Amino acid dipepetide frequency for Theileria parva (East coast fever infection agent)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	1.597AlaAla: 1.597 ± 0.041	0.513AlaCys: 0.513 ± 0.019	1.782AlaAsp: 1.782 ± 0.031	2.007AlaGlu: 2.007 ± 0.04	1.638AlaPhe: 1.638 ± 0.03	1.609AlaGly: 1.609 ± 0.037	0.725AlaHis: 0.725 ± 0.021	2.253AlaIle: 2.253 ± 0.036	2.832AlaLys: 2.832 ± 0.043	3.734AlaLeu: 3.734 ± 0.046	0.696AlaMet: 0.696 ± 0.019	2.109AlaAsn: 2.109 ± 0.035	1.359AlaPro: 1.359 ± 0.041	1.173AlaGln: 1.173 ± 0.027	1.441AlaArg: 1.441 ± 0.031	2.766AlaSer: 2.766 ± 0.04	2.169AlaThr: 2.169 ± 0.057	2.344AlaVal: 2.344 ± 0.039	0.231AlaTrp: 0.231 ± 0.012	1.234AlaTyr: 1.234 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.542CysAla: 0.542 ± 0.019	0.444CysCys: 0.444 ± 0.025	0.941CysAsp: 0.941 ± 0.021	0.901CysGlu: 0.901 ± 0.024	0.835CysPhe: 0.835 ± 0.021	0.893CysGly: 0.893 ± 0.026	0.358CysHis: 0.358 ± 0.013	1.207CysIle: 1.207 ± 0.029	1.369CysLys: 1.369 ± 0.03	1.693CysLeu: 1.693 ± 0.032	0.31CysMet: 0.31 ± 0.013	1.135CysAsn: 1.135 ± 0.03	0.574CysPro: 0.574 ± 0.024	0.392CysGln: 0.392 ± 0.015	0.68CysArg: 0.68 ± 0.02	1.397CysSer: 1.397 ± 0.03	0.877CysThr: 0.877 ± 0.025	1.21CysVal: 1.21 ± 0.029	0.137CysTrp: 0.137 ± 0.009	0.713CysTyr: 0.713 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	1.759AspAla: 1.759 ± 0.031	0.786AspCys: 0.786 ± 0.021	3.937AspAsp: 3.937 ± 0.07	4.564AspGlu: 4.564 ± 0.065	2.944AspPhe: 2.944 ± 0.045	2.591AspGly: 2.591 ± 0.04	1.126AspHis: 1.126 ± 0.025	3.62AspIle: 3.62 ± 0.055	4.61AspLys: 4.61 ± 0.059	6.047AspLeu: 6.047 ± 0.059	1.076AspMet: 1.076 ± 0.025	3.807AspAsn: 3.807 ± 0.049	2.52AspPro: 2.52 ± 0.043	1.811AspGln: 1.811 ± 0.035	2.12AspArg: 2.12 ± 0.036	5.477AspSer: 5.477 ± 0.072	3.226AspThr: 3.226 ± 0.052	3.647AspVal: 3.647 ± 0.045	0.427AspTrp: 0.427 ± 0.015	2.622AspTyr: 2.622 ± 0.042	0.001AspXaa: 0.001 ± 0.001
Glu	2.307GluAla: 2.307 ± 0.044	0.981GluCys: 0.981 ± 0.024	4.184GluAsp: 4.184 ± 0.066	5.031GluGlu: 5.031 ± 0.071	3.157GluPhe: 3.157 ± 0.046	2.505GluGly: 2.505 ± 0.045	1.349GluHis: 1.349 ± 0.026	4.122GluIle: 4.122 ± 0.06	4.802GluLys: 4.802 ± 0.061	6.656GluLeu: 6.656 ± 0.078	1.478GluMet: 1.478 ± 0.032	4.669GluAsn: 4.669 ± 0.057	2.293GluPro: 2.293 ± 0.047	1.961GluGln: 1.961 ± 0.035	2.571GluArg: 2.571 ± 0.037	5.487GluSer: 5.487 ± 0.068	3.296GluThr: 3.296 ± 0.046	3.639GluVal: 3.639 ± 0.053	0.498GluTrp: 0.498 ± 0.018	2.696GluTyr: 2.696 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	1.526PheAla: 1.526 ± 0.034	0.848PheCys: 0.848 ± 0.023	3.203PheAsp: 3.203 ± 0.047	2.967PheGlu: 2.967 ± 0.043	2.294PhePhe: 2.294 ± 0.043	2.676PheGly: 2.676 ± 0.057	1.048PheHis: 1.048 ± 0.025	3.361PheIle: 3.361 ± 0.052	4.033PheLys: 4.033 ± 0.056	4.824PheLeu: 4.824 ± 0.077	0.98PheMet: 0.98 ± 0.023	3.798PheAsn: 3.798 ± 0.05	1.651PhePro: 1.651 ± 0.032	1.378PheGln: 1.378 ± 0.026	1.897PheArg: 1.897 ± 0.033	4.266PheSer: 4.266 ± 0.05	2.917PheThr: 2.917 ± 0.045	3.098PheVal: 3.098 ± 0.041	0.425PheTrp: 0.425 ± 0.017	2.342PheTyr: 2.342 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	1.665GlyAla: 1.665 ± 0.035	0.665GlyCys: 0.665 ± 0.021	2.778GlyAsp: 2.778 ± 0.042	2.623GlyGlu: 2.623 ± 0.042	2.353GlyPhe: 2.353 ± 0.037	2.363GlyGly: 2.363 ± 0.047	0.941GlyHis: 0.941 ± 0.024	3.021GlyIle: 3.021 ± 0.051	3.433GlyLys: 3.433 ± 0.051	4.145GlyLeu: 4.145 ± 0.069	0.906GlyMet: 0.906 ± 0.023	2.934GlyAsn: 2.934 ± 0.042	1.516GlyPro: 1.516 ± 0.042	1.258GlyGln: 1.258 ± 0.043	1.849GlyArg: 1.849 ± 0.036	3.891GlySer: 3.891 ± 0.056	2.84GlyThr: 2.84 ± 0.058	3.084GlyVal: 3.084 ± 0.05	0.363GlyTrp: 0.363 ± 0.014	2.065GlyTyr: 2.065 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	0.583HisAla: 0.583 ± 0.017	0.34HisCys: 0.34 ± 0.012	1.014HisAsp: 1.014 ± 0.026	1.177HisGlu: 1.177 ± 0.025	1.23HisPhe: 1.23 ± 0.028	0.894HisGly: 0.894 ± 0.023	0.503HisHis: 0.503 ± 0.017	1.515HisIle: 1.515 ± 0.033	1.57HisLys: 1.57 ± 0.029	2.461HisLeu: 2.461 ± 0.04	0.463HisMet: 0.463 ± 0.016	1.483HisAsn: 1.483 ± 0.033	0.985HisPro: 0.985 ± 0.024	0.682HisGln: 0.682 ± 0.02	0.952HisArg: 0.952 ± 0.026	1.912HisSer: 1.912 ± 0.036	1.37HisThr: 1.37 ± 0.033	1.225HisVal: 1.225 ± 0.026	0.19HisTrp: 0.19 ± 0.011	1.048HisTyr: 1.048 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	2.245IleAla: 2.245 ± 0.039	1.228IleCys: 1.228 ± 0.026	3.578IleAsp: 3.578 ± 0.046	3.567IleGlu: 3.567 ± 0.053	3.331IlePhe: 3.331 ± 0.053	2.605IleGly: 2.605 ± 0.045	1.501IleHis: 1.501 ± 0.03	4.673IleIle: 4.673 ± 0.081	5.242IleLys: 5.242 ± 0.066	6.933IleLeu: 6.933 ± 0.079	1.267IleMet: 1.267 ± 0.027	5.076IleAsn: 5.076 ± 0.072	2.913IlePro: 2.913 ± 0.046	2.113IleGln: 2.113 ± 0.043	2.607IleArg: 2.607 ± 0.037	5.716IleSer: 5.716 ± 0.074	3.88IleThr: 3.88 ± 0.054	3.664IleVal: 3.664 ± 0.048	0.677IleTrp: 0.677 ± 0.024	2.836IleTyr: 2.836 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	2.643LysAla: 2.643 ± 0.045	1.521LysCys: 1.521 ± 0.036	4.193LysAsp: 4.193 ± 0.06	4.751LysGlu: 4.751 ± 0.064	4.064LysPhe: 4.064 ± 0.054	2.982LysGly: 2.982 ± 0.047	1.852LysHis: 1.852 ± 0.031	5.407LysIle: 5.407 ± 0.063	5.925LysLys: 5.925 ± 0.082	8.966LysLeu: 8.966 ± 0.089	1.79LysMet: 1.79 ± 0.036	5.242LysAsn: 5.242 ± 0.062	3.03LysPro: 3.03 ± 0.053	2.231LysGln: 2.231 ± 0.038	3.8LysArg: 3.8 ± 0.051	6.795LysSer: 6.795 ± 0.078	4.141LysThr: 4.141 ± 0.052	4.65LysVal: 4.65 ± 0.057	0.654LysTrp: 0.654 ± 0.018	3.656LysTyr: 3.656 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	3.519LeuAla: 3.519 ± 0.049	1.785LeuCys: 1.785 ± 0.031	5.929LeuAsp: 5.929 ± 0.055	6.456LeuGlu: 6.456 ± 0.069	5.221LeuPhe: 5.221 ± 0.072	4.175LeuGly: 4.175 ± 0.054	2.18LeuHis: 2.18 ± 0.042	6.623LeuIle: 6.623 ± 0.086	8.307LeuLys: 8.307 ± 0.081	10.756LeuLeu: 10.756 ± 0.127	2.219LeuMet: 2.219 ± 0.034	7.691LeuAsn: 7.691 ± 0.083	3.384LeuPro: 3.384 ± 0.049	3.158LeuGln: 3.158 ± 0.051	4.289LeuArg: 4.289 ± 0.05	9.098LeuSer: 9.098 ± 0.086	5.727LeuThr: 5.727 ± 0.063	6.175LeuVal: 6.175 ± 0.082	0.798LeuTrp: 0.798 ± 0.023	4.37LeuTyr: 4.37 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	0.934MetAla: 0.934 ± 0.023	0.468MetCys: 0.468 ± 0.018	1.389MetAsp: 1.389 ± 0.032	1.439MetGlu: 1.439 ± 0.029	1.041MetPhe: 1.041 ± 0.026	1.053MetGly: 1.053 ± 0.027	0.305MetHis: 0.305 ± 0.013	1.321MetIle: 1.321 ± 0.031	1.571MetLys: 1.571 ± 0.028	1.856MetLeu: 1.856 ± 0.029	0.471MetMet: 0.471 ± 0.018	1.47MetAsn: 1.47 ± 0.035	0.68MetPro: 0.68 ± 0.022	0.448MetGln: 0.448 ± 0.015	0.84MetArg: 0.84 ± 0.022	1.707MetSer: 1.707 ± 0.035	1.072MetThr: 1.072 ± 0.028	1.286MetVal: 1.286 ± 0.025	0.143MetTrp: 0.143 ± 0.008	0.835MetTyr: 0.835 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.132AsnAla: 2.132 ± 0.037	1.244AsnCys: 1.244 ± 0.029	3.684AsnAsp: 3.684 ± 0.047	4.219AsnGlu: 4.219 ± 0.054	3.61AsnPhe: 3.61 ± 0.053	2.975AsnGly: 2.975 ± 0.042	1.459AsnHis: 1.459 ± 0.031	4.787AsnIle: 4.787 ± 0.067	5.601AsnLys: 5.601 ± 0.067	7.402AsnLeu: 7.402 ± 0.08	1.444AsnMet: 1.444 ± 0.033	5.932AsnAsn: 5.932 ± 0.09	2.805AsnPro: 2.805 ± 0.044	2.196AsnGln: 2.196 ± 0.034	2.616AsnArg: 2.616 ± 0.044	7.204AsnSer: 7.204 ± 0.093	5.058AsnThr: 5.058 ± 0.084	4.401AsnVal: 4.401 ± 0.061	0.569AsnTrp: 0.569 ± 0.018	3.28AsnTyr: 3.28 ± 0.055	0.0AsnXaa: 0.0 ± 0.0
Pro	1.352ProAla: 1.352 ± 0.045	0.464ProCys: 0.464 ± 0.017	2.135ProAsp: 2.135 ± 0.039	3.076ProGlu: 3.076 ± 0.054	1.752ProPhe: 1.752 ± 0.033	1.876ProGly: 1.876 ± 0.047	0.709ProHis: 0.709 ± 0.02	2.442ProIle: 2.442 ± 0.045	3.181ProLys: 3.181 ± 0.057	3.372ProLeu: 3.372 ± 0.048	0.722ProMet: 0.722 ± 0.023	2.823ProAsn: 2.823 ± 0.044	2.052ProPro: 2.052 ± 0.057	1.77ProGln: 1.77 ± 0.068	1.477ProArg: 1.477 ± 0.037	3.281ProSer: 3.281 ± 0.06	2.512ProThr: 2.512 ± 0.055	2.633ProVal: 2.633 ± 0.043	0.28ProTrp: 0.28 ± 0.014	1.545ProTyr: 1.545 ± 0.038	0.001ProXaa: 0.001 ± 0.0
Gln	1.143GlnAla: 1.143 ± 0.029	0.438GlnCys: 0.438 ± 0.016	1.56GlnAsp: 1.56 ± 0.035	1.859GlnGlu: 1.859 ± 0.034	1.587GlnPhe: 1.587 ± 0.032	1.189GlnGly: 1.189 ± 0.038	0.748GlnHis: 0.748 ± 0.022	2.263GlnIle: 2.263 ± 0.04	2.124GlnLys: 2.124 ± 0.035	3.547GlnLeu: 3.547 ± 0.051	0.782GlnMet: 0.782 ± 0.019	2.203GlnAsn: 2.203 ± 0.037	1.908GlnPro: 1.908 ± 0.098	1.514GlnGln: 1.514 ± 0.06	1.248GlnArg: 1.248 ± 0.028	2.488GlnSer: 2.488 ± 0.038	1.838GlnThr: 1.838 ± 0.037	1.782GlnVal: 1.782 ± 0.036	0.232GlnTrp: 0.232 ± 0.012	1.484GlnTyr: 1.484 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	1.501ArgAla: 1.501 ± 0.028	0.747ArgCys: 0.747 ± 0.022	2.359ArgAsp: 2.359 ± 0.047	2.547ArgGlu: 2.547 ± 0.042	2.226ArgPhe: 2.226 ± 0.036	1.861ArgGly: 1.861 ± 0.035	0.899ArgHis: 0.899 ± 0.023	2.944ArgIle: 2.944 ± 0.039	3.232ArgLys: 3.232 ± 0.049	4.29ArgLeu: 4.29 ± 0.048	0.925ArgMet: 0.925 ± 0.022	2.845ArgAsn: 2.845 ± 0.043	1.407ArgPro: 1.407 ± 0.031	1.101ArgGln: 1.101 ± 0.025	2.527ArgArg: 2.527 ± 0.045	3.13ArgSer: 3.13 ± 0.054	2.09ArgThr: 2.09 ± 0.037	2.629ArgVal: 2.629 ± 0.046	0.336ArgTrp: 0.336 ± 0.014	1.794ArgTyr: 1.794 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	2.896SerAla: 2.896 ± 0.044	1.33SerCys: 1.33 ± 0.03	5.639SerAsp: 5.639 ± 0.064	5.734SerGlu: 5.734 ± 0.064	4.132SerPhe: 4.132 ± 0.064	4.465SerGly: 4.465 ± 0.065	1.926SerHis: 1.926 ± 0.039	5.362SerIle: 5.362 ± 0.064	6.817SerLys: 6.817 ± 0.07	8.463SerLeu: 8.463 ± 0.078	1.591SerMet: 1.591 ± 0.029	6.324SerAsn: 6.324 ± 0.07	2.98SerPro: 2.98 ± 0.049	2.988SerGln: 2.988 ± 0.046	3.459SerArg: 3.459 ± 0.057	8.35SerSer: 8.35 ± 0.109	5.185SerThr: 5.185 ± 0.069	5.797SerVal: 5.797 ± 0.085	0.573SerTrp: 0.573 ± 0.018	3.241SerTyr: 3.241 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	2.201ThrAla: 2.201 ± 0.049	0.9ThrCys: 0.9 ± 0.022	3.257ThrAsp: 3.257 ± 0.049	3.538ThrGlu: 3.538 ± 0.046	2.757ThrPhe: 2.757 ± 0.035	2.977ThrGly: 2.977 ± 0.059	1.569ThrHis: 1.569 ± 0.035	3.599ThrIle: 3.599 ± 0.053	4.237ThrLys: 4.237 ± 0.06	5.646ThrLeu: 5.646 ± 0.056	1.069ThrMet: 1.069 ± 0.027	4.409ThrAsn: 4.409 ± 0.067	3.021ThrPro: 3.021 ± 0.079	2.33ThrGln: 2.33 ± 0.052	2.223ThrArg: 2.223 ± 0.038	4.91ThrSer: 4.91 ± 0.061	4.088ThrThr: 4.088 ± 0.09	4.004ThrVal: 4.004 ± 0.058	0.369ThrTrp: 0.369 ± 0.012	1.909ThrTyr: 1.909 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	2.09ValAla: 2.09 ± 0.04	1.04ValCys: 1.04 ± 0.026	4.191ValAsp: 4.191 ± 0.065	4.211ValGlu: 4.211 ± 0.054	2.852ValPhe: 2.852 ± 0.047	2.759ValGly: 2.759 ± 0.045	1.221ValHis: 1.221 ± 0.031	3.852ValIle: 3.852 ± 0.052	5.192ValLys: 5.192 ± 0.061	6.067ValLeu: 6.067 ± 0.071	1.155ValMet: 1.155 ± 0.022	4.694ValAsn: 4.694 ± 0.079	2.578ValPro: 2.578 ± 0.052	1.764ValGln: 1.764 ± 0.039	2.515ValArg: 2.515 ± 0.04	5.018ValSer: 5.018 ± 0.056	3.788ValThr: 3.788 ± 0.073	4.098ValVal: 4.098 ± 0.054	0.655ValTrp: 0.655 ± 0.023	2.606ValTyr: 2.606 ± 0.038	0.001ValXaa: 0.001 ± 0.001
Trp	0.295TrpAla: 0.295 ± 0.012	0.139TrpCys: 0.139 ± 0.01	0.488TrpAsp: 0.488 ± 0.017	0.557TrpGlu: 0.557 ± 0.023	0.348TrpPhe: 0.348 ± 0.014	0.297TrpGly: 0.297 ± 0.014	0.203TrpHis: 0.203 ± 0.01	0.563TrpIle: 0.563 ± 0.018	0.711TrpLys: 0.711 ± 0.028	0.75TrpLeu: 0.75 ± 0.022	0.164TrpMet: 0.164 ± 0.01	0.605TrpAsn: 0.605 ± 0.019	0.235TrpPro: 0.235 ± 0.01	0.193TrpGln: 0.193 ± 0.01	0.395TrpArg: 0.395 ± 0.015	0.669TrpSer: 0.669 ± 0.021	0.466TrpThr: 0.466 ± 0.016	0.482TrpVal: 0.482 ± 0.017	0.071TrpTrp: 0.071 ± 0.007	0.324TrpTyr: 0.324 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.28TyrAla: 1.28 ± 0.028	0.728TyrCys: 0.728 ± 0.024	2.477TyrAsp: 2.477 ± 0.04	2.457TyrGlu: 2.457 ± 0.039	2.161TyrPhe: 2.161 ± 0.043	1.95TyrGly: 1.95 ± 0.036	0.971TyrHis: 0.971 ± 0.027	2.716TyrIle: 2.716 ± 0.046	3.506TyrLys: 3.506 ± 0.051	4.251TyrLeu: 4.251 ± 0.052	0.821TyrMet: 0.821 ± 0.022	3.369TyrAsn: 3.369 ± 0.058	1.563TyrPro: 1.563 ± 0.037	1.479TyrGln: 1.479 ± 0.048	1.883TyrArg: 1.883 ± 0.035	3.692TyrSer: 3.692 ± 0.047	2.471TyrThr: 2.471 ± 0.039	2.499TyrVal: 2.499 ± 0.032	0.327TyrTrp: 0.327 ± 0.015	2.256TyrTyr: 2.256 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4071 proteins (1895349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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