Amino acid dipepetide frequency for Daejeonella lutea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.293AlaAla: 6.293 ± 0.109	0.607AlaCys: 0.607 ± 0.025	4.211AlaAsp: 4.211 ± 0.075	4.616AlaGlu: 4.616 ± 0.071	3.458AlaPhe: 3.458 ± 0.057	6.039AlaGly: 6.039 ± 0.098	1.131AlaHis: 1.131 ± 0.035	5.386AlaIle: 5.386 ± 0.072	4.597AlaLys: 4.597 ± 0.072	6.741AlaLeu: 6.741 ± 0.087	1.675AlaMet: 1.675 ± 0.043	3.538AlaAsn: 3.538 ± 0.07	2.382AlaPro: 2.382 ± 0.06	2.636AlaGln: 2.636 ± 0.05	2.867AlaArg: 2.867 ± 0.051	4.948AlaSer: 4.948 ± 0.083	3.746AlaThr: 3.746 ± 0.1	4.716AlaVal: 4.716 ± 0.073	0.744AlaTrp: 0.744 ± 0.026	2.517AlaTyr: 2.517 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.507CysAla: 0.507 ± 0.026	0.13CysCys: 0.13 ± 0.012	0.41CysAsp: 0.41 ± 0.02	0.403CysGlu: 0.403 ± 0.02	0.429CysPhe: 0.429 ± 0.028	0.629CysGly: 0.629 ± 0.024	0.186CysHis: 0.186 ± 0.014	0.601CysIle: 0.601 ± 0.023	0.411CysLys: 0.411 ± 0.017	0.736CysLeu: 0.736 ± 0.024	0.147CysMet: 0.147 ± 0.011	0.36CysAsn: 0.36 ± 0.02	0.365CysPro: 0.365 ± 0.023	0.197CysGln: 0.197 ± 0.013	0.314CysArg: 0.314 ± 0.015	0.588CysSer: 0.588 ± 0.034	0.405CysThr: 0.405 ± 0.019	0.446CysVal: 0.446 ± 0.018	0.079CysTrp: 0.079 ± 0.008	0.28CysTyr: 0.28 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.666AspAla: 3.666 ± 0.059	0.385AspCys: 0.385 ± 0.017	2.559AspAsp: 2.559 ± 0.052	3.466AspGlu: 3.466 ± 0.068	3.036AspPhe: 3.036 ± 0.058	3.79AspGly: 3.79 ± 0.061	1.047AspHis: 1.047 ± 0.03	4.122AspIle: 4.122 ± 0.059	3.911AspLys: 3.911 ± 0.058	5.476AspLeu: 5.476 ± 0.07	1.242AspMet: 1.242 ± 0.033	2.58AspAsn: 2.58 ± 0.048	2.378AspPro: 2.378 ± 0.049	1.991AspGln: 1.991 ± 0.042	2.4AspArg: 2.4 ± 0.05	3.135AspSer: 3.135 ± 0.059	2.514AspThr: 2.514 ± 0.049	3.447AspVal: 3.447 ± 0.053	0.692AspTrp: 0.692 ± 0.026	2.326AspTyr: 2.326 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.159GluAla: 4.159 ± 0.068	0.328GluCys: 0.328 ± 0.015	2.86GluAsp: 2.86 ± 0.06	3.801GluGlu: 3.801 ± 0.073	2.782GluPhe: 2.782 ± 0.05	3.542GluGly: 3.542 ± 0.048	1.112GluHis: 1.112 ± 0.03	4.781GluIle: 4.781 ± 0.065	4.724GluLys: 4.724 ± 0.078	5.934GluLeu: 5.934 ± 0.071	1.554GluMet: 1.554 ± 0.041	3.377GluAsn: 3.377 ± 0.058	1.731GluPro: 1.731 ± 0.042	2.184GluGln: 2.184 ± 0.045	2.796GluArg: 2.796 ± 0.056	3.2GluSer: 3.2 ± 0.055	2.936GluThr: 2.936 ± 0.052	3.93GluVal: 3.93 ± 0.07	0.677GluTrp: 0.677 ± 0.025	2.092GluTyr: 2.092 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.395PheAla: 3.395 ± 0.052	0.472PheCys: 0.472 ± 0.021	2.854PheAsp: 2.854 ± 0.051	2.778PheGlu: 2.778 ± 0.053	2.445PhePhe: 2.445 ± 0.056	3.448PheGly: 3.448 ± 0.061	0.885PheHis: 0.885 ± 0.027	3.593PheIle: 3.593 ± 0.061	3.26PheLys: 3.26 ± 0.052	4.507PheLeu: 4.507 ± 0.07	1.119PheMet: 1.119 ± 0.033	2.935PheAsn: 2.935 ± 0.053	1.812PhePro: 1.812 ± 0.037	1.436PheGln: 1.436 ± 0.035	2.105PheArg: 2.105 ± 0.047	3.898PheSer: 3.898 ± 0.065	3.055PheThr: 3.055 ± 0.056	3.002PheVal: 3.002 ± 0.057	0.575PheTrp: 0.575 ± 0.023	1.991PheTyr: 1.991 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.707GlyAla: 4.707 ± 0.087	0.642GlyCys: 0.642 ± 0.033	3.464GlyAsp: 3.464 ± 0.057	3.502GlyGlu: 3.502 ± 0.052	3.75GlyPhe: 3.75 ± 0.061	5.313GlyGly: 5.313 ± 0.118	1.246GlyHis: 1.246 ± 0.031	5.591GlyIle: 5.591 ± 0.076	5.387GlyLys: 5.387 ± 0.075	6.477GlyLeu: 6.477 ± 0.08	1.895GlyMet: 1.895 ± 0.045	3.647GlyAsn: 3.647 ± 0.059	1.818GlyPro: 1.818 ± 0.042	2.149GlyGln: 2.149 ± 0.044	2.909GlyArg: 2.909 ± 0.057	4.993GlySer: 4.993 ± 0.08	4.45GlyThr: 4.45 ± 0.081	4.622GlyVal: 4.622 ± 0.062	0.889GlyTrp: 0.889 ± 0.027	2.933GlyTyr: 2.933 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.144HisAla: 1.144 ± 0.035	0.176HisCys: 0.176 ± 0.012	0.927HisAsp: 0.927 ± 0.031	1.044HisGlu: 1.044 ± 0.03	1.032HisPhe: 1.032 ± 0.031	1.213HisGly: 1.213 ± 0.034	0.462HisHis: 0.462 ± 0.023	1.264HisIle: 1.264 ± 0.034	0.981HisLys: 0.981 ± 0.03	1.772HisLeu: 1.772 ± 0.036	0.355HisMet: 0.355 ± 0.018	0.855HisAsn: 0.855 ± 0.028	0.96HisPro: 0.96 ± 0.03	0.67HisGln: 0.67 ± 0.023	0.787HisArg: 0.787 ± 0.024	1.14HisSer: 1.14 ± 0.031	0.951HisThr: 0.951 ± 0.031	1.058HisVal: 1.058 ± 0.03	0.236HisTrp: 0.236 ± 0.015	0.76HisTyr: 0.76 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.817IleAla: 5.817 ± 0.078	0.747IleCys: 0.747 ± 0.029	4.343IleAsp: 4.343 ± 0.054	4.317IleGlu: 4.317 ± 0.071	3.424IlePhe: 3.424 ± 0.063	4.968IleGly: 4.968 ± 0.076	1.314IleHis: 1.314 ± 0.037	5.475IleIle: 5.475 ± 0.081	4.914IleLys: 4.914 ± 0.07	6.834IleLeu: 6.834 ± 0.091	1.524IleMet: 1.524 ± 0.034	4.019IleAsn: 4.019 ± 0.067	3.291IlePro: 3.291 ± 0.05	2.217IleGln: 2.217 ± 0.048	3.325IleArg: 3.325 ± 0.057	5.729IleSer: 5.729 ± 0.086	4.405IleThr: 4.405 ± 0.077	4.46IleVal: 4.46 ± 0.056	0.72IleTrp: 0.72 ± 0.023	2.537IleTyr: 2.537 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.978LysAla: 4.978 ± 0.081	0.332LysCys: 0.332 ± 0.017	3.985LysAsp: 3.985 ± 0.062	4.364LysGlu: 4.364 ± 0.07	2.863LysPhe: 2.863 ± 0.053	4.52LysGly: 4.52 ± 0.076	1.252LysHis: 1.252 ± 0.032	5.208LysIle: 5.208 ± 0.076	5.105LysLys: 5.105 ± 0.081	6.356LysLeu: 6.356 ± 0.079	1.85LysMet: 1.85 ± 0.044	4.075LysAsn: 4.075 ± 0.061	2.774LysPro: 2.774 ± 0.054	2.358LysGln: 2.358 ± 0.042	2.84LysArg: 2.84 ± 0.046	4.39LysSer: 4.39 ± 0.067	3.981LysThr: 3.981 ± 0.056	4.449LysVal: 4.449 ± 0.066	0.714LysTrp: 0.714 ± 0.026	2.698LysTyr: 2.698 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.967LeuAla: 6.967 ± 0.078	0.767LeuCys: 0.767 ± 0.029	4.911LeuAsp: 4.911 ± 0.069	5.263LeuGlu: 5.263 ± 0.065	4.552LeuPhe: 4.552 ± 0.072	6.074LeuGly: 6.074 ± 0.084	1.543LeuHis: 1.543 ± 0.042	7.004LeuIle: 7.004 ± 0.095	7.166LeuLys: 7.166 ± 0.083	8.867LeuLeu: 8.867 ± 0.122	2.269LeuMet: 2.269 ± 0.051	5.529LeuAsn: 5.529 ± 0.07	3.843LeuPro: 3.843 ± 0.058	3.163LeuGln: 3.163 ± 0.058	3.999LeuArg: 3.999 ± 0.059	7.201LeuSer: 7.201 ± 0.077	5.546LeuThr: 5.546 ± 0.101	5.702LeuVal: 5.702 ± 0.069	0.823LeuTrp: 0.823 ± 0.03	3.067LeuTyr: 3.067 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	1.829MetAla: 1.829 ± 0.036	0.146MetCys: 0.146 ± 0.012	1.3MetAsp: 1.3 ± 0.034	1.4MetGlu: 1.4 ± 0.038	0.932MetPhe: 0.932 ± 0.033	1.62MetGly: 1.62 ± 0.039	0.423MetHis: 0.423 ± 0.02	1.779MetIle: 1.779 ± 0.04	2.098MetLys: 2.098 ± 0.047	2.204MetLeu: 2.204 ± 0.042	0.62MetMet: 0.62 ± 0.02	1.338MetAsn: 1.338 ± 0.037	1.064MetPro: 1.064 ± 0.028	0.871MetGln: 0.871 ± 0.028	1.048MetArg: 1.048 ± 0.032	1.458MetSer: 1.458 ± 0.034	1.168MetThr: 1.168 ± 0.033	1.466MetVal: 1.466 ± 0.037	0.182MetTrp: 0.182 ± 0.012	0.675MetTyr: 0.675 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.648AsnAla: 3.648 ± 0.059	0.418AsnCys: 0.418 ± 0.029	2.605AsnAsp: 2.605 ± 0.05	2.895AsnGlu: 2.895 ± 0.053	2.745AsnPhe: 2.745 ± 0.057	3.813AsnGly: 3.813 ± 0.07	0.92AsnHis: 0.92 ± 0.028	4.053AsnIle: 4.053 ± 0.06	3.48AsnLys: 3.48 ± 0.059	5.151AsnLeu: 5.151 ± 0.072	1.306AsnMet: 1.306 ± 0.032	3.067AsnAsn: 3.067 ± 0.057	2.739AsnPro: 2.739 ± 0.049	1.814AsnGln: 1.814 ± 0.049	2.342AsnArg: 2.342 ± 0.047	3.779AsnSer: 3.779 ± 0.066	3.107AsnThr: 3.107 ± 0.061	3.317AsnVal: 3.317 ± 0.055	0.684AsnTrp: 0.684 ± 0.029	2.419AsnTyr: 2.419 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	3.427ProAla: 3.427 ± 0.064	0.226ProCys: 0.226 ± 0.014	2.66ProAsp: 2.66 ± 0.045	3.099ProGlu: 3.099 ± 0.052	1.945ProPhe: 1.945 ± 0.039	3.164ProGly: 3.164 ± 0.057	0.692ProHis: 0.692 ± 0.027	2.399ProIle: 2.399 ± 0.041	2.206ProLys: 2.206 ± 0.04	3.334ProLeu: 3.334 ± 0.048	0.78ProMet: 0.78 ± 0.027	1.861ProAsn: 1.861 ± 0.038	1.079ProPro: 1.079 ± 0.034	1.328ProGln: 1.328 ± 0.035	1.308ProArg: 1.308 ± 0.038	2.43ProSer: 2.43 ± 0.046	1.847ProThr: 1.847 ± 0.04	3.357ProVal: 3.357 ± 0.053	0.409ProTrp: 0.409 ± 0.02	1.403ProTyr: 1.403 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.405GlnAla: 2.405 ± 0.048	0.162GlnCys: 0.162 ± 0.011	1.622GlnAsp: 1.622 ± 0.039	1.959GlnGlu: 1.959 ± 0.04	1.589GlnPhe: 1.589 ± 0.038	2.095GlnGly: 2.095 ± 0.043	0.627GlnHis: 0.627 ± 0.023	2.496GlnIle: 2.496 ± 0.048	2.465GlnLys: 2.465 ± 0.051	3.236GlnLeu: 3.236 ± 0.051	0.873GlnMet: 0.873 ± 0.027	1.952GlnAsn: 1.952 ± 0.045	1.357GlnPro: 1.357 ± 0.035	1.479GlnGln: 1.479 ± 0.043	1.519GlnArg: 1.519 ± 0.036	2.144GlnSer: 2.144 ± 0.042	1.978GlnThr: 1.978 ± 0.039	2.204GlnVal: 2.204 ± 0.046	0.354GlnTrp: 0.354 ± 0.018	1.245GlnTyr: 1.245 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.661ArgAla: 2.661 ± 0.045	0.234ArgCys: 0.234 ± 0.014	2.26ArgAsp: 2.26 ± 0.04	2.646ArgGlu: 2.646 ± 0.058	2.18ArgPhe: 2.18 ± 0.044	2.511ArgGly: 2.511 ± 0.045	0.736ArgHis: 0.736 ± 0.026	3.423ArgIle: 3.423 ± 0.054	3.093ArgLys: 3.093 ± 0.05	4.159ArgLeu: 4.159 ± 0.054	1.147ArgMet: 1.147 ± 0.034	2.452ArgAsn: 2.452 ± 0.049	1.563ArgPro: 1.563 ± 0.038	1.479ArgGln: 1.479 ± 0.038	1.851ArgArg: 1.851 ± 0.04	2.811ArgSer: 2.811 ± 0.054	2.37ArgThr: 2.37 ± 0.045	2.741ArgVal: 2.741 ± 0.052	0.477ArgTrp: 0.477 ± 0.019	1.732ArgTyr: 1.732 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.101SerAla: 5.101 ± 0.077	0.562SerCys: 0.562 ± 0.024	3.643SerAsp: 3.643 ± 0.061	3.814SerGlu: 3.814 ± 0.057	3.734SerPhe: 3.734 ± 0.063	5.604SerGly: 5.604 ± 0.077	1.176SerHis: 1.176 ± 0.033	4.908SerIle: 4.908 ± 0.068	4.301SerLys: 4.301 ± 0.066	6.533SerLeu: 6.533 ± 0.073	1.497SerMet: 1.497 ± 0.034	3.425SerAsn: 3.425 ± 0.059	2.669SerPro: 2.669 ± 0.053	2.297SerGln: 2.297 ± 0.047	2.929SerArg: 2.929 ± 0.052	4.918SerSer: 4.918 ± 0.066	3.743SerThr: 3.743 ± 0.079	4.491SerVal: 4.491 ± 0.063	0.782SerTrp: 0.782 ± 0.035	2.752SerTyr: 2.752 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	4.357ThrAla: 4.357 ± 0.101	0.333ThrCys: 0.333 ± 0.018	3.24ThrAsp: 3.24 ± 0.057	3.087ThrGlu: 3.087 ± 0.059	2.817ThrPhe: 2.817 ± 0.057	4.752ThrGly: 4.752 ± 0.104	0.958ThrHis: 0.958 ± 0.026	4.161ThrIle: 4.161 ± 0.068	3.099ThrLys: 3.099 ± 0.055	5.121ThrLeu: 5.121 ± 0.063	1.114ThrMet: 1.114 ± 0.031	2.813ThrAsn: 2.813 ± 0.057	2.541ThrPro: 2.541 ± 0.058	1.708ThrGln: 1.708 ± 0.046	2.152ThrArg: 2.152 ± 0.044	3.889ThrSer: 3.889 ± 0.071	3.248ThrThr: 3.248 ± 0.08	3.944ThrVal: 3.944 ± 0.087	0.579ThrTrp: 0.579 ± 0.022	2.154ThrTyr: 2.154 ± 0.07	0.0ThrXaa: 0.0 ± 0.0
Val	4.576ValAla: 4.576 ± 0.073	0.553ValCys: 0.553 ± 0.021	3.53ValAsp: 3.53 ± 0.056	3.542ValGlu: 3.542 ± 0.064	3.173ValPhe: 3.173 ± 0.057	3.927ValGly: 3.927 ± 0.068	1.103ValHis: 1.103 ± 0.035	4.972ValIle: 4.972 ± 0.073	4.572ValLys: 4.572 ± 0.063	6.137ValLeu: 6.137 ± 0.077	1.565ValMet: 1.565 ± 0.038	3.617ValAsn: 3.617 ± 0.072	2.598ValPro: 2.598 ± 0.049	1.951ValGln: 1.951 ± 0.037	2.705ValArg: 2.705 ± 0.051	4.769ValSer: 4.769 ± 0.068	3.683ValThr: 3.683 ± 0.08	4.321ValVal: 4.321 ± 0.062	0.703ValTrp: 0.703 ± 0.025	2.371ValTyr: 2.371 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.713TrpAla: 0.713 ± 0.024	0.089TrpCys: 0.089 ± 0.009	0.678TrpAsp: 0.678 ± 0.028	0.606TrpGlu: 0.606 ± 0.024	0.549TrpPhe: 0.549 ± 0.025	0.765TrpGly: 0.765 ± 0.027	0.221TrpHis: 0.221 ± 0.015	0.749TrpIle: 0.749 ± 0.027	0.818TrpLys: 0.818 ± 0.028	1.078TrpLeu: 1.078 ± 0.033	0.344TrpMet: 0.344 ± 0.014	0.63TrpAsn: 0.63 ± 0.025	0.337TrpPro: 0.337 ± 0.02	0.415TrpGln: 0.415 ± 0.018	0.443TrpArg: 0.443 ± 0.02	0.665TrpSer: 0.665 ± 0.023	0.649TrpThr: 0.649 ± 0.033	0.622TrpVal: 0.622 ± 0.026	0.188TrpTrp: 0.188 ± 0.012	0.405TrpTyr: 0.405 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.501TyrAla: 2.501 ± 0.049	0.315TyrCys: 0.315 ± 0.018	2.099TyrAsp: 2.099 ± 0.048	1.897TyrGlu: 1.897 ± 0.042	2.132TyrPhe: 2.132 ± 0.044	2.596TyrGly: 2.596 ± 0.054	0.754TyrHis: 0.754 ± 0.023	2.416TyrIle: 2.416 ± 0.046	2.504TyrLys: 2.504 ± 0.049	3.602TyrLeu: 3.602 ± 0.058	0.743TyrMet: 0.743 ± 0.025	2.232TyrAsn: 2.232 ± 0.053	1.654TyrPro: 1.654 ± 0.038	1.415TyrGln: 1.415 ± 0.037	1.888TyrArg: 1.888 ± 0.033	2.794TyrSer: 2.794 ± 0.061	2.287TyrThr: 2.287 ± 0.063	2.072TyrVal: 2.072 ± 0.044	0.457TyrTrp: 0.457 ± 0.02	1.595TyrTyr: 1.595 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3561 proteins (1196146 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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