Amino acid dipepetide frequency for Blautia sp. An249

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.218AlaAla: 7.218 ± 0.104	1.161AlaCys: 1.161 ± 0.035	4.279AlaAsp: 4.279 ± 0.065	5.447AlaGlu: 5.447 ± 0.083	3.061AlaPhe: 3.061 ± 0.058	6.283AlaGly: 6.283 ± 0.104	1.104AlaHis: 1.104 ± 0.032	4.523AlaIle: 4.523 ± 0.064	4.507AlaLys: 4.507 ± 0.063	6.869AlaLeu: 6.869 ± 0.088	2.218AlaMet: 2.218 ± 0.047	2.257AlaAsn: 2.257 ± 0.043	2.045AlaPro: 2.045 ± 0.044	2.556AlaGln: 2.556 ± 0.055	3.154AlaArg: 3.154 ± 0.051	3.95AlaSer: 3.95 ± 0.069	2.947AlaThr: 2.947 ± 0.067	6.305AlaVal: 6.305 ± 0.083	0.6AlaTrp: 0.6 ± 0.023	2.72AlaTyr: 2.72 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.033	0.301CysCys: 0.301 ± 0.018	0.757CysAsp: 0.757 ± 0.027	0.887CysGlu: 0.887 ± 0.028	0.636CysPhe: 0.636 ± 0.023	1.489CysGly: 1.489 ± 0.046	0.302CysHis: 0.302 ± 0.016	1.102CysIle: 1.102 ± 0.035	0.818CysLys: 0.818 ± 0.029	1.252CysLeu: 1.252 ± 0.036	0.457CysMet: 0.457 ± 0.02	0.511CysAsn: 0.511 ± 0.019	0.681CysPro: 0.681 ± 0.026	0.533CysGln: 0.533 ± 0.022	0.896CysArg: 0.896 ± 0.03	0.947CysSer: 0.947 ± 0.034	0.805CysThr: 0.805 ± 0.027	1.028CysVal: 1.028 ± 0.032	0.122CysTrp: 0.122 ± 0.009	0.591CysTyr: 0.591 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.798AspAla: 3.798 ± 0.065	0.797AspCys: 0.797 ± 0.026	2.29AspAsp: 2.29 ± 0.05	4.066AspGlu: 4.066 ± 0.065	2.587AspPhe: 2.587 ± 0.045	4.296AspGly: 4.296 ± 0.076	0.767AspHis: 0.767 ± 0.03	3.787AspIle: 3.787 ± 0.064	3.103AspLys: 3.103 ± 0.055	4.643AspLeu: 4.643 ± 0.076	1.705AspMet: 1.705 ± 0.04	1.902AspAsn: 1.902 ± 0.043	1.873AspPro: 1.873 ± 0.041	1.403AspGln: 1.403 ± 0.036	2.366AspArg: 2.366 ± 0.053	3.075AspSer: 3.075 ± 0.055	3.13AspThr: 3.13 ± 0.056	3.469AspVal: 3.469 ± 0.065	0.606AspTrp: 0.606 ± 0.023	2.629AspTyr: 2.629 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	5.872GluAla: 5.872 ± 0.087	0.812GluCys: 0.812 ± 0.03	4.569GluAsp: 4.569 ± 0.068	9.312GluGlu: 9.312 ± 0.124	2.666GluPhe: 2.666 ± 0.046	4.938GluGly: 4.938 ± 0.068	1.335GluHis: 1.335 ± 0.034	6.162GluIle: 6.162 ± 0.078	7.525GluLys: 7.525 ± 0.108	6.696GluLeu: 6.696 ± 0.087	2.604GluMet: 2.604 ± 0.052	4.398GluAsn: 4.398 ± 0.066	2.104GluPro: 2.104 ± 0.05	3.311GluGln: 3.311 ± 0.067	3.69GluArg: 3.69 ± 0.065	3.575GluSer: 3.575 ± 0.058	4.366GluThr: 4.366 ± 0.07	4.557GluVal: 4.557 ± 0.066	0.73GluTrp: 0.73 ± 0.025	3.213GluTyr: 3.213 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.811PheAla: 2.811 ± 0.05	0.801PheCys: 0.801 ± 0.028	2.273PheAsp: 2.273 ± 0.043	2.486PheGlu: 2.486 ± 0.051	1.842PhePhe: 1.842 ± 0.051	2.863PheGly: 2.863 ± 0.055	0.894PheHis: 0.894 ± 0.028	2.631PheIle: 2.631 ± 0.055	1.72PheLys: 1.72 ± 0.048	4.395PheLeu: 4.395 ± 0.085	1.102PheMet: 1.102 ± 0.034	1.312PheAsn: 1.312 ± 0.036	1.466PhePro: 1.466 ± 0.035	1.709PheGln: 1.709 ± 0.035	1.8PheArg: 1.8 ± 0.038	3.035PheSer: 3.035 ± 0.061	2.351PheThr: 2.351 ± 0.05	2.613PheVal: 2.613 ± 0.052	0.5PheTrp: 0.5 ± 0.022	1.764PheTyr: 1.764 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.055GlyAla: 5.055 ± 0.074	1.267GlyCys: 1.267 ± 0.041	3.375GlyAsp: 3.375 ± 0.06	5.432GlyGlu: 5.432 ± 0.075	3.115GlyPhe: 3.115 ± 0.058	4.899GlyGly: 4.899 ± 0.084	1.197GlyHis: 1.197 ± 0.038	6.492GlyIle: 6.492 ± 0.081	5.822GlyLys: 5.822 ± 0.087	5.911GlyLeu: 5.911 ± 0.078	2.403GlyMet: 2.403 ± 0.042	3.236GlyAsn: 3.236 ± 0.056	1.282GlyPro: 1.282 ± 0.044	2.405GlyGln: 2.405 ± 0.055	3.204GlyArg: 3.204 ± 0.065	4.156GlySer: 4.156 ± 0.076	4.45GlyThr: 4.45 ± 0.084	4.799GlyVal: 4.799 ± 0.07	0.798GlyTrp: 0.798 ± 0.032	3.317GlyTyr: 3.317 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.019HisAla: 1.019 ± 0.031	0.318HisCys: 0.318 ± 0.014	0.751HisAsp: 0.751 ± 0.03	1.013HisGlu: 1.013 ± 0.032	0.785HisPhe: 0.785 ± 0.027	1.243HisGly: 1.243 ± 0.036	0.394HisHis: 0.394 ± 0.022	1.279HisIle: 1.279 ± 0.036	0.94HisLys: 0.94 ± 0.027	1.571HisLeu: 1.571 ± 0.038	0.529HisMet: 0.529 ± 0.022	0.678HisAsn: 0.678 ± 0.025	0.9HisPro: 0.9 ± 0.032	0.594HisGln: 0.594 ± 0.024	0.888HisArg: 0.888 ± 0.031	0.945HisSer: 0.945 ± 0.031	0.911HisThr: 0.911 ± 0.027	1.031HisVal: 1.031 ± 0.034	0.184HisTrp: 0.184 ± 0.012	0.755HisTyr: 0.755 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.157IleAla: 5.157 ± 0.058	1.349IleCys: 1.349 ± 0.037	3.52IleAsp: 3.52 ± 0.062	4.718IleGlu: 4.718 ± 0.073	2.807IlePhe: 2.807 ± 0.065	4.99IleGly: 4.99 ± 0.069	1.345IleHis: 1.345 ± 0.035	4.347IleIle: 4.347 ± 0.071	3.669IleLys: 3.669 ± 0.064	7.559IleLeu: 7.559 ± 0.113	1.836IleMet: 1.836 ± 0.043	2.407IleAsn: 2.407 ± 0.048	3.263IlePro: 3.263 ± 0.058	2.865IleGln: 2.865 ± 0.046	3.715IleArg: 3.715 ± 0.062	4.805IleSer: 4.805 ± 0.079	4.045IleThr: 4.045 ± 0.065	4.368IleVal: 4.368 ± 0.071	0.654IleTrp: 0.654 ± 0.024	2.947IleTyr: 2.947 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	5.181LysAla: 5.181 ± 0.07	0.73LysCys: 0.73 ± 0.029	3.699LysAsp: 3.699 ± 0.054	7.833LysGlu: 7.833 ± 0.107	1.844LysPhe: 1.844 ± 0.042	4.595LysGly: 4.595 ± 0.071	0.928LysHis: 0.928 ± 0.031	4.775LysIle: 4.775 ± 0.062	6.282LysLys: 6.282 ± 0.08	5.108LysLeu: 5.108 ± 0.069	2.172LysMet: 2.172 ± 0.044	3.237LysAsn: 3.237 ± 0.053	1.941LysPro: 1.941 ± 0.041	2.433LysGln: 2.433 ± 0.054	3.311LysArg: 3.311 ± 0.061	3.266LysSer: 3.266 ± 0.05	3.836LysThr: 3.836 ± 0.059	4.063LysVal: 4.063 ± 0.066	0.613LysTrp: 0.613 ± 0.024	2.672LysTyr: 2.672 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.803LeuAla: 6.803 ± 0.087	1.543LeuCys: 1.543 ± 0.039	4.84LeuAsp: 4.84 ± 0.072	7.117LeuGlu: 7.117 ± 0.105	3.848LeuPhe: 3.848 ± 0.073	6.063LeuGly: 6.063 ± 0.085	1.567LeuHis: 1.567 ± 0.04	5.894LeuIle: 5.894 ± 0.094	6.619LeuLys: 6.619 ± 0.084	9.295LeuLeu: 9.295 ± 0.139	2.568LeuMet: 2.568 ± 0.048	3.593LeuAsn: 3.593 ± 0.053	3.657LeuPro: 3.657 ± 0.062	3.096LeuGln: 3.096 ± 0.054	3.81LeuArg: 3.81 ± 0.073	6.407LeuSer: 6.407 ± 0.087	5.214LeuThr: 5.214 ± 0.07	5.382LeuVal: 5.382 ± 0.077	0.832LeuTrp: 0.832 ± 0.033	3.45LeuTyr: 3.45 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.4MetAla: 2.4 ± 0.045	0.341MetCys: 0.341 ± 0.017	1.795MetAsp: 1.795 ± 0.043	2.996MetGlu: 2.996 ± 0.058	0.95MetPhe: 0.95 ± 0.029	2.219MetGly: 2.219 ± 0.05	0.39MetHis: 0.39 ± 0.018	2.026MetIle: 2.026 ± 0.043	2.588MetLys: 2.588 ± 0.049	2.561MetLeu: 2.561 ± 0.055	0.823MetMet: 0.823 ± 0.028	1.404MetAsn: 1.404 ± 0.034	1.092MetPro: 1.092 ± 0.037	1.033MetGln: 1.033 ± 0.03	1.251MetArg: 1.251 ± 0.035	1.648MetSer: 1.648 ± 0.041	1.635MetThr: 1.635 ± 0.034	1.764MetVal: 1.764 ± 0.041	0.193MetTrp: 0.193 ± 0.011	0.786MetTyr: 0.786 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.699AsnAla: 2.699 ± 0.054	0.624AsnCys: 0.624 ± 0.023	1.704AsnAsp: 1.704 ± 0.042	2.508AsnGlu: 2.508 ± 0.047	1.513AsnPhe: 1.513 ± 0.036	3.347AsnGly: 3.347 ± 0.065	0.771AsnHis: 0.771 ± 0.027	2.807AsnIle: 2.807 ± 0.055	2.279AsnLys: 2.279 ± 0.047	3.87AsnLeu: 3.87 ± 0.064	1.26AsnMet: 1.26 ± 0.037	1.474AsnAsn: 1.474 ± 0.042	2.034AsnPro: 2.034 ± 0.042	1.635AsnGln: 1.635 ± 0.036	2.069AsnArg: 2.069 ± 0.045	2.161AsnSer: 2.161 ± 0.043	2.293AsnThr: 2.293 ± 0.054	2.552AsnVal: 2.552 ± 0.053	0.461AsnTrp: 0.461 ± 0.023	1.809AsnTyr: 1.809 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.475ProAla: 2.475 ± 0.053	0.511ProCys: 0.511 ± 0.023	2.224ProAsp: 2.224 ± 0.049	3.507ProGlu: 3.507 ± 0.065	1.558ProPhe: 1.558 ± 0.043	2.462ProGly: 2.462 ± 0.052	0.578ProHis: 0.578 ± 0.022	2.02ProIle: 2.02 ± 0.039	1.935ProLys: 1.935 ± 0.05	2.875ProLeu: 2.875 ± 0.057	0.894ProMet: 0.894 ± 0.029	1.12ProAsn: 1.12 ± 0.032	0.814ProPro: 0.814 ± 0.029	1.345ProGln: 1.345 ± 0.036	1.28ProArg: 1.28 ± 0.039	1.926ProSer: 1.926 ± 0.044	1.632ProThr: 1.632 ± 0.044	3.108ProVal: 3.108 ± 0.059	0.332ProTrp: 0.332 ± 0.019	1.5ProTyr: 1.5 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.744GlnAla: 2.744 ± 0.056	0.366GlnCys: 0.366 ± 0.017	1.721GlnAsp: 1.721 ± 0.04	3.723GlnGlu: 3.723 ± 0.063	1.184GlnPhe: 1.184 ± 0.033	2.409GlnGly: 2.409 ± 0.051	0.423GlnHis: 0.423 ± 0.023	2.917GlnIle: 2.917 ± 0.055	3.302GlnLys: 3.302 ± 0.059	2.865GlnLeu: 2.865 ± 0.052	1.283GlnMet: 1.283 ± 0.035	1.634GlnAsn: 1.634 ± 0.036	1.031GlnPro: 1.031 ± 0.035	1.279GlnGln: 1.279 ± 0.035	1.636GlnArg: 1.636 ± 0.048	1.781GlnSer: 1.781 ± 0.044	1.963GlnThr: 1.963 ± 0.041	2.411GlnVal: 2.411 ± 0.049	0.414GlnTrp: 0.414 ± 0.02	1.455GlnTyr: 1.455 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.637ArgAla: 2.637 ± 0.053	0.599ArgCys: 0.599 ± 0.023	2.181ArgAsp: 2.181 ± 0.049	4.553ArgGlu: 4.553 ± 0.073	1.835ArgPhe: 1.835 ± 0.045	2.683ArgGly: 2.683 ± 0.051	0.826ArgHis: 0.826 ± 0.028	3.666ArgIle: 3.666 ± 0.056	4.151ArgLys: 4.151 ± 0.065	4.199ArgLeu: 4.199 ± 0.071	1.579ArgMet: 1.579 ± 0.039	2.147ArgAsn: 2.147 ± 0.046	1.398ArgPro: 1.398 ± 0.037	2.015ArgGln: 2.015 ± 0.042	2.489ArgArg: 2.489 ± 0.058	2.237ArgSer: 2.237 ± 0.043	2.257ArgThr: 2.257 ± 0.044	2.577ArgVal: 2.577 ± 0.047	0.401ArgTrp: 0.401 ± 0.017	1.962ArgTyr: 1.962 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.161SerAla: 4.161 ± 0.067	0.916SerCys: 0.916 ± 0.027	3.025SerAsp: 3.025 ± 0.051	3.903SerGlu: 3.903 ± 0.069	2.75SerPhe: 2.75 ± 0.052	5.029SerGly: 5.029 ± 0.095	1.098SerHis: 1.098 ± 0.032	3.905SerIle: 3.905 ± 0.061	2.903SerLys: 2.903 ± 0.057	5.462SerLeu: 5.462 ± 0.081	1.822SerMet: 1.822 ± 0.038	1.987SerAsn: 1.987 ± 0.045	2.04SerPro: 2.04 ± 0.05	2.232SerGln: 2.232 ± 0.049	3.053SerArg: 3.053 ± 0.052	3.715SerSer: 3.715 ± 0.086	2.689SerThr: 2.689 ± 0.053	4.347SerVal: 4.347 ± 0.065	0.597SerTrp: 0.597 ± 0.027	2.608SerTyr: 2.608 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.58ThrAla: 4.58 ± 0.079	0.673ThrCys: 0.673 ± 0.023	3.022ThrAsp: 3.022 ± 0.055	4.202ThrGlu: 4.202 ± 0.068	2.142ThrPhe: 2.142 ± 0.045	4.9ThrGly: 4.9 ± 0.097	0.799ThrHis: 0.799 ± 0.026	3.825ThrIle: 3.825 ± 0.062	2.903ThrLys: 2.903 ± 0.056	4.816ThrLeu: 4.816 ± 0.071	1.403ThrMet: 1.403 ± 0.04	1.809ThrAsn: 1.809 ± 0.048	2.194ThrPro: 2.194 ± 0.045	1.667ThrGln: 1.667 ± 0.042	2.225ThrArg: 2.225 ± 0.044	3.003ThrSer: 3.003 ± 0.053	2.688ThrThr: 2.688 ± 0.064	4.636ThrVal: 4.636 ± 0.082	0.564ThrTrp: 0.564 ± 0.027	2.21ThrTyr: 2.21 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.263ValAla: 4.263 ± 0.078	1.204ValCys: 1.204 ± 0.032	3.439ValAsp: 3.439 ± 0.059	4.575ValGlu: 4.575 ± 0.072	3.008ValPhe: 3.008 ± 0.06	4.101ValGly: 4.101 ± 0.066	1.056ValHis: 1.056 ± 0.033	4.945ValIle: 4.945 ± 0.064	4.437ValLys: 4.437 ± 0.066	6.702ValLeu: 6.702 ± 0.089	1.906ValMet: 1.906 ± 0.042	2.736ValAsn: 2.736 ± 0.055	2.507ValPro: 2.507 ± 0.043	2.15ValGln: 2.15 ± 0.042	2.845ValArg: 2.845 ± 0.049	4.772ValSer: 4.772 ± 0.066	4.205ValThr: 4.205 ± 0.085	4.306ValVal: 4.306 ± 0.062	0.619ValTrp: 0.619 ± 0.023	2.6ValTyr: 2.6 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.601TrpAla: 0.601 ± 0.026	0.151TrpCys: 0.151 ± 0.013	0.556TrpAsp: 0.556 ± 0.023	0.901TrpGlu: 0.901 ± 0.032	0.42TrpPhe: 0.42 ± 0.023	0.712TrpGly: 0.712 ± 0.025	0.135TrpHis: 0.135 ± 0.012	0.711TrpIle: 0.711 ± 0.026	0.866TrpLys: 0.866 ± 0.029	0.866TrpLeu: 0.866 ± 0.029	0.329TrpMet: 0.329 ± 0.018	0.531TrpAsn: 0.531 ± 0.023	0.212TrpPro: 0.212 ± 0.014	0.367TrpGln: 0.367 ± 0.019	0.393TrpArg: 0.393 ± 0.016	0.502TrpSer: 0.502 ± 0.023	0.457TrpThr: 0.457 ± 0.023	0.512TrpVal: 0.512 ± 0.025	0.102TrpTrp: 0.102 ± 0.009	0.387TrpTyr: 0.387 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.684TyrAla: 2.684 ± 0.049	0.698TyrCys: 0.698 ± 0.028	2.272TyrAsp: 2.272 ± 0.046	3.251TyrGlu: 3.251 ± 0.054	1.818TyrPhe: 1.818 ± 0.047	3.096TyrGly: 3.096 ± 0.055	0.823TyrHis: 0.823 ± 0.026	2.556TyrIle: 2.556 ± 0.048	2.146TyrLys: 2.146 ± 0.05	4.085TyrLeu: 4.085 ± 0.064	1.001TyrMet: 1.001 ± 0.027	1.497TyrAsn: 1.497 ± 0.036	1.558TyrPro: 1.558 ± 0.042	1.914TyrGln: 1.914 ± 0.043	2.317TyrArg: 2.317 ± 0.046	2.335TyrSer: 2.335 ± 0.045	2.389TyrThr: 2.389 ± 0.056	2.547TyrVal: 2.547 ± 0.056	0.388TyrTrp: 0.388 ± 0.018	1.948TyrTyr: 1.948 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3735 proteins (1167479 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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