Amino acid dipepetide frequency for Paenibacillus darwinianus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.583AlaAla: 12.583 ± 0.225	0.841AlaCys: 0.841 ± 0.029	5.68AlaAsp: 5.68 ± 0.095	6.984AlaGlu: 6.984 ± 0.105	3.764AlaPhe: 3.764 ± 0.073	9.115AlaGly: 9.115 ± 0.123	1.555AlaHis: 1.555 ± 0.042	5.391AlaIle: 5.391 ± 0.093	4.468AlaLys: 4.468 ± 0.07	9.48AlaLeu: 9.48 ± 0.127	2.85AlaMet: 2.85 ± 0.061	2.735AlaAsn: 2.735 ± 0.06	3.26AlaPro: 3.26 ± 0.065	2.876AlaGln: 2.876 ± 0.057	4.818AlaArg: 4.818 ± 0.083	5.22AlaSer: 5.22 ± 0.092	3.709AlaThr: 3.709 ± 0.075	8.561AlaVal: 8.561 ± 0.131	1.058AlaTrp: 1.058 ± 0.041	2.872AlaTyr: 2.872 ± 0.067	0.001AlaXaa: 0.001 ± 0.001
Cys	0.666CysAla: 0.666 ± 0.03	0.115CysCys: 0.115 ± 0.011	0.416CysAsp: 0.416 ± 0.021	0.461CysGlu: 0.461 ± 0.024	0.276CysPhe: 0.276 ± 0.019	0.895CysGly: 0.895 ± 0.035	0.171CysHis: 0.171 ± 0.014	0.424CysIle: 0.424 ± 0.02	0.324CysLys: 0.324 ± 0.021	0.681CysLeu: 0.681 ± 0.028	0.234CysMet: 0.234 ± 0.017	0.226CysAsn: 0.226 ± 0.017	0.382CysPro: 0.382 ± 0.024	0.157CysGln: 0.157 ± 0.014	0.553CysArg: 0.553 ± 0.028	0.497CysSer: 0.497 ± 0.025	0.396CysThr: 0.396 ± 0.024	0.484CysVal: 0.484 ± 0.025	0.092CysTrp: 0.092 ± 0.009	0.222CysTyr: 0.222 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.75AspAla: 4.75 ± 0.084	0.398AspCys: 0.398 ± 0.022	2.553AspAsp: 2.553 ± 0.063	3.899AspGlu: 3.899 ± 0.07	2.012AspPhe: 2.012 ± 0.046	4.59AspGly: 4.59 ± 0.077	0.951AspHis: 0.951 ± 0.028	3.522AspIle: 3.522 ± 0.071	2.622AspLys: 2.622 ± 0.059	4.693AspLeu: 4.693 ± 0.08	1.438AspMet: 1.438 ± 0.04	1.694AspAsn: 1.694 ± 0.041	2.475AspPro: 2.475 ± 0.06	1.524AspGln: 1.524 ± 0.043	3.624AspArg: 3.624 ± 0.066	2.422AspSer: 2.422 ± 0.052	2.523AspThr: 2.523 ± 0.052	3.895AspVal: 3.895 ± 0.064	0.789AspTrp: 0.789 ± 0.032	2.016AspTyr: 2.016 ± 0.047	0.002AspXaa: 0.002 ± 0.002
Glu	7.453GluAla: 7.453 ± 0.12	0.355GluCys: 0.355 ± 0.02	2.993GluAsp: 2.993 ± 0.064	5.192GluGlu: 5.192 ± 0.11	1.911GluPhe: 1.911 ± 0.049	4.837GluGly: 4.837 ± 0.075	1.391GluHis: 1.391 ± 0.049	4.002GluIle: 4.002 ± 0.071	3.481GluLys: 3.481 ± 0.067	7.349GluLeu: 7.349 ± 0.109	1.828GluMet: 1.828 ± 0.043	1.946GluAsn: 1.946 ± 0.057	2.533GluPro: 2.533 ± 0.056	3.279GluGln: 3.279 ± 0.074	5.346GluArg: 5.346 ± 0.092	3.454GluSer: 3.454 ± 0.074	3.692GluThr: 3.692 ± 0.069	4.356GluVal: 4.356 ± 0.085	0.948GluTrp: 0.948 ± 0.034	1.713GluTyr: 1.713 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.643PheAla: 3.643 ± 0.072	0.353PheCys: 0.353 ± 0.019	2.289PheAsp: 2.289 ± 0.056	2.393PheGlu: 2.393 ± 0.053	1.697PhePhe: 1.697 ± 0.05	3.62PheGly: 3.62 ± 0.067	0.783PheHis: 0.783 ± 0.033	2.437PheIle: 2.437 ± 0.056	1.584PheLys: 1.584 ± 0.047	3.564PheLeu: 3.564 ± 0.08	1.112PheMet: 1.112 ± 0.037	1.346PheAsn: 1.346 ± 0.042	1.614PhePro: 1.614 ± 0.052	1.176PheGln: 1.176 ± 0.041	2.387PheArg: 2.387 ± 0.051	2.129PheSer: 2.129 ± 0.052	2.168PheThr: 2.168 ± 0.053	2.995PheVal: 2.995 ± 0.058	0.482PheTrp: 0.482 ± 0.028	1.261PheTyr: 1.261 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	7.268GlyAla: 7.268 ± 0.138	0.821GlyCys: 0.821 ± 0.036	3.995GlyAsp: 3.995 ± 0.07	5.135GlyGlu: 5.135 ± 0.082	3.49GlyPhe: 3.49 ± 0.071	7.029GlyGly: 7.029 ± 0.123	1.531GlyHis: 1.531 ± 0.041	5.834GlyIle: 5.834 ± 0.093	4.69GlyLys: 4.69 ± 0.082	8.048GlyLeu: 8.048 ± 0.099	2.834GlyMet: 2.834 ± 0.06	2.625GlyAsn: 2.625 ± 0.063	2.382GlyPro: 2.382 ± 0.052	2.785GlyGln: 2.785 ± 0.06	4.996GlyArg: 4.996 ± 0.09	4.791GlySer: 4.791 ± 0.098	4.566GlyThr: 4.566 ± 0.072	6.127GlyVal: 6.127 ± 0.09	1.163GlyTrp: 1.163 ± 0.041	2.863GlyTyr: 2.863 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.709HisAla: 1.709 ± 0.043	0.188HisCys: 0.188 ± 0.014	0.902HisAsp: 0.902 ± 0.033	1.195HisGlu: 1.195 ± 0.04	0.846HisPhe: 0.846 ± 0.034	1.589HisGly: 1.589 ± 0.049	0.58HisHis: 0.58 ± 0.028	1.234HisIle: 1.234 ± 0.041	0.73HisLys: 0.73 ± 0.031	1.861HisLeu: 1.861 ± 0.076	0.573HisMet: 0.573 ± 0.029	0.582HisAsn: 0.582 ± 0.03	1.314HisPro: 1.314 ± 0.041	0.598HisGln: 0.598 ± 0.026	1.213HisArg: 1.213 ± 0.036	0.932HisSer: 0.932 ± 0.034	1.002HisThr: 1.002 ± 0.034	1.498HisVal: 1.498 ± 0.04	0.257HisTrp: 0.257 ± 0.018	0.764HisTyr: 0.764 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.317IleAla: 6.317 ± 0.087	0.494IleCys: 0.494 ± 0.027	3.656IleAsp: 3.656 ± 0.072	4.174IleGlu: 4.174 ± 0.08	1.966IlePhe: 1.966 ± 0.056	5.75IleGly: 5.75 ± 0.091	1.226IleHis: 1.226 ± 0.035	3.267IleIle: 3.267 ± 0.076	2.334IleLys: 2.334 ± 0.056	4.854IleLeu: 4.854 ± 0.08	1.536IleMet: 1.536 ± 0.043	1.877IleAsn: 1.877 ± 0.052	2.938IlePro: 2.938 ± 0.054	1.826IleGln: 1.826 ± 0.052	4.332IleArg: 4.332 ± 0.071	3.212IleSer: 3.212 ± 0.065	3.169IleThr: 3.169 ± 0.068	5.379IleVal: 5.379 ± 0.086	0.598IleTrp: 0.598 ± 0.027	1.731IleTyr: 1.731 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	4.639LysAla: 4.639 ± 0.076	0.245LysCys: 0.245 ± 0.017	2.517LysAsp: 2.517 ± 0.059	3.542LysGlu: 3.542 ± 0.077	1.234LysPhe: 1.234 ± 0.041	3.43LysGly: 3.43 ± 0.073	0.998LysHis: 0.998 ± 0.034	2.419LysIle: 2.419 ± 0.055	2.516LysLys: 2.516 ± 0.071	5.158LysLeu: 5.158 ± 0.088	1.357LysMet: 1.357 ± 0.044	1.511LysAsn: 1.511 ± 0.05	2.422LysPro: 2.422 ± 0.059	2.056LysGln: 2.056 ± 0.051	3.148LysArg: 3.148 ± 0.063	2.395LysSer: 2.395 ± 0.074	2.544LysThr: 2.544 ± 0.052	3.374LysVal: 3.374 ± 0.08	0.594LysTrp: 0.594 ± 0.026	1.321LysTyr: 1.321 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	9.688LeuAla: 9.688 ± 0.153	0.747LeuCys: 0.747 ± 0.033	5.066LeuAsp: 5.066 ± 0.079	6.441LeuGlu: 6.441 ± 0.109	4.259LeuPhe: 4.259 ± 0.081	7.35LeuGly: 7.35 ± 0.112	2.0LeuHis: 2.0 ± 0.05	5.897LeuIle: 5.897 ± 0.087	4.632LeuLys: 4.632 ± 0.079	10.719LeuLeu: 10.719 ± 0.171	2.585LeuMet: 2.585 ± 0.059	3.399LeuAsn: 3.399 ± 0.06	4.679LeuPro: 4.679 ± 0.081	3.661LeuGln: 3.661 ± 0.065	6.006LeuArg: 6.006 ± 0.099	6.201LeuSer: 6.201 ± 0.095	5.538LeuThr: 5.538 ± 0.083	6.64LeuVal: 6.64 ± 0.094	0.969LeuTrp: 0.969 ± 0.034	2.872LeuTyr: 2.872 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.734MetAla: 2.734 ± 0.058	0.173MetCys: 0.173 ± 0.013	1.492MetAsp: 1.492 ± 0.045	1.874MetGlu: 1.874 ± 0.049	0.992MetPhe: 0.992 ± 0.036	1.898MetGly: 1.898 ± 0.049	0.498MetHis: 0.498 ± 0.022	1.805MetIle: 1.805 ± 0.048	1.855MetLys: 1.855 ± 0.047	3.135MetLeu: 3.135 ± 0.061	0.858MetMet: 0.858 ± 0.031	1.32MetAsn: 1.32 ± 0.041	1.354MetPro: 1.354 ± 0.035	1.005MetGln: 1.005 ± 0.035	1.602MetArg: 1.602 ± 0.051	1.707MetSer: 1.707 ± 0.043	1.779MetThr: 1.779 ± 0.04	1.804MetVal: 1.804 ± 0.043	0.212MetTrp: 0.212 ± 0.017	0.653MetTyr: 0.653 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.074AsnAla: 3.074 ± 0.066	0.234AsnCys: 0.234 ± 0.018	1.703AsnAsp: 1.703 ± 0.047	2.239AsnGlu: 2.239 ± 0.056	1.033AsnPhe: 1.033 ± 0.041	3.214AsnGly: 3.214 ± 0.071	0.579AsnHis: 0.579 ± 0.031	1.859AsnIle: 1.859 ± 0.048	1.536AsnLys: 1.536 ± 0.046	2.854AsnLeu: 2.854 ± 0.057	0.876AsnMet: 0.876 ± 0.032	1.179AsnAsn: 1.179 ± 0.043	1.969AsnPro: 1.969 ± 0.047	1.012AsnGln: 1.012 ± 0.039	2.282AsnArg: 2.282 ± 0.053	1.398AsnSer: 1.398 ± 0.04	1.581AsnThr: 1.581 ± 0.045	2.53AsnVal: 2.53 ± 0.06	0.459AsnTrp: 0.459 ± 0.025	0.984AsnTyr: 0.984 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	4.242ProAla: 4.242 ± 0.085	0.287ProCys: 0.287 ± 0.019	2.93ProAsp: 2.93 ± 0.058	3.637ProGlu: 3.637 ± 0.07	1.988ProPhe: 1.988 ± 0.051	3.655ProGly: 3.655 ± 0.065	0.957ProHis: 0.957 ± 0.035	2.315ProIle: 2.315 ± 0.05	1.62ProLys: 1.62 ± 0.051	4.15ProLeu: 4.15 ± 0.072	1.095ProMet: 1.095 ± 0.036	1.409ProAsn: 1.409 ± 0.045	1.481ProPro: 1.481 ± 0.051	1.425ProGln: 1.425 ± 0.053	1.751ProArg: 1.751 ± 0.046	2.373ProSer: 2.373 ± 0.058	1.757ProThr: 1.757 ± 0.052	3.708ProVal: 3.708 ± 0.072	0.525ProTrp: 0.525 ± 0.024	1.426ProTyr: 1.426 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.692GlnAla: 3.692 ± 0.066	0.202GlnCys: 0.202 ± 0.018	1.432GlnAsp: 1.432 ± 0.042	2.123GlnGlu: 2.123 ± 0.058	1.308GlnPhe: 1.308 ± 0.043	2.533GlnGly: 2.533 ± 0.059	0.638GlnHis: 0.638 ± 0.028	2.036GlnIle: 2.036 ± 0.051	1.496GlnLys: 1.496 ± 0.046	3.678GlnLeu: 3.678 ± 0.074	1.066GlnMet: 1.066 ± 0.036	1.028GlnAsn: 1.028 ± 0.041	1.621GlnPro: 1.621 ± 0.046	1.616GlnGln: 1.616 ± 0.051	1.995GlnArg: 1.995 ± 0.056	2.045GlnSer: 2.045 ± 0.051	1.898GlnThr: 1.898 ± 0.052	2.301GlnVal: 2.301 ± 0.053	0.482GlnTrp: 0.482 ± 0.025	1.032GlnTyr: 1.032 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	4.694ArgAla: 4.694 ± 0.081	0.459ArgCys: 0.459 ± 0.024	2.934ArgAsp: 2.934 ± 0.061	4.476ArgGlu: 4.476 ± 0.093	2.668ArgPhe: 2.668 ± 0.057	3.962ArgGly: 3.962 ± 0.081	1.32ArgHis: 1.32 ± 0.038	4.272ArgIle: 4.272 ± 0.063	3.36ArgLys: 3.36 ± 0.067	6.811ArgLeu: 6.811 ± 0.11	2.125ArgMet: 2.125 ± 0.052	2.108ArgAsn: 2.108 ± 0.059	2.303ArgPro: 2.303 ± 0.058	2.376ArgGln: 2.376 ± 0.055	3.943ArgArg: 3.943 ± 0.092	3.729ArgSer: 3.729 ± 0.076	3.35ArgThr: 3.35 ± 0.062	3.765ArgVal: 3.765 ± 0.08	0.764ArgTrp: 0.764 ± 0.027	2.142ArgTyr: 2.142 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.272SerAla: 5.272 ± 0.091	0.374SerCys: 0.374 ± 0.026	2.817SerAsp: 2.817 ± 0.07	3.484SerGlu: 3.484 ± 0.069	2.564SerPhe: 2.564 ± 0.057	5.742SerGly: 5.742 ± 0.088	1.042SerHis: 1.042 ± 0.035	3.344SerIle: 3.344 ± 0.072	2.337SerLys: 2.337 ± 0.055	5.485SerLeu: 5.485 ± 0.082	1.622SerMet: 1.622 ± 0.055	1.596SerAsn: 1.596 ± 0.048	2.282SerPro: 2.282 ± 0.066	1.615SerGln: 1.615 ± 0.038	3.371SerArg: 3.371 ± 0.071	3.151SerSer: 3.151 ± 0.065	2.571SerThr: 2.571 ± 0.057	4.387SerVal: 4.387 ± 0.096	0.653SerTrp: 0.653 ± 0.027	1.693SerTyr: 1.693 ± 0.053	0.001SerXaa: 0.001 ± 0.001
Thr	5.303ThrAla: 5.303 ± 0.093	0.348ThrCys: 0.348 ± 0.022	2.866ThrAsp: 2.866 ± 0.054	3.173ThrGlu: 3.173 ± 0.061	2.18ThrPhe: 2.18 ± 0.057	4.952ThrGly: 4.952 ± 0.075	0.923ThrHis: 0.923 ± 0.034	3.356ThrIle: 3.356 ± 0.06	2.13ThrLys: 2.13 ± 0.059	5.03ThrLeu: 5.03 ± 0.076	1.376ThrMet: 1.376 ± 0.044	1.596ThrAsn: 1.596 ± 0.053	2.479ThrPro: 2.479 ± 0.057	1.308ThrGln: 1.308 ± 0.041	2.429ThrArg: 2.429 ± 0.057	2.675ThrSer: 2.675 ± 0.059	2.469ThrThr: 2.469 ± 0.057	4.81ThrVal: 4.81 ± 0.096	0.551ThrTrp: 0.551 ± 0.026	1.551ThrTyr: 1.551 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	6.405ValAla: 6.405 ± 0.088	0.691ValCys: 0.691 ± 0.03	3.74ValAsp: 3.74 ± 0.065	4.729ValGlu: 4.729 ± 0.077	2.943ValPhe: 2.943 ± 0.069	5.315ValGly: 5.315 ± 0.093	1.562ValHis: 1.562 ± 0.039	4.738ValIle: 4.738 ± 0.079	3.807ValLys: 3.807 ± 0.077	7.512ValLeu: 7.512 ± 0.108	2.118ValMet: 2.118 ± 0.046	2.722ValAsn: 2.722 ± 0.063	3.448ValPro: 3.448 ± 0.066	2.478ValGln: 2.478 ± 0.058	4.731ValArg: 4.731 ± 0.076	4.67ValSer: 4.67 ± 0.084	4.543ValThr: 4.543 ± 0.086	5.638ValVal: 5.638 ± 0.085	0.956ValTrp: 0.956 ± 0.035	2.404ValTyr: 2.404 ± 0.053	0.001ValXaa: 0.001 ± 0.001
Trp	0.867TrpAla: 0.867 ± 0.034	0.074TrpCys: 0.074 ± 0.009	0.61TrpAsp: 0.61 ± 0.027	0.742TrpGlu: 0.742 ± 0.032	0.546TrpPhe: 0.546 ± 0.028	0.813TrpGly: 0.813 ± 0.032	0.255TrpHis: 0.255 ± 0.02	0.813TrpIle: 0.813 ± 0.033	0.567TrpLys: 0.567 ± 0.03	1.409TrpLeu: 1.409 ± 0.05	0.453TrpMet: 0.453 ± 0.026	0.561TrpAsn: 0.561 ± 0.029	0.422TrpPro: 0.422 ± 0.022	0.486TrpGln: 0.486 ± 0.022	0.771TrpArg: 0.771 ± 0.033	0.758TrpSer: 0.758 ± 0.03	0.714TrpThr: 0.714 ± 0.036	0.747TrpVal: 0.747 ± 0.034	0.185TrpTrp: 0.185 ± 0.015	0.347TrpTyr: 0.347 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.818TyrAla: 2.818 ± 0.052	0.275TyrCys: 0.275 ± 0.019	1.801TyrAsp: 1.801 ± 0.049	2.162TyrGlu: 2.162 ± 0.051	1.357TyrPhe: 1.357 ± 0.046	2.682TyrGly: 2.682 ± 0.057	0.605TyrHis: 0.605 ± 0.027	1.67TyrIle: 1.67 ± 0.04	1.33TyrLys: 1.33 ± 0.045	2.881TyrLeu: 2.881 ± 0.073	0.813TyrMet: 0.813 ± 0.033	1.138TyrAsn: 1.138 ± 0.046	1.371TyrPro: 1.371 ± 0.046	0.962TyrGln: 0.962 ± 0.04	2.264TyrArg: 2.264 ± 0.058	1.642TyrSer: 1.642 ± 0.045	1.537TyrThr: 1.537 ± 0.048	2.154TyrVal: 2.154 ± 0.053	0.403TyrTrp: 0.403 ± 0.024	1.155TyrTyr: 1.155 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2764 proteins (836629 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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