Amino acid dipepetide frequency for Halovirus VNH-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.403AlaAla: 8.403 ± 3.386
0.0AlaCys: 0.0 ± 0.0
8.403AlaAsp: 8.403 ± 2.608
6.723AlaGlu: 6.723 ± 3.812
1.681AlaPhe: 1.681 ± 0.869
3.361AlaGly: 3.361 ± 1.334
0.0AlaHis: 0.0 ± 0.0
2.521AlaIle: 2.521 ± 1.285
4.202AlaLys: 4.202 ± 2.027
10.084AlaLeu: 10.084 ± 2.013
0.84AlaMet: 0.84 ± 1.014
5.042AlaAsn: 5.042 ± 1.974
1.681AlaPro: 1.681 ± 1.138
3.361AlaGln: 3.361 ± 1.736
2.521AlaArg: 2.521 ± 1.126
4.202AlaSer: 4.202 ± 1.212
2.521AlaThr: 2.521 ± 2.48
2.521AlaVal: 2.521 ± 1.128
0.0AlaTrp: 0.0 ± 0.0
3.361AlaTyr: 3.361 ± 1.31
0.0AlaXaa: 0.0 ± 0.0
Cys
0.84CysAla: 0.84 ± 1.05
0.84CysCys: 0.84 ± 0.904
0.84CysAsp: 0.84 ± 0.904
1.681CysGlu: 1.681 ± 2.1
0.0CysPhe: 0.0 ± 0.0
1.681CysGly: 1.681 ± 1.368
0.84CysHis: 0.84 ± 0.904
0.0CysIle: 0.0 ± 0.0
2.521CysLys: 2.521 ± 2.265
0.84CysLeu: 0.84 ± 1.134
0.84CysMet: 0.84 ± 1.05
1.681CysAsn: 1.681 ± 0.868
0.84CysPro: 0.84 ± 0.904
0.84CysGln: 0.84 ± 1.05
0.84CysArg: 0.84 ± 1.05
0.84CysSer: 0.84 ± 1.05
0.0CysThr: 0.0 ± 0.0
0.84CysVal: 0.84 ± 0.847
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.723AspAla: 6.723 ± 2.792
2.521AspCys: 2.521 ± 2.265
2.521AspAsp: 2.521 ± 1.071
8.403AspGlu: 8.403 ± 1.635
0.84AspPhe: 0.84 ± 0.536
5.042AspGly: 5.042 ± 2.211
4.202AspHis: 4.202 ± 2.222
4.202AspIle: 4.202 ± 1.394
4.202AspLys: 4.202 ± 1.167
7.563AspLeu: 7.563 ± 2.681
4.202AspMet: 4.202 ± 1.536
0.84AspAsn: 0.84 ± 0.938
4.202AspPro: 4.202 ± 2.222
0.0AspGln: 0.0 ± 0.0
5.882AspArg: 5.882 ± 1.675
6.723AspSer: 6.723 ± 2.667
11.765AspThr: 11.765 ± 7.282
5.882AspVal: 5.882 ± 1.693
0.84AspTrp: 0.84 ± 0.536
3.361AspTyr: 3.361 ± 1.678
0.0AspXaa: 0.0 ± 0.0
Glu
3.361GluAla: 3.361 ± 1.512
3.361GluCys: 3.361 ± 3.302
10.924GluAsp: 10.924 ± 4.42
4.202GluGlu: 4.202 ± 2.716
1.681GluPhe: 1.681 ± 0.934
8.403GluGly: 8.403 ± 1.203
2.521GluHis: 2.521 ± 1.177
3.361GluIle: 3.361 ± 1.58
3.361GluLys: 3.361 ± 0.892
3.361GluLeu: 3.361 ± 2.838
2.521GluMet: 2.521 ± 1.109
5.882GluAsn: 5.882 ± 1.685
0.0GluPro: 0.0 ± 0.0
5.882GluGln: 5.882 ± 2.894
9.244GluArg: 9.244 ± 2.459
11.765GluSer: 11.765 ± 2.922
13.445GluThr: 13.445 ± 5.241
5.882GluVal: 5.882 ± 4.257
2.521GluTrp: 2.521 ± 1.126
0.84GluTyr: 0.84 ± 1.05
0.0GluXaa: 0.0 ± 0.0
Phe
1.681PheAla: 1.681 ± 0.868
0.0PheCys: 0.0 ± 0.0
0.84PheAsp: 0.84 ± 0.536
1.681PheGlu: 1.681 ± 1.072
0.0PhePhe: 0.0 ± 0.0
1.681PheGly: 1.681 ± 0.868
0.0PheHis: 0.0 ± 0.0
1.681PheIle: 1.681 ± 0.934
0.84PheLys: 0.84 ± 0.536
1.681PheLeu: 1.681 ± 0.869
0.0PheMet: 0.0 ± 0.0
0.0PheAsn: 0.0 ± 0.0
0.0PhePro: 0.0 ± 0.0
0.84PheGln: 0.84 ± 0.536
1.681PheArg: 1.681 ± 1.105
0.84PheSer: 0.84 ± 0.536
0.84PheThr: 0.84 ± 0.938
2.521PheVal: 2.521 ± 0.989
0.0PheTrp: 0.0 ± 0.0
1.681PheTyr: 1.681 ± 0.869
0.0PheXaa: 0.0 ± 0.0
Gly
3.361GlyAla: 3.361 ± 1.656
3.361GlyCys: 3.361 ± 2.358
9.244GlyAsp: 9.244 ± 2.699
9.244GlyGlu: 9.244 ± 4.487
0.84GlyPhe: 0.84 ± 0.536
8.403GlyGly: 8.403 ± 2.268
0.84GlyHis: 0.84 ± 0.536
5.882GlyIle: 5.882 ± 1.983
4.202GlyLys: 4.202 ± 1.382
6.723GlyLeu: 6.723 ± 1.43
2.521GlyMet: 2.521 ± 1.137
3.361GlyAsn: 3.361 ± 2.144
2.521GlyPro: 2.521 ± 1.316
1.681GlyGln: 1.681 ± 1.105
7.563GlyArg: 7.563 ± 2.68
5.042GlySer: 5.042 ± 3.216
3.361GlyThr: 3.361 ± 1.325
3.361GlyVal: 3.361 ± 1.678
0.0GlyTrp: 0.0 ± 0.0
3.361GlyTyr: 3.361 ± 2.144
0.0GlyXaa: 0.0 ± 0.0
His
0.84HisAla: 0.84 ± 0.904
0.0HisCys: 0.0 ± 0.0
2.521HisAsp: 2.521 ± 1.457
2.521HisGlu: 2.521 ± 2.007
0.0HisPhe: 0.0 ± 0.0
1.681HisGly: 1.681 ± 0.868
0.0HisHis: 0.0 ± 0.0
1.681HisIle: 1.681 ± 1.512
0.0HisLys: 0.0 ± 0.0
0.0HisLeu: 0.0 ± 0.0
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
2.521HisArg: 2.521 ± 0.989
0.84HisSer: 0.84 ± 0.536
0.84HisThr: 0.84 ± 0.536
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.681HisTyr: 1.681 ± 0.868
0.0HisXaa: 0.0 ± 0.0
Ile
5.042IleAla: 5.042 ± 3.386
0.0IleCys: 0.0 ± 0.0
5.042IleAsp: 5.042 ± 2.354
11.765IleGlu: 11.765 ± 2.418
0.0IlePhe: 0.0 ± 0.0
2.521IleGly: 2.521 ± 1.126
0.0IleHis: 0.0 ± 0.0
4.202IleIle: 4.202 ± 0.966
5.042IleLys: 5.042 ± 3.432
0.84IleLeu: 0.84 ± 0.938
0.0IleMet: 0.0 ± 0.0
0.84IleAsn: 0.84 ± 1.014
0.84IlePro: 0.84 ± 0.904
3.361IleGln: 3.361 ± 1.979
2.521IleArg: 2.521 ± 1.803
4.202IleSer: 4.202 ± 1.186
2.521IleThr: 2.521 ± 0.989
1.681IleVal: 1.681 ± 1.072
0.84IleTrp: 0.84 ± 0.847
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
4.202LysAla: 4.202 ± 2.68
0.84LysCys: 0.84 ± 0.904
3.361LysAsp: 3.361 ± 2.285
3.361LysGlu: 3.361 ± 2.038
1.681LysPhe: 1.681 ± 1.138
0.0LysGly: 0.0 ± 0.0
0.84LysHis: 0.84 ± 1.05
3.361LysIle: 3.361 ± 1.025
0.84LysLys: 0.84 ± 0.938
2.521LysLeu: 2.521 ± 1.14
0.84LysMet: 0.84 ± 1.134
0.84LysAsn: 0.84 ± 0.536
0.84LysPro: 0.84 ± 1.05
2.521LysGln: 2.521 ± 1.285
7.563LysArg: 7.563 ± 3.13
0.84LysSer: 0.84 ± 1.134
2.521LysThr: 2.521 ± 1.457
2.521LysVal: 2.521 ± 1.284
0.84LysTrp: 0.84 ± 0.536
2.521LysTyr: 2.521 ± 2.344
0.0LysXaa: 0.0 ± 0.0
Leu
5.042LeuAla: 5.042 ± 1.048
0.84LeuCys: 0.84 ± 0.536
5.042LeuAsp: 5.042 ± 2.194
6.723LeuGlu: 6.723 ± 1.505
2.521LeuPhe: 2.521 ± 0.989
5.882LeuGly: 5.882 ± 2.027
1.681LeuHis: 1.681 ± 1.072
2.521LeuIle: 2.521 ± 1.177
0.84LeuLys: 0.84 ± 0.904
4.202LeuLeu: 4.202 ± 1.378
0.0LeuMet: 0.0 ± 0.0
3.361LeuAsn: 3.361 ± 1.567
2.521LeuPro: 2.521 ± 1.084
2.521LeuGln: 2.521 ± 1.852
5.042LeuArg: 5.042 ± 1.681
5.882LeuSer: 5.882 ± 1.846
6.723LeuThr: 6.723 ± 1.226
5.882LeuVal: 5.882 ± 1.88
0.84LeuTrp: 0.84 ± 0.536
1.681LeuTyr: 1.681 ± 1.354
0.0LeuXaa: 0.0 ± 0.0
Met
1.681MetAla: 1.681 ± 1.235
0.0MetCys: 0.0 ± 0.0
0.84MetAsp: 0.84 ± 0.536
0.84MetGlu: 0.84 ± 1.134
0.0MetPhe: 0.0 ± 0.0
0.84MetGly: 0.84 ± 0.938
0.0MetHis: 0.0 ± 0.0
0.84MetIle: 0.84 ± 0.938
0.84MetLys: 0.84 ± 0.938
2.521MetLeu: 2.521 ± 1.457
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.84MetPro: 0.84 ± 0.847
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
4.202MetSer: 4.202 ± 1.772
3.361MetThr: 3.361 ± 1.399
1.681MetVal: 1.681 ± 1.259
0.0MetTrp: 0.0 ± 0.0
0.84MetTyr: 0.84 ± 0.536
0.0MetXaa: 0.0 ± 0.0
Asn
1.681AsnAla: 1.681 ± 0.934
0.84AsnCys: 0.84 ± 1.05
3.361AsnAsp: 3.361 ± 1.428
1.681AsnGlu: 1.681 ± 1.235
0.0AsnPhe: 0.0 ± 0.0
5.882AsnGly: 5.882 ± 2.128
0.84AsnHis: 0.84 ± 0.536
0.84AsnIle: 0.84 ± 0.686
0.84AsnLys: 0.84 ± 0.938
3.361AsnLeu: 3.361 ± 1.703
0.84AsnMet: 0.84 ± 0.794
0.0AsnAsn: 0.0 ± 0.0
2.521AsnPro: 2.521 ± 1.137
2.521AsnGln: 2.521 ± 1.126
2.521AsnArg: 2.521 ± 1.608
0.84AsnSer: 0.84 ± 1.134
5.042AsnThr: 5.042 ± 2.668
0.84AsnVal: 0.84 ± 0.536
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
4.202ProAla: 4.202 ± 1.964
0.0ProCys: 0.0 ± 0.0
4.202ProAsp: 4.202 ± 1.097
3.361ProGlu: 3.361 ± 0.892
0.84ProPhe: 0.84 ± 0.536
4.202ProGly: 4.202 ± 1.084
0.84ProHis: 0.84 ± 1.134
0.84ProIle: 0.84 ± 0.536
0.0ProLys: 0.0 ± 0.0
0.84ProLeu: 0.84 ± 0.904
0.84ProMet: 0.84 ± 1.05
0.0ProAsn: 0.0 ± 0.0
0.84ProPro: 0.84 ± 0.904
1.681ProGln: 1.681 ± 1.072
0.0ProArg: 0.0 ± 0.0
1.681ProSer: 1.681 ± 0.869
2.521ProThr: 2.521 ± 0.945
1.681ProVal: 1.681 ± 1.368
0.0ProTrp: 0.0 ± 0.0
1.681ProTyr: 1.681 ± 0.934
0.0ProXaa: 0.0 ± 0.0
Gln
2.521GlnAla: 2.521 ± 1.285
0.0GlnCys: 0.0 ± 0.0
1.681GlnAsp: 1.681 ± 0.934
6.723GlnGlu: 6.723 ± 2.819
0.84GlnPhe: 0.84 ± 0.536
1.681GlnGly: 1.681 ± 0.868
0.0GlnHis: 0.0 ± 0.0
0.84GlnIle: 0.84 ± 0.965
2.521GlnLys: 2.521 ± 1.14
5.042GlnLeu: 5.042 ± 1.238
0.84GlnMet: 0.84 ± 1.421
0.0GlnAsn: 0.0 ± 0.0
0.84GlnPro: 0.84 ± 0.536
1.681GlnGln: 1.681 ± 1.279
0.84GlnArg: 0.84 ± 0.536
5.042GlnSer: 5.042 ± 2.252
2.521GlnThr: 2.521 ± 1.126
0.84GlnVal: 0.84 ± 0.938
0.84GlnTrp: 0.84 ± 1.134
4.202GlnTyr: 4.202 ± 1.547
0.0GlnXaa: 0.0 ± 0.0
Arg
5.042ArgAla: 5.042 ± 2.035
1.681ArgCys: 1.681 ± 1.368
4.202ArgAsp: 4.202 ± 1.338
7.563ArgGlu: 7.563 ± 1.599
2.521ArgPhe: 2.521 ± 1.126
6.723ArgGly: 6.723 ± 3.671
0.84ArgHis: 0.84 ± 0.536
7.563ArgIle: 7.563 ± 2.87
3.361ArgLys: 3.361 ± 1.428
3.361ArgLeu: 3.361 ± 1.428
1.681ArgMet: 1.681 ± 1.135
0.84ArgAsn: 0.84 ± 0.847
2.521ArgPro: 2.521 ± 1.126
5.042ArgGln: 5.042 ± 1.49
3.361ArgArg: 3.361 ± 1.209
1.681ArgSer: 1.681 ± 0.869
4.202ArgThr: 4.202 ± 1.748
3.361ArgVal: 3.361 ± 1.224
1.681ArgTrp: 1.681 ± 1.072
0.84ArgTyr: 0.84 ± 0.536
0.0ArgXaa: 0.0 ± 0.0
Ser
5.042SerAla: 5.042 ± 1.533
0.84SerCys: 0.84 ± 1.05
6.723SerAsp: 6.723 ± 1.747
5.042SerGlu: 5.042 ± 1.799
0.84SerPhe: 0.84 ± 0.536
7.563SerGly: 7.563 ± 2.159
0.0SerHis: 0.0 ± 0.0
5.042SerIle: 5.042 ± 2.216
3.361SerLys: 3.361 ± 1.678
0.84SerLeu: 0.84 ± 0.904
0.84SerMet: 0.84 ± 0.847
4.202SerAsn: 4.202 ± 0.942
3.361SerPro: 3.361 ± 1.512
4.202SerGln: 4.202 ± 1.938
5.882SerArg: 5.882 ± 2.016
4.202SerSer: 4.202 ± 2.044
4.202SerThr: 4.202 ± 1.985
5.042SerVal: 5.042 ± 3.216
0.84SerTrp: 0.84 ± 1.05
1.681SerTyr: 1.681 ± 1.072
0.0SerXaa: 0.0 ± 0.0
Thr
4.202ThrAla: 4.202 ± 1.985
0.84ThrCys: 0.84 ± 1.05
9.244ThrAsp: 9.244 ± 5.432
11.765ThrGlu: 11.765 ± 3.996
2.521ThrPhe: 2.521 ± 1.26
6.723ThrGly: 6.723 ± 2.197
0.84ThrHis: 0.84 ± 1.05
2.521ThrIle: 2.521 ± 0.945
1.681ThrLys: 1.681 ± 1.235
5.882ThrLeu: 5.882 ± 2.58
0.84ThrMet: 0.84 ± 1.014
0.84ThrAsn: 0.84 ± 1.014
4.202ThrPro: 4.202 ± 1.867
0.84ThrGln: 0.84 ± 0.536
5.042ThrArg: 5.042 ± 2.701
5.042ThrSer: 5.042 ± 1.688
1.681ThrThr: 1.681 ± 0.868
6.723ThrVal: 6.723 ± 1.21
2.521ThrTrp: 2.521 ± 1.126
0.84ThrTyr: 0.84 ± 0.536
0.0ThrXaa: 0.0 ± 0.0
Val
3.361ValAla: 3.361 ± 1.972
0.0ValCys: 0.0 ± 0.0
5.042ValAsp: 5.042 ± 1.61
5.882ValGlu: 5.882 ± 1.707
0.84ValPhe: 0.84 ± 0.536
5.882ValGly: 5.882 ± 1.356
0.84ValHis: 0.84 ± 1.134
1.681ValIle: 1.681 ± 1.105
3.361ValLys: 3.361 ± 1.703
6.723ValLeu: 6.723 ± 2.134
0.0ValMet: 0.0 ± 0.0
3.361ValAsn: 3.361 ± 1.224
1.681ValPro: 1.681 ± 0.868
1.681ValGln: 1.681 ± 1.299
4.202ValArg: 4.202 ± 1.941
3.361ValSer: 3.361 ± 1.224
4.202ValThr: 4.202 ± 2.125
4.202ValVal: 4.202 ± 2.282
0.84ValTrp: 0.84 ± 0.536
0.84ValTyr: 0.84 ± 0.847
0.0ValXaa: 0.0 ± 0.0
Trp
0.84TrpAla: 0.84 ± 0.536
0.0TrpCys: 0.0 ± 0.0
1.681TrpAsp: 1.681 ± 0.849
0.84TrpGlu: 0.84 ± 0.536
0.84TrpPhe: 0.84 ± 0.536
0.84TrpGly: 0.84 ± 0.536
0.0TrpHis: 0.0 ± 0.0
0.84TrpIle: 0.84 ± 0.536
0.0TrpLys: 0.0 ± 0.0
1.681TrpLeu: 1.681 ± 1.072
0.0TrpMet: 0.0 ± 0.0
0.84TrpAsn: 0.84 ± 0.536
0.0TrpPro: 0.0 ± 0.0
0.84TrpGln: 0.84 ± 0.904
0.0TrpArg: 0.0 ± 0.0
1.681TrpSer: 1.681 ± 1.512
1.681TrpThr: 1.681 ± 0.869
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.361TyrAla: 3.361 ± 1.31
0.84TyrCys: 0.84 ± 0.904
4.202TyrAsp: 4.202 ± 2.044
2.521TyrGlu: 2.521 ± 1.116
0.0TyrPhe: 0.0 ± 0.0
5.882TyrGly: 5.882 ± 2.128
0.0TyrHis: 0.0 ± 0.0
0.84TyrIle: 0.84 ± 0.536
0.84TyrLys: 0.84 ± 0.847
1.681TyrLeu: 1.681 ± 0.868
0.84TyrMet: 0.84 ± 0.938
2.521TyrAsn: 2.521 ± 1.608
0.0TyrPro: 0.0 ± 0.0
0.84TyrGln: 0.84 ± 1.014
0.84TyrArg: 0.84 ± 1.05
0.84TyrSer: 0.84 ± 0.847
0.84TyrThr: 0.84 ± 0.536
2.521TyrVal: 2.521 ± 1.084
0.0TyrTrp: 0.0 ± 0.0
0.84TyrTyr: 0.84 ± 0.536
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1191 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski