Amino acid dipepetide frequency for Janibacter melonis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.191AlaAla: 19.191 ± 0.222	0.923AlaCys: 0.923 ± 0.033	8.325AlaAsp: 8.325 ± 0.109	7.466AlaGlu: 7.466 ± 0.094	2.948AlaPhe: 2.948 ± 0.065	12.322AlaGly: 12.322 ± 0.122	2.698AlaHis: 2.698 ± 0.051	4.05AlaIle: 4.05 ± 0.085	2.542AlaLys: 2.542 ± 0.061	14.306AlaLeu: 14.306 ± 0.145	2.983AlaMet: 2.983 ± 0.053	1.501AlaAsn: 1.501 ± 0.045	6.671AlaPro: 6.671 ± 0.128	4.321AlaGln: 4.321 ± 0.075	10.302AlaArg: 10.302 ± 0.121	6.477AlaSer: 6.477 ± 0.09	7.465AlaThr: 7.465 ± 0.106	12.179AlaVal: 12.179 ± 0.135	1.916AlaTrp: 1.916 ± 0.051	2.239AlaTyr: 2.239 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.902CysAla: 0.902 ± 0.031	0.086CysCys: 0.086 ± 0.01	0.473CysAsp: 0.473 ± 0.024	0.365CysGlu: 0.365 ± 0.019	0.191CysPhe: 0.191 ± 0.014	0.813CysGly: 0.813 ± 0.03	0.151CysHis: 0.151 ± 0.012	0.177CysIle: 0.177 ± 0.013	0.078CysLys: 0.078 ± 0.008	0.582CysLeu: 0.582 ± 0.026	0.094CysMet: 0.094 ± 0.01	0.077CysAsn: 0.077 ± 0.009	0.411CysPro: 0.411 ± 0.021	0.141CysGln: 0.141 ± 0.012	0.45CysArg: 0.45 ± 0.021	0.387CysSer: 0.387 ± 0.021	0.478CysThr: 0.478 ± 0.022	0.645CysVal: 0.645 ± 0.026	0.088CysTrp: 0.088 ± 0.01	0.119CysTyr: 0.119 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.324AspAla: 8.324 ± 0.117	0.308AspCys: 0.308 ± 0.017	4.829AspAsp: 4.829 ± 0.082	5.21AspGlu: 5.21 ± 0.076	1.592AspPhe: 1.592 ± 0.049	6.565AspGly: 6.565 ± 0.103	1.511AspHis: 1.511 ± 0.044	1.852AspIle: 1.852 ± 0.047	0.984AspLys: 0.984 ± 0.035	7.472AspLeu: 7.472 ± 0.105	0.83AspMet: 0.83 ± 0.03	0.746AspAsn: 0.746 ± 0.028	4.762AspPro: 4.762 ± 0.07	1.51AspGln: 1.51 ± 0.041	4.604AspArg: 4.604 ± 0.078	2.421AspSer: 2.421 ± 0.048	2.709AspThr: 2.709 ± 0.058	6.67AspVal: 6.67 ± 0.096	0.837AspTrp: 0.837 ± 0.03	1.066AspTyr: 1.066 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.853GluAla: 6.853 ± 0.084	0.311GluCys: 0.311 ± 0.018	3.536GluAsp: 3.536 ± 0.062	3.32GluGlu: 3.32 ± 0.068	0.873GluPhe: 0.873 ± 0.035	5.121GluGly: 5.121 ± 0.076	2.082GluHis: 2.082 ± 0.056	2.51GluIle: 2.51 ± 0.058	0.93GluLys: 0.93 ± 0.04	6.562GluLeu: 6.562 ± 0.088	1.011GluMet: 1.011 ± 0.037	0.582GluAsn: 0.582 ± 0.024	3.179GluPro: 3.179 ± 0.067	2.668GluGln: 2.668 ± 0.064	6.104GluArg: 6.104 ± 0.09	2.737GluSer: 2.737 ± 0.058	2.865GluThr: 2.865 ± 0.051	6.239GluVal: 6.239 ± 0.084	0.685GluTrp: 0.685 ± 0.027	0.95GluTyr: 0.95 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.438PheAla: 3.438 ± 0.05	0.19PheCys: 0.19 ± 0.015	1.728PheAsp: 1.728 ± 0.044	1.544PheGlu: 1.544 ± 0.043	0.836PhePhe: 0.836 ± 0.039	2.787PheGly: 2.787 ± 0.059	0.441PheHis: 0.441 ± 0.019	0.638PheIle: 0.638 ± 0.03	0.345PheLys: 0.345 ± 0.022	1.925PheLeu: 1.925 ± 0.053	0.408PheMet: 0.408 ± 0.019	0.429PheAsn: 0.429 ± 0.023	1.022PhePro: 1.022 ± 0.035	0.461PheGln: 0.461 ± 0.022	1.332PheArg: 1.332 ± 0.04	1.286PheSer: 1.286 ± 0.042	1.515PheThr: 1.515 ± 0.043	2.836PheVal: 2.836 ± 0.064	0.337PheTrp: 0.337 ± 0.02	0.545PheTyr: 0.545 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.219GlyAla: 11.219 ± 0.133	0.787GlyCys: 0.787 ± 0.03	5.594GlyAsp: 5.594 ± 0.079	5.849GlyGlu: 5.849 ± 0.088	2.551GlyPhe: 2.551 ± 0.058	8.642GlyGly: 8.642 ± 0.136	2.2GlyHis: 2.2 ± 0.049	3.444GlyIle: 3.444 ± 0.07	1.779GlyLys: 1.779 ± 0.049	9.653GlyLeu: 9.653 ± 0.121	2.19GlyMet: 2.19 ± 0.043	1.293GlyAsn: 1.293 ± 0.04	4.606GlyPro: 4.606 ± 0.072	2.879GlyGln: 2.879 ± 0.065	7.748GlyArg: 7.748 ± 0.087	5.924GlySer: 5.924 ± 0.091	5.753GlyThr: 5.753 ± 0.089	8.938GlyVal: 8.938 ± 0.1	1.846GlyTrp: 1.846 ± 0.043	2.312GlyTyr: 2.312 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.577HisAla: 2.577 ± 0.063	0.168HisCys: 0.168 ± 0.013	1.731HisAsp: 1.731 ± 0.05	1.484HisGlu: 1.484 ± 0.04	0.489HisPhe: 0.489 ± 0.023	2.36HisGly: 2.36 ± 0.055	0.688HisHis: 0.688 ± 0.031	0.489HisIle: 0.489 ± 0.026	0.278HisLys: 0.278 ± 0.019	2.594HisLeu: 2.594 ± 0.056	0.314HisMet: 0.314 ± 0.018	0.301HisAsn: 0.301 ± 0.02	1.72HisPro: 1.72 ± 0.048	0.528HisGln: 0.528 ± 0.024	1.91HisArg: 1.91 ± 0.047	0.866HisSer: 0.866 ± 0.033	0.975HisThr: 0.975 ± 0.033	2.388HisVal: 2.388 ± 0.053	0.269HisTrp: 0.269 ± 0.016	0.385HisTyr: 0.385 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.586IleAla: 4.586 ± 0.094	0.301IleCys: 0.301 ± 0.018	2.077IleAsp: 2.077 ± 0.052	1.839IleGlu: 1.839 ± 0.046	0.892IlePhe: 0.892 ± 0.032	3.647IleGly: 3.647 ± 0.072	0.613IleHis: 0.613 ± 0.026	1.027IleIle: 1.027 ± 0.036	0.602IleLys: 0.602 ± 0.031	2.144IleLeu: 2.144 ± 0.054	0.472IleMet: 0.472 ± 0.025	0.634IleAsn: 0.634 ± 0.028	1.733IlePro: 1.733 ± 0.044	0.676IleGln: 0.676 ± 0.027	2.074IleArg: 2.074 ± 0.052	1.926IleSer: 1.926 ± 0.058	2.41IleThr: 2.41 ± 0.048	2.215IleVal: 2.215 ± 0.049	0.368IleTrp: 0.368 ± 0.018	0.599IleTyr: 0.599 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.098LysAla: 2.098 ± 0.065	0.073LysCys: 0.073 ± 0.009	1.126LysAsp: 1.126 ± 0.035	0.876LysGlu: 0.876 ± 0.035	0.336LysPhe: 0.336 ± 0.021	1.864LysGly: 1.864 ± 0.053	0.346LysHis: 0.346 ± 0.019	0.811LysIle: 0.811 ± 0.032	0.725LysLys: 0.725 ± 0.041	1.218LysLeu: 1.218 ± 0.041	0.368LysMet: 0.368 ± 0.019	0.349LysAsn: 0.349 ± 0.019	0.874LysPro: 0.874 ± 0.033	0.551LysGln: 0.551 ± 0.027	1.072LysArg: 1.072 ± 0.034	0.99LysSer: 0.99 ± 0.035	1.092LysThr: 1.092 ± 0.041	1.699LysVal: 1.699 ± 0.042	0.16LysTrp: 0.16 ± 0.014	0.349LysTyr: 0.349 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.41LeuAla: 15.41 ± 0.146	0.606LeuCys: 0.606 ± 0.023	7.166LeuAsp: 7.166 ± 0.105	5.367LeuGlu: 5.367 ± 0.084	2.096LeuPhe: 2.096 ± 0.046	10.11LeuGly: 10.11 ± 0.125	2.045LeuHis: 2.045 ± 0.047	2.129LeuIle: 2.129 ± 0.056	1.395LeuLys: 1.395 ± 0.04	10.771LeuLeu: 10.771 ± 0.143	1.596LeuMet: 1.596 ± 0.039	1.1LeuAsn: 1.1 ± 0.035	5.883LeuPro: 5.883 ± 0.09	2.185LeuGln: 2.185 ± 0.047	8.126LeuArg: 8.126 ± 0.102	5.147LeuSer: 5.147 ± 0.081	6.297LeuThr: 6.297 ± 0.081	12.091LeuVal: 12.091 ± 0.145	1.159LeuTrp: 1.159 ± 0.034	1.47LeuTyr: 1.47 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	2.311MetAla: 2.311 ± 0.052	0.134MetCys: 0.134 ± 0.011	0.904MetAsp: 0.904 ± 0.031	0.754MetGlu: 0.754 ± 0.028	0.385MetPhe: 0.385 ± 0.022	1.489MetGly: 1.489 ± 0.045	0.401MetHis: 0.401 ± 0.021	0.732MetIle: 0.732 ± 0.028	0.401MetLys: 0.401 ± 0.022	1.871MetLeu: 1.871 ± 0.048	0.309MetMet: 0.309 ± 0.02	0.282MetAsn: 0.282 ± 0.017	1.194MetPro: 1.194 ± 0.036	0.506MetGln: 0.506 ± 0.024	1.738MetArg: 1.738 ± 0.033	1.716MetSer: 1.716 ± 0.043	1.793MetThr: 1.793 ± 0.042	1.402MetVal: 1.402 ± 0.04	0.235MetTrp: 0.235 ± 0.016	0.325MetTyr: 0.325 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	1.666AsnAla: 1.666 ± 0.04	0.096AsnCys: 0.096 ± 0.012	0.723AsnAsp: 0.723 ± 0.03	0.603AsnGlu: 0.603 ± 0.029	0.413AsnPhe: 0.413 ± 0.023	1.123AsnGly: 1.123 ± 0.035	0.304AsnHis: 0.304 ± 0.018	0.508AsnIle: 0.508 ± 0.027	0.284AsnLys: 0.284 ± 0.017	1.455AsnLeu: 1.455 ± 0.045	0.192AsnMet: 0.192 ± 0.015	0.306AsnAsn: 0.306 ± 0.021	1.202AsnPro: 1.202 ± 0.036	0.343AsnGln: 0.343 ± 0.018	0.908AsnArg: 0.908 ± 0.036	0.595AsnSer: 0.595 ± 0.023	0.681AsnThr: 0.681 ± 0.028	1.194AsnVal: 1.194 ± 0.034	0.169AsnTrp: 0.169 ± 0.012	0.282AsnTyr: 0.282 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.157ProAla: 7.157 ± 0.092	0.266ProCys: 0.266 ± 0.016	4.162ProAsp: 4.162 ± 0.073	4.007ProGlu: 4.007 ± 0.067	1.662ProPhe: 1.662 ± 0.046	6.049ProGly: 6.049 ± 0.074	1.268ProHis: 1.268 ± 0.041	1.277ProIle: 1.277 ± 0.035	0.969ProLys: 0.969 ± 0.036	4.926ProLeu: 4.926 ± 0.079	0.989ProMet: 0.989 ± 0.031	0.624ProAsn: 0.624 ± 0.024	2.783ProPro: 2.783 ± 0.067	1.925ProGln: 1.925 ± 0.049	3.959ProArg: 3.959 ± 0.07	3.274ProSer: 3.274 ± 0.067	3.662ProThr: 3.662 ± 0.066	5.737ProVal: 5.737 ± 0.081	0.942ProTrp: 0.942 ± 0.036	1.045ProTyr: 1.045 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.744GlnAla: 3.744 ± 0.065	0.14GlnCys: 0.14 ± 0.012	1.714GlnAsp: 1.714 ± 0.047	1.622GlnGlu: 1.622 ± 0.041	0.469GlnPhe: 0.469 ± 0.024	2.476GlnGly: 2.476 ± 0.058	0.735GlnHis: 0.735 ± 0.025	1.055GlnIle: 1.055 ± 0.032	0.453GlnLys: 0.453 ± 0.023	2.869GlnLeu: 2.869 ± 0.061	0.614GlnMet: 0.614 ± 0.025	0.339GlnAsn: 0.339 ± 0.02	1.597GlnPro: 1.597 ± 0.042	1.176GlnGln: 1.176 ± 0.039	2.579GlnArg: 2.579 ± 0.054	1.303GlnSer: 1.303 ± 0.036	1.558GlnThr: 1.558 ± 0.04	3.154GlnVal: 3.154 ± 0.056	0.503GlnTrp: 0.503 ± 0.023	0.509GlnTyr: 0.509 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	9.819ArgAla: 9.819 ± 0.116	0.52ArgCys: 0.52 ± 0.023	4.835ArgAsp: 4.835 ± 0.072	5.021ArgGlu: 5.021 ± 0.074	1.937ArgPhe: 1.937 ± 0.052	6.123ArgGly: 6.123 ± 0.094	1.863ArgHis: 1.863 ± 0.047	2.379ArgIle: 2.379 ± 0.052	1.095ArgLys: 1.095 ± 0.038	8.055ArgLeu: 8.055 ± 0.108	1.851ArgMet: 1.851 ± 0.046	0.946ArgAsn: 0.946 ± 0.032	4.477ArgPro: 4.477 ± 0.069	2.083ArgGln: 2.083 ± 0.048	7.817ArgArg: 7.817 ± 0.117	4.568ArgSer: 4.568 ± 0.084	5.151ArgThr: 5.151 ± 0.075	7.369ArgVal: 7.369 ± 0.1	1.587ArgTrp: 1.587 ± 0.039	1.646ArgTyr: 1.646 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.848SerAla: 6.848 ± 0.096	0.368SerCys: 0.368 ± 0.021	2.936SerAsp: 2.936 ± 0.064	2.608SerGlu: 2.608 ± 0.05	1.466SerPhe: 1.466 ± 0.043	5.855SerGly: 5.855 ± 0.108	0.985SerHis: 0.985 ± 0.029	1.87SerIle: 1.87 ± 0.051	0.933SerLys: 0.933 ± 0.032	5.002SerLeu: 5.002 ± 0.075	1.32SerMet: 1.32 ± 0.036	0.776SerAsn: 0.776 ± 0.024	3.228SerPro: 3.228 ± 0.055	1.491SerGln: 1.491 ± 0.042	3.869SerArg: 3.869 ± 0.061	3.634SerSer: 3.634 ± 0.091	4.116SerThr: 4.116 ± 0.08	4.848SerVal: 4.848 ± 0.068	0.97SerTrp: 0.97 ± 0.034	1.2SerTyr: 1.2 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.322ThrAla: 7.322 ± 0.096	0.441ThrCys: 0.441 ± 0.023	3.613ThrAsp: 3.613 ± 0.064	2.81ThrGlu: 2.81 ± 0.057	1.72ThrPhe: 1.72 ± 0.045	6.129ThrGly: 6.129 ± 0.091	1.319ThrHis: 1.319 ± 0.035	2.133ThrIle: 2.133 ± 0.057	1.232ThrLys: 1.232 ± 0.033	5.615ThrLeu: 5.615 ± 0.091	1.119ThrMet: 1.119 ± 0.033	0.935ThrAsn: 0.935 ± 0.033	4.077ThrPro: 4.077 ± 0.066	1.799ThrGln: 1.799 ± 0.044	4.333ThrArg: 4.333 ± 0.069	4.068ThrSer: 4.068 ± 0.069	4.645ThrThr: 4.645 ± 0.079	5.458ThrVal: 5.458 ± 0.084	1.038ThrTrp: 1.038 ± 0.034	1.352ThrTyr: 1.352 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	13.435ValAla: 13.435 ± 0.136	0.695ValCys: 0.695 ± 0.032	7.084ValAsp: 7.084 ± 0.091	6.593ValGlu: 6.593 ± 0.09	2.192ValPhe: 2.192 ± 0.052	8.8ValGly: 8.8 ± 0.114	2.18ValHis: 2.18 ± 0.059	2.953ValIle: 2.953 ± 0.065	1.403ValLys: 1.403 ± 0.044	11.321ValLeu: 11.321 ± 0.138	1.691ValMet: 1.691 ± 0.045	1.268ValAsn: 1.268 ± 0.042	5.399ValPro: 5.399 ± 0.074	2.266ValGln: 2.266 ± 0.056	7.374ValArg: 7.374 ± 0.083	4.992ValSer: 4.992 ± 0.074	6.085ValThr: 6.085 ± 0.082	13.101ValVal: 13.101 ± 0.161	1.148ValTrp: 1.148 ± 0.037	1.462ValTyr: 1.462 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.685TrpAla: 1.685 ± 0.044	0.164TrpCys: 0.164 ± 0.014	0.809TrpAsp: 0.809 ± 0.031	0.675TrpGlu: 0.675 ± 0.027	0.448TrpPhe: 0.448 ± 0.023	1.084TrpGly: 1.084 ± 0.034	0.343TrpHis: 0.343 ± 0.021	0.376TrpIle: 0.376 ± 0.022	0.21TrpLys: 0.21 ± 0.014	1.701TrpLeu: 1.701 ± 0.046	0.291TrpMet: 0.291 ± 0.016	0.228TrpAsn: 0.228 ± 0.016	0.796TrpPro: 0.796 ± 0.027	0.604TrpGln: 0.604 ± 0.025	1.333TrpArg: 1.333 ± 0.043	1.069TrpSer: 1.069 ± 0.035	0.949TrpThr: 0.949 ± 0.032	1.473TrpVal: 1.473 ± 0.046	0.433TrpTrp: 0.433 ± 0.023	0.284TrpTyr: 0.284 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.24TyrAla: 2.24 ± 0.051	0.131TyrCys: 0.131 ± 0.011	1.439TyrAsp: 1.439 ± 0.045	1.106TyrGlu: 1.106 ± 0.037	0.549TyrPhe: 0.549 ± 0.026	1.843TyrGly: 1.843 ± 0.047	0.339TyrHis: 0.339 ± 0.018	0.429TyrIle: 0.429 ± 0.023	0.341TyrLys: 0.341 ± 0.02	2.107TyrLeu: 2.107 ± 0.049	0.236TyrMet: 0.236 ± 0.017	0.33TyrAsn: 0.33 ± 0.021	1.066TyrPro: 1.066 ± 0.032	0.497TyrGln: 0.497 ± 0.022	1.511TyrArg: 1.511 ± 0.04	0.945TyrSer: 0.945 ± 0.036	0.959TyrThr: 0.959 ± 0.036	1.807TyrVal: 1.807 ± 0.046	0.264TyrTrp: 0.264 ± 0.017	0.443TyrTyr: 0.443 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2936 proteins (947235 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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