Amino acid dipepetide frequency for Corynebacterium alimapuense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.083AlaAla: 15.083 ± 0.192	0.798AlaCys: 0.798 ± 0.035	6.899AlaAsp: 6.899 ± 0.121	8.352AlaGlu: 8.352 ± 0.117	3.522AlaPhe: 3.522 ± 0.075	10.128AlaGly: 10.128 ± 0.122	2.242AlaHis: 2.242 ± 0.054	5.633AlaIle: 5.633 ± 0.106	3.307AlaLys: 3.307 ± 0.099	11.577AlaLeu: 11.577 ± 0.157	2.63AlaMet: 2.63 ± 0.067	2.695AlaAsn: 2.695 ± 0.072	4.795AlaPro: 4.795 ± 0.118	4.286AlaGln: 4.286 ± 0.09	6.473AlaArg: 6.473 ± 0.113	6.086AlaSer: 6.086 ± 0.093	6.855AlaThr: 6.855 ± 0.106	9.488AlaVal: 9.488 ± 0.142	1.47AlaTrp: 1.47 ± 0.055	2.161AlaTyr: 2.161 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.712CysAla: 0.712 ± 0.035	0.069CysCys: 0.069 ± 0.011	0.377CysAsp: 0.377 ± 0.024	0.374CysGlu: 0.374 ± 0.028	0.205CysPhe: 0.205 ± 0.018	0.683CysGly: 0.683 ± 0.035	0.183CysHis: 0.183 ± 0.016	0.275CysIle: 0.275 ± 0.019	0.109CysLys: 0.109 ± 0.011	0.559CysLeu: 0.559 ± 0.029	0.118CysMet: 0.118 ± 0.014	0.155CysAsn: 0.155 ± 0.015	0.419CysPro: 0.419 ± 0.031	0.228CysGln: 0.228 ± 0.019	0.377CysArg: 0.377 ± 0.027	0.492CysSer: 0.492 ± 0.028	0.44CysThr: 0.44 ± 0.025	0.54CysVal: 0.54 ± 0.028	0.075CysTrp: 0.075 ± 0.01	0.137CysTyr: 0.137 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.503AspAla: 6.503 ± 0.104	0.406AspCys: 0.406 ± 0.029	3.393AspAsp: 3.393 ± 0.083	4.076AspGlu: 4.076 ± 0.087	2.036AspPhe: 2.036 ± 0.06	4.779AspGly: 4.779 ± 0.085	1.429AspHis: 1.429 ± 0.058	3.122AspIle: 3.122 ± 0.071	1.459AspLys: 1.459 ± 0.05	6.338AspLeu: 6.338 ± 0.107	1.097AspMet: 1.097 ± 0.038	1.702AspAsn: 1.702 ± 0.054	3.855AspPro: 3.855 ± 0.075	2.109AspGln: 2.109 ± 0.06	3.812AspArg: 3.812 ± 0.077	3.874AspSer: 3.874 ± 0.071	3.209AspThr: 3.209 ± 0.066	4.348AspVal: 4.348 ± 0.091	0.908AspTrp: 0.908 ± 0.037	1.594AspTyr: 1.594 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.738GluAla: 6.738 ± 0.125	0.303GluCys: 0.303 ± 0.024	3.695GluAsp: 3.695 ± 0.088	4.171GluGlu: 4.171 ± 0.099	2.075GluPhe: 2.075 ± 0.057	4.37GluGly: 4.37 ± 0.082	1.654GluHis: 1.654 ± 0.053	4.033GluIle: 4.033 ± 0.083	2.064GluLys: 2.064 ± 0.065	7.468GluLeu: 7.468 ± 0.117	1.279GluMet: 1.279 ± 0.045	1.731GluAsn: 1.731 ± 0.05	2.661GluPro: 2.661 ± 0.081	3.016GluGln: 3.016 ± 0.072	3.995GluArg: 3.995 ± 0.086	3.802GluSer: 3.802 ± 0.078	3.435GluThr: 3.435 ± 0.082	5.209GluVal: 5.209 ± 0.096	0.774GluTrp: 0.774 ± 0.035	1.213GluTyr: 1.213 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.571PheAla: 3.571 ± 0.079	0.234PheCys: 0.234 ± 0.017	2.34PheAsp: 2.34 ± 0.056	1.796PheGlu: 1.796 ± 0.047	1.219PhePhe: 1.219 ± 0.054	3.499PheGly: 3.499 ± 0.079	0.733PheHis: 0.733 ± 0.038	1.703PheIle: 1.703 ± 0.062	0.611PheLys: 0.611 ± 0.033	3.165PheLeu: 3.165 ± 0.082	0.615PheMet: 0.615 ± 0.034	1.001PheAsn: 1.001 ± 0.034	1.404PhePro: 1.404 ± 0.05	0.913PheGln: 0.913 ± 0.037	1.653PheArg: 1.653 ± 0.048	2.411PheSer: 2.411 ± 0.067	2.034PheThr: 2.034 ± 0.062	2.362PheVal: 2.362 ± 0.065	0.453PheTrp: 0.453 ± 0.026	0.732PheTyr: 0.732 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.405GlyAla: 8.405 ± 0.133	0.626GlyCys: 0.626 ± 0.03	4.391GlyAsp: 4.391 ± 0.091	5.057GlyGlu: 5.057 ± 0.081	3.135GlyPhe: 3.135 ± 0.067	6.657GlyGly: 6.657 ± 0.132	1.865GlyHis: 1.865 ± 0.055	4.918GlyIle: 4.918 ± 0.079	2.574GlyLys: 2.574 ± 0.061	8.677GlyLeu: 8.677 ± 0.122	2.224GlyMet: 2.224 ± 0.055	2.202GlyAsn: 2.202 ± 0.06	3.399GlyPro: 3.399 ± 0.073	3.223GlyGln: 3.223 ± 0.067	5.23GlyArg: 5.23 ± 0.092	5.381GlySer: 5.381 ± 0.09	5.08GlyThr: 5.08 ± 0.099	7.153GlyVal: 7.153 ± 0.093	1.415GlyTrp: 1.415 ± 0.047	2.12GlyTyr: 2.12 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.994HisAla: 1.994 ± 0.06	0.174HisCys: 0.174 ± 0.014	1.279HisAsp: 1.279 ± 0.05	1.189HisGlu: 1.189 ± 0.04	0.664HisPhe: 0.664 ± 0.033	1.878HisGly: 1.878 ± 0.062	0.623HisHis: 0.623 ± 0.031	0.988HisIle: 0.988 ± 0.041	0.449HisLys: 0.449 ± 0.027	2.193HisLeu: 2.193 ± 0.063	0.393HisMet: 0.393 ± 0.023	0.603HisAsn: 0.603 ± 0.032	1.462HisPro: 1.462 ± 0.047	0.78HisGln: 0.78 ± 0.033	1.581HisArg: 1.581 ± 0.051	1.357HisSer: 1.357 ± 0.052	1.164HisThr: 1.164 ± 0.044	1.406HisVal: 1.406 ± 0.048	0.268HisTrp: 0.268 ± 0.02	0.502HisTyr: 0.502 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.638IleAla: 6.638 ± 0.108	0.371IleCys: 0.371 ± 0.027	4.108IleAsp: 4.108 ± 0.083	3.304IleGlu: 3.304 ± 0.075	1.674IlePhe: 1.674 ± 0.058	4.8IleGly: 4.8 ± 0.098	1.02IleHis: 1.02 ± 0.044	3.032IleIle: 3.032 ± 0.082	1.306IleLys: 1.306 ± 0.046	4.528IleLeu: 4.528 ± 0.091	1.017IleMet: 1.017 ± 0.047	1.685IleAsn: 1.685 ± 0.052	2.873IlePro: 2.873 ± 0.071	1.348IleGln: 1.348 ± 0.044	2.979IleArg: 2.979 ± 0.074	3.653IleSer: 3.653 ± 0.078	3.43IleThr: 3.43 ± 0.074	4.227IleVal: 4.227 ± 0.082	0.584IleTrp: 0.584 ± 0.029	1.101IleTyr: 1.101 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.057LysAla: 3.057 ± 0.08	0.1LysCys: 0.1 ± 0.012	1.503LysAsp: 1.503 ± 0.047	1.607LysGlu: 1.607 ± 0.052	0.742LysPhe: 0.742 ± 0.034	1.893LysGly: 1.893 ± 0.051	0.581LysHis: 0.581 ± 0.028	1.576LysIle: 1.576 ± 0.052	1.347LysLys: 1.347 ± 0.06	2.677LysLeu: 2.677 ± 0.068	0.668LysMet: 0.668 ± 0.034	0.815LysAsn: 0.815 ± 0.037	1.294LysPro: 1.294 ± 0.067	1.063LysGln: 1.063 ± 0.047	1.696LysArg: 1.696 ± 0.06	1.575LysSer: 1.575 ± 0.052	1.591LysThr: 1.591 ± 0.058	2.158LysVal: 2.158 ± 0.062	0.33LysTrp: 0.33 ± 0.023	0.599LysTyr: 0.599 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	13.135LeuAla: 13.135 ± 0.184	0.62LeuCys: 0.62 ± 0.028	6.472LeuAsp: 6.472 ± 0.098	5.689LeuGlu: 5.689 ± 0.108	2.875LeuPhe: 2.875 ± 0.075	8.886LeuGly: 8.886 ± 0.144	1.978LeuHis: 1.978 ± 0.061	5.696LeuIle: 5.696 ± 0.11	2.477LeuLys: 2.477 ± 0.065	10.034LeuLeu: 10.034 ± 0.154	2.021LeuMet: 2.021 ± 0.053	2.688LeuAsn: 2.688 ± 0.058	5.527LeuPro: 5.527 ± 0.092	2.729LeuGln: 2.729 ± 0.065	6.366LeuArg: 6.366 ± 0.107	7.161LeuSer: 7.161 ± 0.119	5.969LeuThr: 5.969 ± 0.1	8.28LeuVal: 8.28 ± 0.139	1.236LeuTrp: 1.236 ± 0.047	1.713LeuTyr: 1.713 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.576MetAla: 2.576 ± 0.066	0.127MetCys: 0.127 ± 0.014	1.077MetAsp: 1.077 ± 0.041	1.022MetGlu: 1.022 ± 0.038	0.737MetPhe: 0.737 ± 0.037	1.585MetGly: 1.585 ± 0.051	0.358MetHis: 0.358 ± 0.024	1.347MetIle: 1.347 ± 0.05	0.624MetLys: 0.624 ± 0.028	2.203MetLeu: 2.203 ± 0.062	0.533MetMet: 0.533 ± 0.031	0.705MetAsn: 0.705 ± 0.035	1.145MetPro: 1.145 ± 0.048	0.537MetGln: 0.537 ± 0.027	1.251MetArg: 1.251 ± 0.038	1.908MetSer: 1.908 ± 0.054	1.753MetThr: 1.753 ± 0.051	1.734MetVal: 1.734 ± 0.055	0.287MetTrp: 0.287 ± 0.02	0.339MetTyr: 0.339 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.783AsnAla: 2.783 ± 0.064	0.194AsnCys: 0.194 ± 0.018	1.571AsnAsp: 1.571 ± 0.056	1.466AsnGlu: 1.466 ± 0.046	0.873AsnPhe: 0.873 ± 0.035	2.099AsnGly: 2.099 ± 0.062	0.602AsnHis: 0.602 ± 0.035	1.353AsnIle: 1.353 ± 0.047	0.723AsnLys: 0.723 ± 0.031	2.764AsnLeu: 2.764 ± 0.068	0.599AsnMet: 0.599 ± 0.032	0.879AsnAsn: 0.879 ± 0.045	1.933AsnPro: 1.933 ± 0.058	1.016AsnGln: 1.016 ± 0.05	1.769AsnArg: 1.769 ± 0.062	1.796AsnSer: 1.796 ± 0.056	1.485AsnThr: 1.485 ± 0.051	1.902AsnVal: 1.902 ± 0.058	0.428AsnTrp: 0.428 ± 0.025	0.732AsnTyr: 0.732 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	5.911ProAla: 5.911 ± 0.107	0.228ProCys: 0.228 ± 0.017	3.285ProAsp: 3.285 ± 0.062	4.432ProGlu: 4.432 ± 0.094	1.484ProPhe: 1.484 ± 0.047	4.589ProGly: 4.589 ± 0.1	0.938ProHis: 0.938 ± 0.039	2.168ProIle: 2.168 ± 0.057	1.415ProLys: 1.415 ± 0.049	4.47ProLeu: 4.47 ± 0.088	1.064ProMet: 1.064 ± 0.038	1.339ProAsn: 1.339 ± 0.045	1.716ProPro: 1.716 ± 0.068	1.657ProGln: 1.657 ± 0.048	2.682ProArg: 2.682 ± 0.066	3.009ProSer: 3.009 ± 0.071	3.1ProThr: 3.1 ± 0.068	4.61ProVal: 4.61 ± 0.089	0.68ProTrp: 0.68 ± 0.039	0.982ProTyr: 0.982 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.108GlnAla: 4.108 ± 0.084	0.159GlnCys: 0.159 ± 0.014	1.725GlnAsp: 1.725 ± 0.054	2.148GlnGlu: 2.148 ± 0.059	0.966GlnPhe: 0.966 ± 0.034	2.492GlnGly: 2.492 ± 0.057	0.617GlnHis: 0.617 ± 0.027	1.939GlnIle: 1.939 ± 0.061	0.77GlnLys: 0.77 ± 0.031	4.207GlnLeu: 4.207 ± 0.098	0.824GlnMet: 0.824 ± 0.035	0.752GlnAsn: 0.752 ± 0.039	1.76GlnPro: 1.76 ± 0.061	1.593GlnGln: 1.593 ± 0.061	2.56GlnArg: 2.56 ± 0.064	1.863GlnSer: 1.863 ± 0.048	1.61GlnThr: 1.61 ± 0.052	3.019GlnVal: 3.019 ± 0.068	0.596GlnTrp: 0.596 ± 0.034	0.609GlnTyr: 0.609 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	6.108ArgAla: 6.108 ± 0.107	0.346ArgCys: 0.346 ± 0.02	3.458ArgAsp: 3.458 ± 0.077	4.261ArgGlu: 4.261 ± 0.073	2.015ArgPhe: 2.015 ± 0.056	4.52ArgGly: 4.52 ± 0.084	1.32ArgHis: 1.32 ± 0.053	3.521ArgIle: 3.521 ± 0.081	1.875ArgLys: 1.875 ± 0.057	6.15ArgLeu: 6.15 ± 0.111	1.556ArgMet: 1.556 ± 0.046	1.743ArgAsn: 1.743 ± 0.056	2.851ArgPro: 2.851 ± 0.076	2.329ArgGln: 2.329 ± 0.06	5.027ArgArg: 5.027 ± 0.119	3.921ArgSer: 3.921 ± 0.069	3.525ArgThr: 3.525 ± 0.073	4.589ArgVal: 4.589 ± 0.084	0.98ArgTrp: 0.98 ± 0.042	1.543ArgTyr: 1.543 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	7.106SerAla: 7.106 ± 0.099	0.452SerCys: 0.452 ± 0.03	3.503SerAsp: 3.503 ± 0.076	3.777SerGlu: 3.777 ± 0.082	2.245SerPhe: 2.245 ± 0.067	6.181SerGly: 6.181 ± 0.091	1.295SerHis: 1.295 ± 0.045	3.038SerIle: 3.038 ± 0.076	1.569SerLys: 1.569 ± 0.053	6.153SerLeu: 6.153 ± 0.094	1.64SerMet: 1.64 ± 0.05	1.626SerAsn: 1.626 ± 0.051	3.354SerPro: 3.354 ± 0.083	2.253SerGln: 2.253 ± 0.055	3.898SerArg: 3.898 ± 0.084	4.609SerSer: 4.609 ± 0.102	4.363SerThr: 4.363 ± 0.089	5.099SerVal: 5.099 ± 0.097	0.995SerTrp: 0.995 ± 0.037	1.445SerTyr: 1.445 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	6.741ThrAla: 6.741 ± 0.116	0.406ThrCys: 0.406 ± 0.031	3.481ThrAsp: 3.481 ± 0.075	3.603ThrGlu: 3.603 ± 0.079	1.865ThrPhe: 1.865 ± 0.063	5.52ThrGly: 5.52 ± 0.09	1.158ThrHis: 1.158 ± 0.039	3.079ThrIle: 3.079 ± 0.063	1.563ThrLys: 1.563 ± 0.052	5.779ThrLeu: 5.779 ± 0.091	1.247ThrMet: 1.247 ± 0.041	1.47ThrAsn: 1.47 ± 0.048	3.564ThrPro: 3.564 ± 0.073	1.78ThrGln: 1.78 ± 0.056	3.343ThrArg: 3.343 ± 0.074	3.842ThrSer: 3.842 ± 0.078	3.973ThrThr: 3.973 ± 0.085	5.477ThrVal: 5.477 ± 0.095	0.957ThrTrp: 0.957 ± 0.038	1.276ThrTyr: 1.276 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	9.684ValAla: 9.684 ± 0.124	0.609ValCys: 0.609 ± 0.031	5.499ValAsp: 5.499 ± 0.112	5.35ValGlu: 5.35 ± 0.102	2.711ValPhe: 2.711 ± 0.063	6.398ValGly: 6.398 ± 0.103	1.64ValHis: 1.64 ± 0.057	4.664ValIle: 4.664 ± 0.094	1.865ValLys: 1.865 ± 0.054	8.34ValLeu: 8.34 ± 0.117	1.688ValMet: 1.688 ± 0.053	2.214ValAsn: 2.214 ± 0.052	3.942ValPro: 3.942 ± 0.085	1.941ValGln: 1.941 ± 0.051	4.414ValArg: 4.414 ± 0.084	5.45ValSer: 5.45 ± 0.095	5.193ValThr: 5.193 ± 0.082	7.563ValVal: 7.563 ± 0.137	0.976ValTrp: 0.976 ± 0.039	1.475ValTyr: 1.475 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.472TrpAla: 1.472 ± 0.051	0.135TrpCys: 0.135 ± 0.013	0.681TrpAsp: 0.681 ± 0.034	0.814TrpGlu: 0.814 ± 0.039	0.595TrpPhe: 0.595 ± 0.033	0.92TrpGly: 0.92 ± 0.045	0.274TrpHis: 0.274 ± 0.019	0.817TrpIle: 0.817 ± 0.039	0.392TrpLys: 0.392 ± 0.024	1.722TrpLeu: 1.722 ± 0.055	0.35TrpMet: 0.35 ± 0.028	0.409TrpAsn: 0.409 ± 0.025	0.649TrpPro: 0.649 ± 0.034	0.592TrpGln: 0.592 ± 0.027	0.913TrpArg: 0.913 ± 0.037	0.911TrpSer: 0.911 ± 0.037	0.767TrpThr: 0.767 ± 0.032	1.061TrpVal: 1.061 ± 0.046	0.378TrpTrp: 0.378 ± 0.024	0.268TrpTyr: 0.268 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.153TyrAla: 2.153 ± 0.06	0.169TyrCys: 0.169 ± 0.016	1.313TyrAsp: 1.313 ± 0.04	1.2TyrGlu: 1.2 ± 0.044	0.812TyrPhe: 0.812 ± 0.038	1.853TyrGly: 1.853 ± 0.052	0.437TyrHis: 0.437 ± 0.028	0.777TyrIle: 0.777 ± 0.036	0.375TyrLys: 0.375 ± 0.024	2.548TyrLeu: 2.548 ± 0.063	0.283TyrMet: 0.283 ± 0.021	0.55TyrAsn: 0.55 ± 0.034	1.155TyrPro: 1.155 ± 0.041	0.923TyrGln: 0.923 ± 0.033	1.621TyrArg: 1.621 ± 0.053	1.5TyrSer: 1.5 ± 0.048	1.148TyrThr: 1.148 ± 0.041	1.392TyrVal: 1.392 ± 0.047	0.328TyrTrp: 0.328 ± 0.024	0.499TyrTyr: 0.499 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2040 proteins (679389 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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