Amino acid dipepetide frequency for Sulfolobales Beppu rod-shaped virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.203AlaCys: 0.203 ± 0.192
1.933AlaAsp: 1.933 ± 0.375
2.035AlaGlu: 2.035 ± 0.391
2.747AlaPhe: 2.747 ± 0.493
1.831AlaGly: 1.831 ± 0.41
0.203AlaHis: 0.203 ± 0.139
4.781AlaIle: 4.781 ± 0.689
4.069AlaLys: 4.069 ± 0.732
4.68AlaLeu: 4.68 ± 0.778
0.509AlaMet: 0.509 ± 0.217
3.561AlaAsn: 3.561 ± 0.596
1.119AlaPro: 1.119 ± 0.317
3.052AlaGln: 3.052 ± 0.646
1.424AlaArg: 1.424 ± 0.332
1.831AlaSer: 1.831 ± 0.401
1.017AlaThr: 1.017 ± 0.311
2.136AlaVal: 2.136 ± 0.514
0.509AlaTrp: 0.509 ± 0.25
3.459AlaTyr: 3.459 ± 0.612
0.0AlaXaa: 0.0 ± 0.0
Cys
0.203CysAla: 0.203 ± 0.16
0.0CysCys: 0.0 ± 0.0
0.305CysAsp: 0.305 ± 0.179
0.916CysGlu: 0.916 ± 0.375
0.305CysPhe: 0.305 ± 0.212
0.203CysGly: 0.203 ± 0.157
0.0CysHis: 0.0 ± 0.0
0.509CysIle: 0.509 ± 0.24
1.119CysLys: 1.119 ± 0.407
1.017CysLeu: 1.017 ± 0.313
0.305CysMet: 0.305 ± 0.188
0.712CysAsn: 0.712 ± 0.313
0.305CysPro: 0.305 ± 0.222
0.305CysGln: 0.305 ± 0.166
0.203CysArg: 0.203 ± 0.143
0.509CysSer: 0.509 ± 0.266
0.712CysThr: 0.712 ± 0.339
0.814CysVal: 0.814 ± 0.268
0.203CysTrp: 0.203 ± 0.135
0.61CysTyr: 0.61 ± 0.251
0.0CysXaa: 0.0 ± 0.0
Asp
1.933AspAla: 1.933 ± 0.388
0.712AspCys: 0.712 ± 0.312
2.34AspAsp: 2.34 ± 0.533
3.662AspGlu: 3.662 ± 0.684
3.052AspPhe: 3.052 ± 0.552
1.526AspGly: 1.526 ± 0.349
0.407AspHis: 0.407 ± 0.18
5.086AspIle: 5.086 ± 0.747
3.459AspLys: 3.459 ± 0.666
5.799AspLeu: 5.799 ± 0.737
1.119AspMet: 1.119 ± 0.345
2.543AspAsn: 2.543 ± 0.488
1.119AspPro: 1.119 ± 0.248
1.221AspGln: 1.221 ± 0.426
1.628AspArg: 1.628 ± 0.436
2.136AspSer: 2.136 ± 0.467
1.424AspThr: 1.424 ± 0.329
2.543AspVal: 2.543 ± 0.495
0.509AspTrp: 0.509 ± 0.217
3.255AspTyr: 3.255 ± 0.521
0.0AspXaa: 0.0 ± 0.0
Glu
1.831GluAla: 1.831 ± 0.418
1.221GluCys: 1.221 ± 0.455
2.95GluAsp: 2.95 ± 0.655
4.781GluGlu: 4.781 ± 0.892
4.374GluPhe: 4.374 ± 0.659
1.322GluGly: 1.322 ± 0.321
0.712GluHis: 0.712 ± 0.237
7.325GluIle: 7.325 ± 1.011
7.325GluLys: 7.325 ± 1.267
4.578GluLeu: 4.578 ± 1.034
1.526GluMet: 1.526 ± 0.434
4.578GluAsn: 4.578 ± 0.714
1.424GluPro: 1.424 ± 0.414
2.645GluGln: 2.645 ± 0.553
1.628GluArg: 1.628 ± 0.427
2.035GluSer: 2.035 ± 0.338
2.34GluThr: 2.34 ± 0.505
4.578GluVal: 4.578 ± 0.718
0.509GluTrp: 0.509 ± 0.207
2.645GluTyr: 2.645 ± 0.415
0.0GluXaa: 0.0 ± 0.0
Phe
3.154PheAla: 3.154 ± 0.453
0.814PheCys: 0.814 ± 0.304
3.967PheAsp: 3.967 ± 0.611
3.561PheGlu: 3.561 ± 0.586
3.255PhePhe: 3.255 ± 0.415
2.442PheGly: 2.442 ± 0.651
0.916PheHis: 0.916 ± 0.463
5.493PheIle: 5.493 ± 0.638
4.273PheLys: 4.273 ± 0.687
7.121PheLeu: 7.121 ± 0.849
1.119PheMet: 1.119 ± 0.314
3.662PheAsn: 3.662 ± 0.563
2.035PhePro: 2.035 ± 0.372
3.052PheGln: 3.052 ± 0.568
1.221PheArg: 1.221 ± 0.391
4.781PheSer: 4.781 ± 0.749
2.442PheThr: 2.442 ± 0.504
3.459PheVal: 3.459 ± 0.638
0.407PheTrp: 0.407 ± 0.213
3.764PheTyr: 3.764 ± 0.739
0.0PheXaa: 0.0 ± 0.0
Gly
1.628GlyAla: 1.628 ± 0.551
0.203GlyCys: 0.203 ± 0.15
0.814GlyAsp: 0.814 ± 0.266
2.543GlyGlu: 2.543 ± 0.389
3.052GlyPhe: 3.052 ± 0.455
1.424GlyGly: 1.424 ± 0.468
0.305GlyHis: 0.305 ± 0.181
4.273GlyIle: 4.273 ± 0.774
2.238GlyLys: 2.238 ± 0.545
4.273GlyLeu: 4.273 ± 0.455
1.017GlyMet: 1.017 ± 0.299
2.238GlyAsn: 2.238 ± 0.538
0.203GlyPro: 0.203 ± 0.147
1.933GlyGln: 1.933 ± 0.442
1.017GlyArg: 1.017 ± 0.319
2.238GlySer: 2.238 ± 0.813
2.442GlyThr: 2.442 ± 0.395
2.442GlyVal: 2.442 ± 0.544
0.305GlyTrp: 0.305 ± 0.157
2.848GlyTyr: 2.848 ± 0.485
0.0GlyXaa: 0.0 ± 0.0
His
0.203HisAla: 0.203 ± 0.153
0.102HisCys: 0.102 ± 0.101
0.61HisAsp: 0.61 ± 0.326
1.017HisGlu: 1.017 ± 0.334
1.424HisPhe: 1.424 ± 0.43
0.814HisGly: 0.814 ± 0.278
0.305HisHis: 0.305 ± 0.192
1.628HisIle: 1.628 ± 0.367
0.916HisLys: 0.916 ± 0.335
1.831HisLeu: 1.831 ± 0.383
0.407HisMet: 0.407 ± 0.217
1.322HisAsn: 1.322 ± 0.377
0.203HisPro: 0.203 ± 0.131
0.407HisGln: 0.407 ± 0.195
0.305HisArg: 0.305 ± 0.21
0.61HisSer: 0.61 ± 0.34
0.814HisThr: 0.814 ± 0.3
0.916HisVal: 0.916 ± 0.326
0.0HisTrp: 0.0 ± 0.0
0.407HisTyr: 0.407 ± 0.209
0.0HisXaa: 0.0 ± 0.0
Ile
6.511IleAla: 6.511 ± 0.842
0.916IleCys: 0.916 ± 0.345
4.069IleAsp: 4.069 ± 0.817
7.223IleGlu: 7.223 ± 1.052
4.781IlePhe: 4.781 ± 0.674
3.255IleGly: 3.255 ± 0.668
1.729IleHis: 1.729 ± 0.385
9.766IleIle: 9.766 ± 1.297
7.223IleLys: 7.223 ± 1.045
9.766IleLeu: 9.766 ± 0.999
0.916IleMet: 0.916 ± 0.289
7.63IleAsn: 7.63 ± 0.801
4.578IlePro: 4.578 ± 0.713
3.866IleGln: 3.866 ± 0.766
2.645IleArg: 2.645 ± 0.415
8.545IleSer: 8.545 ± 1.229
5.188IleThr: 5.188 ± 0.723
7.223IleVal: 7.223 ± 0.918
0.712IleTrp: 0.712 ± 0.27
6.104IleTyr: 6.104 ± 0.866
0.0IleXaa: 0.0 ± 0.0
Lys
3.561LysAla: 3.561 ± 0.785
0.814LysCys: 0.814 ± 0.316
3.052LysAsp: 3.052 ± 0.641
5.188LysGlu: 5.188 ± 0.971
4.069LysPhe: 4.069 ± 0.604
1.424LysGly: 1.424 ± 0.31
1.119LysHis: 1.119 ± 0.391
12.208LysIle: 12.208 ± 1.22
8.24LysLys: 8.24 ± 1.461
7.223LysLeu: 7.223 ± 0.895
3.561LysMet: 3.561 ± 0.773
6.205LysAsn: 6.205 ± 0.903
1.119LysPro: 1.119 ± 0.327
3.561LysGln: 3.561 ± 0.796
2.238LysArg: 2.238 ± 0.642
3.764LysSer: 3.764 ± 0.655
3.866LysThr: 3.866 ± 0.591
4.578LysVal: 4.578 ± 0.776
0.712LysTrp: 0.712 ± 0.224
5.799LysTyr: 5.799 ± 0.802
0.0LysXaa: 0.0 ± 0.0
Leu
4.273LeuAla: 4.273 ± 0.701
0.509LeuCys: 0.509 ± 0.227
4.273LeuAsp: 4.273 ± 0.657
6.816LeuGlu: 6.816 ± 1.004
4.476LeuPhe: 4.476 ± 0.678
4.476LeuGly: 4.476 ± 0.868
2.645LeuHis: 2.645 ± 0.533
9.868LeuIle: 9.868 ± 1.301
8.647LeuLys: 8.647 ± 1.122
10.987LeuLeu: 10.987 ± 1.069
1.729LeuMet: 1.729 ± 0.317
8.444LeuAsn: 8.444 ± 1.216
3.357LeuPro: 3.357 ± 0.49
8.037LeuGln: 8.037 ± 1.217
3.154LeuArg: 3.154 ± 0.648
6.612LeuSer: 6.612 ± 0.929
5.493LeuThr: 5.493 ± 0.701
4.68LeuVal: 4.68 ± 0.756
0.61LeuTrp: 0.61 ± 0.204
6.205LeuTyr: 6.205 ± 1.016
0.0LeuXaa: 0.0 ± 0.0
Met
0.61MetAla: 0.61 ± 0.249
0.0MetCys: 0.0 ± 0.0
0.509MetAsp: 0.509 ± 0.193
0.509MetGlu: 0.509 ± 0.191
1.526MetPhe: 1.526 ± 0.432
0.61MetGly: 0.61 ± 0.302
0.305MetHis: 0.305 ± 0.199
1.831MetIle: 1.831 ± 0.475
3.662MetLys: 3.662 ± 0.659
1.933MetLeu: 1.933 ± 0.555
0.203MetMet: 0.203 ± 0.17
0.916MetAsn: 0.916 ± 0.251
1.119MetPro: 1.119 ± 0.323
1.017MetGln: 1.017 ± 0.28
1.119MetArg: 1.119 ± 0.37
1.526MetSer: 1.526 ± 0.378
1.322MetThr: 1.322 ± 0.271
0.712MetVal: 0.712 ± 0.281
0.407MetTrp: 0.407 ± 0.196
1.322MetTyr: 1.322 ± 0.389
0.0MetXaa: 0.0 ± 0.0
Asn
2.442AsnAla: 2.442 ± 0.548
1.526AsnCys: 1.526 ± 0.467
2.747AsnAsp: 2.747 ± 0.642
4.069AsnGlu: 4.069 ± 0.704
5.493AsnPhe: 5.493 ± 0.802
3.459AsnGly: 3.459 ± 0.794
0.509AsnHis: 0.509 ± 0.224
6.002AsnIle: 6.002 ± 0.748
4.374AsnLys: 4.374 ± 0.69
8.85AsnLeu: 8.85 ± 1.247
1.424AsnMet: 1.424 ± 0.464
5.595AsnAsn: 5.595 ± 0.974
2.747AsnPro: 2.747 ± 0.681
3.561AsnGln: 3.561 ± 0.59
2.136AsnArg: 2.136 ± 0.477
4.578AsnSer: 4.578 ± 1.07
2.442AsnThr: 2.442 ± 0.588
4.171AsnVal: 4.171 ± 0.709
0.712AsnTrp: 0.712 ± 0.185
5.595AsnTyr: 5.595 ± 0.724
0.0AsnXaa: 0.0 ± 0.0
Pro
1.017ProAla: 1.017 ± 0.38
0.102ProCys: 0.102 ± 0.093
1.831ProAsp: 1.831 ± 0.416
1.424ProGlu: 1.424 ± 0.421
1.933ProPhe: 1.933 ± 0.319
0.509ProGly: 0.509 ± 0.239
0.407ProHis: 0.407 ± 0.213
3.052ProIle: 3.052 ± 0.363
1.119ProLys: 1.119 ± 0.334
2.645ProLeu: 2.645 ± 0.569
0.305ProMet: 0.305 ± 0.235
2.238ProAsn: 2.238 ± 0.499
0.916ProPro: 0.916 ± 0.255
1.424ProGln: 1.424 ± 0.29
0.814ProArg: 0.814 ± 0.286
2.747ProSer: 2.747 ± 0.526
2.543ProThr: 2.543 ± 0.517
2.848ProVal: 2.848 ± 0.551
0.203ProTrp: 0.203 ± 0.143
2.442ProTyr: 2.442 ± 0.53
0.0ProXaa: 0.0 ± 0.0
Gln
0.916GlnAla: 0.916 ± 0.296
0.102GlnCys: 0.102 ± 0.087
2.238GlnAsp: 2.238 ± 0.547
1.933GlnGlu: 1.933 ± 0.429
3.764GlnPhe: 3.764 ± 0.7
1.831GlnGly: 1.831 ± 0.432
1.119GlnHis: 1.119 ± 0.304
4.68GlnIle: 4.68 ± 0.603
3.561GlnLys: 3.561 ± 0.576
7.223GlnLeu: 7.223 ± 1.632
0.61GlnMet: 0.61 ± 0.257
5.392GlnAsn: 5.392 ± 0.859
1.221GlnPro: 1.221 ± 0.36
4.069GlnGln: 4.069 ± 0.795
0.916GlnArg: 0.916 ± 0.281
3.764GlnSer: 3.764 ± 0.675
2.543GlnThr: 2.543 ± 0.724
1.831GlnVal: 1.831 ± 0.41
0.203GlnTrp: 0.203 ± 0.144
4.273GlnTyr: 4.273 ± 0.629
0.0GlnXaa: 0.0 ± 0.0
Arg
1.424ArgAla: 1.424 ± 0.322
0.203ArgCys: 0.203 ± 0.117
1.322ArgAsp: 1.322 ± 0.367
1.933ArgGlu: 1.933 ± 0.367
1.628ArgPhe: 1.628 ± 0.454
1.221ArgGly: 1.221 ± 0.291
0.407ArgHis: 0.407 ± 0.259
2.442ArgIle: 2.442 ± 0.607
3.052ArgLys: 3.052 ± 0.539
2.848ArgLeu: 2.848 ± 0.567
1.119ArgMet: 1.119 ± 0.354
1.322ArgAsn: 1.322 ± 0.338
0.407ArgPro: 0.407 ± 0.213
1.424ArgGln: 1.424 ± 0.317
1.628ArgArg: 1.628 ± 0.319
2.136ArgSer: 2.136 ± 0.385
0.712ArgThr: 0.712 ± 0.248
1.526ArgVal: 1.526 ± 0.446
0.509ArgTrp: 0.509 ± 0.235
1.729ArgTyr: 1.729 ± 0.403
0.0ArgXaa: 0.0 ± 0.0
Ser
3.561SerAla: 3.561 ± 0.921
0.407SerCys: 0.407 ± 0.192
2.747SerAsp: 2.747 ± 0.536
3.459SerGlu: 3.459 ± 0.597
4.069SerPhe: 4.069 ± 0.772
3.764SerGly: 3.764 ± 0.723
0.712SerHis: 0.712 ± 0.233
5.29SerIle: 5.29 ± 0.942
4.069SerLys: 4.069 ± 0.504
6.511SerLeu: 6.511 ± 1.142
1.831SerMet: 1.831 ± 0.387
3.866SerAsn: 3.866 ± 0.946
2.747SerPro: 2.747 ± 0.625
3.561SerGln: 3.561 ± 0.81
1.628SerArg: 1.628 ± 0.366
3.459SerSer: 3.459 ± 0.677
3.866SerThr: 3.866 ± 0.549
3.459SerVal: 3.459 ± 0.508
0.305SerTrp: 0.305 ± 0.16
2.442SerTyr: 2.442 ± 0.449
0.0SerXaa: 0.0 ± 0.0
Thr
1.424ThrAla: 1.424 ± 0.416
0.509ThrCys: 0.509 ± 0.326
2.136ThrAsp: 2.136 ± 0.726
3.154ThrGlu: 3.154 ± 0.613
3.052ThrPhe: 3.052 ± 0.509
2.543ThrGly: 2.543 ± 0.528
0.203ThrHis: 0.203 ± 0.139
7.325ThrIle: 7.325 ± 0.968
4.273ThrLys: 4.273 ± 0.726
4.273ThrLeu: 4.273 ± 0.623
1.119ThrMet: 1.119 ± 0.315
3.459ThrAsn: 3.459 ± 0.583
1.729ThrPro: 1.729 ± 0.507
1.933ThrGln: 1.933 ± 0.359
0.916ThrArg: 0.916 ± 0.322
3.255ThrSer: 3.255 ± 0.689
1.933ThrThr: 1.933 ± 0.34
1.424ThrVal: 1.424 ± 0.385
0.509ThrTrp: 0.509 ± 0.189
2.442ThrTyr: 2.442 ± 0.619
0.0ThrXaa: 0.0 ± 0.0
Val
1.729ValAla: 1.729 ± 0.512
0.203ValCys: 0.203 ± 0.151
3.764ValAsp: 3.764 ± 0.521
3.255ValGlu: 3.255 ± 0.507
2.95ValPhe: 2.95 ± 0.488
1.933ValGly: 1.933 ± 0.431
0.509ValHis: 0.509 ± 0.164
4.171ValIle: 4.171 ± 0.662
5.392ValLys: 5.392 ± 0.781
6.002ValLeu: 6.002 ± 0.966
0.916ValMet: 0.916 ± 0.396
3.764ValAsn: 3.764 ± 0.484
1.933ValPro: 1.933 ± 0.517
3.255ValGln: 3.255 ± 0.616
2.34ValArg: 2.34 ± 0.49
3.561ValSer: 3.561 ± 0.729
2.95ValThr: 2.95 ± 0.713
2.136ValVal: 2.136 ± 0.464
0.509ValTrp: 0.509 ± 0.203
3.866ValTyr: 3.866 ± 0.79
0.0ValXaa: 0.0 ± 0.0
Trp
0.407TrpAla: 0.407 ± 0.195
0.203TrpCys: 0.203 ± 0.132
0.407TrpAsp: 0.407 ± 0.179
0.102TrpGlu: 0.102 ± 0.102
0.305TrpPhe: 0.305 ± 0.157
0.203TrpGly: 0.203 ± 0.143
0.203TrpHis: 0.203 ± 0.142
0.814TrpIle: 0.814 ± 0.361
0.916TrpLys: 0.916 ± 0.285
0.916TrpLeu: 0.916 ± 0.324
0.203TrpMet: 0.203 ± 0.136
0.712TrpAsn: 0.712 ± 0.365
0.0TrpPro: 0.0 ± 0.0
0.61TrpGln: 0.61 ± 0.23
0.407TrpArg: 0.407 ± 0.172
0.61TrpSer: 0.61 ± 0.239
0.61TrpThr: 0.61 ± 0.241
0.407TrpVal: 0.407 ± 0.156
0.102TrpTrp: 0.102 ± 0.099
0.305TrpTyr: 0.305 ± 0.166
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.273TyrAla: 4.273 ± 0.544
0.509TyrCys: 0.509 ± 0.266
3.459TyrAsp: 3.459 ± 0.675
2.848TyrGlu: 2.848 ± 0.561
4.68TyrPhe: 4.68 ± 0.72
2.645TyrGly: 2.645 ± 0.582
1.526TyrHis: 1.526 ± 0.386
6.104TyrIle: 6.104 ± 0.79
4.374TyrLys: 4.374 ± 0.908
6.816TyrLeu: 6.816 ± 0.986
1.119TyrMet: 1.119 ± 0.337
4.273TyrAsn: 4.273 ± 0.672
2.238TyrPro: 2.238 ± 0.437
3.255TyrGln: 3.255 ± 0.731
1.628TyrArg: 1.628 ± 0.42
3.052TyrSer: 3.052 ± 0.577
2.95TyrThr: 2.95 ± 0.455
3.255TyrVal: 3.255 ± 0.607
0.509TyrTrp: 0.509 ± 0.234
3.255TyrTyr: 3.255 ± 0.576
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (9831 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski