Amino acid dipepetide frequency for Vibrio phage fs2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.047AlaAla: 11.047 ± 3.035
0.818AlaCys: 0.818 ± 0.353
1.637AlaAsp: 1.637 ± 0.427
4.501AlaGlu: 4.501 ± 0.781
4.501AlaPhe: 4.501 ± 0.99
2.455AlaGly: 2.455 ± 0.93
2.864AlaHis: 2.864 ± 1.411
7.774AlaIle: 7.774 ± 2.064
5.728AlaLys: 5.728 ± 1.781
8.183AlaLeu: 8.183 ± 1.623
3.273AlaMet: 3.273 ± 1.103
2.455AlaAsn: 2.455 ± 1.046
3.682AlaPro: 3.682 ± 1.414
2.864AlaGln: 2.864 ± 0.724
2.046AlaArg: 2.046 ± 0.581
5.319AlaSer: 5.319 ± 1.09
4.501AlaThr: 4.501 ± 1.267
6.547AlaVal: 6.547 ± 0.942
0.409AlaTrp: 0.409 ± 0.485
2.864AlaTyr: 2.864 ± 0.949
0.0AlaXaa: 0.0 ± 0.0
Cys
0.409CysAla: 0.409 ± 0.296
0.409CysCys: 0.409 ± 0.367
1.637CysAsp: 1.637 ± 1.611
2.046CysGlu: 2.046 ± 0.63
0.0CysPhe: 0.0 ± 0.0
1.227CysGly: 1.227 ± 0.447
0.0CysHis: 0.0 ± 0.0
0.409CysIle: 0.409 ± 0.403
1.637CysLys: 1.637 ± 0.648
1.637CysLeu: 1.637 ± 0.563
0.409CysMet: 0.409 ± 0.388
0.0CysAsn: 0.0 ± 0.0
0.409CysPro: 0.409 ± 0.403
0.409CysGln: 0.409 ± 0.296
0.0CysArg: 0.0 ± 0.0
1.227CysSer: 1.227 ± 0.581
0.0CysThr: 0.0 ± 0.0
1.637CysVal: 1.637 ± 0.651
0.409CysTrp: 0.409 ± 0.296
0.818CysTyr: 0.818 ± 0.353
0.0CysXaa: 0.0 ± 0.0
Asp
4.91AspAla: 4.91 ± 1.315
0.818AspCys: 0.818 ± 0.353
2.864AspAsp: 2.864 ± 0.683
4.092AspGlu: 4.092 ± 1.691
3.682AspPhe: 3.682 ± 1.182
4.501AspGly: 4.501 ± 0.595
0.409AspHis: 0.409 ± 0.296
2.864AspIle: 2.864 ± 0.434
6.137AspLys: 6.137 ± 1.767
3.682AspLeu: 3.682 ± 1.068
1.227AspMet: 1.227 ± 0.852
3.273AspAsn: 3.273 ± 1.107
1.637AspPro: 1.637 ± 1.083
0.818AspGln: 0.818 ± 0.806
2.864AspArg: 2.864 ± 0.708
1.637AspSer: 1.637 ± 0.644
4.501AspThr: 4.501 ± 1.298
4.501AspVal: 4.501 ± 1.55
0.818AspTrp: 0.818 ± 0.592
1.227AspTyr: 1.227 ± 0.634
0.0AspXaa: 0.0 ± 0.0
Glu
3.682GluAla: 3.682 ± 0.966
1.227GluCys: 1.227 ± 0.675
3.273GluAsp: 3.273 ± 1.042
3.273GluGlu: 3.273 ± 1.357
1.637GluPhe: 1.637 ± 0.736
2.046GluGly: 2.046 ± 1.001
1.227GluHis: 1.227 ± 0.675
4.501GluIle: 4.501 ± 1.111
2.455GluLys: 2.455 ± 1.309
5.319GluLeu: 5.319 ± 1.723
1.637GluMet: 1.637 ± 0.927
1.227GluAsn: 1.227 ± 0.512
2.046GluPro: 2.046 ± 0.785
2.046GluGln: 2.046 ± 0.819
2.455GluArg: 2.455 ± 1.044
5.319GluSer: 5.319 ± 1.264
2.455GluThr: 2.455 ± 0.385
2.864GluVal: 2.864 ± 1.134
0.0GluTrp: 0.0 ± 0.0
1.637GluTyr: 1.637 ± 0.427
0.0GluXaa: 0.0 ± 0.0
Phe
3.273PheAla: 3.273 ± 0.895
0.0PheCys: 0.0 ± 0.0
1.637PheAsp: 1.637 ± 0.77
4.092PheGlu: 4.092 ± 1.021
2.046PhePhe: 2.046 ± 0.785
0.818PheGly: 0.818 ± 0.647
0.409PheHis: 0.409 ± 0.296
2.864PheIle: 2.864 ± 0.796
4.092PheLys: 4.092 ± 2.165
4.092PheLeu: 4.092 ± 1.454
0.409PheMet: 0.409 ± 0.384
2.864PheAsn: 2.864 ± 0.664
0.0PhePro: 0.0 ± 0.0
1.637PheGln: 1.637 ± 0.776
2.046PheArg: 2.046 ± 0.703
4.501PheSer: 4.501 ± 1.992
5.319PheThr: 5.319 ± 0.958
3.682PheVal: 3.682 ± 0.536
1.227PheTrp: 1.227 ± 0.402
1.227PheTyr: 1.227 ± 0.512
0.0PheXaa: 0.0 ± 0.0
Gly
4.91GlyAla: 4.91 ± 1.432
1.227GlyCys: 1.227 ± 0.512
4.91GlyAsp: 4.91 ± 1.111
1.227GlyGlu: 1.227 ± 0.695
2.864GlyPhe: 2.864 ± 1.077
3.682GlyGly: 3.682 ± 0.846
0.818GlyHis: 0.818 ± 0.385
2.864GlyIle: 2.864 ± 0.439
2.046GlyLys: 2.046 ± 0.96
7.774GlyLeu: 7.774 ± 1.039
0.818GlyMet: 0.818 ± 0.648
1.637GlyAsn: 1.637 ± 1.181
0.409GlyPro: 0.409 ± 0.418
3.682GlyGln: 3.682 ± 1.122
2.046GlyArg: 2.046 ± 0.785
2.455GlySer: 2.455 ± 0.582
5.319GlyThr: 5.319 ± 0.804
5.728GlyVal: 5.728 ± 0.846
1.637GlyTrp: 1.637 ± 0.732
2.046GlyTyr: 2.046 ± 0.794
0.0GlyXaa: 0.0 ± 0.0
His
0.818HisAla: 0.818 ± 0.734
0.818HisCys: 0.818 ± 0.836
1.227HisAsp: 1.227 ± 0.888
0.409HisGlu: 0.409 ± 0.296
1.227HisPhe: 1.227 ± 0.675
2.046HisGly: 2.046 ± 0.833
1.227HisHis: 1.227 ± 0.888
1.637HisIle: 1.637 ± 0.74
0.409HisLys: 0.409 ± 0.296
0.409HisLeu: 0.409 ± 0.296
0.409HisMet: 0.409 ± 0.296
1.227HisAsn: 1.227 ± 0.512
0.0HisPro: 0.0 ± 0.0
0.409HisGln: 0.409 ± 0.403
0.0HisArg: 0.0 ± 0.0
0.818HisSer: 0.818 ± 0.592
0.409HisThr: 0.409 ± 0.296
1.637HisVal: 1.637 ± 0.584
0.0HisTrp: 0.0 ± 0.0
0.409HisTyr: 0.409 ± 0.418
0.0HisXaa: 0.0 ± 0.0
Ile
6.547IleAla: 6.547 ± 2.035
0.818IleCys: 0.818 ± 0.385
4.501IleAsp: 4.501 ± 1.295
2.455IleGlu: 2.455 ± 0.63
3.682IlePhe: 3.682 ± 0.715
3.682IleGly: 3.682 ± 1.321
1.227IleHis: 1.227 ± 0.809
1.637IleIle: 1.637 ± 0.868
4.092IleLys: 4.092 ± 0.935
7.774IleLeu: 7.774 ± 1.726
1.227IleMet: 1.227 ± 0.671
4.91IleAsn: 4.91 ± 1.35
2.864IlePro: 2.864 ± 1.298
1.227IleGln: 1.227 ± 0.564
4.092IleArg: 4.092 ± 1.37
4.092IleSer: 4.092 ± 0.78
5.728IleThr: 5.728 ± 2.081
5.319IleVal: 5.319 ± 1.445
0.0IleTrp: 0.0 ± 0.0
1.637IleTyr: 1.637 ± 0.706
0.0IleXaa: 0.0 ± 0.0
Lys
6.137LysAla: 6.137 ± 2.02
0.409LysCys: 0.409 ± 0.403
4.91LysAsp: 4.91 ± 1.889
2.864LysGlu: 2.864 ± 0.548
0.409LysPhe: 0.409 ± 0.296
2.046LysGly: 2.046 ± 0.879
0.0LysHis: 0.0 ± 0.0
3.273LysIle: 3.273 ± 1.167
4.092LysLys: 4.092 ± 1.352
6.137LysLeu: 6.137 ± 1.384
0.818LysMet: 0.818 ± 0.393
2.455LysAsn: 2.455 ± 0.412
3.273LysPro: 3.273 ± 1.297
3.273LysGln: 3.273 ± 0.462
4.092LysArg: 4.092 ± 1.054
7.365LysSer: 7.365 ± 0.867
1.637LysThr: 1.637 ± 1.083
2.455LysVal: 2.455 ± 1.232
1.227LysTrp: 1.227 ± 0.669
2.046LysTyr: 2.046 ± 0.785
0.0LysXaa: 0.0 ± 0.0
Leu
7.774LeuAla: 7.774 ± 2.644
0.409LeuCys: 0.409 ± 0.403
4.501LeuAsp: 4.501 ± 1.289
4.91LeuGlu: 4.91 ± 1.583
4.501LeuPhe: 4.501 ± 0.927
6.547LeuGly: 6.547 ± 1.954
0.818LeuHis: 0.818 ± 0.836
7.774LeuIle: 7.774 ± 1.428
5.319LeuLys: 5.319 ± 1.675
6.547LeuLeu: 6.547 ± 0.994
2.046LeuMet: 2.046 ± 0.685
2.455LeuAsn: 2.455 ± 1.382
5.728LeuPro: 5.728 ± 1.003
2.455LeuGln: 2.455 ± 0.452
3.682LeuArg: 3.682 ± 1.139
11.457LeuSer: 11.457 ± 1.486
4.91LeuThr: 4.91 ± 1.944
6.547LeuVal: 6.547 ± 2.315
1.637LeuTrp: 1.637 ± 0.737
2.455LeuTyr: 2.455 ± 0.894
0.0LeuXaa: 0.0 ± 0.0
Met
1.227MetAla: 1.227 ± 0.622
0.818MetCys: 0.818 ± 0.353
0.409MetAsp: 0.409 ± 0.367
0.0MetGlu: 0.0 ± 0.0
2.046MetPhe: 2.046 ± 0.631
2.046MetGly: 2.046 ± 0.731
0.409MetHis: 0.409 ± 0.296
1.637MetIle: 1.637 ± 0.736
2.046MetLys: 2.046 ± 0.68
2.046MetLeu: 2.046 ± 0.833
0.409MetMet: 0.409 ± 0.296
0.818MetAsn: 0.818 ± 0.806
0.818MetPro: 0.818 ± 0.618
1.227MetGln: 1.227 ± 0.675
1.637MetArg: 1.637 ± 0.74
0.409MetSer: 0.409 ± 0.296
2.046MetThr: 2.046 ± 0.958
0.818MetVal: 0.818 ± 0.618
0.409MetTrp: 0.409 ± 0.397
0.818MetTyr: 0.818 ± 0.524
0.0MetXaa: 0.0 ± 0.0
Asn
5.319AsnAla: 5.319 ± 1.78
0.818AsnCys: 0.818 ± 0.806
2.046AsnAsp: 2.046 ± 1.536
2.046AsnGlu: 2.046 ± 0.819
0.409AsnPhe: 0.409 ± 0.403
2.046AsnGly: 2.046 ± 0.719
1.227AsnHis: 1.227 ± 0.675
4.092AsnIle: 4.092 ± 0.944
2.864AsnLys: 2.864 ± 0.924
4.91AsnLeu: 4.91 ± 1.273
0.0AsnMet: 0.0 ± 0.0
2.046AsnAsn: 2.046 ± 1.471
4.501AsnPro: 4.501 ± 1.295
1.227AsnGln: 1.227 ± 0.432
1.227AsnArg: 1.227 ± 0.675
3.682AsnSer: 3.682 ± 0.846
3.273AsnThr: 3.273 ± 1.663
2.046AsnVal: 2.046 ± 0.956
0.409AsnTrp: 0.409 ± 0.296
0.818AsnTyr: 0.818 ± 0.734
0.0AsnXaa: 0.0 ± 0.0
Pro
3.273ProAla: 3.273 ± 1.611
0.818ProCys: 0.818 ± 0.524
5.728ProAsp: 5.728 ± 2.083
3.682ProGlu: 3.682 ± 0.862
2.455ProPhe: 2.455 ± 1.037
0.0ProGly: 0.0 ± 0.0
2.864ProHis: 2.864 ± 0.477
1.227ProIle: 1.227 ± 0.529
1.637ProLys: 1.637 ± 0.505
2.046ProLeu: 2.046 ± 0.463
0.409ProMet: 0.409 ± 0.418
2.864ProAsn: 2.864 ± 0.949
2.864ProPro: 2.864 ± 0.5
1.227ProGln: 1.227 ± 0.567
0.409ProArg: 0.409 ± 0.367
3.682ProSer: 3.682 ± 1.458
3.273ProThr: 3.273 ± 1.011
3.682ProVal: 3.682 ± 1.493
0.409ProTrp: 0.409 ± 0.418
2.864ProTyr: 2.864 ± 1.218
0.0ProXaa: 0.0 ± 0.0
Gln
2.455GlnAla: 2.455 ± 1.215
1.227GlnCys: 1.227 ± 1.208
1.227GlnAsp: 1.227 ± 0.512
2.046GlnGlu: 2.046 ± 0.493
3.273GlnPhe: 3.273 ± 1.411
1.227GlnGly: 1.227 ± 0.511
0.409GlnHis: 0.409 ± 0.296
2.046GlnIle: 2.046 ± 0.856
0.818GlnLys: 0.818 ± 0.385
3.682GlnLeu: 3.682 ± 0.93
0.818GlnMet: 0.818 ± 0.484
2.455GlnAsn: 2.455 ± 1.485
0.818GlnPro: 0.818 ± 0.484
2.864GlnGln: 2.864 ± 0.902
1.637GlnArg: 1.637 ± 0.723
3.682GlnSer: 3.682 ± 0.395
2.864GlnThr: 2.864 ± 0.732
2.455GlnVal: 2.455 ± 0.798
0.0GlnTrp: 0.0 ± 0.0
0.818GlnTyr: 0.818 ± 0.353
0.0GlnXaa: 0.0 ± 0.0
Arg
2.455ArgAla: 2.455 ± 1.108
0.409ArgCys: 0.409 ± 0.418
3.273ArgAsp: 3.273 ± 1.083
2.046ArgGlu: 2.046 ± 0.611
3.682ArgPhe: 3.682 ± 1.604
1.637ArgGly: 1.637 ± 0.644
0.409ArgHis: 0.409 ± 0.296
2.864ArgIle: 2.864 ± 0.618
2.864ArgLys: 2.864 ± 1.208
5.319ArgLeu: 5.319 ± 1.257
2.046ArgMet: 2.046 ± 0.665
2.455ArgAsn: 2.455 ± 0.63
1.637ArgPro: 1.637 ± 0.427
3.273ArgGln: 3.273 ± 0.778
4.092ArgArg: 4.092 ± 2.061
0.818ArgSer: 0.818 ± 0.385
3.682ArgThr: 3.682 ± 1.039
1.227ArgVal: 1.227 ± 0.714
0.818ArgTrp: 0.818 ± 0.561
1.637ArgTyr: 1.637 ± 0.954
0.0ArgXaa: 0.0 ± 0.0
Ser
6.137SerAla: 6.137 ± 1.427
1.227SerCys: 1.227 ± 0.344
4.092SerAsp: 4.092 ± 1.558
2.046SerGlu: 2.046 ± 0.904
2.864SerPhe: 2.864 ± 0.732
5.728SerGly: 5.728 ± 1.738
0.409SerHis: 0.409 ± 0.296
5.319SerIle: 5.319 ± 3.382
4.91SerLys: 4.91 ± 1.576
6.137SerLeu: 6.137 ± 1.553
1.637SerMet: 1.637 ± 0.954
4.91SerAsn: 4.91 ± 1.578
4.501SerPro: 4.501 ± 0.495
2.455SerGln: 2.455 ± 0.872
4.501SerArg: 4.501 ± 1.867
6.137SerSer: 6.137 ± 1.848
6.547SerThr: 6.547 ± 2.893
6.547SerVal: 6.547 ± 1.072
0.818SerTrp: 0.818 ± 0.561
2.046SerTyr: 2.046 ± 0.838
0.0SerXaa: 0.0 ± 0.0
Thr
4.092ThrAla: 4.092 ± 0.831
0.409ThrCys: 0.409 ± 0.403
3.273ThrAsp: 3.273 ± 0.91
3.273ThrGlu: 3.273 ± 0.829
0.818ThrPhe: 0.818 ± 0.647
6.137ThrGly: 6.137 ± 1.995
0.0ThrHis: 0.0 ± 0.0
4.501ThrIle: 4.501 ± 1.29
3.273ThrLys: 3.273 ± 0.745
5.728ThrLeu: 5.728 ± 1.702
2.046ThrMet: 2.046 ± 0.921
4.092ThrAsn: 4.092 ± 0.611
4.91ThrPro: 4.91 ± 2.353
2.046ThrGln: 2.046 ± 1.261
4.092ThrArg: 4.092 ± 0.712
7.774ThrSer: 7.774 ± 1.559
3.273ThrThr: 3.273 ± 1.472
6.137ThrVal: 6.137 ± 0.67
1.637ThrTrp: 1.637 ± 0.74
0.818ThrTyr: 0.818 ± 0.484
0.0ThrXaa: 0.0 ± 0.0
Val
6.956ValAla: 6.956 ± 1.52
0.409ValCys: 0.409 ± 0.296
3.273ValAsp: 3.273 ± 0.992
4.092ValGlu: 4.092 ± 0.654
3.273ValPhe: 3.273 ± 0.932
5.728ValGly: 5.728 ± 2.21
0.409ValHis: 0.409 ± 0.418
7.774ValIle: 7.774 ± 2.32
4.501ValLys: 4.501 ± 2.023
6.137ValLeu: 6.137 ± 1.48
1.227ValMet: 1.227 ± 0.581
2.046ValAsn: 2.046 ± 1.208
3.682ValPro: 3.682 ± 1.321
2.455ValGln: 2.455 ± 1.027
2.046ValArg: 2.046 ± 1.481
5.728ValSer: 5.728 ± 1.683
4.91ValThr: 4.91 ± 0.522
4.91ValVal: 4.91 ± 0.958
1.227ValTrp: 1.227 ± 0.622
0.409ValTyr: 0.409 ± 0.418
0.0ValXaa: 0.0 ± 0.0
Trp
0.409TrpAla: 0.409 ± 0.296
0.409TrpCys: 0.409 ± 0.296
0.409TrpAsp: 0.409 ± 0.418
0.0TrpGlu: 0.0 ± 0.0
1.637TrpPhe: 1.637 ± 0.752
2.046TrpGly: 2.046 ± 1.052
0.409TrpHis: 0.409 ± 0.418
0.409TrpIle: 0.409 ± 0.418
0.0TrpLys: 0.0 ± 0.0
1.637TrpLeu: 1.637 ± 0.844
0.818TrpMet: 0.818 ± 0.631
0.409TrpAsn: 0.409 ± 0.418
0.818TrpPro: 0.818 ± 0.806
0.409TrpGln: 0.409 ± 0.485
1.227TrpArg: 1.227 ± 0.634
0.0TrpSer: 0.0 ± 0.0
0.409TrpThr: 0.409 ± 0.296
0.818TrpVal: 0.818 ± 0.561
0.409TrpTrp: 0.409 ± 0.406
0.818TrpTyr: 0.818 ± 0.456
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.637TyrAla: 1.637 ± 0.839
1.227TyrCys: 1.227 ± 0.489
1.637TyrAsp: 1.637 ± 0.74
1.227TyrGlu: 1.227 ± 0.402
1.637TyrPhe: 1.637 ± 0.231
2.455TyrGly: 2.455 ± 0.998
0.0TyrHis: 0.0 ± 0.0
2.046TyrIle: 2.046 ± 0.463
0.0TyrLys: 0.0 ± 0.0
3.273TyrLeu: 3.273 ± 1.12
0.0TyrMet: 0.0 ± 0.0
0.409TyrAsn: 0.409 ± 0.403
0.818TyrPro: 0.818 ± 0.456
0.818TyrGln: 0.818 ± 0.353
2.455TyrArg: 2.455 ± 0.535
2.864TyrSer: 2.864 ± 1.233
3.273TyrThr: 3.273 ± 1.223
1.637TyrVal: 1.637 ± 0.649
0.0TyrTrp: 0.0 ± 0.0
0.818TyrTyr: 0.818 ± 0.48
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (2445 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski