Amino acid dipepetide frequency for Candidatus Hodgkinia cicadicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.525AlaAla: 1.525 ± 0.131
0.594AlaCys: 0.594 ± 0.082
1.733AlaAsp: 1.733 ± 0.16
1.238AlaGlu: 1.238 ± 0.131
1.327AlaPhe: 1.327 ± 0.103
1.495AlaGly: 1.495 ± 0.151
0.475AlaHis: 0.475 ± 0.069
3.119AlaIle: 3.119 ± 0.184
2.416AlaLys: 2.416 ± 0.189
3.515AlaLeu: 3.515 ± 0.192
0.594AlaMet: 0.594 ± 0.076
2.287AlaAsn: 2.287 ± 0.14
0.683AlaPro: 0.683 ± 0.076
0.762AlaGln: 0.762 ± 0.078
1.683AlaArg: 1.683 ± 0.105
1.98AlaSer: 1.98 ± 0.139
1.832AlaThr: 1.832 ± 0.125
2.94AlaVal: 2.94 ± 0.177
0.297AlaTrp: 0.297 ± 0.058
1.317AlaTyr: 1.317 ± 0.123
0.0AlaXaa: 0.0 ± 0.0
Cys
0.574CysAla: 0.574 ± 0.077
1.049CysCys: 1.049 ± 0.115
0.99CysAsp: 0.99 ± 0.11
0.842CysGlu: 0.842 ± 0.086
1.099CysPhe: 1.099 ± 0.107
1.426CysGly: 1.426 ± 0.103
0.426CysHis: 0.426 ± 0.065
1.921CysIle: 1.921 ± 0.139
1.802CysLys: 1.802 ± 0.134
2.851CysLeu: 2.851 ± 0.169
0.406CysMet: 0.406 ± 0.056
1.624CysAsn: 1.624 ± 0.124
0.812CysPro: 0.812 ± 0.077
0.782CysGln: 0.782 ± 0.101
0.614CysArg: 0.614 ± 0.08
2.148CysSer: 2.148 ± 0.139
0.743CysThr: 0.743 ± 0.085
1.376CysVal: 1.376 ± 0.122
0.327CysTrp: 0.327 ± 0.055
1.267CysTyr: 1.267 ± 0.102
0.0CysXaa: 0.0 ± 0.0
Asp
1.089AspAla: 1.089 ± 0.136
0.832AspCys: 0.832 ± 0.094
2.386AspAsp: 2.386 ± 0.194
2.129AspGlu: 2.129 ± 0.161
1.426AspPhe: 1.426 ± 0.108
3.119AspGly: 3.119 ± 0.246
0.921AspHis: 0.921 ± 0.092
4.505AspIle: 4.505 ± 0.226
3.663AspLys: 3.663 ± 0.228
5.504AspLeu: 5.504 ± 0.245
1.297AspMet: 1.297 ± 0.104
3.178AspAsn: 3.178 ± 0.19
1.426AspPro: 1.426 ± 0.11
1.257AspGln: 1.257 ± 0.11
2.039AspArg: 2.039 ± 0.145
2.861AspSer: 2.861 ± 0.137
1.911AspThr: 1.911 ± 0.111
4.742AspVal: 4.742 ± 0.285
0.564AspTrp: 0.564 ± 0.078
1.97AspTyr: 1.97 ± 0.148
0.0AspXaa: 0.0 ± 0.0
Glu
1.574GluAla: 1.574 ± 0.155
1.04GluCys: 1.04 ± 0.125
1.921GluAsp: 1.921 ± 0.141
1.851GluGlu: 1.851 ± 0.166
1.673GluPhe: 1.673 ± 0.112
2.237GluGly: 2.237 ± 0.166
0.911GluHis: 0.911 ± 0.093
4.079GluIle: 4.079 ± 0.236
1.871GluLys: 1.871 ± 0.153
5.871GluLeu: 5.871 ± 0.213
1.307GluMet: 1.307 ± 0.115
1.822GluAsn: 1.822 ± 0.129
1.287GluPro: 1.287 ± 0.11
0.941GluGln: 0.941 ± 0.105
2.168GluArg: 2.168 ± 0.137
2.663GluSer: 2.663 ± 0.182
2.455GluThr: 2.455 ± 0.16
4.0GluVal: 4.0 ± 0.216
0.653GluTrp: 0.653 ± 0.069
1.634GluTyr: 1.634 ± 0.122
0.0GluXaa: 0.0 ± 0.0
Phe
0.812PheAla: 0.812 ± 0.094
1.0PheCys: 1.0 ± 0.116
2.723PheAsp: 2.723 ± 0.141
2.059PheGlu: 2.059 ± 0.147
0.861PhePhe: 0.861 ± 0.11
2.841PheGly: 2.841 ± 0.163
0.772PheHis: 0.772 ± 0.07
3.911PheIle: 3.911 ± 0.273
3.94PheLys: 3.94 ± 0.197
2.772PheLeu: 2.772 ± 0.179
0.941PheMet: 0.941 ± 0.091
3.94PheAsn: 3.94 ± 0.222
0.723PhePro: 0.723 ± 0.085
0.822PheGln: 0.822 ± 0.09
1.802PheArg: 1.802 ± 0.123
2.317PheSer: 2.317 ± 0.139
1.475PheThr: 1.475 ± 0.112
2.455PheVal: 2.455 ± 0.155
0.436PheTrp: 0.436 ± 0.067
1.178PheTyr: 1.178 ± 0.113
0.0PheXaa: 0.0 ± 0.0
Gly
1.515GlyAla: 1.515 ± 0.126
1.287GlyCys: 1.287 ± 0.091
2.643GlyAsp: 2.643 ± 0.187
2.257GlyGlu: 2.257 ± 0.156
2.643GlyPhe: 2.643 ± 0.164
2.515GlyGly: 2.515 ± 0.175
0.95GlyHis: 0.95 ± 0.093
6.277GlyIle: 6.277 ± 0.278
3.92GlyLys: 3.92 ± 0.168
7.653GlyLeu: 7.653 ± 0.237
1.218GlyMet: 1.218 ± 0.117
3.119GlyAsn: 3.119 ± 0.173
1.01GlyPro: 1.01 ± 0.082
1.653GlyGln: 1.653 ± 0.142
3.049GlyArg: 3.049 ± 0.181
4.079GlySer: 4.079 ± 0.203
3.406GlyThr: 3.406 ± 0.151
3.138GlyVal: 3.138 ± 0.222
0.762GlyTrp: 0.762 ± 0.098
2.089GlyTyr: 2.089 ± 0.156
0.0GlyXaa: 0.0 ± 0.0
His
0.792HisAla: 0.792 ± 0.103
0.277HisCys: 0.277 ± 0.045
0.703HisAsp: 0.703 ± 0.084
0.901HisGlu: 0.901 ± 0.088
0.495HisPhe: 0.495 ± 0.071
1.723HisGly: 1.723 ± 0.126
0.446HisHis: 0.446 ± 0.078
2.089HisIle: 2.089 ± 0.139
1.683HisLys: 1.683 ± 0.135
2.257HisLeu: 2.257 ± 0.142
0.386HisMet: 0.386 ± 0.062
1.742HisAsn: 1.742 ± 0.137
0.96HisPro: 0.96 ± 0.125
0.584HisGln: 0.584 ± 0.082
0.812HisArg: 0.812 ± 0.093
1.267HisSer: 1.267 ± 0.108
0.901HisThr: 0.901 ± 0.089
1.723HisVal: 1.723 ± 0.113
0.178HisTrp: 0.178 ± 0.041
0.653HisTyr: 0.653 ± 0.064
0.0HisXaa: 0.0 ± 0.0
Ile
3.178IleAla: 3.178 ± 0.224
2.723IleCys: 2.723 ± 0.157
5.712IleAsp: 5.712 ± 0.222
4.534IleGlu: 4.534 ± 0.258
2.782IlePhe: 2.782 ± 0.182
5.485IleGly: 5.485 ± 0.235
1.782IleHis: 1.782 ± 0.147
9.385IleIle: 9.385 ± 0.399
9.959IleLys: 9.959 ± 0.326
9.791IleLeu: 9.791 ± 0.349
2.049IleMet: 2.049 ± 0.126
8.148IleAsn: 8.148 ± 0.288
3.138IlePro: 3.138 ± 0.185
2.426IleGln: 2.426 ± 0.133
4.821IleArg: 4.821 ± 0.217
8.247IleSer: 8.247 ± 0.291
6.494IleThr: 6.494 ± 0.308
5.148IleVal: 5.148 ± 0.234
1.04IleTrp: 1.04 ± 0.097
3.455IleTyr: 3.455 ± 0.184
0.0IleXaa: 0.0 ± 0.0
Lys
2.158LysAla: 2.158 ± 0.142
1.525LysCys: 1.525 ± 0.126
3.237LysAsp: 3.237 ± 0.255
2.604LysGlu: 2.604 ± 0.177
2.683LysPhe: 2.683 ± 0.176
2.95LysGly: 2.95 ± 0.196
3.029LysHis: 3.029 ± 0.176
8.207LysIle: 8.207 ± 0.342
5.009LysLys: 5.009 ± 0.276
10.692LysLeu: 10.692 ± 0.321
2.119LysMet: 2.119 ± 0.163
4.0LysAsn: 4.0 ± 0.183
3.168LysPro: 3.168 ± 0.211
3.604LysGln: 3.604 ± 0.201
4.079LysArg: 4.079 ± 0.17
5.168LysSer: 5.168 ± 0.219
6.425LysThr: 6.425 ± 0.267
4.178LysVal: 4.178 ± 0.217
1.059LysTrp: 1.059 ± 0.098
3.524LysTyr: 3.524 ± 0.175
0.0LysXaa: 0.0 ± 0.0
Leu
3.98LeuAla: 3.98 ± 0.201
2.426LeuCys: 2.426 ± 0.14
4.445LeuAsp: 4.445 ± 0.206
5.168LeuGlu: 5.168 ± 0.259
4.554LeuPhe: 4.554 ± 0.2
4.95LeuGly: 4.95 ± 0.194
2.534LeuHis: 2.534 ± 0.167
11.732LeuIle: 11.732 ± 0.379
8.276LeuLys: 8.276 ± 0.271
9.732LeuLeu: 9.732 ± 0.413
2.822LeuMet: 2.822 ± 0.171
8.93LeuAsn: 8.93 ± 0.326
3.574LeuPro: 3.574 ± 0.171
2.287LeuGln: 2.287 ± 0.134
4.495LeuArg: 4.495 ± 0.196
9.851LeuSer: 9.851 ± 0.307
7.861LeuThr: 7.861 ± 0.3
6.494LeuVal: 6.494 ± 0.225
1.208LeuTrp: 1.208 ± 0.116
3.227LeuTyr: 3.227 ± 0.17
0.0LeuXaa: 0.0 ± 0.0
Met
1.673MetAla: 1.673 ± 0.101
0.584MetCys: 0.584 ± 0.092
1.109MetAsp: 1.109 ± 0.099
1.01MetGlu: 1.01 ± 0.095
1.416MetPhe: 1.416 ± 0.115
0.941MetGly: 0.941 ± 0.102
0.248MetHis: 0.248 ± 0.049
2.633MetIle: 2.633 ± 0.171
1.544MetLys: 1.544 ± 0.139
3.277MetLeu: 3.277 ± 0.209
0.545MetMet: 0.545 ± 0.072
1.416MetAsn: 1.416 ± 0.13
0.703MetPro: 0.703 ± 0.088
0.208MetGln: 0.208 ± 0.043
0.95MetArg: 0.95 ± 0.079
1.693MetSer: 1.693 ± 0.115
1.119MetThr: 1.119 ± 0.096
2.247MetVal: 2.247 ± 0.18
0.208MetTrp: 0.208 ± 0.045
0.752MetTyr: 0.752 ± 0.079
0.0MetXaa: 0.0 ± 0.0
Asn
1.643AsnAla: 1.643 ± 0.121
1.406AsnCys: 1.406 ± 0.148
3.109AsnAsp: 3.109 ± 0.206
3.891AsnGlu: 3.891 ± 0.204
2.228AsnPhe: 2.228 ± 0.13
3.742AsnGly: 3.742 ± 0.186
1.515AsnHis: 1.515 ± 0.143
8.019AsnIle: 8.019 ± 0.304
8.643AsnLys: 8.643 ± 0.272
6.861AsnLeu: 6.861 ± 0.296
2.01AsnMet: 2.01 ± 0.152
7.296AsnAsn: 7.296 ± 0.311
2.148AsnPro: 2.148 ± 0.145
2.168AsnGln: 2.168 ± 0.147
3.277AsnArg: 3.277 ± 0.184
4.762AsnSer: 4.762 ± 0.27
4.178AsnThr: 4.178 ± 0.254
6.098AsnVal: 6.098 ± 0.281
0.941AsnTrp: 0.941 ± 0.109
2.525AsnTyr: 2.525 ± 0.147
0.0AsnXaa: 0.0 ± 0.0
Pro
0.792ProAla: 0.792 ± 0.091
0.861ProCys: 0.861 ± 0.091
1.089ProAsp: 1.089 ± 0.121
1.238ProGlu: 1.238 ± 0.107
1.584ProPhe: 1.584 ± 0.129
1.911ProGly: 1.911 ± 0.143
0.416ProHis: 0.416 ± 0.062
3.604ProIle: 3.604 ± 0.191
2.277ProLys: 2.277 ± 0.171
3.277ProLeu: 3.277 ± 0.169
0.653ProMet: 0.653 ± 0.068
2.485ProAsn: 2.485 ± 0.168
0.792ProPro: 0.792 ± 0.092
0.743ProGln: 0.743 ± 0.089
1.03ProArg: 1.03 ± 0.096
2.475ProSer: 2.475 ± 0.125
2.297ProThr: 2.297 ± 0.139
1.762ProVal: 1.762 ± 0.143
0.386ProTrp: 0.386 ± 0.067
0.96ProTyr: 0.96 ± 0.106
0.0ProXaa: 0.0 ± 0.0
Gln
0.941GlnAla: 0.941 ± 0.08
0.386GlnCys: 0.386 ± 0.058
1.158GlnAsp: 1.158 ± 0.085
1.139GlnGlu: 1.139 ± 0.1
1.089GlnPhe: 1.089 ± 0.098
1.198GlnGly: 1.198 ± 0.106
0.822GlnHis: 0.822 ± 0.08
2.564GlnIle: 2.564 ± 0.16
1.267GlnLys: 1.267 ± 0.104
2.881GlnLeu: 2.881 ± 0.141
1.099GlnMet: 1.099 ± 0.112
1.703GlnAsn: 1.703 ± 0.146
0.95GlnPro: 0.95 ± 0.11
1.366GlnGln: 1.366 ± 0.114
1.841GlnArg: 1.841 ± 0.136
1.911GlnSer: 1.911 ± 0.14
1.95GlnThr: 1.95 ± 0.153
1.881GlnVal: 1.881 ± 0.125
0.337GlnTrp: 0.337 ± 0.06
0.663GlnTyr: 0.663 ± 0.078
0.0GlnXaa: 0.0 ± 0.0
Arg
1.069ArgAla: 1.069 ± 0.092
1.416ArgCys: 1.416 ± 0.125
1.663ArgAsp: 1.663 ± 0.143
1.129ArgGlu: 1.129 ± 0.116
2.416ArgPhe: 2.416 ± 0.174
2.297ArgGly: 2.297 ± 0.165
0.98ArgHis: 0.98 ± 0.103
4.475ArgIle: 4.475 ± 0.22
2.534ArgLys: 2.534 ± 0.169
6.306ArgLeu: 6.306 ± 0.245
1.069ArgMet: 1.069 ± 0.084
2.95ArgAsn: 2.95 ± 0.161
1.247ArgPro: 1.247 ± 0.096
1.069ArgGln: 1.069 ± 0.092
2.416ArgArg: 2.416 ± 0.185
4.653ArgSer: 4.653 ± 0.214
2.564ArgThr: 2.564 ± 0.174
2.267ArgVal: 2.267 ± 0.123
0.683ArgTrp: 0.683 ± 0.091
2.208ArgTyr: 2.208 ± 0.151
0.0ArgXaa: 0.0 ± 0.0
Ser
2.109SerAla: 2.109 ± 0.144
1.495SerCys: 1.495 ± 0.117
4.128SerAsp: 4.128 ± 0.189
3.406SerGlu: 3.406 ± 0.145
2.643SerPhe: 2.643 ± 0.159
5.029SerGly: 5.029 ± 0.263
1.198SerHis: 1.198 ± 0.136
7.514SerIle: 7.514 ± 0.288
5.92SerLys: 5.92 ± 0.227
8.019SerLeu: 8.019 ± 0.276
1.871SerMet: 1.871 ± 0.143
6.475SerAsn: 6.475 ± 0.246
2.247SerPro: 2.247 ± 0.14
1.97SerGln: 1.97 ± 0.109
3.257SerArg: 3.257 ± 0.193
6.257SerSer: 6.257 ± 0.261
4.059SerThr: 4.059 ± 0.193
4.534SerVal: 4.534 ± 0.192
0.98SerTrp: 0.98 ± 0.092
2.97SerTyr: 2.97 ± 0.162
0.0SerXaa: 0.0 ± 0.0
Thr
1.921ThrAla: 1.921 ± 0.121
1.584ThrCys: 1.584 ± 0.097
2.475ThrAsp: 2.475 ± 0.138
2.594ThrGlu: 2.594 ± 0.139
2.178ThrPhe: 2.178 ± 0.172
3.505ThrGly: 3.505 ± 0.196
0.96ThrHis: 0.96 ± 0.112
4.475ThrIle: 4.475 ± 0.233
5.772ThrLys: 5.772 ± 0.24
5.485ThrLeu: 5.485 ± 0.229
1.386ThrMet: 1.386 ± 0.134
5.623ThrAsn: 5.623 ± 0.253
2.089ThrPro: 2.089 ± 0.147
1.535ThrGln: 1.535 ± 0.126
2.732ThrArg: 2.732 ± 0.173
4.901ThrSer: 4.901 ± 0.222
4.683ThrThr: 4.683 ± 0.266
2.871ThrVal: 2.871 ± 0.166
0.851ThrTrp: 0.851 ± 0.082
1.96ThrTyr: 1.96 ± 0.136
0.0ThrXaa: 0.0 ± 0.0
Val
2.534ValAla: 2.534 ± 0.19
1.624ValCys: 1.624 ± 0.154
3.633ValAsp: 3.633 ± 0.201
2.327ValGlu: 2.327 ± 0.144
2.455ValPhe: 2.455 ± 0.16
4.633ValGly: 4.633 ± 0.228
1.119ValHis: 1.119 ± 0.115
7.593ValIle: 7.593 ± 0.272
4.643ValLys: 4.643 ± 0.199
6.92ValLeu: 6.92 ± 0.253
1.406ValMet: 1.406 ± 0.118
5.069ValAsn: 5.069 ± 0.231
2.059ValPro: 2.059 ± 0.14
1.505ValGln: 1.505 ± 0.132
2.534ValArg: 2.534 ± 0.211
4.178ValSer: 4.178 ± 0.205
3.188ValThr: 3.188 ± 0.187
5.95ValVal: 5.95 ± 0.281
0.604ValTrp: 0.604 ± 0.069
2.138ValTyr: 2.138 ± 0.145
0.0ValXaa: 0.0 ± 0.0
Trp
0.515TrpAla: 0.515 ± 0.083
0.277TrpCys: 0.277 ± 0.044
0.485TrpAsp: 0.485 ± 0.074
0.317TrpGlu: 0.317 ± 0.062
0.644TrpPhe: 0.644 ± 0.089
0.475TrpGly: 0.475 ± 0.07
0.406TrpHis: 0.406 ± 0.059
1.049TrpIle: 1.049 ± 0.128
0.792TrpLys: 0.792 ± 0.096
1.614TrpLeu: 1.614 ± 0.144
0.426TrpMet: 0.426 ± 0.063
0.871TrpAsn: 0.871 ± 0.096
0.267TrpPro: 0.267 ± 0.056
0.465TrpGln: 0.465 ± 0.068
0.396TrpArg: 0.396 ± 0.064
1.287TrpSer: 1.287 ± 0.123
0.584TrpThr: 0.584 ± 0.077
0.525TrpVal: 0.525 ± 0.066
0.149TrpTrp: 0.149 ± 0.037
0.604TrpTyr: 0.604 ± 0.095
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.416TyrAla: 1.416 ± 0.094
0.693TyrCys: 0.693 ± 0.095
1.475TyrAsp: 1.475 ± 0.135
1.327TyrGlu: 1.327 ± 0.099
1.584TyrPhe: 1.584 ± 0.117
2.713TyrGly: 2.713 ± 0.136
0.663TyrHis: 0.663 ± 0.065
3.158TyrIle: 3.158 ± 0.136
3.485TyrLys: 3.485 ± 0.201
3.267TyrLeu: 3.267 ± 0.231
0.663TyrMet: 0.663 ± 0.059
3.782TyrAsn: 3.782 ± 0.183
1.346TyrPro: 1.346 ± 0.136
1.0TyrGln: 1.0 ± 0.099
1.416TyrArg: 1.416 ± 0.116
3.386TyrSer: 3.386 ± 0.178
1.455TyrThr: 1.455 ± 0.135
1.782TyrVal: 1.782 ± 0.131
0.485TyrTrp: 0.485 ± 0.059
1.614TyrTyr: 1.614 ± 0.111
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 252 proteins (101011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski