Amino acid dipepetide frequency for Vibrio phage vB_VspP_pVa5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.802AlaAla: 7.802 ± 1.248
0.98AlaCys: 0.98 ± 0.251
5.842AlaAsp: 5.842 ± 0.435
6.332AlaGlu: 6.332 ± 0.595
2.369AlaPhe: 2.369 ± 0.338
5.147AlaGly: 5.147 ± 0.681
1.757AlaHis: 1.757 ± 0.237
3.922AlaIle: 3.922 ± 0.395
6.046AlaLys: 6.046 ± 0.542
7.312AlaLeu: 7.312 ± 0.469
3.309AlaMet: 3.309 ± 0.454
3.676AlaAsn: 3.676 ± 0.339
3.35AlaPro: 3.35 ± 0.407
3.84AlaGln: 3.84 ± 0.597
3.309AlaArg: 3.309 ± 0.509
3.799AlaSer: 3.799 ± 0.395
4.657AlaThr: 4.657 ± 0.791
5.515AlaVal: 5.515 ± 0.547
0.899AlaTrp: 0.899 ± 0.188
2.533AlaTyr: 2.533 ± 0.295
0.0AlaXaa: 0.0 ± 0.0
Cys
0.735CysAla: 0.735 ± 0.222
0.245CysCys: 0.245 ± 0.091
0.817CysAsp: 0.817 ± 0.22
0.694CysGlu: 0.694 ± 0.193
0.163CysPhe: 0.163 ± 0.072
0.899CysGly: 0.899 ± 0.257
0.286CysHis: 0.286 ± 0.124
0.531CysIle: 0.531 ± 0.176
0.735CysLys: 0.735 ± 0.213
0.694CysLeu: 0.694 ± 0.189
0.449CysMet: 0.449 ± 0.148
0.776CysAsn: 0.776 ± 0.203
0.613CysPro: 0.613 ± 0.172
0.204CysGln: 0.204 ± 0.088
0.531CysArg: 0.531 ± 0.188
0.368CysSer: 0.368 ± 0.127
0.572CysThr: 0.572 ± 0.147
0.694CysVal: 0.694 ± 0.179
0.123CysTrp: 0.123 ± 0.07
0.654CysTyr: 0.654 ± 0.202
0.0CysXaa: 0.0 ± 0.0
Asp
6.127AspAla: 6.127 ± 0.762
0.858AspCys: 0.858 ± 0.213
4.248AspAsp: 4.248 ± 0.485
5.27AspGlu: 5.27 ± 0.477
2.492AspPhe: 2.492 ± 0.336
5.27AspGly: 5.27 ± 0.53
1.307AspHis: 1.307 ± 0.249
4.33AspIle: 4.33 ± 0.412
3.84AspLys: 3.84 ± 0.444
5.556AspLeu: 5.556 ± 0.481
2.655AspMet: 2.655 ± 0.339
3.676AspAsn: 3.676 ± 0.351
2.982AspPro: 2.982 ± 0.286
1.92AspGln: 1.92 ± 0.247
2.042AspArg: 2.042 ± 0.336
3.881AspSer: 3.881 ± 0.347
4.739AspThr: 4.739 ± 0.509
5.637AspVal: 5.637 ± 0.407
1.471AspTrp: 1.471 ± 0.256
3.064AspTyr: 3.064 ± 0.451
0.0AspXaa: 0.0 ± 0.0
Glu
7.067GluAla: 7.067 ± 0.591
0.899GluCys: 0.899 ± 0.24
5.556GluAsp: 5.556 ± 0.482
5.76GluGlu: 5.76 ± 0.625
3.145GluPhe: 3.145 ± 0.306
4.657GluGly: 4.657 ± 0.498
1.43GluHis: 1.43 ± 0.28
4.739GluIle: 4.739 ± 0.339
3.268GluLys: 3.268 ± 0.409
7.761GluLeu: 7.761 ± 0.634
2.451GluMet: 2.451 ± 0.387
3.023GluAsn: 3.023 ± 0.33
1.961GluPro: 1.961 ± 0.361
3.145GluGln: 3.145 ± 0.371
2.819GluArg: 2.819 ± 0.306
3.595GluSer: 3.595 ± 0.354
3.84GluThr: 3.84 ± 0.466
5.392GluVal: 5.392 ± 0.543
0.776GluTrp: 0.776 ± 0.205
2.778GluTyr: 2.778 ± 0.381
0.0GluXaa: 0.0 ± 0.0
Phe
2.614PheAla: 2.614 ± 0.326
0.408PheCys: 0.408 ± 0.14
2.574PheAsp: 2.574 ± 0.384
2.492PheGlu: 2.492 ± 0.303
1.225PhePhe: 1.225 ± 0.258
2.247PheGly: 2.247 ± 0.286
0.694PheHis: 0.694 ± 0.178
2.247PheIle: 2.247 ± 0.354
2.778PheLys: 2.778 ± 0.42
2.288PheLeu: 2.288 ± 0.294
1.103PheMet: 1.103 ± 0.203
2.165PheAsn: 2.165 ± 0.339
1.43PhePro: 1.43 ± 0.246
1.471PheGln: 1.471 ± 0.233
1.797PheArg: 1.797 ± 0.283
2.328PheSer: 2.328 ± 0.432
1.838PheThr: 1.838 ± 0.257
1.961PheVal: 1.961 ± 0.288
0.368PheTrp: 0.368 ± 0.098
1.103PheTyr: 1.103 ± 0.154
0.0PheXaa: 0.0 ± 0.0
Gly
4.779GlyAla: 4.779 ± 0.491
0.572GlyCys: 0.572 ± 0.2
5.188GlyAsp: 5.188 ± 0.449
4.616GlyGlu: 4.616 ± 0.357
2.859GlyPhe: 2.859 ± 0.401
4.698GlyGly: 4.698 ± 0.646
1.348GlyHis: 1.348 ± 0.27
4.248GlyIle: 4.248 ± 0.43
3.881GlyLys: 3.881 ± 0.412
4.33GlyLeu: 4.33 ± 0.413
1.838GlyMet: 1.838 ± 0.222
4.412GlyAsn: 4.412 ± 0.398
1.511GlyPro: 1.511 ± 0.468
2.533GlyGln: 2.533 ± 0.324
2.206GlyArg: 2.206 ± 0.357
4.412GlySer: 4.412 ± 0.533
4.779GlyThr: 4.779 ± 0.535
4.779GlyVal: 4.779 ± 0.503
1.348GlyTrp: 1.348 ± 0.201
2.369GlyTyr: 2.369 ± 0.294
0.0GlyXaa: 0.0 ± 0.0
His
1.185HisAla: 1.185 ± 0.213
0.286HisCys: 0.286 ± 0.107
1.348HisAsp: 1.348 ± 0.245
1.593HisGlu: 1.593 ± 0.266
0.694HisPhe: 0.694 ± 0.167
1.144HisGly: 1.144 ± 0.252
0.49HisHis: 0.49 ± 0.12
1.389HisIle: 1.389 ± 0.238
1.021HisLys: 1.021 ± 0.241
1.675HisLeu: 1.675 ± 0.247
0.694HisMet: 0.694 ± 0.143
1.144HisAsn: 1.144 ± 0.216
0.613HisPro: 0.613 ± 0.173
0.899HisGln: 0.899 ± 0.26
1.225HisArg: 1.225 ± 0.209
1.021HisSer: 1.021 ± 0.195
1.225HisThr: 1.225 ± 0.207
1.879HisVal: 1.879 ± 0.262
0.408HisTrp: 0.408 ± 0.104
1.307HisTyr: 1.307 ± 0.274
0.0HisXaa: 0.0 ± 0.0
Ile
4.412IleAla: 4.412 ± 0.388
0.368IleCys: 0.368 ± 0.108
4.82IleAsp: 4.82 ± 0.388
4.861IleGlu: 4.861 ± 0.45
1.552IlePhe: 1.552 ± 0.259
3.554IleGly: 3.554 ± 0.372
1.552IleHis: 1.552 ± 0.223
2.655IleIle: 2.655 ± 0.303
4.126IleLys: 4.126 ± 0.433
3.758IleLeu: 3.758 ± 0.278
1.389IleMet: 1.389 ± 0.214
3.145IleAsn: 3.145 ± 0.326
2.247IlePro: 2.247 ± 0.261
2.696IleGln: 2.696 ± 0.286
2.614IleArg: 2.614 ± 0.289
2.574IleSer: 2.574 ± 0.374
3.513IleThr: 3.513 ± 0.421
3.309IleVal: 3.309 ± 0.427
0.654IleTrp: 0.654 ± 0.153
2.083IleTyr: 2.083 ± 0.345
0.0IleXaa: 0.0 ± 0.0
Lys
5.474LysAla: 5.474 ± 0.462
0.531LysCys: 0.531 ± 0.156
4.698LysAsp: 4.698 ± 0.366
4.33LysGlu: 4.33 ± 0.463
1.879LysPhe: 1.879 ± 0.409
4.493LysGly: 4.493 ± 0.502
1.593LysHis: 1.593 ± 0.258
3.145LysIle: 3.145 ± 0.41
3.595LysLys: 3.595 ± 0.487
5.76LysLeu: 5.76 ± 0.507
2.124LysMet: 2.124 ± 0.301
3.145LysAsn: 3.145 ± 0.346
2.614LysPro: 2.614 ± 0.366
2.819LysGln: 2.819 ± 0.332
2.696LysArg: 2.696 ± 0.404
2.819LysSer: 2.819 ± 0.366
4.044LysThr: 4.044 ± 0.313
3.513LysVal: 3.513 ± 0.411
0.858LysTrp: 0.858 ± 0.156
2.247LysTyr: 2.247 ± 0.365
0.0LysXaa: 0.0 ± 0.0
Leu
6.373LeuAla: 6.373 ± 0.422
0.531LeuCys: 0.531 ± 0.161
6.005LeuAsp: 6.005 ± 0.487
7.394LeuGlu: 7.394 ± 0.628
3.064LeuPhe: 3.064 ± 0.337
5.27LeuGly: 5.27 ± 0.577
1.757LeuHis: 1.757 ± 0.281
4.208LeuIle: 4.208 ± 0.506
5.31LeuLys: 5.31 ± 0.619
5.964LeuLeu: 5.964 ± 0.726
2.696LeuMet: 2.696 ± 0.346
4.453LeuAsn: 4.453 ± 0.389
3.227LeuPro: 3.227 ± 0.319
3.186LeuGln: 3.186 ± 0.483
3.023LeuArg: 3.023 ± 0.44
5.065LeuSer: 5.065 ± 0.423
4.902LeuThr: 4.902 ± 0.493
4.984LeuVal: 4.984 ± 0.395
0.776LeuTrp: 0.776 ± 0.176
2.083LeuTyr: 2.083 ± 0.328
0.0LeuXaa: 0.0 ± 0.0
Met
2.778MetAla: 2.778 ± 0.368
0.327MetCys: 0.327 ± 0.142
1.43MetAsp: 1.43 ± 0.209
2.574MetGlu: 2.574 ± 0.418
1.266MetPhe: 1.266 ± 0.214
1.43MetGly: 1.43 ± 0.245
0.735MetHis: 0.735 ± 0.189
2.042MetIle: 2.042 ± 0.319
1.389MetLys: 1.389 ± 0.24
2.655MetLeu: 2.655 ± 0.268
0.858MetMet: 0.858 ± 0.199
1.593MetAsn: 1.593 ± 0.245
1.144MetPro: 1.144 ± 0.243
1.471MetGln: 1.471 ± 0.249
1.471MetArg: 1.471 ± 0.28
2.574MetSer: 2.574 ± 0.393
1.757MetThr: 1.757 ± 0.25
1.634MetVal: 1.634 ± 0.245
0.408MetTrp: 0.408 ± 0.149
1.103MetTyr: 1.103 ± 0.197
0.0MetXaa: 0.0 ± 0.0
Asn
4.616AsnAla: 4.616 ± 0.652
0.817AsnCys: 0.817 ± 0.234
2.9AsnAsp: 2.9 ± 0.337
3.105AsnGlu: 3.105 ± 0.398
1.797AsnPhe: 1.797 ± 0.296
2.614AsnGly: 2.614 ± 0.295
0.94AsnHis: 0.94 ± 0.215
3.595AsnIle: 3.595 ± 0.39
3.472AsnLys: 3.472 ± 0.319
4.616AsnLeu: 4.616 ± 0.41
1.593AsnMet: 1.593 ± 0.344
3.35AsnAsn: 3.35 ± 0.352
2.859AsnPro: 2.859 ± 0.354
2.451AsnGln: 2.451 ± 0.296
2.41AsnArg: 2.41 ± 0.274
3.227AsnSer: 3.227 ± 0.347
3.35AsnThr: 3.35 ± 0.381
3.391AsnVal: 3.391 ± 0.381
0.776AsnTrp: 0.776 ± 0.185
2.042AsnTyr: 2.042 ± 0.305
0.0AsnXaa: 0.0 ± 0.0
Pro
2.9ProAla: 2.9 ± 0.292
0.163ProCys: 0.163 ± 0.081
3.064ProAsp: 3.064 ± 0.409
2.655ProGlu: 2.655 ± 0.282
1.511ProPhe: 1.511 ± 0.33
2.083ProGly: 2.083 ± 0.286
0.654ProHis: 0.654 ± 0.15
1.92ProIle: 1.92 ± 0.29
2.369ProLys: 2.369 ± 0.246
2.41ProLeu: 2.41 ± 0.345
0.858ProMet: 0.858 ± 0.166
2.451ProAsn: 2.451 ± 0.324
1.103ProPro: 1.103 ± 0.378
1.716ProGln: 1.716 ± 0.282
1.225ProArg: 1.225 ± 0.212
2.737ProSer: 2.737 ± 0.366
2.655ProThr: 2.655 ± 0.303
3.023ProVal: 3.023 ± 0.264
0.368ProTrp: 0.368 ± 0.16
1.062ProTyr: 1.062 ± 0.255
0.0ProXaa: 0.0 ± 0.0
Gln
3.962GlnAla: 3.962 ± 0.568
0.368GlnCys: 0.368 ± 0.132
1.879GlnAsp: 1.879 ± 0.261
2.819GlnGlu: 2.819 ± 0.284
1.307GlnPhe: 1.307 ± 0.224
3.431GlnGly: 3.431 ± 0.459
1.185GlnHis: 1.185 ± 0.231
2.165GlnIle: 2.165 ± 0.279
2.574GlnLys: 2.574 ± 0.323
3.595GlnLeu: 3.595 ± 0.336
1.675GlnMet: 1.675 ± 0.251
1.348GlnAsn: 1.348 ± 0.242
0.776GlnPro: 0.776 ± 0.215
1.879GlnGln: 1.879 ± 0.302
2.124GlnArg: 2.124 ± 0.333
2.288GlnSer: 2.288 ± 0.283
2.206GlnThr: 2.206 ± 0.344
2.737GlnVal: 2.737 ± 0.37
0.408GlnTrp: 0.408 ± 0.177
1.389GlnTyr: 1.389 ± 0.281
0.0GlnXaa: 0.0 ± 0.0
Arg
3.309ArgAla: 3.309 ± 0.367
0.817ArgCys: 0.817 ± 0.232
2.778ArgAsp: 2.778 ± 0.388
3.186ArgGlu: 3.186 ± 0.362
1.389ArgPhe: 1.389 ± 0.242
2.492ArgGly: 2.492 ± 0.348
0.817ArgHis: 0.817 ± 0.179
2.124ArgIle: 2.124 ± 0.303
3.636ArgLys: 3.636 ± 0.36
3.881ArgLeu: 3.881 ± 0.457
1.348ArgMet: 1.348 ± 0.263
2.083ArgAsn: 2.083 ± 0.299
0.94ArgPro: 0.94 ± 0.243
1.471ArgGln: 1.471 ± 0.226
1.92ArgArg: 1.92 ± 0.284
2.042ArgSer: 2.042 ± 0.26
2.9ArgThr: 2.9 ± 0.307
2.165ArgVal: 2.165 ± 0.267
0.817ArgTrp: 0.817 ± 0.202
1.634ArgTyr: 1.634 ± 0.244
0.0ArgXaa: 0.0 ± 0.0
Ser
4.739SerAla: 4.739 ± 0.51
0.613SerCys: 0.613 ± 0.158
4.248SerAsp: 4.248 ± 0.397
3.145SerGlu: 3.145 ± 0.331
1.879SerPhe: 1.879 ± 0.3
4.779SerGly: 4.779 ± 0.519
0.899SerHis: 0.899 ± 0.235
3.391SerIle: 3.391 ± 0.42
3.472SerLys: 3.472 ± 0.443
5.106SerLeu: 5.106 ± 0.516
1.797SerMet: 1.797 ± 0.234
2.9SerAsn: 2.9 ± 0.423
2.328SerPro: 2.328 ± 0.302
1.716SerGln: 1.716 ± 0.254
2.083SerArg: 2.083 ± 0.267
3.799SerSer: 3.799 ± 0.397
3.186SerThr: 3.186 ± 0.291
4.657SerVal: 4.657 ± 0.472
0.817SerTrp: 0.817 ± 0.215
1.593SerTyr: 1.593 ± 0.265
0.0SerXaa: 0.0 ± 0.0
Thr
5.025ThrAla: 5.025 ± 0.519
0.49ThrCys: 0.49 ± 0.166
4.33ThrAsp: 4.33 ± 0.383
4.167ThrGlu: 4.167 ± 0.418
2.042ThrPhe: 2.042 ± 0.26
4.33ThrGly: 4.33 ± 0.576
1.021ThrHis: 1.021 ± 0.27
3.309ThrIle: 3.309 ± 0.328
3.962ThrLys: 3.962 ± 0.466
4.902ThrLeu: 4.902 ± 0.575
0.94ThrMet: 0.94 ± 0.192
3.268ThrAsn: 3.268 ± 0.463
3.268ThrPro: 3.268 ± 0.433
2.124ThrGln: 2.124 ± 0.385
2.696ThrArg: 2.696 ± 0.35
3.513ThrSer: 3.513 ± 0.432
3.309ThrThr: 3.309 ± 0.622
4.861ThrVal: 4.861 ± 0.444
0.735ThrTrp: 0.735 ± 0.16
2.778ThrTyr: 2.778 ± 0.407
0.0ThrXaa: 0.0 ± 0.0
Val
5.229ValAla: 5.229 ± 0.587
0.817ValCys: 0.817 ± 0.208
5.882ValAsp: 5.882 ± 0.441
5.76ValGlu: 5.76 ± 0.467
2.288ValPhe: 2.288 ± 0.25
5.025ValGly: 5.025 ± 0.42
1.43ValHis: 1.43 ± 0.197
3.35ValIle: 3.35 ± 0.427
3.881ValLys: 3.881 ± 0.436
4.371ValLeu: 4.371 ± 0.379
1.511ValMet: 1.511 ± 0.239
3.962ValAsn: 3.962 ± 0.384
2.328ValPro: 2.328 ± 0.37
2.614ValGln: 2.614 ± 0.27
3.145ValArg: 3.145 ± 0.355
4.412ValSer: 4.412 ± 0.366
4.698ValThr: 4.698 ± 0.343
5.147ValVal: 5.147 ± 0.489
0.817ValTrp: 0.817 ± 0.165
2.206ValTyr: 2.206 ± 0.415
0.0ValXaa: 0.0 ± 0.0
Trp
0.817TrpAla: 0.817 ± 0.211
0.204TrpCys: 0.204 ± 0.095
1.185TrpAsp: 1.185 ± 0.265
0.899TrpGlu: 0.899 ± 0.162
0.654TrpPhe: 0.654 ± 0.144
0.694TrpGly: 0.694 ± 0.166
0.449TrpHis: 0.449 ± 0.152
0.654TrpIle: 0.654 ± 0.148
0.858TrpLys: 0.858 ± 0.196
0.98TrpLeu: 0.98 ± 0.192
0.327TrpMet: 0.327 ± 0.136
0.98TrpAsn: 0.98 ± 0.231
0.286TrpPro: 0.286 ± 0.122
0.408TrpGln: 0.408 ± 0.135
0.449TrpArg: 0.449 ± 0.125
0.572TrpSer: 0.572 ± 0.175
0.98TrpThr: 0.98 ± 0.173
1.185TrpVal: 1.185 ± 0.208
0.123TrpTrp: 0.123 ± 0.064
0.572TrpTyr: 0.572 ± 0.146
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.451TyrAla: 2.451 ± 0.324
0.49TyrCys: 0.49 ± 0.185
2.574TyrAsp: 2.574 ± 0.256
2.41TyrGlu: 2.41 ± 0.423
1.552TyrPhe: 1.552 ± 0.279
2.492TyrGly: 2.492 ± 0.316
0.899TyrHis: 0.899 ± 0.234
1.92TyrIle: 1.92 ± 0.277
2.165TyrLys: 2.165 ± 0.465
2.655TyrLeu: 2.655 ± 0.364
0.98TyrMet: 0.98 ± 0.234
2.369TyrAsn: 2.369 ± 0.31
1.348TyrPro: 1.348 ± 0.278
1.552TyrGln: 1.552 ± 0.291
1.961TyrArg: 1.961 ± 0.271
2.124TyrSer: 2.124 ± 0.392
1.92TyrThr: 1.92 ± 0.373
2.41TyrVal: 2.41 ± 0.294
0.327TyrTrp: 0.327 ± 0.124
1.471TyrTyr: 1.471 ± 0.283
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 106 proteins (24481 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski