Amino acid dipepetide frequency for Streptococcus phage Javan436

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.768AlaAla: 2.768 ± 0.854
0.83AlaCys: 0.83 ± 0.537
4.428AlaAsp: 4.428 ± 1.386
6.919AlaGlu: 6.919 ± 1.257
2.768AlaPhe: 2.768 ± 0.75
2.214AlaGly: 2.214 ± 0.542
0.277AlaHis: 0.277 ± 0.279
4.705AlaIle: 4.705 ± 1.295
6.366AlaLys: 6.366 ± 1.305
6.643AlaLeu: 6.643 ± 1.542
1.937AlaMet: 1.937 ± 0.79
3.045AlaAsn: 3.045 ± 1.021
0.83AlaPro: 0.83 ± 0.457
3.045AlaGln: 3.045 ± 1.047
1.661AlaArg: 1.661 ± 0.706
2.214AlaSer: 2.214 ± 0.626
3.321AlaThr: 3.321 ± 0.679
5.812AlaVal: 5.812 ± 1.867
0.83AlaTrp: 0.83 ± 0.534
2.214AlaTyr: 2.214 ± 0.762
0.0AlaXaa: 0.0 ± 0.0
Cys
0.277CysAla: 0.277 ± 0.344
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
1.107CysGlu: 1.107 ± 0.572
0.0CysPhe: 0.0 ± 0.0
0.554CysGly: 0.554 ± 0.429
0.277CysHis: 0.277 ± 0.344
0.0CysIle: 0.0 ± 0.0
1.384CysLys: 1.384 ± 0.671
1.107CysLeu: 1.107 ± 0.543
0.277CysMet: 0.277 ± 0.301
0.277CysAsn: 0.277 ± 0.286
0.0CysPro: 0.0 ± 0.0
0.277CysGln: 0.277 ± 0.237
1.384CysArg: 1.384 ± 0.619
0.277CysSer: 0.277 ± 0.272
0.277CysThr: 0.277 ± 0.279
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.277CysTyr: 0.277 ± 0.25
0.0CysXaa: 0.0 ± 0.0
Asp
2.768AspAla: 2.768 ± 1.001
0.277AspCys: 0.277 ± 0.25
2.214AspAsp: 2.214 ± 0.712
4.705AspGlu: 4.705 ± 0.908
3.045AspPhe: 3.045 ± 0.928
4.152AspGly: 4.152 ± 1.835
1.107AspHis: 1.107 ± 0.448
5.259AspIle: 5.259 ± 1.437
7.473AspLys: 7.473 ± 1.474
4.982AspLeu: 4.982 ± 1.104
1.937AspMet: 1.937 ± 0.754
4.152AspAsn: 4.152 ± 0.822
1.661AspPro: 1.661 ± 0.547
0.83AspGln: 0.83 ± 0.422
1.937AspArg: 1.937 ± 0.769
2.768AspSer: 2.768 ± 0.932
3.598AspThr: 3.598 ± 1.484
3.321AspVal: 3.321 ± 0.847
0.554AspTrp: 0.554 ± 0.383
4.705AspTyr: 4.705 ± 1.291
0.0AspXaa: 0.0 ± 0.0
Glu
4.705GluAla: 4.705 ± 0.896
0.277GluCys: 0.277 ± 0.305
4.982GluAsp: 4.982 ± 1.154
5.812GluGlu: 5.812 ± 1.306
4.152GluPhe: 4.152 ± 1.016
2.214GluGly: 2.214 ± 0.985
0.277GluHis: 0.277 ± 0.237
6.089GluIle: 6.089 ± 1.276
7.473GluLys: 7.473 ± 1.739
9.964GluLeu: 9.964 ± 1.973
3.875GluMet: 3.875 ± 1.094
5.259GluAsn: 5.259 ± 1.066
1.937GluPro: 1.937 ± 1.1
5.812GluGln: 5.812 ± 1.201
3.875GluArg: 3.875 ± 1.243
5.259GluSer: 5.259 ± 1.428
2.768GluThr: 2.768 ± 0.992
5.259GluVal: 5.259 ± 1.478
1.384GluTrp: 1.384 ± 0.743
1.937GluTyr: 1.937 ± 0.608
0.0GluXaa: 0.0 ± 0.0
Phe
2.768PheAla: 2.768 ± 0.798
0.554PheCys: 0.554 ± 0.292
1.661PheAsp: 1.661 ± 0.903
3.875PheGlu: 3.875 ± 0.956
1.384PhePhe: 1.384 ± 0.598
2.491PheGly: 2.491 ± 0.674
0.554PheHis: 0.554 ± 0.356
3.321PheIle: 3.321 ± 0.899
3.598PheLys: 3.598 ± 0.7
3.875PheLeu: 3.875 ± 1.035
1.661PheMet: 1.661 ± 0.665
1.937PheAsn: 1.937 ± 0.682
0.83PhePro: 0.83 ± 0.435
1.661PheGln: 1.661 ± 0.784
1.937PheArg: 1.937 ± 0.693
3.598PheSer: 3.598 ± 0.829
2.768PheThr: 2.768 ± 0.714
1.661PheVal: 1.661 ± 0.624
0.0PheTrp: 0.0 ± 0.0
0.83PheTyr: 0.83 ± 0.495
0.0PheXaa: 0.0 ± 0.0
Gly
3.598GlyAla: 3.598 ± 1.128
0.277GlyCys: 0.277 ± 0.279
2.214GlyAsp: 2.214 ± 1.108
3.045GlyGlu: 3.045 ± 0.704
4.152GlyPhe: 4.152 ± 0.816
3.321GlyGly: 3.321 ± 0.943
0.554GlyHis: 0.554 ± 0.329
4.152GlyIle: 4.152 ± 1.103
4.152GlyLys: 4.152 ± 0.795
4.428GlyLeu: 4.428 ± 1.158
1.661GlyMet: 1.661 ± 1.028
2.768GlyAsn: 2.768 ± 1.202
0.277GlyPro: 0.277 ± 0.279
1.384GlyGln: 1.384 ± 0.654
3.321GlyArg: 3.321 ± 0.993
1.937GlySer: 1.937 ± 0.832
1.937GlyThr: 1.937 ± 0.983
3.598GlyVal: 3.598 ± 0.845
1.661GlyTrp: 1.661 ± 1.06
4.428GlyTyr: 4.428 ± 1.102
0.0GlyXaa: 0.0 ± 0.0
His
1.384HisAla: 1.384 ± 0.568
0.277HisCys: 0.277 ± 0.25
0.554HisAsp: 0.554 ± 0.373
1.384HisGlu: 1.384 ± 0.552
0.554HisPhe: 0.554 ± 0.338
1.384HisGly: 1.384 ± 0.493
0.277HisHis: 0.277 ± 0.309
1.661HisIle: 1.661 ± 0.673
1.107HisLys: 1.107 ± 0.525
1.384HisLeu: 1.384 ± 0.605
0.0HisMet: 0.0 ± 0.0
0.83HisAsn: 0.83 ± 0.41
0.83HisPro: 0.83 ± 0.467
0.83HisGln: 0.83 ± 0.477
0.554HisArg: 0.554 ± 0.326
1.107HisSer: 1.107 ± 1.117
1.107HisThr: 1.107 ± 0.442
1.107HisVal: 1.107 ± 0.657
0.554HisTrp: 0.554 ± 0.436
1.107HisTyr: 1.107 ± 0.392
0.0HisXaa: 0.0 ± 0.0
Ile
6.643IleAla: 6.643 ± 1.704
1.107IleCys: 1.107 ± 0.642
5.536IleAsp: 5.536 ± 1.375
6.366IleGlu: 6.366 ± 1.649
2.214IlePhe: 2.214 ± 0.81
3.598IleGly: 3.598 ± 0.989
0.83IleHis: 0.83 ± 0.44
5.812IleIle: 5.812 ± 1.355
5.812IleLys: 5.812 ± 1.413
6.366IleLeu: 6.366 ± 1.129
1.107IleMet: 1.107 ± 0.481
3.875IleAsn: 3.875 ± 0.975
1.107IlePro: 1.107 ± 0.463
3.321IleGln: 3.321 ± 0.773
2.768IleArg: 2.768 ± 1.01
5.259IleSer: 5.259 ± 1.266
4.982IleThr: 4.982 ± 0.972
2.214IleVal: 2.214 ± 0.595
1.107IleTrp: 1.107 ± 0.773
1.937IleTyr: 1.937 ± 0.848
0.0IleXaa: 0.0 ± 0.0
Lys
4.152LysAla: 4.152 ± 0.94
0.554LysCys: 0.554 ± 0.404
7.196LysAsp: 7.196 ± 1.032
7.75LysGlu: 7.75 ± 1.14
2.214LysPhe: 2.214 ± 0.642
3.321LysGly: 3.321 ± 1.052
3.321LysHis: 3.321 ± 0.81
9.134LysIle: 9.134 ± 1.286
9.964LysLys: 9.964 ± 1.423
8.303LysLeu: 8.303 ± 1.861
2.214LysMet: 2.214 ± 0.673
7.196LysAsn: 7.196 ± 1.71
3.045LysPro: 3.045 ± 1.067
4.428LysGln: 4.428 ± 0.769
5.259LysArg: 5.259 ± 1.625
2.491LysSer: 2.491 ± 1.05
3.045LysThr: 3.045 ± 0.937
3.875LysVal: 3.875 ± 1.0
1.661LysTrp: 1.661 ± 0.663
4.982LysTyr: 4.982 ± 1.083
0.0LysXaa: 0.0 ± 0.0
Leu
8.027LeuAla: 8.027 ± 1.383
0.554LeuCys: 0.554 ± 0.392
8.027LeuAsp: 8.027 ± 1.682
6.089LeuGlu: 6.089 ± 1.387
4.152LeuPhe: 4.152 ± 1.17
4.982LeuGly: 4.982 ± 0.913
0.83LeuHis: 0.83 ± 0.41
5.812LeuIle: 5.812 ± 1.39
7.75LeuLys: 7.75 ± 1.463
9.687LeuLeu: 9.687 ± 1.572
3.875LeuMet: 3.875 ± 1.196
2.491LeuAsn: 2.491 ± 0.742
3.598LeuPro: 3.598 ± 1.06
2.491LeuGln: 2.491 ± 0.704
6.089LeuArg: 6.089 ± 1.238
5.812LeuSer: 5.812 ± 1.501
5.259LeuThr: 5.259 ± 1.079
4.152LeuVal: 4.152 ± 1.181
0.554LeuTrp: 0.554 ± 0.474
3.321LeuTyr: 3.321 ± 0.731
0.0LeuXaa: 0.0 ± 0.0
Met
1.107MetAla: 1.107 ± 0.542
0.277MetCys: 0.277 ± 0.234
1.384MetAsp: 1.384 ± 0.571
3.045MetGlu: 3.045 ± 0.825
0.83MetPhe: 0.83 ± 0.492
0.83MetGly: 0.83 ± 0.514
0.0MetHis: 0.0 ± 0.0
2.214MetIle: 2.214 ± 0.791
2.768MetLys: 2.768 ± 0.634
2.491MetLeu: 2.491 ± 0.759
0.83MetMet: 0.83 ± 0.456
1.937MetAsn: 1.937 ± 0.667
0.83MetPro: 0.83 ± 0.443
0.277MetGln: 0.277 ± 0.265
1.107MetArg: 1.107 ± 0.523
2.768MetSer: 2.768 ± 0.907
1.661MetThr: 1.661 ± 0.592
1.384MetVal: 1.384 ± 0.8
0.554MetTrp: 0.554 ± 0.38
1.107MetTyr: 1.107 ± 0.53
0.0MetXaa: 0.0 ± 0.0
Asn
3.598AsnAla: 3.598 ± 1.066
0.83AsnCys: 0.83 ± 0.453
3.045AsnAsp: 3.045 ± 0.7
4.152AsnGlu: 4.152 ± 0.738
1.107AsnPhe: 1.107 ± 0.485
3.875AsnGly: 3.875 ± 1.259
1.384AsnHis: 1.384 ± 0.42
3.875AsnIle: 3.875 ± 1.066
4.428AsnLys: 4.428 ± 1.378
3.598AsnLeu: 3.598 ± 0.919
0.277AsnMet: 0.277 ± 0.302
4.152AsnAsn: 4.152 ± 0.905
1.107AsnPro: 1.107 ± 0.505
2.768AsnGln: 2.768 ± 0.751
3.045AsnArg: 3.045 ± 0.798
1.937AsnSer: 1.937 ± 0.747
2.768AsnThr: 2.768 ± 0.76
4.152AsnVal: 4.152 ± 1.606
0.83AsnTrp: 0.83 ± 0.557
1.384AsnTyr: 1.384 ± 0.641
0.0AsnXaa: 0.0 ± 0.0
Pro
1.384ProAla: 1.384 ± 0.611
0.0ProCys: 0.0 ± 0.0
3.045ProAsp: 3.045 ± 1.196
1.937ProGlu: 1.937 ± 0.869
0.83ProPhe: 0.83 ± 0.467
0.277ProGly: 0.277 ± 0.301
1.107ProHis: 1.107 ± 0.639
1.661ProIle: 1.661 ± 0.597
2.491ProLys: 2.491 ± 0.828
1.937ProLeu: 1.937 ± 0.659
0.0ProMet: 0.0 ± 0.0
0.83ProAsn: 0.83 ± 0.576
1.107ProPro: 1.107 ± 0.769
0.83ProGln: 0.83 ± 0.416
0.83ProArg: 0.83 ± 0.465
1.661ProSer: 1.661 ± 0.678
1.661ProThr: 1.661 ± 0.565
1.384ProVal: 1.384 ± 0.575
0.277ProTrp: 0.277 ± 0.242
1.661ProTyr: 1.661 ± 0.847
0.0ProXaa: 0.0 ± 0.0
Gln
3.598GlnAla: 3.598 ± 0.839
0.0GlnCys: 0.0 ± 0.0
1.384GlnAsp: 1.384 ± 0.409
3.321GlnGlu: 3.321 ± 1.154
1.384GlnPhe: 1.384 ± 0.681
2.491GlnGly: 2.491 ± 0.654
0.277GlnHis: 0.277 ± 0.29
1.384GlnIle: 1.384 ± 0.655
3.598GlnLys: 3.598 ± 0.868
2.491GlnLeu: 2.491 ± 0.943
1.107GlnMet: 1.107 ± 0.576
2.491GlnAsn: 2.491 ± 0.657
1.937GlnPro: 1.937 ± 0.661
1.937GlnGln: 1.937 ± 0.642
1.107GlnArg: 1.107 ± 0.563
2.491GlnSer: 2.491 ± 0.792
3.045GlnThr: 3.045 ± 0.936
3.598GlnVal: 3.598 ± 1.079
0.277GlnTrp: 0.277 ± 0.25
0.554GlnTyr: 0.554 ± 0.406
0.0GlnXaa: 0.0 ± 0.0
Arg
1.937ArgAla: 1.937 ± 0.876
0.0ArgCys: 0.0 ± 0.0
1.384ArgAsp: 1.384 ± 0.624
5.812ArgGlu: 5.812 ± 1.13
2.491ArgPhe: 2.491 ± 0.996
1.384ArgGly: 1.384 ± 0.501
1.107ArgHis: 1.107 ± 0.439
3.045ArgIle: 3.045 ± 0.796
4.982ArgLys: 4.982 ± 1.237
6.089ArgLeu: 6.089 ± 1.04
1.107ArgMet: 1.107 ± 0.486
2.491ArgAsn: 2.491 ± 1.005
1.107ArgPro: 1.107 ± 0.474
2.214ArgGln: 2.214 ± 0.487
2.491ArgArg: 2.491 ± 0.815
1.661ArgSer: 1.661 ± 0.62
3.321ArgThr: 3.321 ± 0.835
2.214ArgVal: 2.214 ± 0.55
1.107ArgTrp: 1.107 ± 0.52
1.937ArgTyr: 1.937 ± 0.699
0.0ArgXaa: 0.0 ± 0.0
Ser
3.045SerAla: 3.045 ± 0.877
0.277SerCys: 0.277 ± 0.272
3.045SerAsp: 3.045 ± 0.824
5.259SerGlu: 5.259 ± 1.304
2.214SerPhe: 2.214 ± 0.907
3.598SerGly: 3.598 ± 1.014
1.661SerHis: 1.661 ± 0.726
2.214SerIle: 2.214 ± 0.723
4.428SerLys: 4.428 ± 1.193
3.875SerLeu: 3.875 ± 0.734
2.214SerMet: 2.214 ± 0.924
3.045SerAsn: 3.045 ± 1.098
1.107SerPro: 1.107 ± 0.471
1.661SerGln: 1.661 ± 0.629
3.045SerArg: 3.045 ± 0.754
3.045SerSer: 3.045 ± 0.982
2.768SerThr: 2.768 ± 1.077
2.214SerVal: 2.214 ± 0.689
0.83SerTrp: 0.83 ± 0.712
3.321SerTyr: 3.321 ± 0.706
0.0SerXaa: 0.0 ± 0.0
Thr
3.321ThrAla: 3.321 ± 0.812
0.277ThrCys: 0.277 ± 0.312
4.428ThrAsp: 4.428 ± 1.024
3.875ThrGlu: 3.875 ± 1.009
1.384ThrPhe: 1.384 ± 0.623
4.982ThrGly: 4.982 ± 1.693
1.661ThrHis: 1.661 ± 0.551
3.045ThrIle: 3.045 ± 0.658
4.152ThrLys: 4.152 ± 0.843
5.812ThrLeu: 5.812 ± 1.31
0.83ThrMet: 0.83 ± 0.416
1.661ThrAsn: 1.661 ± 0.573
1.107ThrPro: 1.107 ± 0.462
1.937ThrGln: 1.937 ± 0.945
1.937ThrArg: 1.937 ± 0.679
2.768ThrSer: 2.768 ± 0.712
6.089ThrThr: 6.089 ± 1.529
3.598ThrVal: 3.598 ± 0.958
1.384ThrTrp: 1.384 ± 0.721
1.661ThrTyr: 1.661 ± 0.683
0.0ThrXaa: 0.0 ± 0.0
Val
3.875ValAla: 3.875 ± 1.232
0.277ValCys: 0.277 ± 0.234
5.259ValAsp: 5.259 ± 0.981
4.428ValGlu: 4.428 ± 1.022
1.937ValPhe: 1.937 ± 0.644
3.875ValGly: 3.875 ± 1.637
1.107ValHis: 1.107 ± 0.63
4.428ValIle: 4.428 ± 1.147
5.536ValLys: 5.536 ± 1.133
4.152ValLeu: 4.152 ± 0.803
1.107ValMet: 1.107 ± 0.69
2.491ValAsn: 2.491 ± 0.655
0.83ValPro: 0.83 ± 0.476
0.83ValGln: 0.83 ± 0.514
1.661ValArg: 1.661 ± 0.67
4.152ValSer: 4.152 ± 1.42
3.045ValThr: 3.045 ± 1.287
4.982ValVal: 4.982 ± 1.256
0.0ValTrp: 0.0 ± 0.0
1.661ValTyr: 1.661 ± 0.596
0.0ValXaa: 0.0 ± 0.0
Trp
0.83TrpAla: 0.83 ± 0.484
0.277TrpCys: 0.277 ± 0.301
0.277TrpAsp: 0.277 ± 0.279
2.214TrpGlu: 2.214 ± 0.647
1.107TrpPhe: 1.107 ± 0.476
0.83TrpGly: 0.83 ± 0.414
0.554TrpHis: 0.554 ± 0.392
0.554TrpIle: 0.554 ± 0.336
2.214TrpLys: 2.214 ± 0.856
0.83TrpLeu: 0.83 ± 0.407
0.554TrpMet: 0.554 ± 0.391
0.277TrpAsn: 0.277 ± 0.279
0.0TrpPro: 0.0 ± 0.0
0.554TrpGln: 0.554 ± 0.381
0.554TrpArg: 0.554 ± 0.422
0.83TrpSer: 0.83 ± 0.473
0.0TrpThr: 0.0 ± 0.0
0.554TrpVal: 0.554 ± 0.369
0.0TrpTrp: 0.0 ± 0.0
1.661TrpTyr: 1.661 ± 1.676
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.045TyrAla: 3.045 ± 0.927
0.83TyrCys: 0.83 ± 0.402
1.384TyrAsp: 1.384 ± 0.528
2.214TyrGlu: 2.214 ± 0.751
3.045TyrPhe: 3.045 ± 0.681
2.491TyrGly: 2.491 ± 1.053
0.83TyrHis: 0.83 ± 0.466
3.598TyrIle: 3.598 ± 1.067
4.428TyrLys: 4.428 ± 1.22
5.536TyrLeu: 5.536 ± 1.095
0.554TyrMet: 0.554 ± 0.349
1.107TyrAsn: 1.107 ± 0.52
1.661TyrPro: 1.661 ± 0.791
1.661TyrGln: 1.661 ± 0.684
3.321TyrArg: 3.321 ± 1.049
0.83TyrSer: 0.83 ± 0.561
2.491TyrThr: 2.491 ± 0.86
0.554TyrVal: 0.554 ± 0.38
1.107TyrTrp: 1.107 ± 0.6
2.491TyrTyr: 2.491 ± 1.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 29 proteins (3614 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski