Amino acid dipepetide frequency for Marixanthomonas sp. HN-E44

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.698AlaAla: 4.698 ± 0.096	0.572AlaCys: 0.572 ± 0.026	3.331AlaAsp: 3.331 ± 0.064	4.517AlaGlu: 4.517 ± 0.077	3.414AlaPhe: 3.414 ± 0.064	4.347AlaGly: 4.347 ± 0.087	1.215AlaHis: 1.215 ± 0.041	5.332AlaIle: 5.332 ± 0.072	4.774AlaLys: 4.774 ± 0.089	6.571AlaLeu: 6.571 ± 0.097	1.683AlaMet: 1.683 ± 0.041	3.372AlaAsn: 3.372 ± 0.068	2.069AlaPro: 2.069 ± 0.057	2.655AlaGln: 2.655 ± 0.055	2.063AlaArg: 2.063 ± 0.055	4.297AlaSer: 4.297 ± 0.074	4.233AlaThr: 4.233 ± 0.106	4.699AlaVal: 4.699 ± 0.067	0.588AlaTrp: 0.588 ± 0.027	2.58AlaTyr: 2.58 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.442CysAla: 0.442 ± 0.024	0.109CysCys: 0.109 ± 0.012	0.424CysAsp: 0.424 ± 0.028	0.484CysGlu: 0.484 ± 0.021	0.378CysPhe: 0.378 ± 0.02	0.633CysGly: 0.633 ± 0.032	0.161CysHis: 0.161 ± 0.015	0.528CysIle: 0.528 ± 0.023	0.43CysLys: 0.43 ± 0.02	0.622CysLeu: 0.622 ± 0.027	0.13CysMet: 0.13 ± 0.01	0.395CysAsn: 0.395 ± 0.02	0.301CysPro: 0.301 ± 0.023	0.219CysGln: 0.219 ± 0.021	0.203CysArg: 0.203 ± 0.014	0.536CysSer: 0.536 ± 0.031	0.469CysThr: 0.469 ± 0.034	0.438CysVal: 0.438 ± 0.02	0.065CysTrp: 0.065 ± 0.008	0.291CysTyr: 0.291 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.923AspAla: 3.923 ± 0.07	0.439AspCys: 0.439 ± 0.029	3.185AspAsp: 3.185 ± 0.071	3.837AspGlu: 3.837 ± 0.063	3.526AspPhe: 3.526 ± 0.054	4.054AspGly: 4.054 ± 0.114	0.975AspHis: 0.975 ± 0.033	4.209AspIle: 4.209 ± 0.078	3.811AspLys: 3.811 ± 0.078	4.793AspLeu: 4.793 ± 0.071	1.122AspMet: 1.122 ± 0.039	3.122AspAsn: 3.122 ± 0.074	1.988AspPro: 1.988 ± 0.062	1.441AspGln: 1.441 ± 0.036	2.009AspArg: 2.009 ± 0.045	3.117AspSer: 3.117 ± 0.071	3.214AspThr: 3.214 ± 0.08	3.775AspVal: 3.775 ± 0.072	0.708AspTrp: 0.708 ± 0.03	2.8AspTyr: 2.8 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	5.044GluAla: 5.044 ± 0.089	0.33GluCys: 0.33 ± 0.019	3.864GluAsp: 3.864 ± 0.063	5.509GluGlu: 5.509 ± 0.106	2.833GluPhe: 2.833 ± 0.062	4.006GluGly: 4.006 ± 0.073	1.315GluHis: 1.315 ± 0.039	5.412GluIle: 5.412 ± 0.073	6.381GluLys: 6.381 ± 0.098	6.004GluLeu: 6.004 ± 0.087	1.617GluMet: 1.617 ± 0.04	4.926GluAsn: 4.926 ± 0.084	1.706GluPro: 1.706 ± 0.045	2.525GluGln: 2.525 ± 0.055	2.726GluArg: 2.726 ± 0.065	2.935GluSer: 2.935 ± 0.052	4.589GluThr: 4.589 ± 0.076	4.442GluVal: 4.442 ± 0.076	0.554GluTrp: 0.554 ± 0.024	2.478GluTyr: 2.478 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	2.938PheAla: 2.938 ± 0.057	0.403PheCys: 0.403 ± 0.023	3.036PheAsp: 3.036 ± 0.05	3.462PheGlu: 3.462 ± 0.064	2.811PhePhe: 2.811 ± 0.071	3.575PheGly: 3.575 ± 0.072	0.804PheHis: 0.804 ± 0.026	3.637PheIle: 3.637 ± 0.061	3.787PheLys: 3.787 ± 0.075	4.644PheLeu: 4.644 ± 0.093	1.096PheMet: 1.096 ± 0.033	3.017PheAsn: 3.017 ± 0.066	1.786PhePro: 1.786 ± 0.048	1.609PheGln: 1.609 ± 0.048	1.564PheArg: 1.564 ± 0.046	4.059PheSer: 4.059 ± 0.074	3.203PheThr: 3.203 ± 0.066	2.961PheVal: 2.961 ± 0.057	0.56PheTrp: 0.56 ± 0.027	2.119PheTyr: 2.119 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	4.246GlyAla: 4.246 ± 0.086	0.552GlyCys: 0.552 ± 0.035	3.663GlyAsp: 3.663 ± 0.084	3.754GlyGlu: 3.754 ± 0.07	3.611GlyPhe: 3.611 ± 0.071	4.775GlyGly: 4.775 ± 0.144	1.137GlyHis: 1.137 ± 0.038	5.144GlyIle: 5.144 ± 0.08	4.906GlyLys: 4.906 ± 0.079	5.603GlyLeu: 5.603 ± 0.084	1.703GlyMet: 1.703 ± 0.045	3.815GlyAsn: 3.815 ± 0.08	1.494GlyPro: 1.494 ± 0.051	1.86GlyGln: 1.86 ± 0.047	2.123GlyArg: 2.123 ± 0.047	4.017GlySer: 4.017 ± 0.088	4.408GlyThr: 4.408 ± 0.124	4.356GlyVal: 4.356 ± 0.076	0.757GlyTrp: 0.757 ± 0.027	2.782GlyTyr: 2.782 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.999HisAla: 0.999 ± 0.032	0.172HisCys: 0.172 ± 0.015	0.848HisAsp: 0.848 ± 0.031	0.974HisGlu: 0.974 ± 0.032	1.109HisPhe: 1.109 ± 0.036	1.061HisGly: 1.061 ± 0.033	0.477HisHis: 0.477 ± 0.02	1.437HisIle: 1.437 ± 0.038	1.294HisLys: 1.294 ± 0.041	1.785HisLeu: 1.785 ± 0.046	0.28HisMet: 0.28 ± 0.018	0.993HisAsn: 0.993 ± 0.036	0.96HisPro: 0.96 ± 0.035	0.685HisGln: 0.685 ± 0.024	0.697HisArg: 0.697 ± 0.027	1.044HisSer: 1.044 ± 0.036	1.125HisThr: 1.125 ± 0.036	0.962HisVal: 0.962 ± 0.031	0.204HisTrp: 0.204 ± 0.014	0.861HisTyr: 0.861 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.727IleAla: 5.727 ± 0.082	0.567IleCys: 0.567 ± 0.023	4.926IleAsp: 4.926 ± 0.08	5.296IleGlu: 5.296 ± 0.077	3.222IlePhe: 3.222 ± 0.069	4.783IleGly: 4.783 ± 0.067	1.193IleHis: 1.193 ± 0.037	5.076IleIle: 5.076 ± 0.095	5.076IleLys: 5.076 ± 0.085	6.481IleLeu: 6.481 ± 0.098	1.227IleMet: 1.227 ± 0.039	4.014IleAsn: 4.014 ± 0.073	3.148IlePro: 3.148 ± 0.054	2.338IleGln: 2.338 ± 0.048	2.403IleArg: 2.403 ± 0.045	5.28IleSer: 5.28 ± 0.07	4.645IleThr: 4.645 ± 0.087	4.647IleVal: 4.647 ± 0.067	0.641IleTrp: 0.641 ± 0.027	2.515IleTyr: 2.515 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	5.169LysAla: 5.169 ± 0.101	0.294LysCys: 0.294 ± 0.018	4.353LysAsp: 4.353 ± 0.077	6.54LysGlu: 6.54 ± 0.105	2.627LysPhe: 2.627 ± 0.059	4.482LysGly: 4.482 ± 0.079	1.447LysHis: 1.447 ± 0.046	5.512LysIle: 5.512 ± 0.084	7.802LysLys: 7.802 ± 0.108	6.566LysLeu: 6.566 ± 0.089	2.038LysMet: 2.038 ± 0.054	5.257LysAsn: 5.257 ± 0.086	2.64LysPro: 2.64 ± 0.057	3.05LysGln: 3.05 ± 0.058	3.269LysArg: 3.269 ± 0.06	3.889LysSer: 3.889 ± 0.083	5.09LysThr: 5.09 ± 0.081	4.344LysVal: 4.344 ± 0.074	0.687LysTrp: 0.687 ± 0.025	2.693LysTyr: 2.693 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	6.027LeuAla: 6.027 ± 0.088	0.668LeuCys: 0.668 ± 0.031	4.826LeuAsp: 4.826 ± 0.067	5.896LeuGlu: 5.896 ± 0.079	5.044LeuPhe: 5.044 ± 0.085	5.64LeuGly: 5.64 ± 0.081	1.633LeuHis: 1.633 ± 0.043	6.311LeuIle: 6.311 ± 0.085	7.786LeuLys: 7.786 ± 0.123	9.273LeuLeu: 9.273 ± 0.145	1.998LeuMet: 1.998 ± 0.054	5.133LeuAsn: 5.133 ± 0.074	3.574LeuPro: 3.574 ± 0.06	3.832LeuGln: 3.832 ± 0.059	3.317LeuArg: 3.317 ± 0.067	6.35LeuSer: 6.35 ± 0.08	5.196LeuThr: 5.196 ± 0.077	5.564LeuVal: 5.564 ± 0.077	0.842LeuTrp: 0.842 ± 0.035	3.305LeuTyr: 3.305 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	1.845MetAla: 1.845 ± 0.048	0.123MetCys: 0.123 ± 0.01	1.312MetAsp: 1.312 ± 0.037	1.537MetGlu: 1.537 ± 0.047	0.745MetPhe: 0.745 ± 0.025	1.475MetGly: 1.475 ± 0.043	0.415MetHis: 0.415 ± 0.023	1.32MetIle: 1.32 ± 0.038	2.221MetLys: 2.221 ± 0.049	1.933MetLeu: 1.933 ± 0.05	0.578MetMet: 0.578 ± 0.029	1.175MetAsn: 1.175 ± 0.035	0.871MetPro: 0.871 ± 0.028	0.857MetGln: 0.857 ± 0.03	0.891MetArg: 0.891 ± 0.032	1.192MetSer: 1.192 ± 0.034	1.135MetThr: 1.135 ± 0.037	1.399MetVal: 1.399 ± 0.037	0.158MetTrp: 0.158 ± 0.013	0.723MetTyr: 0.723 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.663AsnAla: 3.663 ± 0.063	0.49AsnCys: 0.49 ± 0.023	3.288AsnAsp: 3.288 ± 0.089	3.686AsnGlu: 3.686 ± 0.068	2.856AsnPhe: 2.856 ± 0.059	4.047AsnGly: 4.047 ± 0.099	1.009AsnHis: 1.009 ± 0.033	4.272AsnIle: 4.272 ± 0.076	4.174AsnLys: 4.174 ± 0.075	5.159AsnLeu: 5.159 ± 0.075	1.256AsnMet: 1.256 ± 0.037	3.699AsnAsn: 3.699 ± 0.082	2.93AsnPro: 2.93 ± 0.056	2.037AsnGln: 2.037 ± 0.05	2.308AsnArg: 2.308 ± 0.054	3.423AsnSer: 3.423 ± 0.068	3.821AsnThr: 3.821 ± 0.072	3.467AsnVal: 3.467 ± 0.086	0.74AsnTrp: 0.74 ± 0.029	2.496AsnTyr: 2.496 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	2.046ProAla: 2.046 ± 0.05	0.216ProCys: 0.216 ± 0.015	2.188ProAsp: 2.188 ± 0.058	3.001ProGlu: 3.001 ± 0.053	2.011ProPhe: 2.011 ± 0.041	2.042ProGly: 2.042 ± 0.047	0.654ProHis: 0.654 ± 0.029	2.55ProIle: 2.55 ± 0.05	2.792ProLys: 2.792 ± 0.063	3.144ProLeu: 3.144 ± 0.054	0.733ProMet: 0.733 ± 0.031	2.24ProAsn: 2.24 ± 0.059	1.046ProPro: 1.046 ± 0.039	1.266ProGln: 1.266 ± 0.036	0.965ProArg: 0.965 ± 0.031	2.207ProSer: 2.207 ± 0.055	2.084ProThr: 2.084 ± 0.051	2.6ProVal: 2.6 ± 0.053	0.339ProTrp: 0.339 ± 0.02	1.426ProTyr: 1.426 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.369GlnAla: 2.369 ± 0.048	0.181GlnCys: 0.181 ± 0.014	1.744GlnAsp: 1.744 ± 0.045	2.418GlnGlu: 2.418 ± 0.046	1.743GlnPhe: 1.743 ± 0.041	1.911GlnGly: 1.911 ± 0.04	0.672GlnHis: 0.672 ± 0.024	2.296GlnIle: 2.296 ± 0.047	2.981GlnLys: 2.981 ± 0.063	3.843GlnLeu: 3.843 ± 0.074	0.857GlnMet: 0.857 ± 0.028	2.11GlnAsn: 2.11 ± 0.049	1.293GlnPro: 1.293 ± 0.042	1.775GlnGln: 1.775 ± 0.048	1.338GlnArg: 1.338 ± 0.042	1.8GlnSer: 1.8 ± 0.044	2.038GlnThr: 2.038 ± 0.046	2.108GlnVal: 2.108 ± 0.049	0.353GlnTrp: 0.353 ± 0.021	1.373GlnTyr: 1.373 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.118ArgAla: 2.118 ± 0.045	0.197ArgCys: 0.197 ± 0.015	1.933ArgAsp: 1.933 ± 0.041	2.362ArgGlu: 2.362 ± 0.058	2.019ArgPhe: 2.019 ± 0.048	1.954ArgGly: 1.954 ± 0.048	0.629ArgHis: 0.629 ± 0.024	2.742ArgIle: 2.742 ± 0.055	3.071ArgLys: 3.071 ± 0.068	3.357ArgLeu: 3.357 ± 0.064	0.943ArgMet: 0.943 ± 0.033	2.203ArgAsn: 2.203 ± 0.047	1.141ArgPro: 1.141 ± 0.034	1.15ArgGln: 1.15 ± 0.032	1.407ArgArg: 1.407 ± 0.045	1.935ArgSer: 1.935 ± 0.047	1.878ArgThr: 1.878 ± 0.049	2.143ArgVal: 2.143 ± 0.05	0.398ArgTrp: 0.398 ± 0.019	1.637ArgTyr: 1.637 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.626SerAla: 3.626 ± 0.063	0.61SerCys: 0.61 ± 0.025	2.987SerAsp: 2.987 ± 0.059	4.798SerGlu: 4.798 ± 0.086	3.479SerPhe: 3.479 ± 0.067	4.552SerGly: 4.552 ± 0.092	0.932SerHis: 0.932 ± 0.036	4.645SerIle: 4.645 ± 0.08	4.604SerLys: 4.604 ± 0.078	5.702SerLeu: 5.702 ± 0.083	1.195SerMet: 1.195 ± 0.035	3.424SerAsn: 3.424 ± 0.069	2.071SerPro: 2.071 ± 0.046	2.041SerGln: 2.041 ± 0.048	2.014SerArg: 2.014 ± 0.044	3.723SerSer: 3.723 ± 0.075	3.387SerThr: 3.387 ± 0.071	4.142SerVal: 4.142 ± 0.065	0.636SerTrp: 0.636 ± 0.029	2.515SerTyr: 2.515 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.475ThrAla: 4.475 ± 0.104	0.411ThrCys: 0.411 ± 0.029	3.646ThrAsp: 3.646 ± 0.097	4.018ThrGlu: 4.018 ± 0.06	3.12ThrPhe: 3.12 ± 0.073	4.294ThrGly: 4.294 ± 0.092	1.11ThrHis: 1.11 ± 0.036	4.954ThrIle: 4.954 ± 0.095	3.804ThrLys: 3.804 ± 0.062	5.742ThrLeu: 5.742 ± 0.093	1.073ThrMet: 1.073 ± 0.031	3.284ThrAsn: 3.284 ± 0.073	2.482ThrPro: 2.482 ± 0.059	1.983ThrGln: 1.983 ± 0.048	1.673ThrArg: 1.673 ± 0.047	3.544ThrSer: 3.544 ± 0.06	3.805ThrThr: 3.805 ± 0.093	4.875ThrVal: 4.875 ± 0.127	0.627ThrTrp: 0.627 ± 0.03	2.51ThrTyr: 2.51 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	4.531ValAla: 4.531 ± 0.072	0.523ValCys: 0.523 ± 0.023	3.554ValAsp: 3.554 ± 0.064	4.155ValGlu: 4.155 ± 0.068	3.562ValPhe: 3.562 ± 0.067	3.842ValGly: 3.842 ± 0.062	1.127ValHis: 1.127 ± 0.034	4.594ValIle: 4.594 ± 0.074	4.297ValLys: 4.297 ± 0.062	6.284ValLeu: 6.284 ± 0.093	1.417ValMet: 1.417 ± 0.039	3.484ValAsn: 3.484 ± 0.07	2.362ValPro: 2.362 ± 0.048	2.002ValGln: 2.002 ± 0.046	2.14ValArg: 2.14 ± 0.046	4.756ValSer: 4.756 ± 0.077	4.113ValThr: 4.113 ± 0.114	4.446ValVal: 4.446 ± 0.066	0.631ValTrp: 0.631 ± 0.026	2.52ValTyr: 2.52 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.642TrpAla: 0.642 ± 0.028	0.081TrpCys: 0.081 ± 0.009	0.555TrpAsp: 0.555 ± 0.026	0.645TrpGlu: 0.645 ± 0.028	0.57TrpPhe: 0.57 ± 0.024	0.587TrpGly: 0.587 ± 0.026	0.234TrpHis: 0.234 ± 0.016	0.705TrpIle: 0.705 ± 0.028	0.765TrpLys: 0.765 ± 0.027	1.028TrpLeu: 1.028 ± 0.037	0.294TrpMet: 0.294 ± 0.02	0.693TrpAsn: 0.693 ± 0.028	0.254TrpPro: 0.254 ± 0.017	0.444TrpGln: 0.444 ± 0.022	0.394TrpArg: 0.394 ± 0.021	0.506TrpSer: 0.506 ± 0.022	0.487TrpThr: 0.487 ± 0.023	0.626TrpVal: 0.626 ± 0.026	0.139TrpTrp: 0.139 ± 0.012	0.454TrpTyr: 0.454 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.484TyrAla: 2.484 ± 0.058	0.318TyrCys: 0.318 ± 0.021	2.383TyrAsp: 2.383 ± 0.049	2.306TyrGlu: 2.306 ± 0.049	2.391TyrPhe: 2.391 ± 0.052	2.645TyrGly: 2.645 ± 0.055	0.828TyrHis: 0.828 ± 0.032	2.532TyrIle: 2.532 ± 0.059	2.989TyrLys: 2.989 ± 0.059	3.68TyrLeu: 3.68 ± 0.075	0.662TyrMet: 0.662 ± 0.025	2.467TyrAsn: 2.467 ± 0.059	1.437TyrPro: 1.437 ± 0.041	1.433TyrGln: 1.433 ± 0.043	1.713TyrArg: 1.713 ± 0.041	2.477TyrSer: 2.477 ± 0.055	2.509TyrThr: 2.509 ± 0.086	2.347TyrVal: 2.347 ± 0.049	0.478TyrTrp: 0.478 ± 0.024	1.837TyrTyr: 1.837 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3068 proteins (1006229 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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