 ± 0.05	3.337SerThr: 3.337 ± 0.043	4.386SerVal: 4.386 ± 0.042	0.997SerTrp: 0.997 ± 0.022	1.326SerTyr: 1.326 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	9.31ThrAla: 9.31 ± 0.063	0.453ThrCys: 0.453 ± 0.014	3.803ThrAsp: 3.803 ± 0.041	3.253ThrGlu: 3.253 ± 0.036	1.641ThrPhe: 1.641 ± 0.027	6.805ThrGly: 6.805 ± 0.058	1.278ThrHis: 1.278 ± 0.024	1.806ThrIle: 1.806 ± 0.028	1.327ThrLys: 1.327 ± 0.029	5.866ThrLeu: 5.866 ± 0.044	0.948ThrMet: 0.948 ± 0.02	1.142ThrAsn: 1.142 ± 0.028	4.367ThrPro: 4.367 ± 0.051	1.479ThrGln: 1.479 ± 0.027	3.968ThrArg: 3.968 ± 0.038	3.46ThrSer: 3.46 ± 0.043	4.249ThrThr: 4.249 ± 0.05	6.224ThrVal: 6.224 ± 0.061	0.97ThrTrp: 0.97 ± 0.02	1.472ThrTyr: 1.472 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	10.535ValAla: 10.535 ± 0.075	0.761ValCys: 0.761 ± 0.016	4.964ValAsp: 4.964 ± 0.049	4.67ValGlu: 4.67 ± 0.047	2.423ValPhe: 2.423 ± 0.03	6.565ValGly: 6.565 ± 0.056	1.991ValHis: 1.991 ± 0.027	2.816ValIle: 2.816 ± 0.038	1.847ValLys: 1.847 ± 0.036	9.241ValLeu: 9.241 ± 0.072	1.421ValMet: 1.421 ± 0.028	1.761ValAsn: 1.761 ± 0.03	5.142ValPro: 5.142 ± 0.049	2.236ValGln: 2.236 ± 0.028	7.052ValArg: 7.052 ± 0.063	4.436ValSer: 4.436 ± 0.045	5.719ValThr: 5.719 ± 0.052	7.911ValVal: 7.911 ± 0.063	1.173ValTrp: 1.173 ± 0.021	1.659ValTyr: 1.659 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.705TrpAla: 1.705 ± 0.026	0.148TrpCys: 0.148 ± 0.008	0.874TrpAsp: 0.874 ± 0.018	0.716TrpGlu: 0.716 ± 0.017	0.513TrpPhe: 0.513 ± 0.014	1.132TrpGly: 1.132 ± 0.021	0.404TrpHis: 0.404 ± 0.013	0.584TrpIle: 0.584 ± 0.016	0.411TrpLys: 0.411 ± 0.015	1.779TrpLeu: 1.779 ± 0.029	0.282TrpMet: 0.282 ± 0.009	0.448TrpAsn: 0.448 ± 0.012	0.773TrpPro: 0.773 ± 0.015	0.662TrpGln: 0.662 ± 0.019	1.316TrpArg: 1.316 ± 0.023	0.992TrpSer: 0.992 ± 0.022	1.153TrpThr: 1.153 ± 0.024	1.005TrpVal: 1.005 ± 0.019	0.338TrpTrp: 0.338 ± 0.013	0.384TrpTyr: 0.384 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.828TyrAla: 2.828 ± 0.033	0.191TyrCys: 0.191 ± 0.009	1.687TyrAsp: 1.687 ± 0.04	1.252TyrGlu: 1.252 ± 0.026	0.647TyrPhe: 0.647 ± 0.016	2.375TyrGly: 2.375 ± 0.033	0.4TyrHis: 0.4 ± 0.012	0.51TyrIle: 0.51 ± 0.015	0.433TyrLys: 0.433 ± 0.014	2.105TyrLeu: 2.105 ± 0.029	0.267TyrMet: 0.267 ± 0.01	0.467TyrAsn: 0.467 ± 0.018	1.114TyrPro: 1.114 ± 0.019	0.669TyrGln: 0.669 ± 0.018	1.797TyrArg: 1.797 ± 0.026	1.023TyrSer: 1.023 ± 0.021	1.273TyrThr: 1.273 ± 0.027	1.713TyrVal: 1.713 ± 0.026	0.373TyrTrp: 0.373 ± 0.013	0.506TyrTyr: 0.506 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8041 proteins (2692240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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