Amino acid dipepetide frequency for Fretibacterium fastidiosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.329AlaAla: 13.329 ± 0.244
1.503AlaCys: 1.503 ± 0.063
5.23AlaAsp: 5.23 ± 0.122
7.42AlaGlu: 7.42 ± 0.153
4.253AlaPhe: 4.253 ± 0.104
8.682AlaGly: 8.682 ± 0.147
1.719AlaHis: 1.719 ± 0.064
5.093AlaIle: 5.093 ± 0.137
3.624AlaLys: 3.624 ± 0.103
12.772AlaLeu: 12.772 ± 0.209
3.455AlaMet: 3.455 ± 0.092
2.38AlaAsn: 2.38 ± 0.077
4.199AlaPro: 4.199 ± 0.104
3.051AlaGln: 3.051 ± 0.098
7.062AlaArg: 7.062 ± 0.14
5.821AlaSer: 5.821 ± 0.137
3.766AlaThr: 3.766 ± 0.104
8.441AlaVal: 8.441 ± 0.147
1.329AlaTrp: 1.329 ± 0.057
2.302AlaTyr: 2.302 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.429CysAla: 1.429 ± 0.057
0.216CysCys: 0.216 ± 0.022
0.675CysAsp: 0.675 ± 0.041
0.601CysGlu: 0.601 ± 0.037
0.538CysPhe: 0.538 ± 0.034
1.545CysGly: 1.545 ± 0.064
0.269CysHis: 0.269 ± 0.024
0.645CysIle: 0.645 ± 0.044
0.374CysLys: 0.374 ± 0.033
1.295CysLeu: 1.295 ± 0.056
0.316CysMet: 0.316 ± 0.027
0.32CysAsn: 0.32 ± 0.027
0.821CysPro: 0.821 ± 0.043
0.306CysGln: 0.306 ± 0.025
1.128CysArg: 1.128 ± 0.066
0.735CysSer: 0.735 ± 0.045
0.673CysThr: 0.673 ± 0.037
1.116CysVal: 1.116 ± 0.056
0.167CysTrp: 0.167 ± 0.02
0.334CysTyr: 0.334 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
5.888AspAla: 5.888 ± 0.147
0.652AspCys: 0.652 ± 0.04
2.378AspAsp: 2.378 ± 0.087
4.357AspGlu: 4.357 ± 0.104
2.29AspPhe: 2.29 ± 0.073
4.93AspGly: 4.93 ± 0.13
0.77AspHis: 0.77 ± 0.041
2.677AspIle: 2.677 ± 0.089
1.954AspLys: 1.954 ± 0.081
5.733AspLeu: 5.733 ± 0.129
1.503AspMet: 1.503 ± 0.057
1.262AspAsn: 1.262 ± 0.065
2.817AspPro: 2.817 ± 0.08
1.067AspGln: 1.067 ± 0.052
3.877AspArg: 3.877 ± 0.101
2.32AspSer: 2.32 ± 0.071
2.183AspThr: 2.183 ± 0.08
5.06AspVal: 5.06 ± 0.128
0.719AspTrp: 0.719 ± 0.043
1.55AspTyr: 1.55 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
8.058GluAla: 8.058 ± 0.16
0.613GluCys: 0.613 ± 0.036
3.875GluAsp: 3.875 ± 0.102
5.007GluGlu: 5.007 ± 0.124
1.954GluPhe: 1.954 ± 0.063
5.958GluGly: 5.958 ± 0.13
1.058GluHis: 1.058 ± 0.049
3.183GluIle: 3.183 ± 0.11
3.552GluLys: 3.552 ± 0.096
6.315GluLeu: 6.315 ± 0.122
1.916GluMet: 1.916 ± 0.061
2.067GluAsn: 2.067 ± 0.072
2.443GluPro: 2.443 ± 0.084
1.907GluGln: 1.907 ± 0.088
5.735GluArg: 5.735 ± 0.142
2.759GluSer: 2.759 ± 0.081
2.956GluThr: 2.956 ± 0.088
4.986GluVal: 4.986 ± 0.109
0.684GluTrp: 0.684 ± 0.047
1.668GluTyr: 1.668 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.724PheAla: 3.724 ± 0.108
0.738PheCys: 0.738 ± 0.042
2.197PheAsp: 2.197 ± 0.074
2.102PheGlu: 2.102 ± 0.065
1.9PhePhe: 1.9 ± 0.083
3.16PheGly: 3.16 ± 0.09
0.691PheHis: 0.691 ± 0.043
2.016PheIle: 2.016 ± 0.076
1.427PheLys: 1.427 ± 0.061
4.22PheLeu: 4.22 ± 0.114
1.065PheMet: 1.065 ± 0.049
1.183PheAsn: 1.183 ± 0.057
1.578PhePro: 1.578 ± 0.064
1.016PheGln: 1.016 ± 0.048
2.443PheArg: 2.443 ± 0.079
2.745PheSer: 2.745 ± 0.077
2.067PheThr: 2.067 ± 0.074
3.009PheVal: 3.009 ± 0.094
0.592PheTrp: 0.592 ± 0.044
1.179PheTyr: 1.179 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
8.988GlyAla: 8.988 ± 0.163
1.274GlyCys: 1.274 ± 0.061
4.223GlyAsp: 4.223 ± 0.115
5.315GlyGlu: 5.315 ± 0.12
3.23GlyPhe: 3.23 ± 0.101
7.584GlyGly: 7.584 ± 0.178
1.494GlyHis: 1.494 ± 0.057
4.919GlyIle: 4.919 ± 0.136
3.858GlyLys: 3.858 ± 0.098
8.61GlyLeu: 8.61 ± 0.148
2.624GlyMet: 2.624 ± 0.071
2.199GlyAsn: 2.199 ± 0.082
2.661GlyPro: 2.661 ± 0.077
2.262GlyGln: 2.262 ± 0.079
6.619GlyArg: 6.619 ± 0.158
4.652GlySer: 4.652 ± 0.104
4.926GlyThr: 4.926 ± 0.117
6.956GlyVal: 6.956 ± 0.16
1.241GlyTrp: 1.241 ± 0.057
2.515GlyTyr: 2.515 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.51HisAla: 1.51 ± 0.053
0.264HisCys: 0.264 ± 0.028
1.042HisAsp: 1.042 ± 0.053
0.944HisGlu: 0.944 ± 0.045
0.752HisPhe: 0.752 ± 0.045
1.448HisGly: 1.448 ± 0.061
0.367HisHis: 0.367 ± 0.031
0.891HisIle: 0.891 ± 0.044
0.541HisLys: 0.541 ± 0.036
1.541HisLeu: 1.541 ± 0.057
0.48HisMet: 0.48 ± 0.031
0.506HisAsn: 0.506 ± 0.033
1.095HisPro: 1.095 ± 0.054
0.397HisGln: 0.397 ± 0.031
1.248HisArg: 1.248 ± 0.053
0.814HisSer: 0.814 ± 0.046
0.775HisThr: 0.775 ± 0.042
1.23HisVal: 1.23 ± 0.049
0.218HisTrp: 0.218 ± 0.021
0.527HisTyr: 0.527 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
5.652IleAla: 5.652 ± 0.143
0.626IleCys: 0.626 ± 0.034
2.858IleAsp: 2.858 ± 0.095
3.206IleGlu: 3.206 ± 0.1
1.893IlePhe: 1.893 ± 0.074
4.09IleGly: 4.09 ± 0.109
0.819IleHis: 0.819 ± 0.045
2.151IleIle: 2.151 ± 0.083
1.724IleLys: 1.724 ± 0.072
5.341IleLeu: 5.341 ± 0.138
1.169IleMet: 1.169 ± 0.052
1.392IleAsn: 1.392 ± 0.059
2.775IlePro: 2.775 ± 0.089
1.399IleGln: 1.399 ± 0.06
3.308IleArg: 3.308 ± 0.086
2.949IleSer: 2.949 ± 0.092
2.466IleThr: 2.466 ± 0.082
4.278IleVal: 4.278 ± 0.117
0.455IleTrp: 0.455 ± 0.036
1.248IleTyr: 1.248 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.19LysAla: 4.19 ± 0.113
0.362LysCys: 0.362 ± 0.03
2.617LysAsp: 2.617 ± 0.103
2.947LysGlu: 2.947 ± 0.099
1.237LysPhe: 1.237 ± 0.047
3.673LysGly: 3.673 ± 0.088
0.613LysHis: 0.613 ± 0.038
1.884LysIle: 1.884 ± 0.078
2.605LysLys: 2.605 ± 0.089
3.907LysLeu: 3.907 ± 0.113
1.186LysMet: 1.186 ± 0.049
1.534LysAsn: 1.534 ± 0.062
1.659LysPro: 1.659 ± 0.072
1.03LysGln: 1.03 ± 0.053
2.763LysArg: 2.763 ± 0.077
2.053LysSer: 2.053 ± 0.072
2.174LysThr: 2.174 ± 0.072
3.262LysVal: 3.262 ± 0.092
0.406LysTrp: 0.406 ± 0.031
1.123LysTyr: 1.123 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
10.591LeuAla: 10.591 ± 0.174
1.64LeuCys: 1.64 ± 0.062
5.826LeuAsp: 5.826 ± 0.114
6.487LeuGlu: 6.487 ± 0.143
4.162LeuPhe: 4.162 ± 0.094
8.308LeuGly: 8.308 ± 0.156
1.81LeuHis: 1.81 ± 0.068
4.963LeuIle: 4.963 ± 0.129
5.16LeuLys: 5.16 ± 0.122
11.266LeuLeu: 11.266 ± 0.242
3.065LeuMet: 3.065 ± 0.095
3.264LeuAsn: 3.264 ± 0.094
5.22LeuPro: 5.22 ± 0.116
2.703LeuGln: 2.703 ± 0.083
7.062LeuArg: 7.062 ± 0.169
7.594LeuSer: 7.594 ± 0.17
5.68LeuThr: 5.68 ± 0.112
6.578LeuVal: 6.578 ± 0.144
1.378LeuTrp: 1.378 ± 0.059
2.701LeuTyr: 2.701 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
3.169MetAla: 3.169 ± 0.095
0.248MetCys: 0.248 ± 0.026
1.666MetAsp: 1.666 ± 0.054
2.172MetGlu: 2.172 ± 0.074
0.8MetPhe: 0.8 ± 0.045
2.471MetGly: 2.471 ± 0.086
0.45MetHis: 0.45 ± 0.032
1.483MetIle: 1.483 ± 0.065
1.705MetLys: 1.705 ± 0.061
2.74MetLeu: 2.74 ± 0.089
0.849MetMet: 0.849 ± 0.051
1.058MetAsn: 1.058 ± 0.049
1.297MetPro: 1.297 ± 0.052
0.821MetGln: 0.821 ± 0.043
1.889MetArg: 1.889 ± 0.069
1.659MetSer: 1.659 ± 0.067
1.879MetThr: 1.879 ± 0.062
1.749MetVal: 1.749 ± 0.064
0.255MetTrp: 0.255 ± 0.024
0.497MetTyr: 0.497 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.241AsnAla: 3.241 ± 0.088
0.427AsnCys: 0.427 ± 0.032
1.462AsnAsp: 1.462 ± 0.07
1.515AsnGlu: 1.515 ± 0.06
1.183AsnPhe: 1.183 ± 0.05
2.445AsnGly: 2.445 ± 0.081
0.457AsnHis: 0.457 ± 0.03
1.329AsnIle: 1.329 ± 0.054
1.097AsnLys: 1.097 ± 0.059
3.174AsnLeu: 3.174 ± 0.086
0.712AsnMet: 0.712 ± 0.037
0.745AsnAsn: 0.745 ± 0.049
1.882AsnPro: 1.882 ± 0.081
0.687AsnGln: 0.687 ± 0.043
1.828AsnArg: 1.828 ± 0.071
1.339AsnSer: 1.339 ± 0.052
1.234AsnThr: 1.234 ± 0.06
2.541AsnVal: 2.541 ± 0.094
0.401AsnTrp: 0.401 ± 0.033
0.838AsnTyr: 0.838 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.362ProAla: 4.362 ± 0.118
0.592ProCys: 0.592 ± 0.046
3.109ProAsp: 3.109 ± 0.092
3.919ProGlu: 3.919 ± 0.097
2.093ProPhe: 2.093 ± 0.074
3.626ProGly: 3.626 ± 0.103
0.814ProHis: 0.814 ± 0.048
2.141ProIle: 2.141 ± 0.073
1.575ProLys: 1.575 ± 0.056
4.605ProLeu: 4.605 ± 0.111
1.153ProMet: 1.153 ± 0.047
1.278ProAsn: 1.278 ± 0.053
1.703ProPro: 1.703 ± 0.073
1.508ProGln: 1.508 ± 0.07
2.561ProArg: 2.561 ± 0.094
2.499ProSer: 2.499 ± 0.082
1.986ProThr: 1.986 ± 0.069
3.74ProVal: 3.74 ± 0.103
0.619ProTrp: 0.619 ± 0.042
1.304ProTyr: 1.304 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.942GlnAla: 2.942 ± 0.094
0.306GlnCys: 0.306 ± 0.031
1.684GlnAsp: 1.684 ± 0.06
2.232GlnGlu: 2.232 ± 0.082
0.877GlnPhe: 0.877 ± 0.048
2.355GlnGly: 2.355 ± 0.086
0.441GlnHis: 0.441 ± 0.036
1.448GlnIle: 1.448 ± 0.059
1.332GlnLys: 1.332 ± 0.058
2.288GlnLeu: 2.288 ± 0.071
0.849GlnMet: 0.849 ± 0.039
0.921GlnAsn: 0.921 ± 0.052
1.121GlnPro: 1.121 ± 0.048
0.898GlnGln: 0.898 ± 0.047
1.97GlnArg: 1.97 ± 0.091
1.341GlnSer: 1.341 ± 0.047
1.202GlnThr: 1.202 ± 0.053
1.87GlnVal: 1.87 ± 0.067
0.346GlnTrp: 0.346 ± 0.031
0.684GlnTyr: 0.684 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
6.731ArgAla: 6.731 ± 0.164
0.949ArgCys: 0.949 ± 0.05
3.807ArgAsp: 3.807 ± 0.094
5.401ArgGlu: 5.401 ± 0.117
2.796ArgPhe: 2.796 ± 0.079
5.58ArgGly: 5.58 ± 0.122
1.271ArgHis: 1.271 ± 0.055
3.833ArgIle: 3.833 ± 0.098
2.657ArgLys: 2.657 ± 0.099
7.042ArgLeu: 7.042 ± 0.147
2.276ArgMet: 2.276 ± 0.07
1.933ArgAsn: 1.933 ± 0.067
2.909ArgPro: 2.909 ± 0.099
2.065ArgGln: 2.065 ± 0.072
6.076ArgArg: 6.076 ± 0.143
4.009ArgSer: 4.009 ± 0.105
3.515ArgThr: 3.515 ± 0.097
5.216ArgVal: 5.216 ± 0.126
1.021ArgTrp: 1.021 ± 0.058
2.0ArgTyr: 2.0 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
5.564SerAla: 5.564 ± 0.12
0.821SerCys: 0.821 ± 0.046
2.761SerAsp: 2.761 ± 0.075
3.225SerGlu: 3.225 ± 0.098
2.55SerPhe: 2.55 ± 0.078
5.805SerGly: 5.805 ± 0.12
0.886SerHis: 0.886 ± 0.049
3.044SerIle: 3.044 ± 0.093
1.703SerLys: 1.703 ± 0.061
6.35SerLeu: 6.35 ± 0.125
1.817SerMet: 1.817 ± 0.062
1.385SerAsn: 1.385 ± 0.054
2.677SerPro: 2.677 ± 0.081
1.364SerGln: 1.364 ± 0.049
3.914SerArg: 3.914 ± 0.092
3.269SerSer: 3.269 ± 0.092
2.503SerThr: 2.503 ± 0.07
4.585SerVal: 4.585 ± 0.12
0.835SerTrp: 0.835 ± 0.046
1.339SerTyr: 1.339 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
5.22ThrAla: 5.22 ± 0.116
0.659ThrCys: 0.659 ± 0.044
2.471ThrAsp: 2.471 ± 0.075
2.8ThrGlu: 2.8 ± 0.084
1.942ThrPhe: 1.942 ± 0.066
4.378ThrGly: 4.378 ± 0.104
0.886ThrHis: 0.886 ± 0.048
2.508ThrIle: 2.508 ± 0.082
1.615ThrLys: 1.615 ± 0.062
5.431ThrLeu: 5.431 ± 0.13
1.297ThrMet: 1.297 ± 0.052
1.304ThrAsn: 1.304 ± 0.071
2.916ThrPro: 2.916 ± 0.09
1.253ThrGln: 1.253 ± 0.063
2.87ThrArg: 2.87 ± 0.088
2.77ThrSer: 2.77 ± 0.077
2.406ThrThr: 2.406 ± 0.079
4.042ThrVal: 4.042 ± 0.098
0.578ThrTrp: 0.578 ± 0.03
1.176ThrTyr: 1.176 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
7.162ValAla: 7.162 ± 0.151
1.086ValCys: 1.086 ± 0.047
3.926ValAsp: 3.926 ± 0.106
4.83ValGlu: 4.83 ± 0.114
3.005ValPhe: 3.005 ± 0.09
6.185ValGly: 6.185 ± 0.137
1.16ValHis: 1.16 ± 0.056
3.854ValIle: 3.854 ± 0.113
3.204ValLys: 3.204 ± 0.088
8.958ValLeu: 8.958 ± 0.158
2.195ValMet: 2.195 ± 0.073
2.404ValAsn: 2.404 ± 0.075
3.705ValPro: 3.705 ± 0.095
2.237ValGln: 2.237 ± 0.077
5.682ValArg: 5.682 ± 0.125
4.835ValSer: 4.835 ± 0.112
4.16ValThr: 4.16 ± 0.116
6.297ValVal: 6.297 ± 0.155
0.877ValTrp: 0.877 ± 0.05
1.935ValTyr: 1.935 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.963TrpAla: 0.963 ± 0.05
0.148TrpCys: 0.148 ± 0.02
0.659TrpAsp: 0.659 ± 0.041
0.691TrpGlu: 0.691 ± 0.04
0.492TrpPhe: 0.492 ± 0.034
1.445TrpGly: 1.445 ± 0.072
0.202TrpHis: 0.202 ± 0.021
0.606TrpIle: 0.606 ± 0.04
0.599TrpLys: 0.599 ± 0.038
1.374TrpLeu: 1.374 ± 0.058
0.348TrpMet: 0.348 ± 0.03
0.503TrpAsn: 0.503 ± 0.033
0.483TrpPro: 0.483 ± 0.037
0.42TrpGln: 0.42 ± 0.029
1.114TrpArg: 1.114 ± 0.062
0.701TrpSer: 0.701 ± 0.039
0.647TrpThr: 0.647 ± 0.045
0.773TrpVal: 0.773 ± 0.04
0.206TrpTrp: 0.206 ± 0.024
0.341TrpTyr: 0.341 ± 0.042
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.719TyrAla: 2.719 ± 0.083
0.378TyrCys: 0.378 ± 0.026
1.524TyrAsp: 1.524 ± 0.059
1.522TyrGlu: 1.522 ± 0.068
1.107TyrPhe: 1.107 ± 0.045
2.48TyrGly: 2.48 ± 0.083
0.411TyrHis: 0.411 ± 0.031
1.135TyrIle: 1.135 ± 0.051
0.919TyrLys: 0.919 ± 0.051
2.496TyrLeu: 2.496 ± 0.075
0.58TyrMet: 0.58 ± 0.035
0.898TyrAsn: 0.898 ± 0.052
1.227TyrPro: 1.227 ± 0.05
0.715TyrGln: 0.715 ± 0.043
1.935TyrArg: 1.935 ± 0.085
1.534TyrSer: 1.534 ± 0.061
1.325TyrThr: 1.325 ± 0.061
1.97TyrVal: 1.97 ± 0.061
0.385TyrTrp: 0.385 ± 0.035
0.742TyrTyr: 0.742 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1434 proteins (431014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski