Amino acid dipepetide frequency for Desulfococcus multivorans DSM 2059

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.405AlaAla: 11.405 ± 0.141	1.298AlaCys: 1.298 ± 0.033	5.597AlaAsp: 5.597 ± 0.079	6.027AlaGlu: 6.027 ± 0.083	4.18AlaPhe: 4.18 ± 0.059	8.102AlaGly: 8.102 ± 0.094	1.711AlaHis: 1.711 ± 0.04	4.561AlaIle: 4.561 ± 0.067	3.245AlaLys: 3.245 ± 0.068	9.794AlaLeu: 9.794 ± 0.096	2.764AlaMet: 2.764 ± 0.044	2.093AlaAsn: 2.093 ± 0.049	3.644AlaPro: 3.644 ± 0.058	2.309AlaGln: 2.309 ± 0.049	6.166AlaArg: 6.166 ± 0.071	4.404AlaSer: 4.404 ± 0.054	3.627AlaThr: 3.627 ± 0.064	9.143AlaVal: 9.143 ± 0.11	1.094AlaTrp: 1.094 ± 0.034	2.621AlaTyr: 2.621 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.959CysAla: 0.959 ± 0.029	0.227CysCys: 0.227 ± 0.015	0.635CysAsp: 0.635 ± 0.024	0.635CysGlu: 0.635 ± 0.025	0.528CysPhe: 0.528 ± 0.021	1.289CysGly: 1.289 ± 0.04	0.379CysHis: 0.379 ± 0.025	0.719CysIle: 0.719 ± 0.025	0.395CysLys: 0.395 ± 0.017	1.111CysLeu: 1.111 ± 0.03	0.312CysMet: 0.312 ± 0.016	0.36CysAsn: 0.36 ± 0.017	0.805CysPro: 0.805 ± 0.028	0.274CysGln: 0.274 ± 0.015	1.165CysArg: 1.165 ± 0.034	0.653CysSer: 0.653 ± 0.025	0.584CysThr: 0.584 ± 0.024	0.735CysVal: 0.735 ± 0.025	0.115CysTrp: 0.115 ± 0.01	0.356CysTyr: 0.356 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.803AspAla: 5.803 ± 0.069	0.576AspCys: 0.576 ± 0.021	3.134AspAsp: 3.134 ± 0.061	3.491AspGlu: 3.491 ± 0.071	2.553AspPhe: 2.553 ± 0.042	4.475AspGly: 4.475 ± 0.07	1.223AspHis: 1.223 ± 0.032	4.33AspIle: 4.33 ± 0.06	2.082AspLys: 2.082 ± 0.044	5.923AspLeu: 5.923 ± 0.065	1.496AspMet: 1.496 ± 0.036	1.552AspAsn: 1.552 ± 0.041	3.49AspPro: 3.49 ± 0.055	1.587AspGln: 1.587 ± 0.039	4.583AspArg: 4.583 ± 0.075	2.068AspSer: 2.068 ± 0.041	2.821AspThr: 2.821 ± 0.05	4.05AspVal: 4.05 ± 0.064	0.712AspTrp: 0.712 ± 0.027	1.744AspTyr: 1.744 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.385GluAla: 6.385 ± 0.081	0.553GluCys: 0.553 ± 0.022	3.315GluAsp: 3.315 ± 0.05	3.892GluGlu: 3.892 ± 0.071	2.005GluPhe: 2.005 ± 0.041	4.155GluGly: 4.155 ± 0.06	1.172GluHis: 1.172 ± 0.03	4.991GluIle: 4.991 ± 0.072	4.491GluLys: 4.491 ± 0.078	5.112GluLeu: 5.112 ± 0.073	1.958GluMet: 1.958 ± 0.044	2.696GluAsn: 2.696 ± 0.052	2.129GluPro: 2.129 ± 0.047	1.849GluGln: 1.849 ± 0.046	4.536GluArg: 4.536 ± 0.068	3.163GluSer: 3.163 ± 0.051	4.163GluThr: 4.163 ± 0.06	3.723GluVal: 3.723 ± 0.065	0.685GluTrp: 0.685 ± 0.024	1.495GluTyr: 1.495 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.118PheAla: 3.118 ± 0.056	0.56PheCys: 0.56 ± 0.021	2.669PheAsp: 2.669 ± 0.043	2.51PheGlu: 2.51 ± 0.044	2.163PhePhe: 2.163 ± 0.052	3.28PheGly: 3.28 ± 0.057	1.013PheHis: 1.013 ± 0.027	2.606PheIle: 2.606 ± 0.059	1.762PheLys: 1.762 ± 0.036	4.16PheLeu: 4.16 ± 0.071	1.108PheMet: 1.108 ± 0.025	1.43PheAsn: 1.43 ± 0.032	2.01PhePro: 2.01 ± 0.038	1.351PheGln: 1.351 ± 0.035	2.725PheArg: 2.725 ± 0.044	2.956PheSer: 2.956 ± 0.052	2.231PheThr: 2.231 ± 0.043	2.695PheVal: 2.695 ± 0.045	0.562PheTrp: 0.562 ± 0.024	1.326PheTyr: 1.326 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.551GlyAla: 6.551 ± 0.08	1.212GlyCys: 1.212 ± 0.037	4.132GlyAsp: 4.132 ± 0.065	4.571GlyGlu: 4.571 ± 0.061	3.532GlyPhe: 3.532 ± 0.06	6.352GlyGly: 6.352 ± 0.097	1.63GlyHis: 1.63 ± 0.038	6.098GlyIle: 6.098 ± 0.074	4.177GlyLys: 4.177 ± 0.066	7.473GlyLeu: 7.473 ± 0.082	2.672GlyMet: 2.672 ± 0.046	2.431GlyAsn: 2.431 ± 0.041	2.714GlyPro: 2.714 ± 0.05	1.96GlyGln: 1.96 ± 0.041	5.775GlyArg: 5.775 ± 0.085	3.958GlySer: 3.958 ± 0.065	4.149GlyThr: 4.149 ± 0.057	5.619GlyVal: 5.619 ± 0.07	1.048GlyTrp: 1.048 ± 0.03	2.632GlyTyr: 2.632 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.726HisAla: 1.726 ± 0.034	0.299HisCys: 0.299 ± 0.015	1.146HisAsp: 1.146 ± 0.029	1.195HisGlu: 1.195 ± 0.03	0.971HisPhe: 0.971 ± 0.031	1.65HisGly: 1.65 ± 0.037	0.668HisHis: 0.668 ± 0.024	1.41HisIle: 1.41 ± 0.028	0.725HisLys: 0.725 ± 0.029	2.288HisLeu: 2.288 ± 0.041	0.483HisMet: 0.483 ± 0.02	0.589HisAsn: 0.589 ± 0.02	1.507HisPro: 1.507 ± 0.04	0.71HisGln: 0.71 ± 0.023	1.718HisArg: 1.718 ± 0.038	0.957HisSer: 0.957 ± 0.028	1.049HisThr: 1.049 ± 0.032	1.384HisVal: 1.384 ± 0.035	0.275HisTrp: 0.275 ± 0.015	0.677HisTyr: 0.677 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.8IleAla: 5.8 ± 0.068	0.8IleCys: 0.8 ± 0.024	4.18IleAsp: 4.18 ± 0.063	4.167IleGlu: 4.167 ± 0.055	2.645IlePhe: 2.645 ± 0.061	5.123IleGly: 5.123 ± 0.066	1.654IleHis: 1.654 ± 0.04	3.729IleIle: 3.729 ± 0.065	2.488IleLys: 2.488 ± 0.047	6.609IleLeu: 6.609 ± 0.074	1.401IleMet: 1.401 ± 0.035	1.928IleAsn: 1.928 ± 0.04	3.509IlePro: 3.509 ± 0.054	2.181IleGln: 2.181 ± 0.047	5.039IleArg: 5.039 ± 0.064	3.848IleSer: 3.848 ± 0.059	3.351IleThr: 3.351 ± 0.064	4.396IleVal: 4.396 ± 0.063	0.586IleTrp: 0.586 ± 0.025	1.722IleTyr: 1.722 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.606LysAla: 4.606 ± 0.072	0.441LysCys: 0.441 ± 0.021	2.553LysAsp: 2.553 ± 0.051	2.779LysGlu: 2.779 ± 0.059	1.311LysPhe: 1.311 ± 0.032	3.6LysGly: 3.6 ± 0.062	0.914LysHis: 0.914 ± 0.028	3.283LysIle: 3.283 ± 0.056	3.043LysLys: 3.043 ± 0.074	3.503LysLeu: 3.503 ± 0.065	1.286LysMet: 1.286 ± 0.036	1.809LysAsn: 1.809 ± 0.043	2.143LysPro: 2.143 ± 0.04	1.396LysGln: 1.396 ± 0.044	3.147LysArg: 3.147 ± 0.054	2.519LysSer: 2.519 ± 0.047	3.166LysThr: 3.166 ± 0.053	2.815LysVal: 2.815 ± 0.05	0.518LysTrp: 0.518 ± 0.022	1.198LysTyr: 1.198 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	9.301LeuAla: 9.301 ± 0.097	1.159LeuCys: 1.159 ± 0.026	5.586LeuAsp: 5.586 ± 0.077	5.94LeuGlu: 5.94 ± 0.079	4.274LeuPhe: 4.274 ± 0.078	7.092LeuGly: 7.092 ± 0.09	1.844LeuHis: 1.844 ± 0.038	5.871LeuIle: 5.871 ± 0.084	5.569LeuLys: 5.569 ± 0.075	9.093LeuLeu: 9.093 ± 0.111	2.661LeuMet: 2.661 ± 0.048	3.343LeuAsn: 3.343 ± 0.051	4.868LeuPro: 4.868 ± 0.067	2.598LeuGln: 2.598 ± 0.051	5.846LeuArg: 5.846 ± 0.075	6.669LeuSer: 6.669 ± 0.061	5.462LeuThr: 5.462 ± 0.059	6.356LeuVal: 6.356 ± 0.075	1.025LeuTrp: 1.025 ± 0.03	2.402LeuTyr: 2.402 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.029MetAla: 3.029 ± 0.05	0.222MetCys: 0.222 ± 0.013	1.629MetAsp: 1.629 ± 0.035	1.721MetGlu: 1.721 ± 0.036	0.82MetPhe: 0.82 ± 0.024	2.264MetGly: 2.264 ± 0.048	0.41MetHis: 0.41 ± 0.019	1.879MetIle: 1.879 ± 0.041	1.695MetLys: 1.695 ± 0.036	2.393MetLeu: 2.393 ± 0.046	0.814MetMet: 0.814 ± 0.028	1.061MetAsn: 1.061 ± 0.031	1.419MetPro: 1.419 ± 0.034	0.662MetGln: 0.662 ± 0.023	1.446MetArg: 1.446 ± 0.03	1.477MetSer: 1.477 ± 0.03	1.962MetThr: 1.962 ± 0.037	1.98MetVal: 1.98 ± 0.041	0.188MetTrp: 0.188 ± 0.013	0.449MetTyr: 0.449 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.843AsnAla: 2.843 ± 0.048	0.37AsnCys: 0.37 ± 0.018	1.674AsnAsp: 1.674 ± 0.037	1.572AsnGlu: 1.572 ± 0.039	1.229AsnPhe: 1.229 ± 0.031	2.397AsnGly: 2.397 ± 0.048	0.686AsnHis: 0.686 ± 0.022	2.329AsnIle: 2.329 ± 0.051	1.117AsnLys: 1.117 ± 0.029	3.312AsnLeu: 3.312 ± 0.057	0.773AsnMet: 0.773 ± 0.027	0.864AsnAsn: 0.864 ± 0.029	2.173AsnPro: 2.173 ± 0.039	0.927AsnGln: 0.927 ± 0.029	2.603AsnArg: 2.603 ± 0.045	1.315AsnSer: 1.315 ± 0.037	1.6AsnThr: 1.6 ± 0.036	2.123AsnVal: 2.123 ± 0.043	0.375AsnTrp: 0.375 ± 0.017	0.881AsnTyr: 0.881 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.32ProAla: 4.32 ± 0.073	0.513ProCys: 0.513 ± 0.021	3.601ProAsp: 3.601 ± 0.059	4.371ProGlu: 4.371 ± 0.067	2.16ProPhe: 2.16 ± 0.043	4.249ProGly: 4.249 ± 0.069	1.001ProHis: 1.001 ± 0.028	2.453ProIle: 2.453 ± 0.044	1.791ProLys: 1.791 ± 0.045	4.288ProLeu: 4.288 ± 0.052	1.358ProMet: 1.358 ± 0.031	1.341ProAsn: 1.341 ± 0.035	2.517ProPro: 2.517 ± 0.059	1.26ProGln: 1.26 ± 0.034	2.794ProArg: 2.794 ± 0.051	2.444ProSer: 2.444 ± 0.046	2.105ProThr: 2.105 ± 0.041	4.104ProVal: 4.104 ± 0.064	0.574ProTrp: 0.574 ± 0.023	1.393ProTyr: 1.393 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.98GlnAla: 2.98 ± 0.048	0.313GlnCys: 0.313 ± 0.015	1.388GlnAsp: 1.388 ± 0.031	1.77GlnGlu: 1.77 ± 0.039	1.009GlnPhe: 1.009 ± 0.026	2.045GlnGly: 2.045 ± 0.044	0.525GlnHis: 0.525 ± 0.021	1.902GlnIle: 1.902 ± 0.042	1.717GlnLys: 1.717 ± 0.043	2.435GlnLeu: 2.435 ± 0.05	0.831GlnMet: 0.831 ± 0.024	1.0GlnAsn: 1.0 ± 0.032	1.2GlnPro: 1.2 ± 0.036	0.907GlnGln: 0.907 ± 0.032	1.951GlnArg: 1.951 ± 0.046	1.496GlnSer: 1.496 ± 0.035	1.587GlnThr: 1.587 ± 0.039	2.075GlnVal: 2.075 ± 0.045	0.43GlnTrp: 0.43 ± 0.02	0.763GlnTyr: 0.763 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.671ArgAla: 4.671 ± 0.072	0.879ArgCys: 0.879 ± 0.03	3.66ArgAsp: 3.66 ± 0.056	5.053ArgGlu: 5.053 ± 0.065	3.457ArgPhe: 3.457 ± 0.055	3.964ArgGly: 3.964 ± 0.059	1.826ArgHis: 1.826 ± 0.043	5.633ArgIle: 5.633 ± 0.077	3.913ArgLys: 3.913 ± 0.071	7.6ArgLeu: 7.6 ± 0.081	2.099ArgMet: 2.099 ± 0.039	2.435ArgAsn: 2.435 ± 0.046	3.079ArgPro: 3.079 ± 0.054	2.456ArgGln: 2.456 ± 0.042	5.821ArgArg: 5.821 ± 0.087	3.544ArgSer: 3.544 ± 0.052	3.333ArgThr: 3.333 ± 0.053	4.359ArgVal: 4.359 ± 0.059	0.863ArgTrp: 0.863 ± 0.028	2.37ArgTyr: 2.37 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.002SerAla: 5.002 ± 0.062	0.631SerCys: 0.631 ± 0.025	3.074SerAsp: 3.074 ± 0.05	3.252SerGlu: 3.252 ± 0.058	2.142SerPhe: 2.142 ± 0.049	5.277SerGly: 5.277 ± 0.07	1.15SerHis: 1.15 ± 0.033	3.142SerIle: 3.142 ± 0.053	1.85SerLys: 1.85 ± 0.039	5.167SerLeu: 5.167 ± 0.071	1.37SerMet: 1.37 ± 0.037	1.334SerAsn: 1.334 ± 0.032	2.993SerPro: 2.993 ± 0.055	1.372SerGln: 1.372 ± 0.036	4.116SerArg: 4.116 ± 0.059	2.667SerSer: 2.667 ± 0.049	2.482SerThr: 2.482 ± 0.053	3.863SerVal: 3.863 ± 0.058	0.584SerTrp: 0.584 ± 0.021	1.346SerTyr: 1.346 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.808ThrAla: 5.808 ± 0.082	0.636ThrCys: 0.636 ± 0.023	3.027ThrAsp: 3.027 ± 0.051	2.943ThrGlu: 2.943 ± 0.049	2.145ThrPhe: 2.145 ± 0.049	4.968ThrGly: 4.968 ± 0.068	1.206ThrHis: 1.206 ± 0.029	3.059ThrIle: 3.059 ± 0.05	1.361ThrLys: 1.361 ± 0.034	5.729ThrLeu: 5.729 ± 0.071	1.068ThrMet: 1.068 ± 0.026	1.282ThrAsn: 1.282 ± 0.031	3.107ThrPro: 3.107 ± 0.047	1.287ThrGln: 1.287 ± 0.031	3.444ThrArg: 3.444 ± 0.05	2.374ThrSer: 2.374 ± 0.042	2.625ThrThr: 2.625 ± 0.053	4.349ThrVal: 4.349 ± 0.066	0.514ThrTrp: 0.514 ± 0.021	1.423ThrTyr: 1.423 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	6.172ValAla: 6.172 ± 0.085	0.989ValCys: 0.989 ± 0.029	4.347ValAsp: 4.347 ± 0.056	4.335ValGlu: 4.335 ± 0.059	3.253ValPhe: 3.253 ± 0.051	5.157ValGly: 5.157 ± 0.076	1.415ValHis: 1.415 ± 0.032	4.789ValIle: 4.789 ± 0.058	3.087ValLys: 3.087 ± 0.058	6.975ValLeu: 6.975 ± 0.089	2.102ValMet: 2.102 ± 0.041	2.354ValAsn: 2.354 ± 0.044	3.422ValPro: 3.422 ± 0.055	1.878ValGln: 1.878 ± 0.039	4.818ValArg: 4.818 ± 0.065	4.41ValSer: 4.41 ± 0.062	4.008ValThr: 4.008 ± 0.068	5.802ValVal: 5.802 ± 0.072	0.805ValTrp: 0.805 ± 0.029	1.947ValTyr: 1.947 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.923TrpAla: 0.923 ± 0.031	0.157TrpCys: 0.157 ± 0.012	0.588TrpAsp: 0.588 ± 0.024	0.704TrpGlu: 0.704 ± 0.022	0.503TrpPhe: 0.503 ± 0.021	0.901TrpGly: 0.901 ± 0.03	0.259TrpHis: 0.259 ± 0.014	0.833TrpIle: 0.833 ± 0.031	0.546TrpLys: 0.546 ± 0.023	1.154TrpLeu: 1.154 ± 0.034	0.346TrpMet: 0.346 ± 0.016	0.399TrpAsn: 0.399 ± 0.016	0.459TrpPro: 0.459 ± 0.022	0.416TrpGln: 0.416 ± 0.019	0.887TrpArg: 0.887 ± 0.031	0.567TrpSer: 0.567 ± 0.021	0.571TrpThr: 0.571 ± 0.024	0.796TrpVal: 0.796 ± 0.026	0.166TrpTrp: 0.166 ± 0.012	0.329TrpTyr: 0.329 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.385TyrAla: 2.385 ± 0.041	0.399TyrCys: 0.399 ± 0.018	1.76TyrAsp: 1.76 ± 0.043	1.539TyrGlu: 1.539 ± 0.04	1.358TyrPhe: 1.358 ± 0.036	2.343TyrGly: 2.343 ± 0.044	0.74TyrHis: 0.74 ± 0.023	1.538TyrIle: 1.538 ± 0.039	0.977TyrLys: 0.977 ± 0.03	2.839TyrLeu: 2.839 ± 0.049	0.615TyrMet: 0.615 ± 0.024	0.861TyrAsn: 0.861 ± 0.027	1.451TyrPro: 1.451 ± 0.037	0.946TyrGln: 0.946 ± 0.032	2.438TyrArg: 2.438 ± 0.043	1.323TyrSer: 1.323 ± 0.036	1.481TyrThr: 1.481 ± 0.039	1.698TyrVal: 1.698 ± 0.039	0.381TyrTrp: 0.381 ± 0.021	0.86TyrTyr: 0.86 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3844 proteins (1279499 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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