Amino acid dipepetide frequency for Oenococcus kitaharae DSM 17330

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.28AlaAla: 9.28 ± 0.181
0.296AlaCys: 0.296 ± 0.025
5.92AlaAsp: 5.92 ± 0.121
4.264AlaGlu: 4.264 ± 0.103
4.057AlaPhe: 4.057 ± 0.098
6.557AlaGly: 6.557 ± 0.135
1.591AlaHis: 1.591 ± 0.05
6.358AlaIle: 6.358 ± 0.128
5.793AlaLys: 5.793 ± 0.116
8.586AlaLeu: 8.586 ± 0.139
2.13AlaMet: 2.13 ± 0.067
3.841AlaAsn: 3.841 ± 0.086
2.317AlaPro: 2.317 ± 0.075
3.915AlaGln: 3.915 ± 0.079
3.382AlaArg: 3.382 ± 0.083
5.532AlaSer: 5.532 ± 0.119
3.854AlaThr: 3.854 ± 0.082
6.2AlaVal: 6.2 ± 0.11
0.771AlaTrp: 0.771 ± 0.039
2.727AlaTyr: 2.727 ± 0.066
0.0AlaXaa: 0.0 ± 0.0
Cys
0.258CysAla: 0.258 ± 0.024
0.038CysCys: 0.038 ± 0.008
0.147CysAsp: 0.147 ± 0.016
0.109CysGlu: 0.109 ± 0.016
0.201CysPhe: 0.201 ± 0.018
0.292CysGly: 0.292 ± 0.026
0.089CysHis: 0.089 ± 0.013
0.191CysIle: 0.191 ± 0.018
0.087CysLys: 0.087 ± 0.014
0.497CysLeu: 0.497 ± 0.032
0.064CysMet: 0.064 ± 0.011
0.093CysAsn: 0.093 ± 0.012
0.132CysPro: 0.132 ± 0.019
0.209CysGln: 0.209 ± 0.025
0.149CysArg: 0.149 ± 0.016
0.212CysSer: 0.212 ± 0.022
0.152CysThr: 0.152 ± 0.015
0.201CysVal: 0.201 ± 0.02
0.06CysTrp: 0.06 ± 0.011
0.122CysTyr: 0.122 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.344AspAla: 4.344 ± 0.098
0.183AspCys: 0.183 ± 0.021
3.554AspAsp: 3.554 ± 0.098
3.407AspGlu: 3.407 ± 0.093
3.418AspPhe: 3.418 ± 0.083
3.676AspGly: 3.676 ± 0.091
1.548AspHis: 1.548 ± 0.058
3.493AspIle: 3.493 ± 0.081
3.607AspLys: 3.607 ± 0.089
6.519AspLeu: 6.519 ± 0.131
1.37AspMet: 1.37 ± 0.052
2.437AspAsn: 2.437 ± 0.08
2.705AspPro: 2.705 ± 0.071
3.758AspGln: 3.758 ± 0.086
2.847AspArg: 2.847 ± 0.073
3.351AspSer: 3.351 ± 0.092
2.564AspThr: 2.564 ± 0.069
3.375AspVal: 3.375 ± 0.091
0.882AspTrp: 0.882 ± 0.044
2.631AspTyr: 2.631 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
3.895GluAla: 3.895 ± 0.096
0.103GluCys: 0.103 ± 0.015
2.696GluAsp: 2.696 ± 0.073
2.453GluGlu: 2.453 ± 0.086
1.885GluPhe: 1.885 ± 0.062
2.25GluGly: 2.25 ± 0.064
1.021GluHis: 1.021 ± 0.052
4.017GluIle: 4.017 ± 0.1
4.443GluLys: 4.443 ± 0.116
4.89GluLeu: 4.89 ± 0.11
1.397GluMet: 1.397 ± 0.053
3.126GluAsn: 3.126 ± 0.078
1.388GluPro: 1.388 ± 0.057
2.282GluGln: 2.282 ± 0.074
1.967GluArg: 1.967 ± 0.066
2.702GluSer: 2.702 ± 0.079
2.682GluThr: 2.682 ± 0.073
2.928GluVal: 2.928 ± 0.077
0.37GluTrp: 0.37 ± 0.027
1.363GluTyr: 1.363 ± 0.054
0.002GluXaa: 0.002 ± 0.002
Phe
4.206PheAla: 4.206 ± 0.086
0.232PheCys: 0.232 ± 0.021
3.248PheAsp: 3.248 ± 0.092
2.023PheGlu: 2.023 ± 0.063
2.747PhePhe: 2.747 ± 0.112
3.629PheGly: 3.629 ± 0.092
0.945PheHis: 0.945 ± 0.046
3.262PheIle: 3.262 ± 0.09
2.616PheLys: 2.616 ± 0.06
4.803PheLeu: 4.803 ± 0.109
1.094PheMet: 1.094 ± 0.051
2.295PheAsn: 2.295 ± 0.065
1.758PhePro: 1.758 ± 0.058
2.268PheGln: 2.268 ± 0.077
1.58PheArg: 1.58 ± 0.055
3.819PheSer: 3.819 ± 0.088
2.451PheThr: 2.451 ± 0.064
3.429PheVal: 3.429 ± 0.08
0.644PheTrp: 0.644 ± 0.037
1.733PheTyr: 1.733 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.676GlyAla: 4.676 ± 0.111
0.22GlyCys: 0.22 ± 0.022
3.284GlyAsp: 3.284 ± 0.091
2.858GlyGlu: 2.858 ± 0.066
3.224GlyPhe: 3.224 ± 0.074
4.133GlyGly: 4.133 ± 0.102
1.559GlyHis: 1.559 ± 0.053
5.361GlyIle: 5.361 ± 0.107
4.246GlyLys: 4.246 ± 0.1
6.827GlyLeu: 6.827 ± 0.118
1.698GlyMet: 1.698 ± 0.072
2.702GlyAsn: 2.702 ± 0.077
1.68GlyPro: 1.68 ± 0.062
3.643GlyGln: 3.643 ± 0.093
3.195GlyArg: 3.195 ± 0.082
4.592GlySer: 4.592 ± 0.101
3.469GlyThr: 3.469 ± 0.096
4.151GlyVal: 4.151 ± 0.099
0.797GlyTrp: 0.797 ± 0.041
2.491GlyTyr: 2.491 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
1.588HisAla: 1.588 ± 0.05
0.071HisCys: 0.071 ± 0.011
1.288HisAsp: 1.288 ± 0.053
1.081HisGlu: 1.081 ± 0.048
1.335HisPhe: 1.335 ± 0.05
1.417HisGly: 1.417 ± 0.06
0.662HisHis: 0.662 ± 0.04
1.383HisIle: 1.383 ± 0.051
0.951HisLys: 0.951 ± 0.046
2.312HisLeu: 2.312 ± 0.072
0.472HisMet: 0.472 ± 0.03
0.869HisAsn: 0.869 ± 0.036
1.036HisPro: 1.036 ± 0.048
0.987HisGln: 0.987 ± 0.045
1.009HisArg: 1.009 ± 0.042
1.118HisSer: 1.118 ± 0.042
0.945HisThr: 0.945 ± 0.046
1.277HisVal: 1.277 ± 0.046
0.336HisTrp: 0.336 ± 0.025
0.943HisTyr: 0.943 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.613IleAla: 6.613 ± 0.118
0.327IleCys: 0.327 ± 0.028
4.73IleAsp: 4.73 ± 0.104
3.509IleGlu: 3.509 ± 0.076
3.874IlePhe: 3.874 ± 0.102
5.312IleGly: 5.312 ± 0.112
1.426IleHis: 1.426 ± 0.044
4.988IleIle: 4.988 ± 0.125
4.322IleLys: 4.322 ± 0.086
7.038IleLeu: 7.038 ± 0.137
1.426IleMet: 1.426 ± 0.054
3.776IleAsn: 3.776 ± 0.092
2.771IlePro: 2.771 ± 0.069
3.015IleGln: 3.015 ± 0.071
2.747IleArg: 2.747 ± 0.08
5.452IleSer: 5.452 ± 0.122
3.748IleThr: 3.748 ± 0.085
5.341IleVal: 5.341 ± 0.1
0.735IleTrp: 0.735 ± 0.044
2.439IleTyr: 2.439 ± 0.064
0.002IleXaa: 0.002 ± 0.002
Lys
5.026LysAla: 5.026 ± 0.109
0.112LysCys: 0.112 ± 0.013
3.465LysAsp: 3.465 ± 0.089
3.694LysGlu: 3.694 ± 0.073
2.154LysPhe: 2.154 ± 0.073
3.201LysGly: 3.201 ± 0.073
1.301LysHis: 1.301 ± 0.054
5.162LysIle: 5.162 ± 0.107
5.269LysLys: 5.269 ± 0.114
5.463LysLeu: 5.463 ± 0.103
1.943LysMet: 1.943 ± 0.061
3.69LysAsn: 3.69 ± 0.099
1.825LysPro: 1.825 ± 0.054
3.248LysGln: 3.248 ± 0.096
2.985LysArg: 2.985 ± 0.081
3.821LysSer: 3.821 ± 0.083
3.937LysThr: 3.937 ± 0.109
3.582LysVal: 3.582 ± 0.087
0.488LysTrp: 0.488 ± 0.029
2.038LysTyr: 2.038 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
10.267LeuAla: 10.267 ± 0.146
0.356LeuCys: 0.356 ± 0.024
5.815LeuAsp: 5.815 ± 0.106
3.975LeuGlu: 3.975 ± 0.1
4.931LeuPhe: 4.931 ± 0.136
6.104LeuGly: 6.104 ± 0.113
1.874LeuHis: 1.874 ± 0.053
8.194LeuIle: 8.194 ± 0.144
6.392LeuLys: 6.392 ± 0.126
10.961LeuLeu: 10.961 ± 0.212
2.379LeuMet: 2.379 ± 0.08
4.612LeuAsn: 4.612 ± 0.089
4.527LeuPro: 4.527 ± 0.103
4.05LeuGln: 4.05 ± 0.104
3.836LeuArg: 3.836 ± 0.092
7.646LeuSer: 7.646 ± 0.12
6.632LeuThr: 6.632 ± 0.118
6.49LeuVal: 6.49 ± 0.118
0.896LeuTrp: 0.896 ± 0.04
2.856LeuTyr: 2.856 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.58MetAla: 2.58 ± 0.071
0.074MetCys: 0.074 ± 0.011
1.187MetAsp: 1.187 ± 0.047
0.78MetGlu: 0.78 ± 0.041
0.853MetPhe: 0.853 ± 0.045
1.279MetGly: 1.279 ± 0.043
0.406MetHis: 0.406 ± 0.029
2.016MetIle: 2.016 ± 0.073
1.559MetLys: 1.559 ± 0.058
2.252MetLeu: 2.252 ± 0.075
0.588MetMet: 0.588 ± 0.036
1.254MetAsn: 1.254 ± 0.049
1.118MetPro: 1.118 ± 0.043
1.081MetGln: 1.081 ± 0.043
1.04MetArg: 1.04 ± 0.044
1.778MetSer: 1.778 ± 0.059
2.079MetThr: 2.079 ± 0.064
1.486MetVal: 1.486 ± 0.058
0.154MetTrp: 0.154 ± 0.018
0.579MetTyr: 0.579 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.453AsnAla: 3.453 ± 0.089
0.16AsnCys: 0.16 ± 0.017
2.68AsnAsp: 2.68 ± 0.079
2.206AsnGlu: 2.206 ± 0.069
2.402AsnPhe: 2.402 ± 0.065
3.386AsnGly: 3.386 ± 0.085
1.134AsnHis: 1.134 ± 0.05
2.883AsnIle: 2.883 ± 0.074
2.62AsnLys: 2.62 ± 0.078
4.761AsnLeu: 4.761 ± 0.088
1.178AsnMet: 1.178 ± 0.044
2.23AsnAsn: 2.23 ± 0.071
2.29AsnPro: 2.29 ± 0.06
2.852AsnGln: 2.852 ± 0.08
2.206AsnArg: 2.206 ± 0.062
2.985AsnSer: 2.985 ± 0.08
2.157AsnThr: 2.157 ± 0.064
2.595AsnVal: 2.595 ± 0.078
0.689AsnTrp: 0.689 ± 0.033
1.881AsnTyr: 1.881 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
3.235ProAla: 3.235 ± 0.089
0.085ProCys: 0.085 ± 0.014
2.613ProAsp: 2.613 ± 0.074
2.417ProGlu: 2.417 ± 0.071
1.778ProPhe: 1.778 ± 0.06
2.204ProGly: 2.204 ± 0.06
0.621ProHis: 0.621 ± 0.035
2.734ProIle: 2.734 ± 0.069
2.415ProLys: 2.415 ± 0.07
3.411ProLeu: 3.411 ± 0.073
0.831ProMet: 0.831 ± 0.041
1.745ProAsn: 1.745 ± 0.057
0.501ProPro: 0.501 ± 0.035
1.43ProGln: 1.43 ± 0.054
1.21ProArg: 1.21 ± 0.051
2.188ProSer: 2.188 ± 0.064
2.057ProThr: 2.057 ± 0.055
2.7ProVal: 2.7 ± 0.077
0.374ProTrp: 0.374 ± 0.028
1.241ProTyr: 1.241 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
4.975GlnAla: 4.975 ± 0.112
0.085GlnCys: 0.085 ± 0.013
2.368GlnAsp: 2.368 ± 0.064
2.284GlnGlu: 2.284 ± 0.064
1.842GlnPhe: 1.842 ± 0.061
2.742GlnGly: 2.742 ± 0.066
1.103GlnHis: 1.103 ± 0.041
3.905GlnIle: 3.905 ± 0.086
2.95GlnLys: 2.95 ± 0.077
5.396GlnLeu: 5.396 ± 0.115
1.232GlnMet: 1.232 ± 0.054
2.184GlnAsn: 2.184 ± 0.073
1.658GlnPro: 1.658 ± 0.054
2.767GlnGln: 2.767 ± 0.089
2.286GlnArg: 2.286 ± 0.069
2.945GlnSer: 2.945 ± 0.081
3.092GlnThr: 3.092 ± 0.074
3.182GlnVal: 3.182 ± 0.071
0.372GlnTrp: 0.372 ± 0.027
1.491GlnTyr: 1.491 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
3.22ArgAla: 3.22 ± 0.082
0.094ArgCys: 0.094 ± 0.014
2.344ArgAsp: 2.344 ± 0.077
2.019ArgGlu: 2.019 ± 0.062
2.304ArgPhe: 2.304 ± 0.06
2.388ArgGly: 2.388 ± 0.074
1.049ArgHis: 1.049 ± 0.045
3.211ArgIle: 3.211 ± 0.073
2.524ArgLys: 2.524 ± 0.068
4.703ArgLeu: 4.703 ± 0.114
1.061ArgMet: 1.061 ± 0.043
1.814ArgAsn: 1.814 ± 0.064
1.693ArgPro: 1.693 ± 0.052
2.6ArgGln: 2.6 ± 0.071
2.204ArgArg: 2.204 ± 0.069
2.482ArgSer: 2.482 ± 0.064
1.994ArgThr: 1.994 ± 0.066
2.705ArgVal: 2.705 ± 0.078
0.397ArgTrp: 0.397 ± 0.03
1.646ArgTyr: 1.646 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
5.363SerAla: 5.363 ± 0.1
0.205SerCys: 0.205 ± 0.021
4.298SerAsp: 4.298 ± 0.095
3.322SerGlu: 3.322 ± 0.081
3.485SerPhe: 3.485 ± 0.089
5.158SerGly: 5.158 ± 0.099
1.344SerHis: 1.344 ± 0.049
4.05SerIle: 4.05 ± 0.085
3.743SerLys: 3.743 ± 0.091
6.935SerLeu: 6.935 ± 0.119
1.555SerMet: 1.555 ± 0.049
2.869SerAsn: 2.869 ± 0.078
2.034SerPro: 2.034 ± 0.065
3.447SerGln: 3.447 ± 0.089
2.898SerArg: 2.898 ± 0.078
4.732SerSer: 4.732 ± 0.13
3.311SerThr: 3.311 ± 0.085
4.217SerVal: 4.217 ± 0.099
0.855SerTrp: 0.855 ± 0.039
2.391SerTyr: 2.391 ± 0.068
0.002SerXaa: 0.002 ± 0.002
Thr
5.267ThrAla: 5.267 ± 0.108
0.142ThrCys: 0.142 ± 0.018
3.295ThrAsp: 3.295 ± 0.083
2.566ThrGlu: 2.566 ± 0.07
2.504ThrPhe: 2.504 ± 0.071
3.966ThrGly: 3.966 ± 0.091
1.087ThrHis: 1.087 ± 0.041
4.538ThrIle: 4.538 ± 0.101
3.246ThrLys: 3.246 ± 0.082
5.165ThrLeu: 5.165 ± 0.098
1.185ThrMet: 1.185 ± 0.055
2.491ThrAsn: 2.491 ± 0.079
2.184ThrPro: 2.184 ± 0.07
2.224ThrGln: 2.224 ± 0.07
2.067ThrArg: 2.067 ± 0.066
3.271ThrSer: 3.271 ± 0.082
3.088ThrThr: 3.088 ± 0.085
4.004ThrVal: 4.004 ± 0.091
0.533ThrTrp: 0.533 ± 0.034
1.657ThrTyr: 1.657 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
5.706ValAla: 5.706 ± 0.117
0.356ValCys: 0.356 ± 0.028
4.073ValAsp: 4.073 ± 0.09
2.745ValGlu: 2.745 ± 0.085
3.21ValPhe: 3.21 ± 0.082
4.246ValGly: 4.246 ± 0.095
1.138ValHis: 1.138 ± 0.043
5.055ValIle: 5.055 ± 0.109
3.696ValLys: 3.696 ± 0.081
6.677ValLeu: 6.677 ± 0.119
1.58ValMet: 1.58 ± 0.048
2.979ValAsn: 2.979 ± 0.071
2.455ValPro: 2.455 ± 0.079
2.395ValGln: 2.395 ± 0.069
2.415ValArg: 2.415 ± 0.073
4.89ValSer: 4.89 ± 0.092
3.993ValThr: 3.993 ± 0.083
4.561ValVal: 4.561 ± 0.113
0.662ValTrp: 0.662 ± 0.038
2.17ValTyr: 2.17 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.709TrpAla: 0.709 ± 0.037
0.033TrpCys: 0.033 ± 0.007
0.521TrpAsp: 0.521 ± 0.033
0.406TrpGlu: 0.406 ± 0.031
0.548TrpPhe: 0.548 ± 0.034
0.586TrpGly: 0.586 ± 0.039
0.316TrpHis: 0.316 ± 0.021
0.795TrpIle: 0.795 ± 0.04
0.39TrpLys: 0.39 ± 0.025
1.468TrpLeu: 1.468 ± 0.061
0.278TrpMet: 0.278 ± 0.022
0.439TrpAsn: 0.439 ± 0.028
0.374TrpPro: 0.374 ± 0.028
0.847TrpGln: 0.847 ± 0.037
0.557TrpArg: 0.557 ± 0.039
0.662TrpSer: 0.662 ± 0.032
0.528TrpThr: 0.528 ± 0.033
0.633TrpVal: 0.633 ± 0.036
0.161TrpTrp: 0.161 ± 0.019
0.332TrpTyr: 0.332 ± 0.024
0.002TrpXaa: 0.002 ± 0.002
Tyr
2.709TyrAla: 2.709 ± 0.073
0.131TyrCys: 0.131 ± 0.015
2.141TyrAsp: 2.141 ± 0.069
1.742TyrGlu: 1.742 ± 0.054
2.03TyrPhe: 2.03 ± 0.072
2.282TyrGly: 2.282 ± 0.065
0.865TyrHis: 0.865 ± 0.039
1.998TyrIle: 1.998 ± 0.068
1.535TyrLys: 1.535 ± 0.06
4.126TyrLeu: 4.126 ± 0.087
0.68TyrMet: 0.68 ± 0.036
1.301TyrAsn: 1.301 ± 0.054
1.344TyrPro: 1.344 ± 0.056
1.84TyrGln: 1.84 ± 0.059
1.876TyrArg: 1.876 ± 0.061
2.036TyrSer: 2.036 ± 0.069
1.744TyrThr: 1.744 ± 0.055
1.943TyrVal: 1.943 ± 0.06
0.408TyrTrp: 0.408 ± 0.029
1.335TyrTyr: 1.335 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.004XaaLeu: 0.004 ± 0.003
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.002XaaThr: 0.002 ± 0.002
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.002XaaTyr: 0.002 ± 0.002
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1818 proteins (551158 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski