Amino acid dipepetide frequency for Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.713AlaAla: 13.713 ± 0.156	1.229AlaCys: 1.229 ± 0.041	6.676AlaAsp: 6.676 ± 0.1	8.495AlaGlu: 8.495 ± 0.125	3.551AlaPhe: 3.551 ± 0.069	11.0AlaGly: 11.0 ± 0.131	2.533AlaHis: 2.533 ± 0.051	4.68AlaIle: 4.68 ± 0.081	1.907AlaLys: 1.907 ± 0.055	14.752AlaLeu: 14.752 ± 0.163	2.834AlaMet: 2.834 ± 0.055	2.206AlaAsn: 2.206 ± 0.055	5.338AlaPro: 5.338 ± 0.097	3.734AlaGln: 3.734 ± 0.068	10.055AlaArg: 10.055 ± 0.128	4.66AlaSer: 4.66 ± 0.082	4.889AlaThr: 4.889 ± 0.078	8.792AlaVal: 8.792 ± 0.107	1.923AlaTrp: 1.923 ± 0.051	2.379AlaTyr: 2.379 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.944CysAla: 0.944 ± 0.033	0.135CysCys: 0.135 ± 0.013	0.525CysAsp: 0.525 ± 0.026	0.537CysGlu: 0.537 ± 0.022	0.283CysPhe: 0.283 ± 0.017	0.953CysGly: 0.953 ± 0.034	0.335CysHis: 0.335 ± 0.02	0.355CysIle: 0.355 ± 0.02	0.16CysLys: 0.16 ± 0.013	0.991CysLeu: 0.991 ± 0.034	0.162CysMet: 0.162 ± 0.012	0.231CysAsn: 0.231 ± 0.015	0.643CysPro: 0.643 ± 0.035	0.287CysGln: 0.287 ± 0.018	0.884CysArg: 0.884 ± 0.029	0.425CysSer: 0.425 ± 0.023	0.445CysThr: 0.445 ± 0.026	0.603CysVal: 0.603 ± 0.029	0.155CysTrp: 0.155 ± 0.013	0.226CysTyr: 0.226 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.978AspAla: 5.978 ± 0.091	0.545AspCys: 0.545 ± 0.029	3.864AspAsp: 3.864 ± 0.101	4.472AspGlu: 4.472 ± 0.076	1.944AspPhe: 1.944 ± 0.053	5.311AspGly: 5.311 ± 0.09	1.588AspHis: 1.588 ± 0.044	2.487AspIle: 2.487 ± 0.056	1.244AspLys: 1.244 ± 0.035	6.232AspLeu: 6.232 ± 0.092	1.191AspMet: 1.191 ± 0.035	1.455AspAsn: 1.455 ± 0.047	3.9AspPro: 3.9 ± 0.072	2.258AspGln: 2.258 ± 0.051	5.268AspArg: 5.268 ± 0.081	2.298AspSer: 2.298 ± 0.048	2.773AspThr: 2.773 ± 0.054	3.648AspVal: 3.648 ± 0.073	1.289AspTrp: 1.289 ± 0.044	1.767AspTyr: 1.767 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	9.424GluAla: 9.424 ± 0.138	0.422GluCys: 0.422 ± 0.023	3.483GluAsp: 3.483 ± 0.069	4.224GluGlu: 4.224 ± 0.103	1.586GluPhe: 1.586 ± 0.045	5.565GluGly: 5.565 ± 0.08	1.828GluHis: 1.828 ± 0.048	2.693GluIle: 2.693 ± 0.055	1.612GluLys: 1.612 ± 0.053	6.944GluLeu: 6.944 ± 0.086	1.397GluMet: 1.397 ± 0.038	1.323GluAsn: 1.323 ± 0.038	3.573GluPro: 3.573 ± 0.085	3.553GluGln: 3.553 ± 0.066	6.847GluArg: 6.847 ± 0.102	2.67GluSer: 2.67 ± 0.053	3.328GluThr: 3.328 ± 0.06	4.879GluVal: 4.879 ± 0.072	0.877GluTrp: 0.877 ± 0.033	1.292GluTyr: 1.292 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.175PheAla: 3.175 ± 0.066	0.35PheCys: 0.35 ± 0.021	2.043PheAsp: 2.043 ± 0.052	1.994PheGlu: 1.994 ± 0.049	1.209PhePhe: 1.209 ± 0.04	2.854PheGly: 2.854 ± 0.058	0.896PheHis: 0.896 ± 0.031	1.415PheIle: 1.415 ± 0.045	0.681PheLys: 0.681 ± 0.03	3.2PheLeu: 3.2 ± 0.069	0.734PheMet: 0.734 ± 0.031	0.898PheAsn: 0.898 ± 0.031	1.48PhePro: 1.48 ± 0.043	1.246PheGln: 1.246 ± 0.034	2.434PheArg: 2.434 ± 0.046	1.764PheSer: 1.764 ± 0.048	1.664PheThr: 1.664 ± 0.05	2.151PheVal: 2.151 ± 0.057	0.492PheTrp: 0.492 ± 0.025	0.812PheTyr: 0.812 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.438GlyAla: 8.438 ± 0.123	0.988GlyCys: 0.988 ± 0.045	5.104GlyAsp: 5.104 ± 0.109	6.352GlyGlu: 6.352 ± 0.095	3.132GlyPhe: 3.132 ± 0.067	7.6GlyGly: 7.6 ± 0.156	2.473GlyHis: 2.473 ± 0.056	3.591GlyIle: 3.591 ± 0.072	2.204GlyLys: 2.204 ± 0.058	10.241GlyLeu: 10.241 ± 0.116	2.255GlyMet: 2.255 ± 0.052	1.974GlyAsn: 1.974 ± 0.054	3.806GlyPro: 3.806 ± 0.063	3.385GlyGln: 3.385 ± 0.057	7.576GlyArg: 7.576 ± 0.111	3.914GlySer: 3.914 ± 0.065	4.114GlyThr: 4.114 ± 0.067	6.828GlyVal: 6.828 ± 0.093	1.498GlyTrp: 1.498 ± 0.048	2.357GlyTyr: 2.357 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.44HisAla: 2.44 ± 0.059	0.348HisCys: 0.348 ± 0.017	1.478HisAsp: 1.478 ± 0.048	1.371HisGlu: 1.371 ± 0.042	0.937HisPhe: 0.937 ± 0.037	2.312HisGly: 2.312 ± 0.055	0.831HisHis: 0.831 ± 0.031	0.985HisIle: 0.985 ± 0.031	0.492HisLys: 0.492 ± 0.023	2.745HisLeu: 2.745 ± 0.059	0.491HisMet: 0.491 ± 0.024	0.571HisAsn: 0.571 ± 0.027	1.854HisPro: 1.854 ± 0.048	1.027HisGln: 1.027 ± 0.035	2.394HisArg: 2.394 ± 0.057	1.065HisSer: 1.065 ± 0.035	1.249HisThr: 1.249 ± 0.051	1.441HisVal: 1.441 ± 0.039	0.582HisTrp: 0.582 ± 0.028	0.855HisTyr: 0.855 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.584IleAla: 4.584 ± 0.078	0.381IleCys: 0.381 ± 0.023	2.596IleAsp: 2.596 ± 0.049	2.682IleGlu: 2.682 ± 0.054	1.124IlePhe: 1.124 ± 0.042	3.659IleGly: 3.659 ± 0.076	1.101IleHis: 1.101 ± 0.038	1.743IleIle: 1.743 ± 0.051	1.07IleLys: 1.07 ± 0.039	3.708IleLeu: 3.708 ± 0.076	0.821IleMet: 0.821 ± 0.03	1.273IleAsn: 1.273 ± 0.041	2.282IlePro: 2.282 ± 0.055	1.331IleGln: 1.331 ± 0.042	3.315IleArg: 3.315 ± 0.052	2.08IleSer: 2.08 ± 0.052	2.466IleThr: 2.466 ± 0.049	2.52IleVal: 2.52 ± 0.054	0.453IleTrp: 0.453 ± 0.021	0.945IleTyr: 0.945 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	2.746LysAla: 2.746 ± 0.066	0.136LysCys: 0.136 ± 0.012	1.169LysAsp: 1.169 ± 0.043	1.219LysGlu: 1.219 ± 0.044	0.46LysPhe: 0.46 ± 0.022	1.948LysGly: 1.948 ± 0.053	0.474LysHis: 0.474 ± 0.02	0.789LysIle: 0.789 ± 0.035	0.728LysLys: 0.728 ± 0.036	2.09LysLeu: 2.09 ± 0.053	0.417LysMet: 0.417 ± 0.025	0.472LysAsn: 0.472 ± 0.024	1.288LysPro: 1.288 ± 0.049	0.862LysGln: 0.862 ± 0.033	1.917LysArg: 1.917 ± 0.05	0.937LysSer: 0.937 ± 0.034	1.085LysThr: 1.085 ± 0.038	1.685LysVal: 1.685 ± 0.051	0.189LysTrp: 0.189 ± 0.013	0.466LysTyr: 0.466 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.68LeuAla: 14.68 ± 0.153	1.002LeuCys: 1.002 ± 0.034	7.16LeuAsp: 7.16 ± 0.103	7.625LeuGlu: 7.625 ± 0.107	3.617LeuPhe: 3.617 ± 0.073	9.194LeuGly: 9.194 ± 0.101	2.72LeuHis: 2.72 ± 0.065	4.372LeuIle: 4.372 ± 0.08	2.383LeuLys: 2.383 ± 0.057	12.36LeuLeu: 12.36 ± 0.166	2.415LeuMet: 2.415 ± 0.061	2.578LeuAsn: 2.578 ± 0.05	6.613LeuPro: 6.613 ± 0.088	4.194LeuGln: 4.194 ± 0.069	9.347LeuArg: 9.347 ± 0.118	5.616LeuSer: 5.616 ± 0.087	5.401LeuThr: 5.401 ± 0.075	8.148LeuVal: 8.148 ± 0.126	1.425LeuTrp: 1.425 ± 0.048	2.418LeuTyr: 2.418 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.044MetAla: 3.044 ± 0.06	0.124MetCys: 0.124 ± 0.011	1.258MetAsp: 1.258 ± 0.037	1.338MetGlu: 1.338 ± 0.037	0.508MetPhe: 0.508 ± 0.024	1.916MetGly: 1.916 ± 0.051	0.465MetHis: 0.465 ± 0.023	0.927MetIle: 0.927 ± 0.034	0.688MetLys: 0.688 ± 0.024	2.135MetLeu: 2.135 ± 0.05	0.538MetMet: 0.538 ± 0.022	0.678MetAsn: 0.678 ± 0.028	1.204MetPro: 1.204 ± 0.031	0.804MetGln: 0.804 ± 0.028	1.606MetArg: 1.606 ± 0.041	1.349MetSer: 1.349 ± 0.039	1.317MetThr: 1.317 ± 0.041	1.609MetVal: 1.609 ± 0.042	0.171MetTrp: 0.171 ± 0.014	0.319MetTyr: 0.319 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.432AsnAla: 2.432 ± 0.05	0.221AsnCys: 0.221 ± 0.016	1.24AsnAsp: 1.24 ± 0.038	1.247AsnGlu: 1.247 ± 0.037	0.67AsnPhe: 0.67 ± 0.03	1.967AsnGly: 1.967 ± 0.05	0.542AsnHis: 0.542 ± 0.024	1.103AsnIle: 1.103 ± 0.034	0.463AsnLys: 0.463 ± 0.022	2.497AsnLeu: 2.497 ± 0.054	0.481AsnMet: 0.481 ± 0.024	0.602AsnAsn: 0.602 ± 0.025	1.81AsnPro: 1.81 ± 0.039	0.781AsnGln: 0.781 ± 0.032	2.094AsnArg: 2.094 ± 0.044	0.892AsnSer: 0.892 ± 0.031	1.183AsnThr: 1.183 ± 0.04	1.503AsnVal: 1.503 ± 0.044	0.33AsnTrp: 0.33 ± 0.02	0.522AsnTyr: 0.522 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.434ProAla: 6.434 ± 0.083	0.409ProCys: 0.409 ± 0.019	4.126ProAsp: 4.126 ± 0.076	5.304ProGlu: 5.304 ± 0.091	1.632ProPhe: 1.632 ± 0.044	5.491ProGly: 5.491 ± 0.083	1.168ProHis: 1.168 ± 0.034	1.73ProIle: 1.73 ± 0.049	0.993ProLys: 0.993 ± 0.034	5.729ProLeu: 5.729 ± 0.079	1.176ProMet: 1.176 ± 0.037	1.057ProAsn: 1.057 ± 0.03	3.034ProPro: 3.034 ± 0.066	1.677ProGln: 1.677 ± 0.043	3.915ProArg: 3.915 ± 0.064	2.156ProSer: 2.156 ± 0.048	2.239ProThr: 2.239 ± 0.047	4.66ProVal: 4.66 ± 0.07	0.977ProTrp: 0.977 ± 0.037	1.139ProTyr: 1.139 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.743GlnAla: 5.743 ± 0.084	0.289GlnCys: 0.289 ± 0.017	1.761GlnAsp: 1.761 ± 0.048	2.03GlnGlu: 2.03 ± 0.052	1.009GlnPhe: 1.009 ± 0.029	3.418GlnGly: 3.418 ± 0.062	0.902GlnHis: 0.902 ± 0.033	1.311GlnIle: 1.311 ± 0.035	0.693GlnLys: 0.693 ± 0.031	3.748GlnLeu: 3.748 ± 0.064	0.747GlnMet: 0.747 ± 0.027	0.598GlnAsn: 0.598 ± 0.026	2.205GlnPro: 2.205 ± 0.053	1.745GlnGln: 1.745 ± 0.049	3.902GlnArg: 3.902 ± 0.069	1.61GlnSer: 1.61 ± 0.045	1.637GlnThr: 1.637 ± 0.037	3.26GlnVal: 3.26 ± 0.054	0.583GlnTrp: 0.583 ± 0.024	0.728GlnTyr: 0.728 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.784ArgAla: 8.784 ± 0.127	0.816ArgCys: 0.816 ± 0.027	4.907ArgAsp: 4.907 ± 0.075	6.202ArgGlu: 6.202 ± 0.097	3.157ArgPhe: 3.157 ± 0.059	5.934ArgGly: 5.934 ± 0.088	2.569ArgHis: 2.569 ± 0.056	3.843ArgIle: 3.843 ± 0.064	1.873ArgLys: 1.873 ± 0.049	10.944ArgLeu: 10.944 ± 0.144	2.071ArgMet: 2.071 ± 0.047	1.888ArgAsn: 1.888 ± 0.051	4.616ArgPro: 4.616 ± 0.083	3.788ArgGln: 3.788 ± 0.078	8.144ArgArg: 8.144 ± 0.121	3.497ArgSer: 3.497 ± 0.069	3.45ArgThr: 3.45 ± 0.053	6.444ArgVal: 6.444 ± 0.079	1.428ArgTrp: 1.428 ± 0.046	2.459ArgTyr: 2.459 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.812SerAla: 4.812 ± 0.063	0.334SerCys: 0.334 ± 0.02	2.66SerAsp: 2.66 ± 0.057	2.804SerGlu: 2.804 ± 0.055	1.374SerPhe: 1.374 ± 0.038	4.98SerGly: 4.98 ± 0.082	1.129SerHis: 1.129 ± 0.035	1.653SerIle: 1.653 ± 0.045	0.875SerLys: 0.875 ± 0.035	4.967SerLeu: 4.967 ± 0.077	1.009SerMet: 1.009 ± 0.033	1.034SerAsn: 1.034 ± 0.031	2.505SerPro: 2.505 ± 0.05	1.432SerGln: 1.432 ± 0.04	3.618SerArg: 3.618 ± 0.067	2.0SerSer: 2.0 ± 0.053	2.066SerThr: 2.066 ± 0.045	3.313SerVal: 3.313 ± 0.065	0.586SerTrp: 0.586 ± 0.025	1.0SerTyr: 1.0 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.385ThrAla: 5.385 ± 0.076	0.394ThrCys: 0.394 ± 0.024	2.644ThrAsp: 2.644 ± 0.055	2.665ThrGlu: 2.665 ± 0.054	1.444ThrPhe: 1.444 ± 0.042	5.008ThrGly: 5.008 ± 0.07	1.128ThrHis: 1.128 ± 0.035	1.696ThrIle: 1.696 ± 0.045	0.704ThrLys: 0.704 ± 0.025	6.486ThrLeu: 6.486 ± 0.098	0.756ThrMet: 0.756 ± 0.026	0.878ThrAsn: 0.878 ± 0.027	3.177ThrPro: 3.177 ± 0.062	1.3ThrGln: 1.3 ± 0.034	3.749ThrArg: 3.749 ± 0.058	1.86ThrSer: 1.86 ± 0.047	2.318ThrThr: 2.318 ± 0.061	4.05ThrVal: 4.05 ± 0.074	0.686ThrTrp: 0.686 ± 0.027	0.978ThrTyr: 0.978 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	8.896ValAla: 8.896 ± 0.114	0.721ValCys: 0.721 ± 0.026	4.791ValAsp: 4.791 ± 0.08	4.937ValGlu: 4.937 ± 0.082	2.44ValPhe: 2.44 ± 0.056	5.66ValGly: 5.66 ± 0.095	1.759ValHis: 1.759 ± 0.04	3.443ValIle: 3.443 ± 0.062	1.59ValLys: 1.59 ± 0.055	8.273ValLeu: 8.273 ± 0.11	1.702ValMet: 1.702 ± 0.048	1.915ValAsn: 1.915 ± 0.051	3.714ValPro: 3.714 ± 0.074	2.577ValGln: 2.577 ± 0.047	5.806ValArg: 5.806 ± 0.073	3.586ValSer: 3.586 ± 0.069	3.936ValThr: 3.936 ± 0.066	6.392ValVal: 6.392 ± 0.11	0.922ValTrp: 0.922 ± 0.034	1.591ValTyr: 1.591 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.459TrpAla: 1.459 ± 0.044	0.164TrpCys: 0.164 ± 0.014	0.729TrpAsp: 0.729 ± 0.028	0.771TrpGlu: 0.771 ± 0.026	0.535TrpPhe: 0.535 ± 0.025	1.071TrpGly: 1.071 ± 0.042	0.395TrpHis: 0.395 ± 0.021	0.524TrpIle: 0.524 ± 0.024	0.264TrpLys: 0.264 ± 0.017	2.4TrpLeu: 2.4 ± 0.064	0.358TrpMet: 0.358 ± 0.019	0.339TrpAsn: 0.339 ± 0.017	0.804TrpPro: 0.804 ± 0.031	0.842TrpGln: 0.842 ± 0.027	1.415TrpArg: 1.415 ± 0.044	0.708TrpSer: 0.708 ± 0.027	0.606TrpThr: 0.606 ± 0.021	1.206TrpVal: 1.206 ± 0.04	0.319TrpTrp: 0.319 ± 0.019	0.39TrpTyr: 0.39 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.235TyrAla: 2.235 ± 0.047	0.272TyrCys: 0.272 ± 0.016	1.298TyrAsp: 1.298 ± 0.037	1.254TyrGlu: 1.254 ± 0.037	0.878TyrPhe: 0.878 ± 0.035	1.989TyrGly: 1.989 ± 0.043	0.631TyrHis: 0.631 ± 0.027	0.796TyrIle: 0.796 ± 0.033	0.451TyrLys: 0.451 ± 0.023	2.826TyrLeu: 2.826 ± 0.059	0.442TyrMet: 0.442 ± 0.025	0.608TyrAsn: 0.608 ± 0.027	1.199TyrPro: 1.199 ± 0.037	1.097TyrGln: 1.097 ± 0.036	2.53TyrArg: 2.53 ± 0.051	1.065TyrSer: 1.065 ± 0.033	1.141TyrThr: 1.141 ± 0.04	1.517TyrVal: 1.517 ± 0.04	0.414TyrTrp: 0.414 ± 0.022	0.667TyrTyr: 0.667 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2862 proteins (983950 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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