Amino acid dipepetide frequency for Sporomusa sphaeroides DSM 2875

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.513AlaAla: 12.513 ± 0.163	1.214AlaCys: 1.214 ± 0.033	4.907AlaAsp: 4.907 ± 0.068	6.339AlaGlu: 6.339 ± 0.072	3.388AlaPhe: 3.388 ± 0.054	9.173AlaGly: 9.173 ± 0.113	1.46AlaHis: 1.46 ± 0.032	6.67AlaIle: 6.67 ± 0.069	5.458AlaLys: 5.458 ± 0.072	9.008AlaLeu: 9.008 ± 0.095	2.74AlaMet: 2.74 ± 0.051	3.381AlaAsn: 3.381 ± 0.057	2.773AlaPro: 2.773 ± 0.052	3.391AlaGln: 3.391 ± 0.053	4.271AlaArg: 4.271 ± 0.066	4.291AlaSer: 4.291 ± 0.054	4.575AlaThr: 4.575 ± 0.125	8.522AlaVal: 8.522 ± 0.083	0.834AlaTrp: 0.834 ± 0.029	2.667AlaTyr: 2.667 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.887CysAla: 0.887 ± 0.025	0.25CysCys: 0.25 ± 0.014	0.548CysAsp: 0.548 ± 0.022	0.587CysGlu: 0.587 ± 0.02	0.476CysPhe: 0.476 ± 0.017	1.318CysGly: 1.318 ± 0.035	0.301CysHis: 0.301 ± 0.014	0.797CysIle: 0.797 ± 0.025	0.584CysLys: 0.584 ± 0.024	1.168CysLeu: 1.168 ± 0.031	0.314CysMet: 0.314 ± 0.014	0.45CysAsn: 0.45 ± 0.019	0.724CysPro: 0.724 ± 0.027	0.547CysGln: 0.547 ± 0.019	0.781CysArg: 0.781 ± 0.023	0.732CysSer: 0.732 ± 0.022	0.596CysThr: 0.596 ± 0.021	0.726CysVal: 0.726 ± 0.026	0.125CysTrp: 0.125 ± 0.009	0.418CysTyr: 0.418 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.877AspAla: 3.877 ± 0.055	0.631AspCys: 0.631 ± 0.022	2.108AspAsp: 2.108 ± 0.044	3.089AspGlu: 3.089 ± 0.05	2.086AspPhe: 2.086 ± 0.042	3.48AspGly: 3.48 ± 0.066	0.763AspHis: 0.763 ± 0.024	4.373AspIle: 4.373 ± 0.063	3.339AspLys: 3.339 ± 0.052	4.31AspLeu: 4.31 ± 0.07	1.396AspMet: 1.396 ± 0.037	2.164AspAsn: 2.164 ± 0.049	1.811AspPro: 1.811 ± 0.036	1.425AspGln: 1.425 ± 0.033	2.44AspArg: 2.44 ± 0.04	2.603AspSer: 2.603 ± 0.042	2.707AspThr: 2.707 ± 0.043	3.357AspVal: 3.357 ± 0.057	0.59AspTrp: 0.59 ± 0.02	1.957AspTyr: 1.957 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.812GluAla: 5.812 ± 0.075	0.636GluCys: 0.636 ± 0.024	2.631GluAsp: 2.631 ± 0.045	4.187GluGlu: 4.187 ± 0.064	2.243GluPhe: 2.243 ± 0.043	3.287GluGly: 3.287 ± 0.05	1.238GluHis: 1.238 ± 0.032	4.718GluIle: 4.718 ± 0.065	4.137GluLys: 4.137 ± 0.055	6.842GluLeu: 6.842 ± 0.088	1.814GluMet: 1.814 ± 0.037	2.563GluAsn: 2.563 ± 0.036	1.966GluPro: 1.966 ± 0.037	3.471GluGln: 3.471 ± 0.054	3.371GluArg: 3.371 ± 0.057	2.516GluSer: 2.516 ± 0.042	3.258GluThr: 3.258 ± 0.047	4.337GluVal: 4.337 ± 0.06	0.582GluTrp: 0.582 ± 0.02	2.126GluTyr: 2.126 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.537PheAla: 3.537 ± 0.056	0.57PheCys: 0.57 ± 0.019	2.052PheAsp: 2.052 ± 0.036	1.851PheGlu: 1.851 ± 0.033	1.668PhePhe: 1.668 ± 0.045	3.124PheGly: 3.124 ± 0.049	0.648PheHis: 0.648 ± 0.02	2.737PheIle: 2.737 ± 0.048	1.762PheLys: 1.762 ± 0.04	3.567PheLeu: 3.567 ± 0.06	0.977PheMet: 0.977 ± 0.028	1.553PheAsn: 1.553 ± 0.036	1.375PhePro: 1.375 ± 0.035	1.107PheGln: 1.107 ± 0.031	1.678PheArg: 1.678 ± 0.036	2.672PheSer: 2.672 ± 0.047	2.392PheThr: 2.392 ± 0.045	2.668PheVal: 2.668 ± 0.051	0.464PheTrp: 0.464 ± 0.02	1.26PheTyr: 1.26 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.45GlyAla: 6.45 ± 0.15	1.12GlyCys: 1.12 ± 0.036	3.316GlyAsp: 3.316 ± 0.061	4.36GlyGlu: 4.36 ± 0.06	3.035GlyPhe: 3.035 ± 0.051	5.871GlyGly: 5.871 ± 0.106	1.425GlyHis: 1.425 ± 0.032	6.219GlyIle: 6.219 ± 0.069	4.991GlyLys: 4.991 ± 0.063	7.474GlyLeu: 7.474 ± 0.083	2.432GlyMet: 2.432 ± 0.046	2.921GlyAsn: 2.921 ± 0.061	2.019GlyPro: 2.019 ± 0.054	3.136GlyGln: 3.136 ± 0.04	3.769GlyArg: 3.769 ± 0.056	4.37GlySer: 4.37 ± 0.075	4.493GlyThr: 4.493 ± 0.077	5.502GlyVal: 5.502 ± 0.076	0.81GlyTrp: 0.81 ± 0.025	2.958GlyTyr: 2.958 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.467HisAla: 1.467 ± 0.03	0.309HisCys: 0.309 ± 0.016	0.88HisAsp: 0.88 ± 0.025	0.993HisGlu: 0.993 ± 0.027	0.767HisPhe: 0.767 ± 0.024	1.357HisGly: 1.357 ± 0.03	0.465HisHis: 0.465 ± 0.021	1.412HisIle: 1.412 ± 0.032	0.923HisLys: 0.923 ± 0.028	1.67HisLeu: 1.67 ± 0.035	0.479HisMet: 0.479 ± 0.019	0.797HisAsn: 0.797 ± 0.025	0.919HisPro: 0.919 ± 0.025	0.661HisGln: 0.661 ± 0.021	0.893HisArg: 0.893 ± 0.022	1.101HisSer: 1.101 ± 0.032	1.085HisThr: 1.085 ± 0.026	1.157HisVal: 1.157 ± 0.029	0.232HisTrp: 0.232 ± 0.013	0.711HisTyr: 0.711 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.254IleAla: 7.254 ± 0.071	0.865IleCys: 0.865 ± 0.026	4.01IleAsp: 4.01 ± 0.058	4.229IleGlu: 4.229 ± 0.062	2.481IlePhe: 2.481 ± 0.052	5.479IleGly: 5.479 ± 0.067	1.32IleHis: 1.32 ± 0.03	5.438IleIle: 5.438 ± 0.074	3.992IleLys: 3.992 ± 0.066	6.395IleLeu: 6.395 ± 0.074	1.781IleMet: 1.781 ± 0.035	3.022IleAsn: 3.022 ± 0.054	3.355IlePro: 3.355 ± 0.049	2.185IleGln: 2.185 ± 0.044	3.224IleArg: 3.224 ± 0.051	4.299IleSer: 4.299 ± 0.055	4.584IleThr: 4.584 ± 0.069	5.36IleVal: 5.36 ± 0.071	0.551IleTrp: 0.551 ± 0.022	2.076IleTyr: 2.076 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.219LysAla: 5.219 ± 0.063	0.496LysCys: 0.496 ± 0.022	2.655LysAsp: 2.655 ± 0.047	3.941LysGlu: 3.941 ± 0.066	1.675LysPhe: 1.675 ± 0.038	3.271LysGly: 3.271 ± 0.051	1.071LysHis: 1.071 ± 0.026	4.04LysIle: 4.04 ± 0.059	3.519LysLys: 3.519 ± 0.069	5.72LysLeu: 5.72 ± 0.072	1.628LysMet: 1.628 ± 0.036	2.533LysAsn: 2.533 ± 0.043	2.415LysPro: 2.415 ± 0.046	2.59LysGln: 2.59 ± 0.039	2.507LysArg: 2.507 ± 0.047	2.681LysSer: 2.681 ± 0.051	3.276LysThr: 3.276 ± 0.052	4.192LysVal: 4.192 ± 0.059	0.515LysTrp: 0.515 ± 0.02	1.864LysTyr: 1.864 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	11.199LeuAla: 11.199 ± 0.105	1.197LeuCys: 1.197 ± 0.03	4.828LeuAsp: 4.828 ± 0.058	5.802LeuGlu: 5.802 ± 0.073	3.749LeuPhe: 3.749 ± 0.057	7.323LeuGly: 7.323 ± 0.084	1.762LeuHis: 1.762 ± 0.034	6.1LeuIle: 6.1 ± 0.083	5.327LeuLys: 5.327 ± 0.071	10.455LeuLeu: 10.455 ± 0.13	2.361LeuMet: 2.361 ± 0.05	3.727LeuAsn: 3.727 ± 0.052	4.695LeuPro: 4.695 ± 0.076	3.551LeuGln: 3.551 ± 0.052	4.461LeuArg: 4.461 ± 0.054	6.075LeuSer: 6.075 ± 0.076	6.393LeuThr: 6.393 ± 0.075	6.968LeuVal: 6.968 ± 0.084	0.861LeuTrp: 0.861 ± 0.025	2.796LeuTyr: 2.796 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.785MetAla: 2.785 ± 0.049	0.243MetCys: 0.243 ± 0.014	1.285MetAsp: 1.285 ± 0.034	1.673MetGlu: 1.673 ± 0.037	0.847MetPhe: 0.847 ± 0.024	1.955MetGly: 1.955 ± 0.043	0.426MetHis: 0.426 ± 0.015	1.687MetIle: 1.687 ± 0.037	1.525MetLys: 1.525 ± 0.032	2.942MetLeu: 2.942 ± 0.059	0.671MetMet: 0.671 ± 0.024	1.174MetAsn: 1.174 ± 0.027	1.268MetPro: 1.268 ± 0.028	1.057MetGln: 1.057 ± 0.027	1.259MetArg: 1.259 ± 0.033	1.656MetSer: 1.656 ± 0.039	1.513MetThr: 1.513 ± 0.034	1.959MetVal: 1.959 ± 0.036	0.189MetTrp: 0.189 ± 0.012	0.681MetTyr: 0.681 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.193AsnAla: 3.193 ± 0.065	0.516AsnCys: 0.516 ± 0.02	1.705AsnAsp: 1.705 ± 0.035	2.033AsnGlu: 2.033 ± 0.041	1.498AsnPhe: 1.498 ± 0.035	2.78AsnGly: 2.78 ± 0.058	0.746AsnHis: 0.746 ± 0.024	3.249AsnIle: 3.249 ± 0.056	2.321AsnLys: 2.321 ± 0.039	3.796AsnLeu: 3.796 ± 0.055	1.105AsnMet: 1.105 ± 0.026	1.767AsnAsn: 1.767 ± 0.053	2.081AsnPro: 2.081 ± 0.039	1.56AsnGln: 1.56 ± 0.036	1.965AsnArg: 1.965 ± 0.038	2.26AsnSer: 2.26 ± 0.047	2.302AsnThr: 2.302 ± 0.052	2.589AsnVal: 2.589 ± 0.055	0.449AsnTrp: 0.449 ± 0.02	1.469AsnTyr: 1.469 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.156ProAla: 4.156 ± 0.064	0.476ProCys: 0.476 ± 0.019	2.435ProAsp: 2.435 ± 0.046	3.334ProGlu: 3.334 ± 0.053	1.552ProPhe: 1.552 ± 0.037	3.482ProGly: 3.482 ± 0.056	0.79ProHis: 0.79 ± 0.024	2.218ProIle: 2.218 ± 0.042	1.715ProLys: 1.715 ± 0.037	3.831ProLeu: 3.831 ± 0.062	0.867ProMet: 0.867 ± 0.024	1.263ProAsn: 1.263 ± 0.029	1.518ProPro: 1.518 ± 0.043	1.482ProGln: 1.482 ± 0.033	1.48ProArg: 1.48 ± 0.033	1.781ProSer: 1.781 ± 0.04	1.804ProThr: 1.804 ± 0.047	3.912ProVal: 3.912 ± 0.065	0.426ProTrp: 0.426 ± 0.017	1.301ProTyr: 1.301 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.634GlnAla: 4.634 ± 0.075	0.386GlnCys: 0.386 ± 0.015	1.842GlnAsp: 1.842 ± 0.035	2.829GlnGlu: 2.829 ± 0.05	1.222GlnPhe: 1.222 ± 0.028	2.76GlnGly: 2.76 ± 0.044	0.714GlnHis: 0.714 ± 0.023	2.524GlnIle: 2.524 ± 0.044	2.037GlnLys: 2.037 ± 0.045	3.873GlnLeu: 3.873 ± 0.048	1.061GlnMet: 1.061 ± 0.029	1.435GlnAsn: 1.435 ± 0.036	1.601GlnPro: 1.601 ± 0.032	2.049GlnGln: 2.049 ± 0.053	1.701GlnArg: 1.701 ± 0.037	1.975GlnSer: 1.975 ± 0.044	2.121GlnThr: 2.121 ± 0.035	2.899GlnVal: 2.899 ± 0.037	0.349GlnTrp: 0.349 ± 0.017	1.285GlnTyr: 1.285 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.377ArgAla: 3.377 ± 0.048	0.556ArgCys: 0.556 ± 0.021	2.264ArgAsp: 2.264 ± 0.037	3.644ArgGlu: 3.644 ± 0.056	1.818ArgPhe: 1.818 ± 0.038	2.897ArgGly: 2.897 ± 0.047	1.01ArgHis: 1.01 ± 0.027	3.414ArgIle: 3.414 ± 0.05	2.686ArgLys: 2.686 ± 0.053	5.311ArgLeu: 5.311 ± 0.072	1.376ArgMet: 1.376 ± 0.031	1.818ArgAsn: 1.818 ± 0.036	1.825ArgPro: 1.825 ± 0.038	2.816ArgGln: 2.816 ± 0.049	2.639ArgArg: 2.639 ± 0.051	2.255ArgSer: 2.255 ± 0.039	2.358ArgThr: 2.358 ± 0.044	3.153ArgVal: 3.153 ± 0.044	0.485ArgTrp: 0.485 ± 0.021	1.713ArgTyr: 1.713 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.651SerAla: 4.651 ± 0.056	0.673SerCys: 0.673 ± 0.026	2.449SerAsp: 2.449 ± 0.042	2.81SerGlu: 2.81 ± 0.048	2.275SerPhe: 2.275 ± 0.042	4.945SerGly: 4.945 ± 0.085	1.086SerHis: 1.086 ± 0.029	3.828SerIle: 3.828 ± 0.059	2.696SerLys: 2.696 ± 0.047	5.767SerLeu: 5.767 ± 0.067	1.459SerMet: 1.459 ± 0.034	1.864SerAsn: 1.864 ± 0.044	2.23SerPro: 2.23 ± 0.038	2.199SerGln: 2.199 ± 0.043	2.869SerArg: 2.869 ± 0.044	3.102SerSer: 3.102 ± 0.052	2.798SerThr: 2.798 ± 0.045	3.87SerVal: 3.87 ± 0.062	0.611SerTrp: 0.611 ± 0.02	1.884SerTyr: 1.884 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.134ThrAla: 6.134 ± 0.088	0.628ThrCys: 0.628 ± 0.023	2.649ThrAsp: 2.649 ± 0.047	3.072ThrGlu: 3.072 ± 0.051	1.969ThrPhe: 1.969 ± 0.042	5.781ThrGly: 5.781 ± 0.177	0.951ThrHis: 0.951 ± 0.024	4.156ThrIle: 4.156 ± 0.063	2.571ThrLys: 2.571 ± 0.042	5.434ThrLeu: 5.434 ± 0.063	1.385ThrMet: 1.385 ± 0.029	2.03ThrAsn: 2.03 ± 0.047	2.577ThrPro: 2.577 ± 0.045	1.736ThrGln: 1.736 ± 0.039	2.225ThrArg: 2.225 ± 0.039	2.701ThrSer: 2.701 ± 0.051	3.121ThrThr: 3.121 ± 0.058	4.985ThrVal: 4.985 ± 0.077	0.473ThrTrp: 0.473 ± 0.021	1.636ThrTyr: 1.636 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.148ValAla: 7.148 ± 0.075	0.948ValCys: 0.948 ± 0.027	3.761ValAsp: 3.761 ± 0.054	4.464ValGlu: 4.464 ± 0.055	3.029ValPhe: 3.029 ± 0.054	5.077ValGly: 5.077 ± 0.076	1.183ValHis: 1.183 ± 0.028	5.584ValIle: 5.584 ± 0.082	4.159ValLys: 4.159 ± 0.061	7.517ValLeu: 7.517 ± 0.084	2.018ValMet: 2.018 ± 0.046	3.147ValAsn: 3.147 ± 0.068	2.883ValPro: 2.883 ± 0.052	2.288ValGln: 2.288 ± 0.045	3.481ValArg: 3.481 ± 0.051	4.534ValSer: 4.534 ± 0.058	4.604ValThr: 4.604 ± 0.075	5.723ValVal: 5.723 ± 0.09	0.67ValTrp: 0.67 ± 0.022	2.291ValTyr: 2.291 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.697TrpAla: 0.697 ± 0.024	0.105TrpCys: 0.105 ± 0.009	0.48TrpAsp: 0.48 ± 0.016	0.606TrpGlu: 0.606 ± 0.021	0.413TrpPhe: 0.413 ± 0.017	0.73TrpGly: 0.73 ± 0.026	0.218TrpHis: 0.218 ± 0.012	0.539TrpIle: 0.539 ± 0.021	0.458TrpLys: 0.458 ± 0.019	1.256TrpLeu: 1.256 ± 0.033	0.241TrpMet: 0.241 ± 0.013	0.391TrpAsn: 0.391 ± 0.017	0.374TrpPro: 0.374 ± 0.019	0.615TrpGln: 0.615 ± 0.021	0.539TrpArg: 0.539 ± 0.022	0.549TrpSer: 0.549 ± 0.022	0.439TrpThr: 0.439 ± 0.018	0.631TrpVal: 0.631 ± 0.022	0.136TrpTrp: 0.136 ± 0.009	0.307TrpTyr: 0.307 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.584TyrAla: 2.584 ± 0.046	0.509TyrCys: 0.509 ± 0.022	1.699TyrAsp: 1.699 ± 0.039	1.89TyrGlu: 1.89 ± 0.034	1.471TyrPhe: 1.471 ± 0.035	2.58TyrGly: 2.58 ± 0.041	0.704TyrHis: 0.704 ± 0.024	2.198TyrIle: 2.198 ± 0.042	1.608TyrLys: 1.608 ± 0.039	3.298TyrLeu: 3.298 ± 0.051	0.69TyrMet: 0.69 ± 0.022	1.382TyrAsn: 1.382 ± 0.034	1.415TyrPro: 1.415 ± 0.031	1.43TyrGln: 1.43 ± 0.032	1.863TyrArg: 1.863 ± 0.039	1.912TyrSer: 1.912 ± 0.038	1.795TyrThr: 1.795 ± 0.043	1.999TyrVal: 1.999 ± 0.04	0.373TyrTrp: 0.373 ± 0.018	1.27TyrTyr: 1.27 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4565 proteins (1425425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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