Amino acid dipepetide frequency for Rhizobium etli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.474AlaAla: 15.474 ± 0.128
0.957AlaCys: 0.957 ± 0.025
6.781AlaAsp: 6.781 ± 0.061
7.045AlaGlu: 7.045 ± 0.086
4.468AlaPhe: 4.468 ± 0.049
9.543AlaGly: 9.543 ± 0.077
2.077AlaHis: 2.077 ± 0.032
7.151AlaIle: 7.151 ± 0.077
4.668AlaLys: 4.668 ± 0.064
12.32AlaLeu: 12.32 ± 0.114
3.504AlaMet: 3.504 ± 0.054
3.204AlaAsn: 3.204 ± 0.056
4.747AlaPro: 4.747 ± 0.061
3.408AlaGln: 3.408 ± 0.055
7.263AlaArg: 7.263 ± 0.066
6.973AlaSer: 6.973 ± 0.071
6.075AlaThr: 6.075 ± 0.079
8.499AlaVal: 8.499 ± 0.08
1.346AlaTrp: 1.346 ± 0.028
2.561AlaTyr: 2.561 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.828CysAla: 0.828 ± 0.021
0.101CysCys: 0.101 ± 0.007
0.473CysAsp: 0.473 ± 0.018
0.414CysGlu: 0.414 ± 0.014
0.307CysPhe: 0.307 ± 0.014
0.86CysGly: 0.86 ± 0.024
0.225CysHis: 0.225 ± 0.011
0.416CysIle: 0.416 ± 0.017
0.209CysLys: 0.209 ± 0.012
0.767CysLeu: 0.767 ± 0.021
0.167CysMet: 0.167 ± 0.01
0.211CysAsn: 0.211 ± 0.01
0.36CysPro: 0.36 ± 0.015
0.225CysGln: 0.225 ± 0.01
0.527CysArg: 0.527 ± 0.017
0.435CysSer: 0.435 ± 0.017
0.38CysThr: 0.38 ± 0.013
0.608CysVal: 0.608 ± 0.019
0.099CysTrp: 0.099 ± 0.008
0.183CysTyr: 0.183 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.664AspAla: 6.664 ± 0.072
0.471AspCys: 0.471 ± 0.015
3.35AspAsp: 3.35 ± 0.057
3.594AspGlu: 3.594 ± 0.056
2.318AspPhe: 2.318 ± 0.038
5.276AspGly: 5.276 ± 0.089
1.279AspHis: 1.279 ± 0.03
3.592AspIle: 3.592 ± 0.044
2.12AspLys: 2.12 ± 0.037
5.667AspLeu: 5.667 ± 0.057
1.42AspMet: 1.42 ± 0.026
1.63AspAsn: 1.63 ± 0.032
3.059AspPro: 3.059 ± 0.05
1.857AspGln: 1.857 ± 0.038
4.048AspArg: 4.048 ± 0.057
2.241AspSer: 2.241 ± 0.039
2.731AspThr: 2.731 ± 0.058
4.42AspVal: 4.42 ± 0.051
0.926AspTrp: 0.926 ± 0.024
1.526AspTyr: 1.526 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.982GluAla: 6.982 ± 0.082
0.321GluCys: 0.321 ± 0.014
2.847GluAsp: 2.847 ± 0.039
3.326GluGlu: 3.326 ± 0.054
1.865GluPhe: 1.865 ± 0.033
4.014GluGly: 4.014 ± 0.048
1.191GluHis: 1.191 ± 0.029
3.86GluIle: 3.86 ± 0.051
2.722GluLys: 2.722 ± 0.044
5.331GluLeu: 5.331 ± 0.063
1.616GluMet: 1.616 ± 0.028
1.846GluAsn: 1.846 ± 0.032
2.494GluPro: 2.494 ± 0.047
2.135GluGln: 2.135 ± 0.039
4.606GluArg: 4.606 ± 0.06
2.284GluSer: 2.284 ± 0.041
3.635GluThr: 3.635 ± 0.043
3.67GluVal: 3.67 ± 0.048
0.736GluTrp: 0.736 ± 0.022
1.002GluTyr: 1.002 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.549PheAla: 4.549 ± 0.047
0.389PheCys: 0.389 ± 0.014
2.771PheAsp: 2.771 ± 0.04
2.188PheGlu: 2.188 ± 0.038
1.549PhePhe: 1.549 ± 0.031
3.645PheGly: 3.645 ± 0.044
0.781PheHis: 0.781 ± 0.022
1.974PheIle: 1.974 ± 0.035
1.268PheLys: 1.268 ± 0.026
3.466PheLeu: 3.466 ± 0.051
0.905PheMet: 0.905 ± 0.023
1.224PheAsn: 1.224 ± 0.03
1.612PhePro: 1.612 ± 0.031
1.092PheGln: 1.092 ± 0.024
2.199PheArg: 2.199 ± 0.033
2.595PheSer: 2.595 ± 0.035
2.055PheThr: 2.055 ± 0.041
2.997PheVal: 2.997 ± 0.045
0.549PheTrp: 0.549 ± 0.017
0.988PheTyr: 0.988 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
8.406GlyAla: 8.406 ± 0.076
0.777GlyCys: 0.777 ± 0.022
4.338GlyAsp: 4.338 ± 0.057
4.539GlyGlu: 4.539 ± 0.061
3.65GlyPhe: 3.65 ± 0.052
6.821GlyGly: 6.821 ± 0.111
1.819GlyHis: 1.819 ± 0.037
4.899GlyIle: 4.899 ± 0.055
3.78GlyLys: 3.78 ± 0.055
8.339GlyLeu: 8.339 ± 0.065
2.391GlyMet: 2.391 ± 0.04
2.489GlyAsn: 2.489 ± 0.06
2.988GlyPro: 2.988 ± 0.044
2.804GlyGln: 2.804 ± 0.046
5.335GlyArg: 5.335 ± 0.054
4.813GlySer: 4.813 ± 0.084
4.505GlyThr: 4.505 ± 0.103
5.869GlyVal: 5.869 ± 0.057
1.23GlyTrp: 1.23 ± 0.032
2.41GlyTyr: 2.41 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.144HisAla: 2.144 ± 0.038
0.206HisCys: 0.206 ± 0.012
1.311HisAsp: 1.311 ± 0.031
1.081HisGlu: 1.081 ± 0.025
0.903HisPhe: 0.903 ± 0.022
1.849HisGly: 1.849 ± 0.036
0.573HisHis: 0.573 ± 0.019
0.999HisIle: 0.999 ± 0.022
0.547HisLys: 0.547 ± 0.018
1.985HisLeu: 1.985 ± 0.032
0.567HisMet: 0.567 ± 0.017
0.494HisAsn: 0.494 ± 0.014
1.249HisPro: 1.249 ± 0.033
0.623HisGln: 0.623 ± 0.019
1.327HisArg: 1.327 ± 0.036
1.04HisSer: 1.04 ± 0.024
0.818HisThr: 0.818 ± 0.021
1.502HisVal: 1.502 ± 0.034
0.3HisTrp: 0.3 ± 0.012
0.545HisTyr: 0.545 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
7.933IleAla: 7.933 ± 0.083
0.534IleCys: 0.534 ± 0.015
4.045IleAsp: 4.045 ± 0.041
3.746IleGlu: 3.746 ± 0.049
1.992IlePhe: 1.992 ± 0.034
5.412IleGly: 5.412 ± 0.057
0.992IleHis: 0.992 ± 0.026
2.882IleIle: 2.882 ± 0.04
1.849IleLys: 1.849 ± 0.037
4.843IleLeu: 4.843 ± 0.063
1.195IleMet: 1.195 ± 0.024
1.728IleAsn: 1.728 ± 0.035
2.481IlePro: 2.481 ± 0.039
1.337IleGln: 1.337 ± 0.031
3.466IleArg: 3.466 ± 0.04
3.69IleSer: 3.69 ± 0.047
2.971IleThr: 2.971 ± 0.053
4.714IleVal: 4.714 ± 0.057
0.671IleTrp: 0.671 ± 0.019
1.291IleTyr: 1.291 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
4.919LysAla: 4.919 ± 0.063
0.177LysCys: 0.177 ± 0.011
2.1LysAsp: 2.1 ± 0.04
1.856LysGlu: 1.856 ± 0.035
1.082LysPhe: 1.082 ± 0.023
2.931LysGly: 2.931 ± 0.049
0.729LysHis: 0.729 ± 0.021
2.193LysIle: 2.193 ± 0.037
1.569LysLys: 1.569 ± 0.034
3.836LysLeu: 3.836 ± 0.048
0.997LysMet: 0.997 ± 0.024
1.107LysAsn: 1.107 ± 0.026
2.318LysPro: 2.318 ± 0.038
1.258LysGln: 1.258 ± 0.027
2.611LysArg: 2.611 ± 0.037
2.374LysSer: 2.374 ± 0.035
2.455LysThr: 2.455 ± 0.04
2.748LysVal: 2.748 ± 0.047
0.402LysTrp: 0.402 ± 0.015
0.689LysTyr: 0.689 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
12.169LeuAla: 12.169 ± 0.099
0.852LeuCys: 0.852 ± 0.021
5.758LeuAsp: 5.758 ± 0.065
5.06LeuGlu: 5.06 ± 0.059
3.7LeuPhe: 3.7 ± 0.053
7.756LeuGly: 7.756 ± 0.079
1.777LeuHis: 1.777 ± 0.033
5.22LeuIle: 5.22 ± 0.059
4.126LeuLys: 4.126 ± 0.055
9.122LeuLeu: 9.122 ± 0.092
2.439LeuMet: 2.439 ± 0.039
2.773LeuAsn: 2.773 ± 0.038
5.11LeuPro: 5.11 ± 0.056
2.865LeuGln: 2.865 ± 0.049
5.923LeuArg: 5.923 ± 0.071
7.028LeuSer: 7.028 ± 0.081
5.68LeuThr: 5.68 ± 0.072
7.304LeuVal: 7.304 ± 0.072
1.053LeuTrp: 1.053 ± 0.026
2.087LeuTyr: 2.087 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
3.044MetAla: 3.044 ± 0.044
0.143MetCys: 0.143 ± 0.008
1.266MetAsp: 1.266 ± 0.029
1.21MetGlu: 1.21 ± 0.027
0.796MetPhe: 0.796 ± 0.023
1.694MetGly: 1.694 ± 0.035
0.476MetHis: 0.476 ± 0.015
1.596MetIle: 1.596 ± 0.028
1.193MetLys: 1.193 ± 0.028
2.545MetLeu: 2.545 ± 0.041
0.722MetMet: 0.722 ± 0.022
0.884MetAsn: 0.884 ± 0.024
1.558MetPro: 1.558 ± 0.031
0.884MetGln: 0.884 ± 0.021
1.832MetArg: 1.832 ± 0.031
1.987MetSer: 1.987 ± 0.033
2.091MetThr: 2.091 ± 0.037
1.784MetVal: 1.784 ± 0.032
0.203MetTrp: 0.203 ± 0.009
0.312MetTyr: 0.312 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.466AsnAla: 3.466 ± 0.054
0.228AsnCys: 0.228 ± 0.01
1.713AsnAsp: 1.713 ± 0.051
1.502AsnGlu: 1.502 ± 0.027
1.126AsnPhe: 1.126 ± 0.025
2.75AsnGly: 2.75 ± 0.08
0.57AsnHis: 0.57 ± 0.015
1.651AsnIle: 1.651 ± 0.031
0.903AsnLys: 0.903 ± 0.023
2.737AsnLeu: 2.737 ± 0.039
0.728AsnMet: 0.728 ± 0.021
0.884AsnAsn: 0.884 ± 0.025
1.881AsnPro: 1.881 ± 0.034
0.855AsnGln: 0.855 ± 0.021
1.891AsnArg: 1.891 ± 0.035
1.547AsnSer: 1.547 ± 0.027
1.464AsnThr: 1.464 ± 0.033
2.174AsnVal: 2.174 ± 0.037
0.467AsnTrp: 0.467 ± 0.016
0.755AsnTyr: 0.755 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
5.377ProAla: 5.377 ± 0.059
0.26ProCys: 0.26 ± 0.013
3.428ProAsp: 3.428 ± 0.05
3.398ProGlu: 3.398 ± 0.04
1.926ProPhe: 1.926 ± 0.031
3.835ProGly: 3.835 ± 0.05
0.978ProHis: 0.978 ± 0.026
2.5ProIle: 2.5 ± 0.035
1.821ProLys: 1.821 ± 0.035
4.434ProLeu: 4.434 ± 0.046
1.156ProMet: 1.156 ± 0.024
1.363ProAsn: 1.363 ± 0.027
2.041ProPro: 2.041 ± 0.04
1.545ProGln: 1.545 ± 0.032
2.535ProArg: 2.535 ± 0.037
2.978ProSer: 2.978 ± 0.041
2.39ProThr: 2.39 ± 0.041
3.997ProVal: 3.997 ± 0.062
0.618ProTrp: 0.618 ± 0.019
1.195ProTyr: 1.195 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.925GlnAla: 3.925 ± 0.047
0.163GlnCys: 0.163 ± 0.011
1.426GlnAsp: 1.426 ± 0.029
1.524GlnGlu: 1.524 ± 0.029
1.119GlnPhe: 1.119 ± 0.024
2.174GlnGly: 2.174 ± 0.032
0.619GlnHis: 0.619 ± 0.019
1.931GlnIle: 1.931 ± 0.058
1.259GlnLys: 1.259 ± 0.026
2.942GlnLeu: 2.942 ± 0.042
0.94GlnMet: 0.94 ± 0.024
0.948GlnAsn: 0.948 ± 0.023
1.797GlnPro: 1.797 ± 0.033
1.409GlnGln: 1.409 ± 0.029
2.244GlnArg: 2.244 ± 0.039
2.012GlnSer: 2.012 ± 0.032
1.813GlnThr: 1.813 ± 0.033
2.136GlnVal: 2.136 ± 0.048
0.385GlnTrp: 0.385 ± 0.015
0.642GlnTyr: 0.642 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
6.63ArgAla: 6.63 ± 0.07
0.424ArgCys: 0.424 ± 0.014
3.878ArgAsp: 3.878 ± 0.053
3.875ArgGlu: 3.875 ± 0.053
2.764ArgPhe: 2.764 ± 0.041
4.303ArgGly: 4.303 ± 0.056
1.587ArgHis: 1.587 ± 0.032
3.882ArgIle: 3.882 ± 0.046
2.504ArgLys: 2.504 ± 0.04
6.862ArgLeu: 6.862 ± 0.082
1.899ArgMet: 1.899 ± 0.028
1.948ArgAsn: 1.948 ± 0.036
3.009ArgPro: 3.009 ± 0.043
2.531ArgGln: 2.531 ± 0.036
4.835ArgArg: 4.835 ± 0.062
3.793ArgSer: 3.793 ± 0.055
3.124ArgThr: 3.124 ± 0.044
4.213ArgVal: 4.213 ± 0.058
0.916ArgTrp: 0.916 ± 0.021
1.737ArgTyr: 1.737 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
6.705SerAla: 6.705 ± 0.068
0.391SerCys: 0.391 ± 0.014
3.428SerAsp: 3.428 ± 0.06
3.138SerGlu: 3.138 ± 0.044
2.596SerPhe: 2.596 ± 0.04
6.048SerGly: 6.048 ± 0.066
1.188SerHis: 1.188 ± 0.024
3.399SerIle: 3.399 ± 0.043
2.07SerLys: 2.07 ± 0.033
5.845SerLeu: 5.845 ± 0.064
1.523SerMet: 1.523 ± 0.027
1.759SerAsn: 1.759 ± 0.03
2.808SerPro: 2.808 ± 0.04
1.836SerGln: 1.836 ± 0.033
3.782SerArg: 3.782 ± 0.054
3.748SerSer: 3.748 ± 0.055
3.116SerThr: 3.116 ± 0.065
4.47SerVal: 4.47 ± 0.061
0.808SerTrp: 0.808 ± 0.023
1.448SerTyr: 1.448 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.271ThrAla: 6.271 ± 0.087
0.4ThrCys: 0.4 ± 0.017
3.05ThrAsp: 3.05 ± 0.058
2.757ThrGlu: 2.757 ± 0.04
2.154ThrPhe: 2.154 ± 0.044
4.913ThrGly: 4.913 ± 0.081
1.032ThrHis: 1.032 ± 0.023
3.41ThrIle: 3.41 ± 0.05
1.852ThrLys: 1.852 ± 0.035
5.718ThrLeu: 5.718 ± 0.063
1.339ThrMet: 1.339 ± 0.03
1.512ThrAsn: 1.512 ± 0.034
3.067ThrPro: 3.067 ± 0.05
1.433ThrGln: 1.433 ± 0.03
3.056ThrArg: 3.056 ± 0.037
3.357ThrSer: 3.357 ± 0.055
3.116ThrThr: 3.116 ± 0.058
4.537ThrVal: 4.537 ± 0.098
0.648ThrTrp: 0.648 ± 0.02
1.321ThrTyr: 1.321 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
8.956ValAla: 8.956 ± 0.081
0.618ValCys: 0.618 ± 0.019
4.14ValAsp: 4.14 ± 0.05
4.407ValGlu: 4.407 ± 0.057
2.945ValPhe: 2.945 ± 0.04
5.434ValGly: 5.434 ± 0.052
1.358ValHis: 1.358 ± 0.027
4.445ValIle: 4.445 ± 0.051
2.631ValLys: 2.631 ± 0.04
7.19ValLeu: 7.19 ± 0.072
1.868ValMet: 1.868 ± 0.03
2.145ValAsn: 2.145 ± 0.061
3.436ValPro: 3.436 ± 0.044
2.002ValGln: 2.002 ± 0.031
4.529ValArg: 4.529 ± 0.055
5.003ValSer: 5.003 ± 0.057
4.596ValThr: 4.596 ± 0.095
5.96ValVal: 5.96 ± 0.067
0.837ValTrp: 0.837 ± 0.023
1.568ValTyr: 1.568 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.171TrpAla: 1.171 ± 0.029
0.138TrpCys: 0.138 ± 0.008
0.632TrpAsp: 0.632 ± 0.018
0.537TrpGlu: 0.537 ± 0.017
0.537TrpPhe: 0.537 ± 0.017
0.824TrpGly: 0.824 ± 0.024
0.32TrpHis: 0.32 ± 0.014
0.695TrpIle: 0.695 ± 0.021
0.533TrpLys: 0.533 ± 0.017
1.536TrpLeu: 1.536 ± 0.031
0.357TrpMet: 0.357 ± 0.013
0.483TrpAsn: 0.483 ± 0.014
0.637TrpPro: 0.637 ± 0.02
0.534TrpGln: 0.534 ± 0.02
0.973TrpArg: 0.973 ± 0.026
0.849TrpSer: 0.849 ± 0.023
0.749TrpThr: 0.749 ± 0.022
0.77TrpVal: 0.77 ± 0.021
0.211TrpTrp: 0.211 ± 0.011
0.285TrpTyr: 0.285 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.449TyrAla: 2.449 ± 0.035
0.246TyrCys: 0.246 ± 0.012
1.454TyrAsp: 1.454 ± 0.031
1.286TyrGlu: 1.286 ± 0.029
0.999TyrPhe: 0.999 ± 0.023
2.118TyrGly: 2.118 ± 0.038
0.494TyrHis: 0.494 ± 0.018
1.076TyrIle: 1.076 ± 0.023
0.727TyrLys: 0.727 ± 0.02
2.316TyrLeu: 2.316 ± 0.039
0.49TyrMet: 0.49 ± 0.016
0.66TyrAsn: 0.66 ± 0.02
1.122TyrPro: 1.122 ± 0.026
0.779TyrGln: 0.779 ± 0.02
1.73TyrArg: 1.73 ± 0.031
1.358TyrSer: 1.358 ± 0.028
1.182TyrThr: 1.182 ± 0.039
1.695TyrVal: 1.695 ± 0.031
0.367TyrTrp: 0.367 ± 0.015
0.641TyrTyr: 0.641 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6373 proteins (1901876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski