Amino acid dipepetide frequency for Bos taurus papillomavirus 11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.603AlaAla: 6.603 ± 1.719
0.413AlaCys: 0.413 ± 0.476
2.889AlaAsp: 2.889 ± 0.815
3.302AlaGlu: 3.302 ± 1.462
2.889AlaPhe: 2.889 ± 0.738
3.714AlaGly: 3.714 ± 0.615
0.413AlaHis: 0.413 ± 0.462
2.476AlaIle: 2.476 ± 1.135
2.889AlaLys: 2.889 ± 1.037
4.54AlaLeu: 4.54 ± 0.99
0.413AlaMet: 0.413 ± 0.348
1.651AlaAsn: 1.651 ± 0.866
2.476AlaPro: 2.476 ± 0.496
3.302AlaGln: 3.302 ± 0.641
3.714AlaArg: 3.714 ± 1.257
4.54AlaSer: 4.54 ± 0.814
5.365AlaThr: 5.365 ± 1.026
3.302AlaVal: 3.302 ± 0.98
0.0AlaTrp: 0.0 ± 0.0
3.302AlaTyr: 3.302 ± 0.977
0.0AlaXaa: 0.0 ± 0.0
Cys
1.238CysAla: 1.238 ± 0.995
1.238CysCys: 1.238 ± 0.705
1.651CysAsp: 1.651 ± 0.62
1.651CysGlu: 1.651 ± 1.116
1.651CysPhe: 1.651 ± 0.694
0.413CysGly: 0.413 ± 0.462
0.0CysHis: 0.0 ± 0.0
3.302CysIle: 3.302 ± 1.274
1.651CysLys: 1.651 ± 0.694
0.0CysLeu: 0.0 ± 0.0
0.825CysMet: 0.825 ± 0.408
1.238CysAsn: 1.238 ± 0.72
1.651CysPro: 1.651 ± 1.009
0.0CysGln: 0.0 ± 0.0
0.825CysArg: 0.825 ± 0.402
1.651CysSer: 1.651 ± 1.116
0.413CysThr: 0.413 ± 0.332
0.825CysVal: 0.825 ± 0.719
0.413CysTrp: 0.413 ± 0.359
1.238CysTyr: 1.238 ± 0.87
0.0CysXaa: 0.0 ± 0.0
Asp
4.54AspAla: 4.54 ± 1.291
1.238AspCys: 1.238 ± 0.351
5.365AspAsp: 5.365 ± 0.922
3.714AspGlu: 3.714 ± 1.379
3.302AspPhe: 3.302 ± 0.996
3.714AspGly: 3.714 ± 1.125
2.064AspHis: 2.064 ± 0.705
4.953AspIle: 4.953 ± 1.452
0.825AspLys: 0.825 ± 0.515
5.778AspLeu: 5.778 ± 1.573
1.651AspMet: 1.651 ± 0.655
2.476AspAsn: 2.476 ± 1.022
4.953AspPro: 4.953 ± 0.855
1.238AspGln: 1.238 ± 0.728
2.889AspArg: 2.889 ± 1.513
3.714AspSer: 3.714 ± 0.951
3.714AspThr: 3.714 ± 1.344
1.651AspVal: 1.651 ± 0.75
0.825AspTrp: 0.825 ± 0.495
0.413AspTyr: 0.413 ± 0.373
0.0AspXaa: 0.0 ± 0.0
Glu
3.302GluAla: 3.302 ± 1.095
1.238GluCys: 1.238 ± 0.705
4.54GluAsp: 4.54 ± 1.418
7.842GluGlu: 7.842 ± 2.485
1.651GluPhe: 1.651 ± 1.007
4.54GluGly: 4.54 ± 1.283
0.413GluHis: 0.413 ± 0.359
3.714GluIle: 3.714 ± 1.688
2.064GluLys: 2.064 ± 0.993
3.714GluLeu: 3.714 ± 1.131
2.064GluMet: 2.064 ± 0.841
4.953GluAsn: 4.953 ± 0.987
2.476GluPro: 2.476 ± 0.681
2.476GluGln: 2.476 ± 0.511
1.238GluArg: 1.238 ± 0.666
5.365GluSer: 5.365 ± 1.516
2.889GluThr: 2.889 ± 0.79
3.714GluVal: 3.714 ± 1.331
0.413GluTrp: 0.413 ± 0.359
0.825GluTyr: 0.825 ± 0.412
0.0GluXaa: 0.0 ± 0.0
Phe
2.476PheAla: 2.476 ± 0.736
0.413PheCys: 0.413 ± 0.476
1.651PheAsp: 1.651 ± 0.554
2.889PheGlu: 2.889 ± 0.901
2.476PhePhe: 2.476 ± 0.912
2.064PheGly: 2.064 ± 0.657
0.413PheHis: 0.413 ± 0.332
3.302PheIle: 3.302 ± 1.065
2.476PheLys: 2.476 ± 0.867
6.191PheLeu: 6.191 ± 0.874
1.651PheMet: 1.651 ± 0.592
2.476PheAsn: 2.476 ± 0.888
1.651PhePro: 1.651 ± 0.927
2.476PheGln: 2.476 ± 0.932
2.476PheArg: 2.476 ± 0.455
2.889PheSer: 2.889 ± 0.889
2.064PheThr: 2.064 ± 0.757
3.302PheVal: 3.302 ± 0.655
2.476PheTrp: 2.476 ± 1.079
1.238PheTyr: 1.238 ± 0.406
0.0PheXaa: 0.0 ± 0.0
Gly
1.238GlyAla: 1.238 ± 0.686
1.651GlyCys: 1.651 ± 0.467
4.953GlyAsp: 4.953 ± 1.301
4.54GlyGlu: 4.54 ± 1.268
2.476GlyPhe: 2.476 ± 0.554
5.365GlyGly: 5.365 ± 2.402
2.476GlyHis: 2.476 ± 0.907
4.127GlyIle: 4.127 ± 1.036
3.302GlyLys: 3.302 ± 0.723
2.476GlyLeu: 2.476 ± 0.691
0.0GlyMet: 0.0 ± 0.0
3.302GlyAsn: 3.302 ± 1.288
4.127GlyPro: 4.127 ± 1.657
3.714GlyGln: 3.714 ± 1.251
6.191GlyArg: 6.191 ± 2.062
4.54GlySer: 4.54 ± 0.668
3.714GlyThr: 3.714 ± 0.737
3.302GlyVal: 3.302 ± 1.302
0.825GlyTrp: 0.825 ± 0.592
2.064GlyTyr: 2.064 ± 0.693
0.0GlyXaa: 0.0 ± 0.0
His
0.825HisAla: 0.825 ± 0.408
0.413HisCys: 0.413 ± 0.477
1.238HisAsp: 1.238 ± 0.392
0.825HisGlu: 0.825 ± 0.495
0.825HisPhe: 0.825 ± 0.408
1.238HisGly: 1.238 ± 0.392
0.413HisHis: 0.413 ± 0.477
0.0HisIle: 0.0 ± 0.0
2.476HisLys: 2.476 ± 0.491
2.064HisLeu: 2.064 ± 1.365
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
2.064HisPro: 2.064 ± 1.036
0.825HisGln: 0.825 ± 0.558
2.476HisArg: 2.476 ± 1.246
2.064HisSer: 2.064 ± 0.829
0.825HisThr: 0.825 ± 0.39
1.651HisVal: 1.651 ± 0.211
0.825HisTrp: 0.825 ± 0.402
1.651HisTyr: 1.651 ± 0.804
0.0HisXaa: 0.0 ± 0.0
Ile
2.889IleAla: 2.889 ± 0.926
1.651IleCys: 1.651 ± 0.62
4.127IleAsp: 4.127 ± 1.063
3.714IleGlu: 3.714 ± 1.576
2.476IlePhe: 2.476 ± 0.511
2.889IleGly: 2.889 ± 1.332
0.825IleHis: 0.825 ± 0.558
2.476IleIle: 2.476 ± 1.076
1.651IleLys: 1.651 ± 0.619
4.953IleLeu: 4.953 ± 1.366
0.825IleMet: 0.825 ± 0.412
3.714IleAsn: 3.714 ± 1.113
2.064IlePro: 2.064 ± 0.9
1.651IleGln: 1.651 ± 1.009
1.238IleArg: 1.238 ± 0.559
4.127IleSer: 4.127 ± 1.057
3.302IleThr: 3.302 ± 1.151
3.714IleVal: 3.714 ± 1.981
0.0IleTrp: 0.0 ± 0.0
2.476IleTyr: 2.476 ± 1.458
0.0IleXaa: 0.0 ± 0.0
Lys
1.238LysAla: 1.238 ± 0.661
1.238LysCys: 1.238 ± 0.604
2.889LysAsp: 2.889 ± 1.125
2.064LysGlu: 2.064 ± 0.705
3.302LysPhe: 3.302 ± 1.359
3.302LysGly: 3.302 ± 0.854
2.889LysHis: 2.889 ± 1.219
2.889LysIle: 2.889 ± 0.586
1.651LysLys: 1.651 ± 0.62
1.238LysLeu: 1.238 ± 0.629
1.238LysMet: 1.238 ± 0.406
2.064LysAsn: 2.064 ± 0.672
2.889LysPro: 2.889 ± 0.686
0.825LysGln: 0.825 ± 0.453
3.714LysArg: 3.714 ± 1.08
3.714LysSer: 3.714 ± 1.719
6.603LysThr: 6.603 ± 1.464
1.238LysVal: 1.238 ± 0.382
0.825LysTrp: 0.825 ± 0.559
2.476LysTyr: 2.476 ± 1.153
0.0LysXaa: 0.0 ± 0.0
Leu
5.778LeuAla: 5.778 ± 1.484
2.889LeuCys: 2.889 ± 1.212
6.191LeuAsp: 6.191 ± 1.497
6.191LeuGlu: 6.191 ± 1.59
3.714LeuPhe: 3.714 ± 1.27
5.778LeuGly: 5.778 ± 1.708
2.064LeuHis: 2.064 ± 0.799
2.889LeuIle: 2.889 ± 1.03
5.778LeuLys: 5.778 ± 1.028
9.492LeuLeu: 9.492 ± 2.391
2.476LeuMet: 2.476 ± 0.953
2.064LeuAsn: 2.064 ± 0.881
5.365LeuPro: 5.365 ± 1.844
4.127LeuGln: 4.127 ± 0.891
4.953LeuArg: 4.953 ± 1.401
4.953LeuSer: 4.953 ± 1.899
2.889LeuThr: 2.889 ± 1.113
3.302LeuVal: 3.302 ± 0.934
1.651LeuTrp: 1.651 ± 0.548
5.365LeuTyr: 5.365 ± 2.042
0.0LeuXaa: 0.0 ± 0.0
Met
1.238MetAla: 1.238 ± 0.708
0.413MetCys: 0.413 ± 0.359
0.825MetAsp: 0.825 ± 0.408
0.0MetGlu: 0.0 ± 0.0
1.651MetPhe: 1.651 ± 0.553
0.825MetGly: 0.825 ± 0.412
0.825MetHis: 0.825 ± 0.515
0.825MetIle: 0.825 ± 0.495
1.651MetLys: 1.651 ± 0.74
1.651MetLeu: 1.651 ± 0.817
0.0MetMet: 0.0 ± 0.0
1.651MetAsn: 1.651 ± 1.009
0.0MetPro: 0.0 ± 0.0
1.238MetGln: 1.238 ± 0.506
0.825MetArg: 0.825 ± 0.39
2.476MetSer: 2.476 ± 0.736
0.825MetThr: 0.825 ± 0.433
1.651MetVal: 1.651 ± 0.963
0.0MetTrp: 0.0 ± 0.0
0.825MetTyr: 0.825 ± 0.39
0.0MetXaa: 0.0 ± 0.0
Asn
2.889AsnAla: 2.889 ± 0.734
1.651AsnCys: 1.651 ± 0.757
1.238AsnAsp: 1.238 ± 0.575
2.889AsnGlu: 2.889 ± 0.738
2.476AsnPhe: 2.476 ± 1.025
2.889AsnGly: 2.889 ± 0.854
0.413AsnHis: 0.413 ± 0.462
2.889AsnIle: 2.889 ± 0.663
2.064AsnLys: 2.064 ± 0.77
4.953AsnLeu: 4.953 ± 1.774
0.825AsnMet: 0.825 ± 0.39
4.953AsnAsn: 4.953 ± 1.974
3.714AsnPro: 3.714 ± 0.845
1.238AsnGln: 1.238 ± 0.673
2.476AsnArg: 2.476 ± 1.116
4.127AsnSer: 4.127 ± 1.533
3.302AsnThr: 3.302 ± 1.434
3.302AsnVal: 3.302 ± 1.229
1.238AsnTrp: 1.238 ± 0.629
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
4.127ProAla: 4.127 ± 1.318
0.825ProCys: 0.825 ± 0.719
4.127ProAsp: 4.127 ± 1.51
4.54ProGlu: 4.54 ± 1.7
2.476ProPhe: 2.476 ± 0.892
5.365ProGly: 5.365 ± 2.058
0.825ProHis: 0.825 ± 0.433
2.476ProIle: 2.476 ± 1.326
4.127ProLys: 4.127 ± 1.547
6.191ProLeu: 6.191 ± 1.214
0.825ProMet: 0.825 ± 0.537
4.953ProAsn: 4.953 ± 1.484
7.842ProPro: 7.842 ± 1.243
1.238ProGln: 1.238 ± 0.526
1.238ProArg: 1.238 ± 0.723
3.302ProSer: 3.302 ± 1.138
4.953ProThr: 4.953 ± 2.134
4.127ProVal: 4.127 ± 0.849
0.0ProTrp: 0.0 ± 0.0
1.238ProTyr: 1.238 ± 1.078
0.0ProXaa: 0.0 ± 0.0
Gln
1.651GlnAla: 1.651 ± 0.679
0.413GlnCys: 0.413 ± 0.332
2.476GlnAsp: 2.476 ± 0.971
2.064GlnGlu: 2.064 ± 0.44
1.238GlnPhe: 1.238 ± 0.728
2.889GlnGly: 2.889 ± 0.995
0.825GlnHis: 0.825 ± 0.453
1.651GlnIle: 1.651 ± 0.62
0.825GlnLys: 0.825 ± 0.408
4.127GlnLeu: 4.127 ± 1.157
0.825GlnMet: 0.825 ± 0.39
1.651GlnAsn: 1.651 ± 0.968
3.714GlnPro: 3.714 ± 1.103
4.54GlnGln: 4.54 ± 0.99
3.302GlnArg: 3.302 ± 0.423
2.064GlnSer: 2.064 ± 0.494
1.651GlnThr: 1.651 ± 1.056
3.714GlnVal: 3.714 ± 1.251
1.651GlnTrp: 1.651 ± 0.583
0.413GlnTyr: 0.413 ± 0.373
0.0GlnXaa: 0.0 ± 0.0
Arg
4.953ArgAla: 4.953 ± 1.007
1.238ArgCys: 1.238 ± 0.629
1.238ArgAsp: 1.238 ± 1.057
2.476ArgGlu: 2.476 ± 1.135
3.714ArgPhe: 3.714 ± 1.139
5.365ArgGly: 5.365 ± 1.801
2.064ArgHis: 2.064 ± 0.72
2.064ArgIle: 2.064 ± 0.657
3.714ArgLys: 3.714 ± 0.888
9.905ArgLeu: 9.905 ± 2.285
1.238ArgMet: 1.238 ± 0.406
2.064ArgAsn: 2.064 ± 0.949
2.476ArgPro: 2.476 ± 0.797
2.476ArgGln: 2.476 ± 0.986
8.667ArgArg: 8.667 ± 2.681
6.603ArgSer: 6.603 ± 1.885
1.651ArgThr: 1.651 ± 0.748
3.302ArgVal: 3.302 ± 0.655
0.413ArgTrp: 0.413 ± 0.373
0.0ArgTyr: 0.0 ± 0.0
0.0ArgXaa: 0.0 ± 0.0
Ser
4.953SerAla: 4.953 ± 1.282
0.413SerCys: 0.413 ± 0.332
3.714SerAsp: 3.714 ± 0.717
3.714SerGlu: 3.714 ± 1.257
4.127SerPhe: 4.127 ± 1.682
4.953SerGly: 4.953 ± 1.272
0.413SerHis: 0.413 ± 0.332
3.714SerIle: 3.714 ± 0.951
2.476SerLys: 2.476 ± 0.455
9.08SerLeu: 9.08 ± 1.843
2.476SerMet: 2.476 ± 0.931
2.889SerAsn: 2.889 ± 0.734
6.603SerPro: 6.603 ± 1.698
4.54SerGln: 4.54 ± 0.921
7.429SerArg: 7.429 ± 2.186
9.905SerSer: 9.905 ± 2.618
4.54SerThr: 4.54 ± 1.752
3.714SerVal: 3.714 ± 0.419
0.825SerTrp: 0.825 ± 0.408
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
4.54ThrAla: 4.54 ± 1.008
1.238ThrCys: 1.238 ± 0.784
3.302ThrAsp: 3.302 ± 0.852
2.476ThrGlu: 2.476 ± 0.597
3.302ThrPhe: 3.302 ± 0.977
3.714ThrGly: 3.714 ± 1.103
2.064ThrHis: 2.064 ± 0.864
2.064ThrIle: 2.064 ± 1.002
2.476ThrLys: 2.476 ± 0.645
2.889ThrLeu: 2.889 ± 1.326
0.413ThrMet: 0.413 ± 0.462
2.889ThrAsn: 2.889 ± 0.98
4.953ThrPro: 4.953 ± 1.754
2.476ThrGln: 2.476 ± 0.878
3.714ThrArg: 3.714 ± 1.191
7.842ThrSer: 7.842 ± 2.358
2.064ThrThr: 2.064 ± 1.082
4.127ThrVal: 4.127 ± 0.855
1.651ThrTrp: 1.651 ± 0.817
0.825ThrTyr: 0.825 ± 0.39
0.0ThrXaa: 0.0 ± 0.0
Val
1.651ValAla: 1.651 ± 0.824
2.476ValCys: 2.476 ± 0.771
3.302ValAsp: 3.302 ± 1.328
2.064ValGlu: 2.064 ± 0.647
1.238ValPhe: 1.238 ± 0.571
2.889ValGly: 2.889 ± 1.311
2.476ValHis: 2.476 ± 1.031
2.064ValIle: 2.064 ± 1.002
3.302ValLys: 3.302 ± 0.753
3.302ValLeu: 3.302 ± 1.467
0.413ValMet: 0.413 ± 0.407
2.064ValAsn: 2.064 ± 0.656
4.953ValPro: 4.953 ± 1.567
2.064ValGln: 2.064 ± 0.43
5.365ValArg: 5.365 ± 1.509
5.778ValSer: 5.778 ± 1.061
4.953ValThr: 4.953 ± 1.771
3.714ValVal: 3.714 ± 0.542
0.413ValTrp: 0.413 ± 0.359
1.651ValTyr: 1.651 ± 0.633
0.0ValXaa: 0.0 ± 0.0
Trp
0.825TrpAla: 0.825 ± 0.39
0.825TrpCys: 0.825 ± 0.924
1.651TrpAsp: 1.651 ± 1.183
1.238TrpGlu: 1.238 ± 0.649
0.413TrpPhe: 0.413 ± 0.348
0.825TrpGly: 0.825 ± 0.39
0.413TrpHis: 0.413 ± 0.373
1.238TrpIle: 1.238 ± 0.629
1.238TrpLys: 1.238 ± 0.995
0.825TrpLeu: 0.825 ± 0.39
0.0TrpMet: 0.0 ± 0.0
0.825TrpAsn: 0.825 ± 0.719
0.0TrpPro: 0.0 ± 0.0
0.413TrpGln: 0.413 ± 0.373
1.238TrpArg: 1.238 ± 0.705
0.0TrpSer: 0.0 ± 0.0
1.651TrpThr: 1.651 ± 1.092
1.238TrpVal: 1.238 ± 0.392
0.413TrpTrp: 0.413 ± 0.332
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.238TyrAla: 1.238 ± 0.382
0.0TyrCys: 0.0 ± 0.0
1.651TyrAsp: 1.651 ± 1.056
1.238TyrGlu: 1.238 ± 0.392
1.651TyrPhe: 1.651 ± 0.211
1.651TyrGly: 1.651 ± 0.554
0.413TyrHis: 0.413 ± 0.359
1.651TyrIle: 1.651 ± 0.669
1.651TyrLys: 1.651 ± 0.931
4.54TyrLeu: 4.54 ± 0.993
0.825TyrMet: 0.825 ± 0.393
1.651TyrAsn: 1.651 ± 0.58
0.825TyrPro: 0.825 ± 0.402
0.825TyrGln: 0.825 ± 0.408
1.651TyrArg: 1.651 ± 0.694
0.825TyrSer: 0.825 ± 0.746
1.651TyrThr: 1.651 ± 1.005
1.651TyrVal: 1.651 ± 0.776
0.413TyrTrp: 0.413 ± 0.373
2.476TyrTyr: 2.476 ± 0.919
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2424 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski