Amino acid dipepetide frequency for Roseovarius nubinhibens (strain ATCC BAA-591 / DSM 15170 / ISM)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.631AlaAla: 16.631 ± 0.182	1.071AlaCys: 1.071 ± 0.034	6.437AlaAsp: 6.437 ± 0.087	9.108AlaGlu: 9.108 ± 0.131	3.91AlaPhe: 3.91 ± 0.069	10.895AlaGly: 10.895 ± 0.11	2.51AlaHis: 2.51 ± 0.049	5.597AlaIle: 5.597 ± 0.076	3.862AlaLys: 3.862 ± 0.071	14.097AlaLeu: 14.097 ± 0.157	3.905AlaMet: 3.905 ± 0.062	2.523AlaAsn: 2.523 ± 0.047	6.056AlaPro: 6.056 ± 0.084	4.766AlaGln: 4.766 ± 0.072	9.622AlaArg: 9.622 ± 0.104	5.511AlaSer: 5.511 ± 0.072	5.719AlaThr: 5.719 ± 0.084	7.895AlaVal: 7.895 ± 0.106	1.362AlaTrp: 1.362 ± 0.035	2.599AlaTyr: 2.599 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.088CysAla: 1.088 ± 0.03	0.119CysCys: 0.119 ± 0.01	0.702CysAsp: 0.702 ± 0.025	0.492CysGlu: 0.492 ± 0.023	0.369CysPhe: 0.369 ± 0.017	0.97CysGly: 0.97 ± 0.033	0.287CysHis: 0.287 ± 0.017	0.406CysIle: 0.406 ± 0.021	0.219CysLys: 0.219 ± 0.013	0.908CysLeu: 0.908 ± 0.027	0.144CysMet: 0.144 ± 0.011	0.228CysAsn: 0.228 ± 0.013	0.503CysPro: 0.503 ± 0.023	0.268CysGln: 0.268 ± 0.017	0.555CysArg: 0.555 ± 0.023	0.454CysSer: 0.454 ± 0.021	0.423CysThr: 0.423 ± 0.018	0.583CysVal: 0.583 ± 0.024	0.115CysTrp: 0.115 ± 0.009	0.236CysTyr: 0.236 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.992AspAla: 6.992 ± 0.094	0.571AspCys: 0.571 ± 0.025	3.204AspAsp: 3.204 ± 0.067	3.719AspGlu: 3.719 ± 0.069	2.095AspPhe: 2.095 ± 0.042	5.302AspGly: 5.302 ± 0.089	1.541AspHis: 1.541 ± 0.041	3.033AspIle: 3.033 ± 0.06	1.779AspLys: 1.779 ± 0.049	6.496AspLeu: 6.496 ± 0.088	1.776AspMet: 1.776 ± 0.04	1.256AspAsn: 1.256 ± 0.037	3.537AspPro: 3.537 ± 0.056	2.034AspGln: 2.034 ± 0.042	4.498AspArg: 4.498 ± 0.076	2.152AspSer: 2.152 ± 0.048	2.941AspThr: 2.941 ± 0.068	3.995AspVal: 3.995 ± 0.066	1.142AspTrp: 1.142 ± 0.031	1.572AspTyr: 1.572 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	9.481GluAla: 9.481 ± 0.119	0.368GluCys: 0.368 ± 0.019	3.564GluAsp: 3.564 ± 0.063	3.967GluGlu: 3.967 ± 0.073	2.032GluPhe: 2.032 ± 0.042	5.174GluGly: 5.174 ± 0.08	1.217GluHis: 1.217 ± 0.034	3.93GluIle: 3.93 ± 0.066	2.176GluLys: 2.176 ± 0.054	5.404GluLeu: 5.404 ± 0.099	2.065GluMet: 2.065 ± 0.048	1.679GluAsn: 1.679 ± 0.04	2.533GluPro: 2.533 ± 0.056	1.777GluGln: 1.777 ± 0.041	4.226GluArg: 4.226 ± 0.063	2.191GluSer: 2.191 ± 0.046	4.039GluThr: 4.039 ± 0.062	4.459GluVal: 4.459 ± 0.062	0.664GluTrp: 0.664 ± 0.024	1.106GluTyr: 1.106 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.395PheAla: 4.395 ± 0.071	0.415PheCys: 0.415 ± 0.018	2.851PheAsp: 2.851 ± 0.058	2.239PheGlu: 2.239 ± 0.047	1.426PhePhe: 1.426 ± 0.037	3.69PheGly: 3.69 ± 0.063	0.821PheHis: 0.821 ± 0.03	1.581PheIle: 1.581 ± 0.041	0.892PheLys: 0.892 ± 0.026	3.486PheLeu: 3.486 ± 0.064	0.854PheMet: 0.854 ± 0.027	1.017PheAsn: 1.017 ± 0.032	1.477PhePro: 1.477 ± 0.039	0.985PheGln: 0.985 ± 0.031	2.036PheArg: 2.036 ± 0.042	1.986PheSer: 1.986 ± 0.045	2.065PheThr: 2.065 ± 0.046	2.581PheVal: 2.581 ± 0.056	0.54PheTrp: 0.54 ± 0.024	0.937PheTyr: 0.937 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.35GlyAla: 10.35 ± 0.112	0.869GlyCys: 0.869 ± 0.026	4.895GlyAsp: 4.895 ± 0.087	5.054GlyGlu: 5.054 ± 0.079	3.792GlyPhe: 3.792 ± 0.062	7.657GlyGly: 7.657 ± 0.117	2.17GlyHis: 2.17 ± 0.051	4.349GlyIle: 4.349 ± 0.072	2.981GlyLys: 2.981 ± 0.063	9.643GlyLeu: 9.643 ± 0.104	2.704GlyMet: 2.704 ± 0.051	2.108GlyAsn: 2.108 ± 0.056	3.881GlyPro: 3.881 ± 0.063	3.359GlyGln: 3.359 ± 0.058	6.001GlyArg: 6.001 ± 0.08	4.205GlySer: 4.205 ± 0.077	4.537GlyThr: 4.537 ± 0.08	6.468GlyVal: 6.468 ± 0.081	1.59GlyTrp: 1.59 ± 0.042	2.45GlyTyr: 2.45 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.404HisAla: 2.404 ± 0.046	0.282HisCys: 0.282 ± 0.017	1.339HisAsp: 1.339 ± 0.036	1.148HisGlu: 1.148 ± 0.031	0.892HisPhe: 0.892 ± 0.029	2.112HisGly: 2.112 ± 0.044	0.647HisHis: 0.647 ± 0.03	1.017HisIle: 1.017 ± 0.032	0.535HisLys: 0.535 ± 0.021	2.282HisLeu: 2.282 ± 0.051	0.61HisMet: 0.61 ± 0.024	0.455HisAsn: 0.455 ± 0.022	1.438HisPro: 1.438 ± 0.043	0.654HisGln: 0.654 ± 0.024	1.447HisArg: 1.447 ± 0.043	0.973HisSer: 0.973 ± 0.029	0.765HisThr: 0.765 ± 0.029	1.642HisVal: 1.642 ± 0.044	0.375HisTrp: 0.375 ± 0.021	0.576HisTyr: 0.576 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.617IleAla: 6.617 ± 0.082	0.65IleCys: 0.65 ± 0.022	3.43IleAsp: 3.43 ± 0.057	3.626IleGlu: 3.626 ± 0.062	1.777IlePhe: 1.777 ± 0.045	4.718IleGly: 4.718 ± 0.073	0.951IleHis: 0.951 ± 0.031	2.237IleIle: 2.237 ± 0.051	1.44IleLys: 1.44 ± 0.037	4.872IleLeu: 4.872 ± 0.083	1.111IleMet: 1.111 ± 0.033	1.341IleAsn: 1.341 ± 0.04	2.263IlePro: 2.263 ± 0.041	1.099IleGln: 1.099 ± 0.03	3.163IleArg: 3.163 ± 0.056	2.957IleSer: 2.957 ± 0.056	2.999IleThr: 2.999 ± 0.051	3.437IleVal: 3.437 ± 0.063	0.74IleTrp: 0.74 ± 0.026	1.226IleTyr: 1.226 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.552LysAla: 3.552 ± 0.065	0.195LysCys: 0.195 ± 0.015	1.704LysAsp: 1.704 ± 0.047	1.592LysGlu: 1.592 ± 0.046	0.933LysPhe: 0.933 ± 0.035	2.678LysGly: 2.678 ± 0.056	0.626LysHis: 0.626 ± 0.026	1.725LysIle: 1.725 ± 0.043	1.153LysLys: 1.153 ± 0.043	2.982LysLeu: 2.982 ± 0.067	0.883LysMet: 0.883 ± 0.034	0.705LysAsn: 0.705 ± 0.025	1.884LysPro: 1.884 ± 0.052	0.882LysGln: 0.882 ± 0.029	2.189LysArg: 2.189 ± 0.046	1.929LysSer: 1.929 ± 0.048	1.921LysThr: 1.921 ± 0.045	2.106LysVal: 2.106 ± 0.056	0.352LysTrp: 0.352 ± 0.019	0.668LysTyr: 0.668 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.245LeuAla: 13.245 ± 0.157	1.063LeuCys: 1.063 ± 0.033	6.24LeuAsp: 6.24 ± 0.082	5.246LeuGlu: 5.246 ± 0.078	3.562LeuPhe: 3.562 ± 0.061	9.232LeuGly: 9.232 ± 0.118	1.936LeuHis: 1.936 ± 0.042	5.245LeuIle: 5.245 ± 0.089	3.015LeuLys: 3.015 ± 0.059	9.227LeuLeu: 9.227 ± 0.129	2.717LeuMet: 2.717 ± 0.06	2.502LeuAsn: 2.502 ± 0.052	5.729LeuPro: 5.729 ± 0.086	2.67LeuGln: 2.67 ± 0.06	7.728LeuArg: 7.728 ± 0.098	6.691LeuSer: 6.691 ± 0.087	5.751LeuThr: 5.751 ± 0.079	6.776LeuVal: 6.776 ± 0.097	1.478LeuTrp: 1.478 ± 0.043	2.053LeuTyr: 2.053 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.703MetAla: 3.703 ± 0.062	0.21MetCys: 0.21 ± 0.014	1.381MetAsp: 1.381 ± 0.039	1.394MetGlu: 1.394 ± 0.035	0.849MetPhe: 0.849 ± 0.029	2.526MetGly: 2.526 ± 0.052	0.462MetHis: 0.462 ± 0.021	1.626MetIle: 1.626 ± 0.041	1.023MetLys: 1.023 ± 0.035	2.711MetLeu: 2.711 ± 0.054	0.83MetMet: 0.83 ± 0.033	0.754MetAsn: 0.754 ± 0.027	1.557MetPro: 1.557 ± 0.038	1.036MetGln: 1.036 ± 0.033	1.999MetArg: 1.999 ± 0.047	1.918MetSer: 1.918 ± 0.042	1.957MetThr: 1.957 ± 0.039	1.912MetVal: 1.912 ± 0.045	0.242MetTrp: 0.242 ± 0.015	0.36MetTyr: 0.36 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.913AsnAla: 2.913 ± 0.053	0.254AsnCys: 0.254 ± 0.016	1.361AsnAsp: 1.361 ± 0.048	1.147AsnGlu: 1.147 ± 0.035	0.944AsnPhe: 0.944 ± 0.032	2.245AsnGly: 2.245 ± 0.056	0.515AsnHis: 0.515 ± 0.02	1.322AsnIle: 1.322 ± 0.035	0.617AsnLys: 0.617 ± 0.024	2.45AsnLeu: 2.45 ± 0.049	0.664AsnMet: 0.664 ± 0.029	0.627AsnAsn: 0.627 ± 0.029	1.734AsnPro: 1.734 ± 0.042	0.664AsnGln: 0.664 ± 0.025	1.636AsnArg: 1.636 ± 0.041	1.191AsnSer: 1.191 ± 0.034	1.242AsnThr: 1.242 ± 0.033	1.699AsnVal: 1.699 ± 0.039	0.441AsnTrp: 0.441 ± 0.019	0.625AsnTyr: 0.625 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.578ProAla: 5.578 ± 0.091	0.388ProCys: 0.388 ± 0.018	3.72ProAsp: 3.72 ± 0.062	4.779ProGlu: 4.779 ± 0.063	1.869ProPhe: 1.869 ± 0.043	4.826ProGly: 4.826 ± 0.071	1.06ProHis: 1.06 ± 0.033	2.223ProIle: 2.223 ± 0.044	1.716ProLys: 1.716 ± 0.047	4.888ProLeu: 4.888 ± 0.076	1.353ProMet: 1.353 ± 0.038	1.252ProAsn: 1.252 ± 0.038	2.192ProPro: 2.192 ± 0.054	1.672ProGln: 1.672 ± 0.04	2.982ProArg: 2.982 ± 0.056	2.438ProSer: 2.438 ± 0.049	2.185ProThr: 2.185 ± 0.047	4.115ProVal: 4.115 ± 0.054	0.683ProTrp: 0.683 ± 0.031	1.194ProTyr: 1.194 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.004GlnAla: 4.004 ± 0.064	0.216GlnCys: 0.216 ± 0.017	1.697GlnAsp: 1.697 ± 0.041	1.79GlnGlu: 1.79 ± 0.048	1.071GlnPhe: 1.071 ± 0.031	2.83GlnGly: 2.83 ± 0.058	0.661GlnHis: 0.661 ± 0.026	1.884GlnIle: 1.884 ± 0.039	1.052GlnLys: 1.052 ± 0.031	2.825GlnLeu: 2.825 ± 0.054	1.143GlnMet: 1.143 ± 0.035	0.867GlnAsn: 0.867 ± 0.028	1.635GlnPro: 1.635 ± 0.043	1.065GlnGln: 1.065 ± 0.04	2.186GlnArg: 2.186 ± 0.049	2.074GlnSer: 2.074 ± 0.047	1.68GlnThr: 1.68 ± 0.04	2.344GlnVal: 2.344 ± 0.053	0.414GlnTrp: 0.414 ± 0.017	0.578GlnTyr: 0.578 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.807ArgAla: 8.807 ± 0.089	0.474ArgCys: 0.474 ± 0.022	4.787ArgAsp: 4.787 ± 0.068	4.176ArgGlu: 4.176 ± 0.065	2.67ArgPhe: 2.67 ± 0.041	5.02ArgGly: 5.02 ± 0.064	1.72ArgHis: 1.72 ± 0.043	3.733ArgIle: 3.733 ± 0.061	2.28ArgLys: 2.28 ± 0.057	7.572ArgLeu: 7.572 ± 0.09	1.924ArgMet: 1.924 ± 0.044	1.755ArgAsn: 1.755 ± 0.039	3.363ArgPro: 3.363 ± 0.066	2.472ArgGln: 2.472 ± 0.052	5.295ArgArg: 5.295 ± 0.089	3.107ArgSer: 3.107 ± 0.06	2.538ArgThr: 2.538 ± 0.05	4.827ArgVal: 4.827 ± 0.072	0.981ArgTrp: 0.981 ± 0.03	1.646ArgTyr: 1.646 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.703SerAla: 5.703 ± 0.073	0.466SerCys: 0.466 ± 0.021	3.325SerAsp: 3.325 ± 0.057	2.998SerGlu: 2.998 ± 0.051	2.196SerPhe: 2.196 ± 0.051	5.34SerGly: 5.34 ± 0.077	1.123SerHis: 1.123 ± 0.033	2.331SerIle: 2.331 ± 0.048	1.454SerLys: 1.454 ± 0.041	5.086SerLeu: 5.086 ± 0.08	1.32SerMet: 1.32 ± 0.039	1.249SerAsn: 1.249 ± 0.041	2.535SerPro: 2.535 ± 0.055	1.676SerGln: 1.676 ± 0.043	3.255SerArg: 3.255 ± 0.049	2.423SerSer: 2.423 ± 0.056	2.372SerThr: 2.372 ± 0.049	3.56SerVal: 3.56 ± 0.056	0.73SerTrp: 0.73 ± 0.026	1.447SerTyr: 1.447 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.826ThrAla: 5.826 ± 0.08	0.46ThrCys: 0.46 ± 0.02	2.849ThrAsp: 2.849 ± 0.048	3.057ThrGlu: 3.057 ± 0.063	1.742ThrPhe: 1.742 ± 0.039	5.392ThrGly: 5.392 ± 0.072	1.108ThrHis: 1.108 ± 0.03	2.53ThrIle: 2.53 ± 0.048	1.397ThrLys: 1.397 ± 0.038	5.932ThrLeu: 5.932 ± 0.072	1.252ThrMet: 1.252 ± 0.038	1.174ThrAsn: 1.174 ± 0.033	3.523ThrPro: 3.523 ± 0.06	1.544ThrGln: 1.544 ± 0.037	3.736ThrArg: 3.736 ± 0.059	2.449ThrSer: 2.449 ± 0.052	2.679ThrThr: 2.679 ± 0.049	3.775ThrVal: 3.775 ± 0.056	0.69ThrTrp: 0.69 ± 0.027	1.222ThrTyr: 1.222 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.682ValAla: 8.682 ± 0.116	0.606ValCys: 0.606 ± 0.026	3.737ValAsp: 3.737 ± 0.068	4.434ValGlu: 4.434 ± 0.068	2.702ValPhe: 2.702 ± 0.05	5.184ValGly: 5.184 ± 0.075	1.291ValHis: 1.291 ± 0.035	4.266ValIle: 4.266 ± 0.065	2.051ValLys: 2.051 ± 0.055	7.177ValLeu: 7.177 ± 0.108	2.217ValMet: 2.217 ± 0.052	1.881ValAsn: 1.881 ± 0.051	3.408ValPro: 3.408 ± 0.059	2.021ValGln: 2.021 ± 0.041	3.885ValArg: 3.885 ± 0.063	4.037ValSer: 4.037 ± 0.064	4.709ValThr: 4.709 ± 0.07	5.413ValVal: 5.413 ± 0.098	0.898ValTrp: 0.898 ± 0.029	1.423ValTyr: 1.423 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.483TrpAla: 1.483 ± 0.041	0.126TrpCys: 0.126 ± 0.01	0.763TrpAsp: 0.763 ± 0.028	0.688TrpGlu: 0.688 ± 0.026	0.542TrpPhe: 0.542 ± 0.026	1.094TrpGly: 1.094 ± 0.036	0.352TrpHis: 0.352 ± 0.019	0.657TrpIle: 0.657 ± 0.026	0.422TrpLys: 0.422 ± 0.018	1.727TrpLeu: 1.727 ± 0.043	0.418TrpMet: 0.418 ± 0.021	0.372TrpAsn: 0.372 ± 0.021	0.743TrpPro: 0.743 ± 0.026	0.673TrpGln: 0.673 ± 0.026	1.075TrpArg: 1.075 ± 0.037	0.766TrpSer: 0.766 ± 0.028	0.727TrpThr: 0.727 ± 0.028	0.903TrpVal: 0.903 ± 0.033	0.227TrpTrp: 0.227 ± 0.016	0.289TrpTyr: 0.289 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.622TyrAla: 2.622 ± 0.051	0.263TyrCys: 0.263 ± 0.015	1.647TyrAsp: 1.647 ± 0.041	1.397TyrGlu: 1.397 ± 0.04	0.902TyrPhe: 0.902 ± 0.029	2.177TyrGly: 2.177 ± 0.039	0.598TyrHis: 0.598 ± 0.025	0.961TyrIle: 0.961 ± 0.029	0.596TyrLys: 0.596 ± 0.024	2.341TyrLeu: 2.341 ± 0.046	0.558TyrMet: 0.558 ± 0.019	0.545TyrAsn: 0.545 ± 0.021	1.12TyrPro: 1.12 ± 0.031	0.7TyrGln: 0.7 ± 0.027	1.637TyrArg: 1.637 ± 0.041	1.137TyrSer: 1.137 ± 0.03	1.088TyrThr: 1.088 ± 0.032	1.534TyrVal: 1.534 ± 0.036	0.38TyrTrp: 0.38 ± 0.021	0.607TyrTyr: 0.607 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3545 proteins (1098103 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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