Amino acid dipepetide frequency for Bolahun virus variant 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.743AlaAla: 2.743 ± 1.149
0.549AlaCys: 0.549 ± 0.31
3.017AlaAsp: 3.017 ± 0.454
4.388AlaGlu: 4.388 ± 0.241
2.743AlaPhe: 2.743 ± 1.067
2.743AlaGly: 2.743 ± 0.422
1.371AlaHis: 1.371 ± 0.363
5.211AlaIle: 5.211 ± 1.447
3.84AlaLys: 3.84 ± 1.291
5.211AlaLeu: 5.211 ± 0.804
0.823AlaMet: 0.823 ± 0.347
1.92AlaAsn: 1.92 ± 0.454
1.097AlaPro: 1.097 ± 1.499
1.097AlaGln: 1.097 ± 0.648
1.646AlaArg: 1.646 ± 0.438
5.211AlaSer: 5.211 ± 1.539
1.646AlaThr: 1.646 ± 0.382
3.291AlaVal: 3.291 ± 0.339
0.823AlaTrp: 0.823 ± 0.968
2.468AlaTyr: 2.468 ± 0.888
0.0AlaXaa: 0.0 ± 0.0
Cys
1.646CysAla: 1.646 ± 0.7
0.274CysCys: 0.274 ± 0.169
0.549CysAsp: 0.549 ± 0.31
0.823CysGlu: 0.823 ± 0.506
0.823CysPhe: 0.823 ± 0.618
1.92CysGly: 1.92 ± 0.721
0.549CysHis: 0.549 ± 0.337
2.194CysIle: 2.194 ± 0.843
1.371CysLys: 1.371 ± 1.083
3.017CysLeu: 3.017 ± 0.923
0.274CysMet: 0.274 ± 0.169
1.646CysAsn: 1.646 ± 1.012
1.646CysPro: 1.646 ± 0.994
0.823CysGln: 0.823 ± 0.574
0.823CysArg: 0.823 ± 0.506
3.017CysSer: 3.017 ± 0.664
1.646CysThr: 1.646 ± 0.843
0.823CysVal: 0.823 ± 0.347
0.0CysTrp: 0.0 ± 0.0
0.823CysTyr: 0.823 ± 0.506
0.0CysXaa: 0.0 ± 0.0
Asp
2.194AspAla: 2.194 ± 0.483
1.371AspCys: 1.371 ± 0.828
2.743AspAsp: 2.743 ± 1.12
4.388AspGlu: 4.388 ± 1.085
4.114AspPhe: 4.114 ± 1.11
3.017AspGly: 3.017 ± 1.438
1.371AspHis: 1.371 ± 0.363
5.76AspIle: 5.76 ± 1.2
3.566AspLys: 3.566 ± 0.815
7.68AspLeu: 7.68 ± 0.754
1.097AspMet: 1.097 ± 0.28
2.194AspAsn: 2.194 ± 0.79
3.017AspPro: 3.017 ± 0.74
1.646AspGln: 1.646 ± 0.579
1.646AspArg: 1.646 ± 0.579
3.84AspSer: 3.84 ± 0.65
2.194AspThr: 2.194 ± 0.257
3.566AspVal: 3.566 ± 0.851
0.823AspTrp: 0.823 ± 0.581
1.646AspTyr: 1.646 ± 0.382
0.0AspXaa: 0.0 ± 0.0
Glu
2.194GluAla: 2.194 ± 0.873
2.743GluCys: 2.743 ± 1.13
3.017GluAsp: 3.017 ± 0.454
4.114GluGlu: 4.114 ± 1.456
3.291GluPhe: 3.291 ± 1.136
3.84GluGly: 3.84 ± 0.551
2.194GluHis: 2.194 ± 0.573
4.388GluIle: 4.388 ± 0.94
2.743GluLys: 2.743 ± 0.278
5.76GluLeu: 5.76 ± 0.65
2.468GluMet: 2.468 ± 1.004
2.468GluAsn: 2.468 ± 1.171
1.646GluPro: 1.646 ± 1.138
2.743GluGln: 2.743 ± 0.762
3.017GluArg: 3.017 ± 0.74
6.034GluSer: 6.034 ± 1.472
2.194GluThr: 2.194 ± 0.26
5.485GluVal: 5.485 ± 1.694
0.0GluTrp: 0.0 ± 0.0
2.743GluTyr: 2.743 ± 0.823
0.0GluXaa: 0.0 ± 0.0
Phe
2.743PheAla: 2.743 ± 0.911
1.371PheCys: 1.371 ± 0.573
1.646PheAsp: 1.646 ± 0.72
2.468PheGlu: 2.468 ± 0.834
3.017PhePhe: 3.017 ± 0.91
2.194PheGly: 2.194 ± 0.559
0.823PheHis: 0.823 ± 0.289
1.92PheIle: 1.92 ± 1.745
1.92PheLys: 1.92 ± 0.515
4.937PheLeu: 4.937 ± 1.022
1.371PheMet: 1.371 ± 0.534
1.646PheAsn: 1.646 ± 0.534
1.92PhePro: 1.92 ± 0.509
1.097PheGln: 1.097 ± 0.28
4.663PheArg: 4.663 ± 1.598
3.291PheSer: 3.291 ± 1.103
2.468PheThr: 2.468 ± 1.244
2.194PheVal: 2.194 ± 1.274
0.823PheTrp: 0.823 ± 0.775
1.92PheTyr: 1.92 ± 1.55
0.0PheXaa: 0.0 ± 0.0
Gly
3.566GlyAla: 3.566 ± 2.269
2.194GlyCys: 2.194 ± 1.23
2.194GlyAsp: 2.194 ± 0.573
4.114GlyGlu: 4.114 ± 1.725
2.468GlyPhe: 2.468 ± 0.582
4.388GlyGly: 4.388 ± 0.631
2.743GlyHis: 2.743 ± 0.799
4.114GlyIle: 4.114 ± 1.374
3.291GlyLys: 3.291 ± 0.562
5.76GlyLeu: 5.76 ± 1.11
2.743GlyMet: 2.743 ± 0.982
2.468GlyAsn: 2.468 ± 0.412
2.194GlyPro: 2.194 ± 1.076
1.371GlyGln: 1.371 ± 0.289
3.017GlyArg: 3.017 ± 0.516
3.566GlySer: 3.566 ± 0.435
3.017GlyThr: 3.017 ± 0.46
2.468GlyVal: 2.468 ± 0.805
0.274GlyTrp: 0.274 ± 0.374
2.468GlyTyr: 2.468 ± 0.591
0.0GlyXaa: 0.0 ± 0.0
His
1.371HisAla: 1.371 ± 0.363
1.646HisCys: 1.646 ± 0.821
1.371HisAsp: 1.371 ± 0.534
1.097HisGlu: 1.097 ± 0.443
1.097HisPhe: 1.097 ± 0.423
1.371HisGly: 1.371 ± 0.843
0.549HisHis: 0.549 ± 0.31
2.468HisIle: 2.468 ± 0.21
0.549HisLys: 0.549 ± 0.31
1.92HisLeu: 1.92 ± 0.74
0.0HisMet: 0.0 ± 0.0
1.371HisAsn: 1.371 ± 0.526
0.549HisPro: 0.549 ± 0.51
1.371HisGln: 1.371 ± 0.534
1.646HisArg: 1.646 ± 1.012
0.823HisSer: 0.823 ± 0.36
1.097HisThr: 1.097 ± 0.423
0.549HisVal: 0.549 ± 0.319
0.549HisTrp: 0.549 ± 0.337
2.194HisTyr: 2.194 ± 0.417
0.0HisXaa: 0.0 ± 0.0
Ile
4.114IleAla: 4.114 ± 1.096
2.194IleCys: 2.194 ± 0.499
3.84IleAsp: 3.84 ± 0.693
3.566IleGlu: 3.566 ± 0.85
3.291IlePhe: 3.291 ± 0.681
2.194IleGly: 2.194 ± 0.257
1.92IleHis: 1.92 ± 0.515
3.566IleIle: 3.566 ± 1.119
4.663IleLys: 4.663 ± 1.372
6.583IleLeu: 6.583 ± 0.947
1.646IleMet: 1.646 ± 0.954
3.566IleAsn: 3.566 ± 0.576
3.566IlePro: 3.566 ± 0.881
0.823IleGln: 0.823 ± 0.506
3.566IleArg: 3.566 ± 0.576
6.308IleSer: 6.308 ± 0.956
3.84IleThr: 3.84 ± 2.213
5.485IleVal: 5.485 ± 1.076
0.549IleTrp: 0.549 ± 0.319
3.017IleTyr: 3.017 ± 1.133
0.0IleXaa: 0.0 ± 0.0
Lys
3.566LysAla: 3.566 ± 1.271
1.097LysCys: 1.097 ± 0.524
3.566LysAsp: 3.566 ± 0.776
4.663LysGlu: 4.663 ± 0.854
2.468LysPhe: 2.468 ± 0.695
4.663LysGly: 4.663 ± 1.187
1.097LysHis: 1.097 ± 0.675
3.017LysIle: 3.017 ± 0.553
2.743LysLys: 2.743 ± 1.106
6.857LysLeu: 6.857 ± 1.897
1.646LysMet: 1.646 ± 0.661
2.468LysAsn: 2.468 ± 1.541
1.646LysPro: 1.646 ± 0.382
0.274LysGln: 0.274 ± 0.169
3.017LysArg: 3.017 ± 0.607
4.937LysSer: 4.937 ± 0.843
4.114LysThr: 4.114 ± 0.634
5.211LysVal: 5.211 ± 1.496
1.097LysTrp: 1.097 ± 0.395
2.194LysTyr: 2.194 ± 0.697
0.0LysXaa: 0.0 ± 0.0
Leu
5.485LeuAla: 5.485 ± 1.174
2.194LeuCys: 2.194 ± 0.664
3.291LeuAsp: 3.291 ± 1.585
5.485LeuGlu: 5.485 ± 1.087
4.663LeuPhe: 4.663 ± 1.228
4.663LeuGly: 4.663 ± 0.54
1.92LeuHis: 1.92 ± 0.786
3.566LeuIle: 3.566 ± 1.475
7.405LeuLys: 7.405 ± 1.639
10.148LeuLeu: 10.148 ± 1.754
2.743LeuMet: 2.743 ± 0.82
4.937LeuAsn: 4.937 ± 0.641
4.663LeuPro: 4.663 ± 0.651
1.371LeuGln: 1.371 ± 0.669
4.114LeuArg: 4.114 ± 1.677
9.874LeuSer: 9.874 ± 2.119
4.388LeuThr: 4.388 ± 0.83
6.857LeuVal: 6.857 ± 1.784
0.274LeuTrp: 0.274 ± 0.169
3.566LeuTyr: 3.566 ± 0.884
0.0LeuXaa: 0.0 ± 0.0
Met
2.743MetAla: 2.743 ± 2.01
0.0MetCys: 0.0 ± 0.0
2.743MetAsp: 2.743 ± 1.11
3.566MetGlu: 3.566 ± 0.822
0.823MetPhe: 0.823 ± 0.574
1.371MetGly: 1.371 ± 0.573
1.097MetHis: 1.097 ± 0.358
1.646MetIle: 1.646 ± 0.382
1.371MetLys: 1.371 ± 0.655
1.646MetLeu: 1.646 ± 0.382
1.371MetMet: 1.371 ± 0.573
0.274MetAsn: 0.274 ± 0.169
0.274MetPro: 0.274 ± 0.169
1.097MetGln: 1.097 ± 0.675
2.468MetArg: 2.468 ± 0.678
0.823MetSer: 0.823 ± 0.634
2.468MetThr: 2.468 ± 1.187
1.371MetVal: 1.371 ± 0.618
0.274MetTrp: 0.274 ± 0.169
1.097MetTyr: 1.097 ± 0.28
0.0MetXaa: 0.0 ± 0.0
Asn
1.371AsnAla: 1.371 ± 0.507
1.371AsnCys: 1.371 ± 0.596
4.114AsnAsp: 4.114 ± 1.034
1.646AsnGlu: 1.646 ± 0.62
3.566AsnPhe: 3.566 ± 0.436
1.646AsnGly: 1.646 ± 0.785
0.823AsnHis: 0.823 ± 0.506
3.84AsnIle: 3.84 ± 1.522
2.468AsnLys: 2.468 ± 0.888
4.388AsnLeu: 4.388 ± 1.124
1.097AsnMet: 1.097 ± 0.28
2.468AsnAsn: 2.468 ± 0.821
2.743AsnPro: 2.743 ± 0.497
1.92AsnGln: 1.92 ± 0.854
3.84AsnArg: 3.84 ± 1.017
3.017AsnSer: 3.017 ± 0.932
1.371AsnThr: 1.371 ± 0.289
1.646AsnVal: 1.646 ± 0.171
0.274AsnTrp: 0.274 ± 0.375
1.92AsnTyr: 1.92 ± 0.139
0.0AsnXaa: 0.0 ± 0.0
Pro
1.371ProAla: 1.371 ± 0.774
0.823ProCys: 0.823 ± 0.506
4.663ProAsp: 4.663 ± 1.015
1.646ProGlu: 1.646 ± 0.616
1.646ProPhe: 1.646 ± 0.993
2.468ProGly: 2.468 ± 1.316
0.0ProHis: 0.0 ± 0.0
3.566ProIle: 3.566 ± 0.435
1.92ProLys: 1.92 ± 1.564
3.017ProLeu: 3.017 ± 0.66
0.823ProMet: 0.823 ± 0.635
2.743ProAsn: 2.743 ± 0.616
3.291ProPro: 3.291 ± 0.806
0.823ProGln: 0.823 ± 0.36
2.743ProArg: 2.743 ± 0.278
3.84ProSer: 3.84 ± 1.859
3.291ProThr: 3.291 ± 1.081
3.84ProVal: 3.84 ± 2.394
0.274ProTrp: 0.274 ± 0.169
1.371ProTyr: 1.371 ± 0.843
0.0ProXaa: 0.0 ± 0.0
Gln
0.549GlnAla: 0.549 ± 0.749
0.823GlnCys: 0.823 ± 0.506
2.468GlnAsp: 2.468 ± 1.077
1.646GlnGlu: 1.646 ± 0.382
0.274GlnPhe: 0.274 ± 0.169
2.194GlnGly: 2.194 ± 0.417
0.0GlnHis: 0.0 ± 0.0
1.92GlnIle: 1.92 ± 0.429
1.646GlnLys: 1.646 ± 0.604
1.92GlnLeu: 1.92 ± 0.666
1.097GlnMet: 1.097 ± 0.542
0.823GlnAsn: 0.823 ± 0.36
1.371GlnPro: 1.371 ± 0.507
1.646GlnGln: 1.646 ± 0.589
1.371GlnArg: 1.371 ± 0.289
2.468GlnSer: 2.468 ± 1.518
2.194GlnThr: 2.194 ± 0.698
2.743GlnVal: 2.743 ± 0.785
0.823GlnTrp: 0.823 ± 0.581
1.097GlnTyr: 1.097 ± 0.675
0.0GlnXaa: 0.0 ± 0.0
Arg
3.84ArgAla: 3.84 ± 0.551
1.92ArgCys: 1.92 ± 0.902
3.84ArgAsp: 3.84 ± 1.69
5.485ArgGlu: 5.485 ± 1.831
2.194ArgPhe: 2.194 ± 1.007
4.663ArgGly: 4.663 ± 0.623
1.097ArgHis: 1.097 ± 0.395
4.114ArgIle: 4.114 ± 1.242
2.743ArgLys: 2.743 ± 0.543
4.663ArgLeu: 4.663 ± 1.381
1.646ArgMet: 1.646 ± 0.63
3.017ArgAsn: 3.017 ± 0.916
2.194ArgPro: 2.194 ± 0.56
1.646ArgGln: 1.646 ± 0.382
3.017ArgArg: 3.017 ± 1.25
3.291ArgSer: 3.291 ± 0.483
2.743ArgThr: 2.743 ± 1.336
3.291ArgVal: 3.291 ± 1.1
0.274ArgTrp: 0.274 ± 0.169
1.92ArgTyr: 1.92 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
3.84SerAla: 3.84 ± 1.555
1.646SerCys: 1.646 ± 0.382
4.937SerAsp: 4.937 ± 0.719
4.114SerGlu: 4.114 ± 1.034
4.114SerPhe: 4.114 ± 1.163
4.937SerGly: 4.937 ± 0.641
1.646SerHis: 1.646 ± 0.686
6.857SerIle: 6.857 ± 0.582
4.663SerLys: 4.663 ± 0.953
7.131SerLeu: 7.131 ± 1.049
2.194SerMet: 2.194 ± 0.417
3.566SerAsn: 3.566 ± 0.746
3.291SerPro: 3.291 ± 1.586
3.017SerGln: 3.017 ± 0.916
6.308SerArg: 6.308 ± 0.785
5.76SerSer: 5.76 ± 0.889
5.211SerThr: 5.211 ± 0.814
3.84SerVal: 3.84 ± 0.897
1.371SerTrp: 1.371 ± 0.842
3.566SerTyr: 3.566 ± 0.395
0.0SerXaa: 0.0 ± 0.0
Thr
2.468ThrAla: 2.468 ± 0.805
1.097ThrCys: 1.097 ± 0.711
3.017ThrAsp: 3.017 ± 1.133
2.468ThrGlu: 2.468 ± 0.949
1.097ThrPhe: 1.097 ± 0.28
3.017ThrGly: 3.017 ± 0.788
0.823ThrHis: 0.823 ± 0.289
4.114ThrIle: 4.114 ± 1.444
4.937ThrLys: 4.937 ± 0.627
4.663ThrLeu: 4.663 ± 1.074
1.92ThrMet: 1.92 ± 0.667
3.566ThrAsn: 3.566 ± 0.692
4.388ThrPro: 4.388 ± 1.53
2.743ThrGln: 2.743 ± 0.278
2.468ThrArg: 2.468 ± 1.061
4.388ThrSer: 4.388 ± 1.043
3.017ThrThr: 3.017 ± 1.769
3.291ThrVal: 3.291 ± 1.742
0.823ThrTrp: 0.823 ± 0.506
1.646ThrTyr: 1.646 ± 0.541
0.0ThrXaa: 0.0 ± 0.0
Val
3.84ValAla: 3.84 ± 0.567
0.274ValCys: 0.274 ± 0.375
4.663ValAsp: 4.663 ± 1.333
3.84ValGlu: 3.84 ± 0.354
1.371ValPhe: 1.371 ± 0.669
2.743ValGly: 2.743 ± 1.141
1.646ValHis: 1.646 ± 0.7
3.017ValIle: 3.017 ± 1.216
3.017ValLys: 3.017 ± 0.46
4.114ValLeu: 4.114 ± 0.555
2.194ValMet: 2.194 ± 0.823
2.194ValAsn: 2.194 ± 0.697
2.194ValPro: 2.194 ± 1.003
1.92ValGln: 1.92 ± 1.328
4.937ValArg: 4.937 ± 1.224
6.034ValSer: 6.034 ± 1.915
6.308ValThr: 6.308 ± 1.927
4.937ValVal: 4.937 ± 2.183
0.549ValTrp: 0.549 ± 0.31
2.743ValTyr: 2.743 ± 1.479
0.0ValXaa: 0.0 ± 0.0
Trp
0.549TrpAla: 0.549 ± 0.749
0.549TrpCys: 0.549 ± 0.337
0.0TrpAsp: 0.0 ± 0.0
0.823TrpGlu: 0.823 ± 0.33
0.549TrpPhe: 0.549 ± 0.664
0.549TrpGly: 0.549 ± 0.262
0.274TrpHis: 0.274 ± 0.169
0.274TrpIle: 0.274 ± 0.169
0.823TrpLys: 0.823 ± 0.383
0.823TrpLeu: 0.823 ± 0.581
0.274TrpMet: 0.274 ± 0.169
0.274TrpAsn: 0.274 ± 0.169
0.549TrpPro: 0.549 ± 0.31
0.274TrpGln: 0.274 ± 0.631
0.549TrpArg: 0.549 ± 0.337
1.371TrpSer: 1.371 ± 0.289
1.371TrpThr: 1.371 ± 0.655
0.274TrpVal: 0.274 ± 0.631
0.0TrpTrp: 0.0 ± 0.0
0.549TrpTyr: 0.549 ± 0.582
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.646TyrAla: 1.646 ± 0.648
0.549TyrCys: 0.549 ± 0.319
2.194TyrAsp: 2.194 ± 1.047
2.743TyrGlu: 2.743 ± 0.97
0.823TyrPhe: 0.823 ± 0.618
3.84TyrGly: 3.84 ± 0.567
1.646TyrHis: 1.646 ± 0.7
2.743TyrIle: 2.743 ± 0.579
4.663TyrLys: 4.663 ± 1.367
1.371TyrLeu: 1.371 ± 0.589
0.823TyrMet: 0.823 ± 0.36
1.92TyrAsn: 1.92 ± 0.845
1.92TyrPro: 1.92 ± 0.74
1.371TyrGln: 1.371 ± 0.538
2.743TyrArg: 2.743 ± 0.944
4.114TyrSer: 4.114 ± 1.334
1.646TyrThr: 1.646 ± 0.468
1.371TyrVal: 1.371 ± 0.363
0.823TyrTrp: 0.823 ± 0.581
0.823TyrTyr: 0.823 ± 0.852
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (3647 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski