Amino acid dipepetide frequency for Acinetobacter phage vB_AbaM_ME3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.652AlaAla: 3.652 ± 0.437
0.586AlaCys: 0.586 ± 0.109
2.998AlaAsp: 2.998 ± 0.279
2.671AlaGlu: 2.671 ± 0.197
2.698AlaPhe: 2.698 ± 0.165
2.916AlaGly: 2.916 ± 0.42
0.681AlaHis: 0.681 ± 0.122
4.02AlaIle: 4.02 ± 0.371
3.775AlaLys: 3.775 ± 0.261
5.029AlaLeu: 5.029 ± 0.28
0.995AlaMet: 0.995 ± 0.117
3.434AlaAsn: 3.434 ± 0.383
1.472AlaPro: 1.472 ± 0.184
1.826AlaGln: 1.826 ± 0.264
1.744AlaArg: 1.744 ± 0.17
4.402AlaSer: 4.402 ± 0.334
3.598AlaThr: 3.598 ± 0.576
3.489AlaVal: 3.489 ± 0.272
0.586AlaTrp: 0.586 ± 0.087
2.439AlaTyr: 2.439 ± 0.224
0.0AlaXaa: 0.0 ± 0.0
Cys
0.409CysAla: 0.409 ± 0.079
0.082CysCys: 0.082 ± 0.036
0.531CysAsp: 0.531 ± 0.095
0.531CysGlu: 0.531 ± 0.09
0.504CysPhe: 0.504 ± 0.095
0.531CysGly: 0.531 ± 0.092
0.286CysHis: 0.286 ± 0.082
0.763CysIle: 0.763 ± 0.111
0.79CysLys: 0.79 ± 0.128
1.077CysLeu: 1.077 ± 0.12
0.245CysMet: 0.245 ± 0.058
0.736CysAsn: 0.736 ± 0.129
0.422CysPro: 0.422 ± 0.096
0.313CysGln: 0.313 ± 0.067
0.354CysArg: 0.354 ± 0.07
1.049CysSer: 1.049 ± 0.141
0.627CysThr: 0.627 ± 0.112
0.572CysVal: 0.572 ± 0.086
0.15CysTrp: 0.15 ± 0.044
0.572CysTyr: 0.572 ± 0.099
0.0CysXaa: 0.0 ± 0.0
Asp
3.093AspAla: 3.093 ± 0.417
0.709AspCys: 0.709 ± 0.118
2.807AspAsp: 2.807 ± 0.21
3.38AspGlu: 3.38 ± 0.239
2.657AspPhe: 2.657 ± 0.203
3.093AspGly: 3.093 ± 0.217
1.022AspHis: 1.022 ± 0.131
4.797AspIle: 4.797 ± 0.238
3.516AspLys: 3.516 ± 0.261
6.31AspLeu: 6.31 ± 0.332
1.24AspMet: 1.24 ± 0.135
3.38AspAsn: 3.38 ± 0.202
2.031AspPro: 2.031 ± 0.189
1.976AspGln: 1.976 ± 0.153
2.249AspArg: 2.249 ± 0.186
5.124AspSer: 5.124 ± 0.246
4.633AspThr: 4.633 ± 0.308
4.129AspVal: 4.129 ± 0.259
0.695AspTrp: 0.695 ± 0.122
3.134AspTyr: 3.134 ± 0.23
0.0AspXaa: 0.0 ± 0.0
Glu
3.598GluAla: 3.598 ± 0.257
0.6GluCys: 0.6 ± 0.095
4.388GluAsp: 4.388 ± 0.363
4.933GluGlu: 4.933 ± 0.441
3.053GluPhe: 3.053 ± 0.241
2.766GluGly: 2.766 ± 0.208
1.295GluHis: 1.295 ± 0.166
4.388GluIle: 4.388 ± 0.286
4.129GluLys: 4.129 ± 0.303
6.214GluLeu: 6.214 ± 0.445
1.322GluMet: 1.322 ± 0.122
3.284GluAsn: 3.284 ± 0.285
1.267GluPro: 1.267 ± 0.126
2.208GluGln: 2.208 ± 0.214
2.303GluArg: 2.303 ± 0.202
3.925GluSer: 3.925 ± 0.24
3.598GluThr: 3.598 ± 0.216
4.429GluVal: 4.429 ± 0.215
0.463GluTrp: 0.463 ± 0.068
3.025GluTyr: 3.025 ± 0.288
0.0GluXaa: 0.0 ± 0.0
Phe
2.221PheAla: 2.221 ± 0.164
0.463PheCys: 0.463 ± 0.071
2.63PheAsp: 2.63 ± 0.191
2.644PheGlu: 2.644 ± 0.216
1.69PhePhe: 1.69 ± 0.19
2.235PheGly: 2.235 ± 0.203
0.722PheHis: 0.722 ± 0.105
3.489PheIle: 3.489 ± 0.261
4.252PheLys: 4.252 ± 0.227
3.666PheLeu: 3.666 ± 0.329
0.641PheMet: 0.641 ± 0.096
4.102PheAsn: 4.102 ± 0.297
1.295PhePro: 1.295 ± 0.115
1.39PheGln: 1.39 ± 0.145
1.649PheArg: 1.649 ± 0.148
3.87PheSer: 3.87 ± 0.22
2.848PheThr: 2.848 ± 0.211
2.698PheVal: 2.698 ± 0.192
0.3PheTrp: 0.3 ± 0.064
1.867PheTyr: 1.867 ± 0.193
0.0PheXaa: 0.0 ± 0.0
Gly
2.562GlyAla: 2.562 ± 0.28
0.6GlyCys: 0.6 ± 0.111
2.998GlyAsp: 2.998 ± 0.217
2.071GlyGlu: 2.071 ± 0.163
2.576GlyPhe: 2.576 ± 0.18
2.875GlyGly: 2.875 ± 0.293
0.654GlyHis: 0.654 ± 0.099
4.047GlyIle: 4.047 ± 0.238
3.679GlyLys: 3.679 ± 0.235
4.851GlyLeu: 4.851 ± 0.295
1.281GlyMet: 1.281 ± 0.163
3.134GlyAsn: 3.134 ± 0.306
0.859GlyPro: 0.859 ± 0.114
1.213GlyGln: 1.213 ± 0.159
1.853GlyArg: 1.853 ± 0.173
4.293GlySer: 4.293 ± 0.382
3.884GlyThr: 3.884 ± 0.594
3.434GlyVal: 3.434 ± 0.243
0.818GlyTrp: 0.818 ± 0.167
2.562GlyTyr: 2.562 ± 0.174
0.0GlyXaa: 0.0 ± 0.0
His
0.709HisAla: 0.709 ± 0.108
0.177HisCys: 0.177 ± 0.053
0.981HisAsp: 0.981 ± 0.124
0.736HisGlu: 0.736 ± 0.108
0.899HisPhe: 0.899 ± 0.12
0.954HisGly: 0.954 ± 0.151
0.422HisHis: 0.422 ± 0.083
1.554HisIle: 1.554 ± 0.162
1.036HisLys: 1.036 ± 0.145
1.649HisLeu: 1.649 ± 0.191
0.477HisMet: 0.477 ± 0.09
1.363HisAsn: 1.363 ± 0.165
0.777HisPro: 0.777 ± 0.127
0.641HisGln: 0.641 ± 0.096
0.695HisArg: 0.695 ± 0.097
1.526HisSer: 1.526 ± 0.158
1.077HisThr: 1.077 ± 0.12
0.927HisVal: 0.927 ± 0.128
0.259HisTrp: 0.259 ± 0.047
1.186HisTyr: 1.186 ± 0.155
0.0HisXaa: 0.0 ± 0.0
Ile
4.361IleAla: 4.361 ± 0.256
1.049IleCys: 1.049 ± 0.14
5.655IleAsp: 5.655 ± 0.319
5.138IleGlu: 5.138 ± 0.305
2.644IlePhe: 2.644 ± 0.225
3.72IleGly: 3.72 ± 0.231
1.458IleHis: 1.458 ± 0.169
5.029IleIle: 5.029 ± 0.282
6.446IleLys: 6.446 ± 0.419
5.383IleLeu: 5.383 ± 0.341
1.104IleMet: 1.104 ± 0.146
5.696IleAsn: 5.696 ± 0.416
3.162IlePro: 3.162 ± 0.234
2.521IleGln: 2.521 ± 0.186
3.203IleArg: 3.203 ± 0.178
6.132IleSer: 6.132 ± 0.32
5.737IleThr: 5.737 ± 0.362
4.538IleVal: 4.538 ± 0.265
0.572IleTrp: 0.572 ± 0.113
3.203IleTyr: 3.203 ± 0.213
0.0IleXaa: 0.0 ± 0.0
Lys
4.892LysAla: 4.892 ± 0.258
0.859LysCys: 0.859 ± 0.117
4.702LysAsp: 4.702 ± 0.305
6.092LysGlu: 6.092 ± 0.56
3.08LysPhe: 3.08 ± 0.228
3.543LysGly: 3.543 ± 0.294
1.445LysHis: 1.445 ± 0.162
4.974LysIle: 4.974 ± 0.228
4.184LysLys: 4.184 ± 0.372
6.814LysLeu: 6.814 ± 0.421
1.295LysMet: 1.295 ± 0.147
3.611LysAsn: 3.611 ± 0.282
2.453LysPro: 2.453 ± 0.19
2.562LysGln: 2.562 ± 0.195
2.521LysArg: 2.521 ± 0.224
4.674LysSer: 4.674 ± 0.284
5.233LysThr: 5.233 ± 0.303
5.097LysVal: 5.097 ± 0.242
0.477LysTrp: 0.477 ± 0.085
3.53LysTyr: 3.53 ± 0.226
0.0LysXaa: 0.0 ± 0.0
Leu
4.606LeuAla: 4.606 ± 0.263
0.927LeuCys: 0.927 ± 0.155
6.432LeuAsp: 6.432 ± 0.34
6.269LeuGlu: 6.269 ± 0.32
4.102LeuPhe: 4.102 ± 0.267
4.797LeuGly: 4.797 ± 0.3
1.717LeuHis: 1.717 ± 0.187
5.996LeuIle: 5.996 ± 0.3
7.604LeuLys: 7.604 ± 0.454
7.85LeuLeu: 7.85 ± 0.407
1.554LeuMet: 1.554 ± 0.191
6.596LeuAsn: 6.596 ± 0.302
3.012LeuPro: 3.012 ± 0.177
3.203LeuGln: 3.203 ± 0.199
3.107LeuArg: 3.107 ± 0.257
8.217LeuSer: 8.217 ± 0.392
6.187LeuThr: 6.187 ± 0.334
5.492LeuVal: 5.492 ± 0.308
0.518LeuTrp: 0.518 ± 0.083
3.925LeuTyr: 3.925 ± 0.272
0.0LeuXaa: 0.0 ± 0.0
Met
0.981MetAla: 0.981 ± 0.134
0.123MetCys: 0.123 ± 0.034
0.886MetAsp: 0.886 ± 0.107
0.722MetGlu: 0.722 ± 0.122
1.213MetPhe: 1.213 ± 0.161
0.668MetGly: 0.668 ± 0.134
0.259MetHis: 0.259 ± 0.07
1.799MetIle: 1.799 ± 0.165
1.635MetLys: 1.635 ± 0.172
1.99MetLeu: 1.99 ± 0.18
0.518MetMet: 0.518 ± 0.069
1.267MetAsn: 1.267 ± 0.142
0.463MetPro: 0.463 ± 0.075
0.709MetGln: 0.709 ± 0.098
0.463MetArg: 0.463 ± 0.078
1.758MetSer: 1.758 ± 0.172
1.308MetThr: 1.308 ± 0.107
0.899MetVal: 0.899 ± 0.125
0.177MetTrp: 0.177 ± 0.048
1.226MetTyr: 1.226 ± 0.141
0.0MetXaa: 0.0 ± 0.0
Asn
2.889AsnAla: 2.889 ± 0.299
0.695AsnCys: 0.695 ± 0.085
3.134AsnAsp: 3.134 ± 0.183
3.339AsnGlu: 3.339 ± 0.207
2.576AsnPhe: 2.576 ± 0.175
4.034AsnGly: 4.034 ± 0.299
1.295AsnHis: 1.295 ± 0.146
5.192AsnIle: 5.192 ± 0.277
5.151AsnLys: 5.151 ± 0.32
6.132AsnLeu: 6.132 ± 0.363
1.09AsnMet: 1.09 ± 0.104
4.293AsnAsn: 4.293 ± 0.316
2.998AsnPro: 2.998 ± 0.192
2.317AsnGln: 2.317 ± 0.211
2.058AsnArg: 2.058 ± 0.178
5.546AsnSer: 5.546 ± 0.322
4.933AsnThr: 4.933 ± 0.406
4.007AsnVal: 4.007 ± 0.278
0.586AsnTrp: 0.586 ± 0.095
2.903AsnTyr: 2.903 ± 0.222
0.0AsnXaa: 0.0 ± 0.0
Pro
1.281ProAla: 1.281 ± 0.178
0.191ProCys: 0.191 ± 0.058
1.472ProAsp: 1.472 ± 0.148
2.371ProGlu: 2.371 ± 0.191
1.581ProPhe: 1.581 ± 0.155
0.886ProGly: 0.886 ± 0.107
0.736ProHis: 0.736 ± 0.134
2.753ProIle: 2.753 ± 0.197
2.167ProLys: 2.167 ± 0.228
3.107ProLeu: 3.107 ± 0.253
0.641ProMet: 0.641 ± 0.087
2.289ProAsn: 2.289 ± 0.234
0.913ProPro: 0.913 ± 0.129
1.049ProGln: 1.049 ± 0.153
1.117ProArg: 1.117 ± 0.128
3.407ProSer: 3.407 ± 0.267
2.153ProThr: 2.153 ± 0.265
2.249ProVal: 2.249 ± 0.184
0.286ProTrp: 0.286 ± 0.063
1.935ProTyr: 1.935 ± 0.143
0.0ProXaa: 0.0 ± 0.0
Gln
2.521GlnAla: 2.521 ± 0.213
0.3GlnCys: 0.3 ± 0.07
1.676GlnAsp: 1.676 ± 0.156
2.344GlnGlu: 2.344 ± 0.156
1.622GlnPhe: 1.622 ± 0.162
1.526GlnGly: 1.526 ± 0.137
0.695GlnHis: 0.695 ± 0.099
2.685GlnIle: 2.685 ± 0.184
2.017GlnLys: 2.017 ± 0.178
3.039GlnLeu: 3.039 ± 0.197
0.818GlnMet: 0.818 ± 0.102
1.812GlnAsn: 1.812 ± 0.164
0.886GlnPro: 0.886 ± 0.114
1.363GlnGln: 1.363 ± 0.144
0.981GlnArg: 0.981 ± 0.133
2.398GlnSer: 2.398 ± 0.192
1.962GlnThr: 1.962 ± 0.152
2.657GlnVal: 2.657 ± 0.229
0.3GlnTrp: 0.3 ± 0.054
1.949GlnTyr: 1.949 ± 0.154
0.0GlnXaa: 0.0 ± 0.0
Arg
1.608ArgAla: 1.608 ± 0.171
0.313ArgCys: 0.313 ± 0.064
2.18ArgAsp: 2.18 ± 0.16
2.344ArgGlu: 2.344 ± 0.221
1.826ArgPhe: 1.826 ± 0.183
1.567ArgGly: 1.567 ± 0.137
0.641ArgHis: 0.641 ± 0.101
3.107ArgIle: 3.107 ± 0.199
2.126ArgLys: 2.126 ± 0.225
3.598ArgLeu: 3.598 ± 0.234
0.872ArgMet: 0.872 ± 0.113
2.085ArgAsn: 2.085 ± 0.138
1.077ArgPro: 1.077 ± 0.12
1.376ArgGln: 1.376 ± 0.199
1.703ArgArg: 1.703 ± 0.167
2.521ArgSer: 2.521 ± 0.198
2.358ArgThr: 2.358 ± 0.239
2.467ArgVal: 2.467 ± 0.205
0.395ArgTrp: 0.395 ± 0.08
2.071ArgTyr: 2.071 ± 0.173
0.0ArgXaa: 0.0 ± 0.0
Ser
3.489SerAla: 3.489 ± 0.363
0.79SerCys: 0.79 ± 0.114
4.77SerAsp: 4.77 ± 0.26
4.225SerGlu: 4.225 ± 0.338
3.816SerPhe: 3.816 ± 0.303
4.334SerGly: 4.334 ± 0.338
1.376SerHis: 1.376 ± 0.149
7.141SerIle: 7.141 ± 0.318
6.16SerLys: 6.16 ± 0.362
8.286SerLeu: 8.286 ± 0.442
1.24SerMet: 1.24 ± 0.153
5.628SerAsn: 5.628 ± 0.405
2.835SerPro: 2.835 ± 0.208
2.998SerGln: 2.998 ± 0.204
3.012SerArg: 3.012 ± 0.224
7.223SerSer: 7.223 ± 0.403
5.492SerThr: 5.492 ± 0.53
5.383SerVal: 5.383 ± 0.289
0.845SerTrp: 0.845 ± 0.117
3.421SerTyr: 3.421 ± 0.185
0.0SerXaa: 0.0 ± 0.0
Thr
3.761ThrAla: 3.761 ± 0.513
0.531ThrCys: 0.531 ± 0.118
3.993ThrAsp: 3.993 ± 0.275
3.816ThrGlu: 3.816 ± 0.257
3.107ThrPhe: 3.107 ± 0.207
3.707ThrGly: 3.707 ± 0.326
1.172ThrHis: 1.172 ± 0.13
5.424ThrIle: 5.424 ± 0.351
4.92ThrLys: 4.92 ± 0.329
6.473ThrLeu: 6.473 ± 0.398
1.199ThrMet: 1.199 ± 0.128
4.661ThrAsn: 4.661 ± 0.355
2.63ThrPro: 2.63 ± 0.217
2.18ThrGln: 2.18 ± 0.195
2.235ThrArg: 2.235 ± 0.171
5.969ThrSer: 5.969 ± 0.595
6.119ThrThr: 6.119 ± 0.963
4.892ThrVal: 4.892 ± 0.547
0.6ThrTrp: 0.6 ± 0.092
3.298ThrTyr: 3.298 ± 0.22
0.0ThrXaa: 0.0 ± 0.0
Val
3.625ValAla: 3.625 ± 0.386
0.886ValCys: 0.886 ± 0.137
4.061ValAsp: 4.061 ± 0.22
4.143ValGlu: 4.143 ± 0.25
2.33ValPhe: 2.33 ± 0.165
3.475ValGly: 3.475 ± 0.313
0.927ValHis: 0.927 ± 0.109
4.879ValIle: 4.879 ± 0.257
4.252ValLys: 4.252 ± 0.255
5.669ValLeu: 5.669 ± 0.288
1.336ValMet: 1.336 ± 0.146
4.17ValAsn: 4.17 ± 0.326
2.439ValPro: 2.439 ± 0.204
1.772ValGln: 1.772 ± 0.177
2.821ValArg: 2.821 ± 0.212
5.615ValSer: 5.615 ± 0.325
4.879ValThr: 4.879 ± 0.292
4.265ValVal: 4.265 ± 0.245
0.504ValTrp: 0.504 ± 0.062
2.807ValTyr: 2.807 ± 0.191
0.0ValXaa: 0.0 ± 0.0
Trp
0.6TrpAla: 0.6 ± 0.106
0.123TrpCys: 0.123 ± 0.045
0.613TrpAsp: 0.613 ± 0.097
0.572TrpGlu: 0.572 ± 0.097
0.518TrpPhe: 0.518 ± 0.088
0.395TrpGly: 0.395 ± 0.059
0.136TrpHis: 0.136 ± 0.038
0.6TrpIle: 0.6 ± 0.091
0.559TrpLys: 0.559 ± 0.071
0.913TrpLeu: 0.913 ± 0.112
0.327TrpMet: 0.327 ± 0.062
0.695TrpAsn: 0.695 ± 0.094
0.068TrpPro: 0.068 ± 0.031
0.232TrpGln: 0.232 ± 0.058
0.341TrpArg: 0.341 ± 0.06
0.845TrpSer: 0.845 ± 0.119
0.641TrpThr: 0.641 ± 0.101
0.504TrpVal: 0.504 ± 0.082
0.123TrpTrp: 0.123 ± 0.043
0.409TrpTyr: 0.409 ± 0.082
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.153TyrAla: 2.153 ± 0.19
0.545TyrCys: 0.545 ± 0.086
3.066TyrAsp: 3.066 ± 0.21
2.848TyrGlu: 2.848 ± 0.254
2.18TyrPhe: 2.18 ± 0.163
2.221TyrGly: 2.221 ± 0.188
1.104TyrHis: 1.104 ± 0.119
4.116TyrIle: 4.116 ± 0.242
3.639TyrLys: 3.639 ± 0.256
4.075TyrLeu: 4.075 ± 0.269
0.859TyrMet: 0.859 ± 0.127
2.93TyrAsn: 2.93 ± 0.183
1.526TyrPro: 1.526 ± 0.127
1.703TyrGln: 1.703 ± 0.174
1.826TyrArg: 1.826 ± 0.154
3.966TyrSer: 3.966 ± 0.228
3.421TyrThr: 3.421 ± 0.231
2.726TyrVal: 2.726 ± 0.203
0.559TyrTrp: 0.559 ± 0.078
2.14TyrTyr: 2.14 ± 0.183
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 326 proteins (73381 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski