Amino acid dipepetide frequency for Streptococcus phage Javan497

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.041AlaAla: 5.041 ± 0.963
0.413AlaCys: 0.413 ± 0.216
4.876AlaAsp: 4.876 ± 0.658
6.446AlaGlu: 6.446 ± 0.697
2.81AlaPhe: 2.81 ± 0.808
4.132AlaGly: 4.132 ± 0.862
0.661AlaHis: 0.661 ± 0.238
7.189AlaIle: 7.189 ± 0.771
7.189AlaLys: 7.189 ± 0.88
7.685AlaLeu: 7.685 ± 0.948
2.066AlaMet: 2.066 ± 0.501
5.289AlaAsn: 5.289 ± 1.087
1.487AlaPro: 1.487 ± 0.39
3.884AlaGln: 3.884 ± 0.829
3.14AlaArg: 3.14 ± 0.605
5.041AlaSer: 5.041 ± 1.186
5.785AlaThr: 5.785 ± 1.11
4.876AlaVal: 4.876 ± 0.878
0.331AlaTrp: 0.331 ± 0.153
3.14AlaTyr: 3.14 ± 0.603
0.0AlaXaa: 0.0 ± 0.0
Cys
0.165CysAla: 0.165 ± 0.132
0.083CysCys: 0.083 ± 0.095
0.248CysAsp: 0.248 ± 0.151
0.578CysGlu: 0.578 ± 0.269
0.083CysPhe: 0.083 ± 0.095
0.165CysGly: 0.165 ± 0.119
0.083CysHis: 0.083 ± 0.08
0.165CysIle: 0.165 ± 0.132
0.248CysLys: 0.248 ± 0.216
0.661CysLeu: 0.661 ± 0.26
0.165CysMet: 0.165 ± 0.136
0.083CysAsn: 0.083 ± 0.079
0.083CysPro: 0.083 ± 0.073
0.413CysGln: 0.413 ± 0.162
0.331CysArg: 0.331 ± 0.176
0.165CysSer: 0.165 ± 0.149
0.248CysThr: 0.248 ± 0.217
0.413CysVal: 0.413 ± 0.199
0.165CysTrp: 0.165 ± 0.107
0.083CysTyr: 0.083 ± 0.095
0.0CysXaa: 0.0 ± 0.0
Asp
3.884AspAla: 3.884 ± 0.487
0.083AspCys: 0.083 ± 0.091
3.388AspAsp: 3.388 ± 0.565
4.71AspGlu: 4.71 ± 0.831
3.471AspPhe: 3.471 ± 0.673
5.124AspGly: 5.124 ± 0.839
0.413AspHis: 0.413 ± 0.212
4.38AspIle: 4.38 ± 0.661
5.619AspLys: 5.619 ± 0.919
6.033AspLeu: 6.033 ± 0.92
1.735AspMet: 1.735 ± 0.407
3.058AspAsn: 3.058 ± 0.582
1.653AspPro: 1.653 ± 0.434
1.24AspGln: 1.24 ± 0.293
2.644AspArg: 2.644 ± 0.564
3.719AspSer: 3.719 ± 0.687
3.306AspThr: 3.306 ± 0.623
3.223AspVal: 3.223 ± 0.64
0.661AspTrp: 0.661 ± 0.225
3.14AspTyr: 3.14 ± 0.678
0.0AspXaa: 0.0 ± 0.0
Glu
5.289GluAla: 5.289 ± 0.802
0.331GluCys: 0.331 ± 0.169
3.223GluAsp: 3.223 ± 0.578
7.189GluGlu: 7.189 ± 1.029
2.231GluPhe: 2.231 ± 0.484
3.967GluGly: 3.967 ± 0.504
1.157GluHis: 1.157 ± 0.452
4.958GluIle: 4.958 ± 0.604
6.198GluLys: 6.198 ± 0.996
7.768GluLeu: 7.768 ± 1.173
1.653GluMet: 1.653 ± 0.369
3.636GluAsn: 3.636 ± 0.702
1.983GluPro: 1.983 ± 0.362
2.562GluGln: 2.562 ± 0.497
3.884GluArg: 3.884 ± 0.77
3.719GluSer: 3.719 ± 0.528
3.967GluThr: 3.967 ± 0.546
4.049GluVal: 4.049 ± 0.761
0.909GluTrp: 0.909 ± 0.277
3.719GluTyr: 3.719 ± 0.641
0.0GluXaa: 0.0 ± 0.0
Phe
3.471PheAla: 3.471 ± 0.843
0.083PheCys: 0.083 ± 0.085
3.14PheAsp: 3.14 ± 0.434
2.396PheGlu: 2.396 ± 0.437
1.074PhePhe: 1.074 ± 0.37
2.562PheGly: 2.562 ± 0.592
0.165PheHis: 0.165 ± 0.134
2.314PheIle: 2.314 ± 0.567
3.801PheLys: 3.801 ± 0.803
2.479PheLeu: 2.479 ± 0.651
0.496PheMet: 0.496 ± 0.224
2.727PheAsn: 2.727 ± 0.443
0.496PhePro: 0.496 ± 0.184
0.496PheGln: 0.496 ± 0.172
1.487PheArg: 1.487 ± 0.312
2.562PheSer: 2.562 ± 0.439
2.562PheThr: 2.562 ± 0.478
2.479PheVal: 2.479 ± 0.363
0.578PheTrp: 0.578 ± 0.24
1.487PheTyr: 1.487 ± 0.37
0.0PheXaa: 0.0 ± 0.0
Gly
5.206GlyAla: 5.206 ± 0.786
0.248GlyCys: 0.248 ± 0.159
3.553GlyAsp: 3.553 ± 0.594
4.049GlyGlu: 4.049 ± 0.514
2.727GlyPhe: 2.727 ± 0.586
4.545GlyGly: 4.545 ± 0.612
1.074GlyHis: 1.074 ± 0.311
4.876GlyIle: 4.876 ± 1.175
6.942GlyLys: 6.942 ± 0.633
6.528GlyLeu: 6.528 ± 0.983
2.066GlyMet: 2.066 ± 0.411
1.983GlyAsn: 1.983 ± 0.458
0.578GlyPro: 0.578 ± 0.204
2.231GlyGln: 2.231 ± 0.318
2.975GlyArg: 2.975 ± 0.658
2.81GlySer: 2.81 ± 0.503
4.462GlyThr: 4.462 ± 0.685
4.545GlyVal: 4.545 ± 0.587
0.661GlyTrp: 0.661 ± 0.398
2.479GlyTyr: 2.479 ± 0.46
0.0GlyXaa: 0.0 ± 0.0
His
0.992HisAla: 0.992 ± 0.331
0.083HisCys: 0.083 ± 0.087
0.578HisAsp: 0.578 ± 0.251
0.744HisGlu: 0.744 ± 0.223
0.578HisPhe: 0.578 ± 0.258
1.157HisGly: 1.157 ± 0.471
0.496HisHis: 0.496 ± 0.203
0.909HisIle: 0.909 ± 0.284
0.826HisLys: 0.826 ± 0.289
1.405HisLeu: 1.405 ± 0.474
0.165HisMet: 0.165 ± 0.123
0.496HisAsn: 0.496 ± 0.17
0.578HisPro: 0.578 ± 0.26
0.165HisGln: 0.165 ± 0.122
0.578HisArg: 0.578 ± 0.223
0.909HisSer: 0.909 ± 0.302
0.992HisThr: 0.992 ± 0.373
0.331HisVal: 0.331 ± 0.192
0.083HisTrp: 0.083 ± 0.097
0.248HisTyr: 0.248 ± 0.146
0.0HisXaa: 0.0 ± 0.0
Ile
5.206IleAla: 5.206 ± 1.001
0.165IleCys: 0.165 ± 0.114
6.694IleAsp: 6.694 ± 0.806
4.71IleGlu: 4.71 ± 0.903
2.149IlePhe: 2.149 ± 0.394
3.719IleGly: 3.719 ± 0.629
0.578IleHis: 0.578 ± 0.196
4.545IleIle: 4.545 ± 0.91
7.189IleLys: 7.189 ± 0.961
4.793IleLeu: 4.793 ± 0.718
1.24IleMet: 1.24 ± 0.253
4.215IleAsn: 4.215 ± 0.771
2.066IlePro: 2.066 ± 0.379
2.562IleGln: 2.562 ± 0.708
1.983IleArg: 1.983 ± 0.348
4.545IleSer: 4.545 ± 0.793
4.297IleThr: 4.297 ± 0.639
4.876IleVal: 4.876 ± 0.659
0.413IleTrp: 0.413 ± 0.186
3.471IleTyr: 3.471 ± 0.647
0.0IleXaa: 0.0 ± 0.0
Lys
7.189LysAla: 7.189 ± 0.661
0.248LysCys: 0.248 ± 0.138
5.537LysAsp: 5.537 ± 0.835
5.289LysGlu: 5.289 ± 0.753
2.149LysPhe: 2.149 ± 0.47
5.619LysGly: 5.619 ± 0.683
1.322LysHis: 1.322 ± 0.468
7.107LysIle: 7.107 ± 0.848
8.016LysLys: 8.016 ± 1.299
7.272LysLeu: 7.272 ± 1.029
2.479LysMet: 2.479 ± 0.503
5.124LysAsn: 5.124 ± 0.679
2.479LysPro: 2.479 ± 0.512
4.049LysGln: 4.049 ± 0.625
4.297LysArg: 4.297 ± 0.744
4.049LysSer: 4.049 ± 0.476
5.206LysThr: 5.206 ± 0.662
4.462LysVal: 4.462 ± 0.672
1.24LysTrp: 1.24 ± 0.382
3.388LysTyr: 3.388 ± 0.698
0.0LysXaa: 0.0 ± 0.0
Leu
7.603LeuAla: 7.603 ± 0.947
0.165LeuCys: 0.165 ± 0.137
6.198LeuAsp: 6.198 ± 0.661
6.776LeuGlu: 6.776 ± 1.083
2.396LeuPhe: 2.396 ± 0.395
5.702LeuGly: 5.702 ± 0.847
0.496LeuHis: 0.496 ± 0.201
4.71LeuIle: 4.71 ± 0.655
8.264LeuLys: 8.264 ± 1.039
6.446LeuLeu: 6.446 ± 0.823
1.818LeuMet: 1.818 ± 0.513
5.289LeuAsn: 5.289 ± 0.642
3.967LeuPro: 3.967 ± 0.859
3.553LeuGln: 3.553 ± 0.464
4.215LeuArg: 4.215 ± 0.702
6.611LeuSer: 6.611 ± 0.97
4.958LeuThr: 4.958 ± 0.628
5.619LeuVal: 5.619 ± 0.632
0.744LeuTrp: 0.744 ± 0.207
2.396LeuTyr: 2.396 ± 0.545
0.0LeuXaa: 0.0 ± 0.0
Met
2.727MetAla: 2.727 ± 0.729
0.083MetCys: 0.083 ± 0.076
1.24MetAsp: 1.24 ± 0.355
1.57MetGlu: 1.57 ± 0.352
0.992MetPhe: 0.992 ± 0.345
1.24MetGly: 1.24 ± 0.3
0.165MetHis: 0.165 ± 0.124
1.487MetIle: 1.487 ± 0.309
0.992MetLys: 0.992 ± 0.304
2.066MetLeu: 2.066 ± 0.36
0.413MetMet: 0.413 ± 0.227
1.405MetAsn: 1.405 ± 0.408
0.744MetPro: 0.744 ± 0.218
1.24MetGln: 1.24 ± 0.289
1.735MetArg: 1.735 ± 0.442
2.562MetSer: 2.562 ± 0.618
1.487MetThr: 1.487 ± 0.389
0.909MetVal: 0.909 ± 0.319
0.083MetTrp: 0.083 ± 0.072
0.413MetTyr: 0.413 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
4.793AsnAla: 4.793 ± 0.603
0.083AsnCys: 0.083 ± 0.077
2.644AsnAsp: 2.644 ± 0.439
3.14AsnGlu: 3.14 ± 0.698
1.983AsnPhe: 1.983 ± 0.574
3.14AsnGly: 3.14 ± 0.615
0.661AsnHis: 0.661 ± 0.203
4.215AsnIle: 4.215 ± 0.556
4.049AsnLys: 4.049 ± 0.651
4.545AsnLeu: 4.545 ± 0.696
1.074AsnMet: 1.074 ± 0.307
2.314AsnAsn: 2.314 ± 0.557
2.314AsnPro: 2.314 ± 0.489
1.735AsnGln: 1.735 ± 0.381
2.149AsnArg: 2.149 ± 0.361
4.462AsnSer: 4.462 ± 0.913
3.058AsnThr: 3.058 ± 0.47
2.81AsnVal: 2.81 ± 0.508
0.578AsnTrp: 0.578 ± 0.217
2.231AsnTyr: 2.231 ± 0.435
0.0AsnXaa: 0.0 ± 0.0
Pro
1.653ProAla: 1.653 ± 0.364
0.331ProCys: 0.331 ± 0.227
1.157ProAsp: 1.157 ± 0.385
2.644ProGlu: 2.644 ± 0.557
0.744ProPhe: 0.744 ± 0.372
1.901ProGly: 1.901 ± 0.398
0.413ProHis: 0.413 ± 0.24
0.909ProIle: 0.909 ± 0.245
2.479ProLys: 2.479 ± 0.495
1.983ProLeu: 1.983 ± 0.401
0.661ProMet: 0.661 ± 0.284
1.653ProAsn: 1.653 ± 0.414
0.496ProPro: 0.496 ± 0.188
1.735ProGln: 1.735 ± 0.467
1.074ProArg: 1.074 ± 0.358
1.983ProSer: 1.983 ± 0.477
1.57ProThr: 1.57 ± 0.356
2.314ProVal: 2.314 ± 0.547
0.165ProTrp: 0.165 ± 0.144
0.744ProTyr: 0.744 ± 0.333
0.0ProXaa: 0.0 ± 0.0
Gln
3.884GlnAla: 3.884 ± 0.772
0.165GlnCys: 0.165 ± 0.136
1.818GlnAsp: 1.818 ± 0.337
2.892GlnGlu: 2.892 ± 0.582
1.57GlnPhe: 1.57 ± 0.371
2.892GlnGly: 2.892 ± 0.46
0.248GlnHis: 0.248 ± 0.14
3.223GlnIle: 3.223 ± 0.735
2.892GlnLys: 2.892 ± 0.523
3.719GlnLeu: 3.719 ± 0.684
1.322GlnMet: 1.322 ± 0.391
2.562GlnAsn: 2.562 ± 0.55
0.496GlnPro: 0.496 ± 0.217
0.909GlnGln: 0.909 ± 0.321
1.322GlnArg: 1.322 ± 0.271
3.388GlnSer: 3.388 ± 0.756
2.562GlnThr: 2.562 ± 0.443
1.157GlnVal: 1.157 ± 0.245
0.413GlnTrp: 0.413 ± 0.231
1.24GlnTyr: 1.24 ± 0.375
0.0GlnXaa: 0.0 ± 0.0
Arg
3.14ArgAla: 3.14 ± 0.588
0.578ArgCys: 0.578 ± 0.191
2.066ArgAsp: 2.066 ± 0.514
3.14ArgGlu: 3.14 ± 0.489
2.314ArgPhe: 2.314 ± 0.474
1.818ArgGly: 1.818 ± 0.384
0.661ArgHis: 0.661 ± 0.247
3.14ArgIle: 3.14 ± 0.412
3.14ArgLys: 3.14 ± 0.617
5.95ArgLeu: 5.95 ± 0.947
1.735ArgMet: 1.735 ± 0.384
2.066ArgAsn: 2.066 ± 0.465
0.744ArgPro: 0.744 ± 0.213
1.57ArgGln: 1.57 ± 0.383
1.735ArgArg: 1.735 ± 0.41
2.231ArgSer: 2.231 ± 0.477
2.975ArgThr: 2.975 ± 0.734
2.479ArgVal: 2.479 ± 0.518
0.496ArgTrp: 0.496 ± 0.213
1.405ArgTyr: 1.405 ± 0.372
0.0ArgXaa: 0.0 ± 0.0
Ser
6.859SerAla: 6.859 ± 1.757
0.331SerCys: 0.331 ± 0.172
3.306SerAsp: 3.306 ± 0.621
4.049SerGlu: 4.049 ± 0.59
2.149SerPhe: 2.149 ± 0.523
5.371SerGly: 5.371 ± 0.939
0.992SerHis: 0.992 ± 0.457
4.38SerIle: 4.38 ± 0.781
5.124SerLys: 5.124 ± 0.669
5.537SerLeu: 5.537 ± 1.686
1.157SerMet: 1.157 ± 0.507
2.644SerAsn: 2.644 ± 0.525
1.487SerPro: 1.487 ± 0.353
2.396SerGln: 2.396 ± 0.594
2.644SerArg: 2.644 ± 0.505
5.371SerSer: 5.371 ± 1.814
3.719SerThr: 3.719 ± 0.853
4.958SerVal: 4.958 ± 0.84
0.661SerTrp: 0.661 ± 0.287
2.479SerTyr: 2.479 ± 0.494
0.0SerXaa: 0.0 ± 0.0
Thr
5.206ThrAla: 5.206 ± 0.757
0.248ThrCys: 0.248 ± 0.172
3.967ThrAsp: 3.967 ± 0.716
3.553ThrGlu: 3.553 ± 0.602
3.058ThrPhe: 3.058 ± 0.618
4.958ThrGly: 4.958 ± 0.78
0.826ThrHis: 0.826 ± 0.305
4.132ThrIle: 4.132 ± 0.641
4.876ThrLys: 4.876 ± 0.57
4.876ThrLeu: 4.876 ± 0.606
1.24ThrMet: 1.24 ± 0.352
1.983ThrAsn: 1.983 ± 0.405
1.735ThrPro: 1.735 ± 0.415
2.727ThrGln: 2.727 ± 0.544
2.231ThrArg: 2.231 ± 0.451
4.297ThrSer: 4.297 ± 1.646
4.958ThrThr: 4.958 ± 0.912
5.041ThrVal: 5.041 ± 0.729
0.661ThrTrp: 0.661 ± 0.345
2.562ThrTyr: 2.562 ± 0.455
0.0ThrXaa: 0.0 ± 0.0
Val
5.289ValAla: 5.289 ± 0.578
0.165ValCys: 0.165 ± 0.132
4.132ValAsp: 4.132 ± 0.624
4.628ValGlu: 4.628 ± 0.771
2.396ValPhe: 2.396 ± 0.485
3.719ValGly: 3.719 ± 0.66
1.24ValHis: 1.24 ± 0.332
4.38ValIle: 4.38 ± 0.513
4.462ValLys: 4.462 ± 0.553
4.297ValLeu: 4.297 ± 0.724
1.653ValMet: 1.653 ± 0.45
2.975ValAsn: 2.975 ± 0.487
1.653ValPro: 1.653 ± 0.481
2.562ValGln: 2.562 ± 0.719
2.644ValArg: 2.644 ± 0.458
4.38ValSer: 4.38 ± 0.874
4.132ValThr: 4.132 ± 0.611
4.297ValVal: 4.297 ± 0.584
0.248ValTrp: 0.248 ± 0.148
2.231ValTyr: 2.231 ± 0.595
0.0ValXaa: 0.0 ± 0.0
Trp
0.661TrpAla: 0.661 ± 0.243
0.0TrpCys: 0.0 ± 0.0
0.744TrpAsp: 0.744 ± 0.172
1.074TrpGlu: 1.074 ± 0.292
0.661TrpPhe: 0.661 ± 0.24
0.744TrpGly: 0.744 ± 0.297
0.165TrpHis: 0.165 ± 0.105
0.578TrpIle: 0.578 ± 0.185
0.578TrpLys: 0.578 ± 0.203
0.661TrpLeu: 0.661 ± 0.271
0.0TrpMet: 0.0 ± 0.0
0.578TrpAsn: 0.578 ± 0.195
0.661TrpPro: 0.661 ± 0.293
0.496TrpGln: 0.496 ± 0.247
0.413TrpArg: 0.413 ± 0.245
0.413TrpSer: 0.413 ± 0.171
0.331TrpThr: 0.331 ± 0.293
0.578TrpVal: 0.578 ± 0.316
0.0TrpTrp: 0.0 ± 0.0
0.083TrpTyr: 0.083 ± 0.079
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.223TyrAla: 3.223 ± 0.417
0.744TyrCys: 0.744 ± 0.289
2.975TyrAsp: 2.975 ± 0.7
2.81TyrGlu: 2.81 ± 0.506
1.322TyrPhe: 1.322 ± 0.341
2.066TyrGly: 2.066 ± 0.454
0.496TyrHis: 0.496 ± 0.211
1.901TyrIle: 1.901 ± 0.434
3.636TyrLys: 3.636 ± 0.785
3.223TyrLeu: 3.223 ± 0.628
0.331TyrMet: 0.331 ± 0.148
1.901TyrAsn: 1.901 ± 0.539
0.909TyrPro: 0.909 ± 0.35
2.149TyrGln: 2.149 ± 0.446
1.901TyrArg: 1.901 ± 0.489
2.396TyrSer: 2.396 ± 0.446
2.562TyrThr: 2.562 ± 0.464
2.066TyrVal: 2.066 ± 0.557
0.331TyrTrp: 0.331 ± 0.162
1.653TyrTyr: 1.653 ± 0.45
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 50 proteins (12102 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski