Amino acid dipepetide frequency for Mycoplasma gallinarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.979AlaAla: 2.979 ± 0.144
0.258AlaCys: 0.258 ± 0.035
2.523AlaAsp: 2.523 ± 0.18
3.357AlaGlu: 3.357 ± 0.14
2.837AlaPhe: 2.837 ± 0.141
2.678AlaGly: 2.678 ± 0.142
0.718AlaHis: 0.718 ± 0.062
5.395AlaIle: 5.395 ± 0.174
6.259AlaLys: 6.259 ± 0.231
5.653AlaLeu: 5.653 ± 0.172
1.092AlaMet: 1.092 ± 0.074
4.514AlaAsn: 4.514 ± 0.185
1.277AlaPro: 1.277 ± 0.086
2.175AlaGln: 2.175 ± 0.117
1.861AlaArg: 1.861 ± 0.118
3.267AlaSer: 3.267 ± 0.165
3.332AlaThr: 3.332 ± 0.237
2.584AlaVal: 2.584 ± 0.115
0.387AlaTrp: 0.387 ± 0.045
2.274AlaTyr: 2.274 ± 0.093
0.0AlaXaa: 0.0 ± 0.0
Cys
0.258CysAla: 0.258 ± 0.034
0.026CysCys: 0.026 ± 0.009
0.215CysAsp: 0.215 ± 0.035
0.206CysGlu: 0.206 ± 0.033
0.262CysPhe: 0.262 ± 0.035
0.275CysGly: 0.275 ± 0.04
0.103CysHis: 0.103 ± 0.025
0.288CysIle: 0.288 ± 0.035
0.267CysLys: 0.267 ± 0.033
0.447CysLeu: 0.447 ± 0.052
0.047CysMet: 0.047 ± 0.013
0.279CysAsn: 0.279 ± 0.038
0.142CysPro: 0.142 ± 0.023
0.146CysGln: 0.146 ± 0.026
0.15CysArg: 0.15 ± 0.025
0.275CysSer: 0.275 ± 0.04
0.138CysThr: 0.138 ± 0.026
0.168CysVal: 0.168 ± 0.025
0.052CysTrp: 0.052 ± 0.014
0.159CysTyr: 0.159 ± 0.031
0.0CysXaa: 0.0 ± 0.0
Asp
3.005AspAla: 3.005 ± 0.177
0.129AspCys: 0.129 ± 0.027
2.476AspAsp: 2.476 ± 0.131
4.428AspGlu: 4.428 ± 0.138
3.577AspPhe: 3.577 ± 0.146
2.472AspGly: 2.472 ± 0.116
0.537AspHis: 0.537 ± 0.048
3.951AspIle: 3.951 ± 0.151
4.896AspLys: 4.896 ± 0.184
6.483AspLeu: 6.483 ± 0.204
0.666AspMet: 0.666 ± 0.064
4.045AspAsn: 4.045 ± 0.218
1.427AspPro: 1.427 ± 0.088
1.737AspGln: 1.737 ± 0.158
1.419AspArg: 1.419 ± 0.092
3.34AspSer: 3.34 ± 0.117
2.141AspThr: 2.141 ± 0.113
2.635AspVal: 2.635 ± 0.116
0.555AspTrp: 0.555 ± 0.052
2.876AspTyr: 2.876 ± 0.115
0.0AspXaa: 0.0 ± 0.0
Glu
3.916GluAla: 3.916 ± 0.177
0.181GluCys: 0.181 ± 0.03
2.618GluAsp: 2.618 ± 0.113
5.107GluGlu: 5.107 ± 0.191
3.71GluPhe: 3.71 ± 0.136
2.296GluGly: 2.296 ± 0.12
0.731GluHis: 0.731 ± 0.061
8.542GluIle: 8.542 ± 0.22
7.373GluLys: 7.373 ± 0.232
7.609GluLeu: 7.609 ± 0.189
1.406GluMet: 1.406 ± 0.088
7.046GluAsn: 7.046 ± 0.189
1.285GluPro: 1.285 ± 0.08
2.691GluGln: 2.691 ± 0.126
1.879GluArg: 1.879 ± 0.102
3.125GluSer: 3.125 ± 0.121
3.852GluThr: 3.852 ± 0.132
3.465GluVal: 3.465 ± 0.128
0.666GluTrp: 0.666 ± 0.052
2.906GluTyr: 2.906 ± 0.12
0.0GluXaa: 0.0 ± 0.0
Phe
3.271PheAla: 3.271 ± 0.129
0.301PheCys: 0.301 ± 0.04
3.749PheAsp: 3.749 ± 0.162
3.34PheGlu: 3.34 ± 0.162
2.799PhePhe: 2.799 ± 0.174
2.73PheGly: 2.73 ± 0.124
0.516PheHis: 0.516 ± 0.051
4.914PheIle: 4.914 ± 0.259
5.09PheLys: 5.09 ± 0.149
5.15PheLeu: 5.15 ± 0.25
0.83PheMet: 0.83 ± 0.055
4.841PheAsn: 4.841 ± 0.193
1.311PhePro: 1.311 ± 0.082
1.371PheGln: 1.371 ± 0.077
1.328PheArg: 1.328 ± 0.071
3.637PheSer: 3.637 ± 0.155
2.682PheThr: 2.682 ± 0.108
3.082PheVal: 3.082 ± 0.106
0.649PheTrp: 0.649 ± 0.055
2.287PheTyr: 2.287 ± 0.123
0.0PheXaa: 0.0 ± 0.0
Gly
2.597GlyAla: 2.597 ± 0.122
0.228GlyCys: 0.228 ± 0.039
2.205GlyAsp: 2.205 ± 0.124
2.485GlyGlu: 2.485 ± 0.121
2.661GlyPhe: 2.661 ± 0.124
2.554GlyGly: 2.554 ± 0.159
0.752GlyHis: 0.752 ± 0.066
4.398GlyIle: 4.398 ± 0.176
3.878GlyLys: 3.878 ± 0.16
4.2GlyLeu: 4.2 ± 0.151
0.946GlyMet: 0.946 ± 0.076
2.682GlyAsn: 2.682 ± 0.117
0.92GlyPro: 0.92 ± 0.075
1.677GlyGln: 1.677 ± 0.082
1.384GlyArg: 1.384 ± 0.089
2.799GlySer: 2.799 ± 0.108
2.657GlyThr: 2.657 ± 0.107
2.399GlyVal: 2.399 ± 0.134
0.469GlyTrp: 0.469 ± 0.051
2.094GlyTyr: 2.094 ± 0.102
0.0GlyXaa: 0.0 ± 0.0
His
0.705HisAla: 0.705 ± 0.068
0.064HisCys: 0.064 ± 0.018
0.546HisAsp: 0.546 ± 0.048
0.825HisGlu: 0.825 ± 0.066
0.804HisPhe: 0.804 ± 0.068
0.645HisGly: 0.645 ± 0.061
0.31HisHis: 0.31 ± 0.039
1.075HisIle: 1.075 ± 0.084
1.126HisLys: 1.126 ± 0.081
1.41HisLeu: 1.41 ± 0.069
0.206HisMet: 0.206 ± 0.03
1.032HisAsn: 1.032 ± 0.078
0.524HisPro: 0.524 ± 0.058
0.469HisGln: 0.469 ± 0.047
0.387HisArg: 0.387 ± 0.049
0.886HisSer: 0.886 ± 0.063
0.494HisThr: 0.494 ± 0.049
0.451HisVal: 0.451 ± 0.046
0.12HisTrp: 0.12 ± 0.022
0.58HisTyr: 0.58 ± 0.051
0.0HisXaa: 0.0 ± 0.0
Ile
5.558IleAla: 5.558 ± 0.183
0.507IleCys: 0.507 ± 0.054
5.683IleAsp: 5.683 ± 0.157
6.637IleGlu: 6.637 ± 0.172
5.133IlePhe: 5.133 ± 0.24
4.221IleGly: 4.221 ± 0.211
1.07IleHis: 1.07 ± 0.077
7.781IleIle: 7.781 ± 0.299
9.277IleLys: 9.277 ± 0.23
8.542IleLeu: 8.542 ± 0.342
1.298IleMet: 1.298 ± 0.1
9.049IleAsn: 9.049 ± 0.29
2.85IlePro: 2.85 ± 0.157
3.121IleGln: 3.121 ± 0.137
2.386IleArg: 2.386 ± 0.132
6.418IleSer: 6.418 ± 0.168
4.798IleThr: 4.798 ± 0.179
5.09IleVal: 5.09 ± 0.165
0.769IleTrp: 0.769 ± 0.06
3.878IleTyr: 3.878 ± 0.151
0.0IleXaa: 0.0 ± 0.0
Lys
4.948LysAla: 4.948 ± 0.225
0.284LysCys: 0.284 ± 0.034
4.69LysAsp: 4.69 ± 0.174
8.099LysGlu: 8.099 ± 0.215
4.415LysPhe: 4.415 ± 0.159
3.357LysGly: 3.357 ± 0.157
1.195LysHis: 1.195 ± 0.096
9.943LysIle: 9.943 ± 0.341
9.049LysLys: 9.049 ± 0.283
9.32LysLeu: 9.32 ± 0.22
2.386LysMet: 2.386 ± 0.123
10.201LysAsn: 10.201 ± 0.278
2.386LysPro: 2.386 ± 0.09
3.547LysGln: 3.547 ± 0.161
2.73LysArg: 2.73 ± 0.122
5.369LysSer: 5.369 ± 0.176
5.584LysThr: 5.584 ± 0.219
4.785LysVal: 4.785 ± 0.167
1.053LysTrp: 1.053 ± 0.07
4.669LysTyr: 4.669 ± 0.144
0.0LysXaa: 0.0 ± 0.0
Leu
5.765LeuAla: 5.765 ± 0.177
0.395LeuCys: 0.395 ± 0.044
5.782LeuAsp: 5.782 ± 0.189
6.487LeuGlu: 6.487 ± 0.202
4.935LeuPhe: 4.935 ± 0.233
4.166LeuGly: 4.166 ± 0.171
1.144LeuHis: 1.144 ± 0.079
10.644LeuIle: 10.644 ± 0.298
10.33LeuLys: 10.33 ± 0.257
8.464LeuLeu: 8.464 ± 0.277
1.689LeuMet: 1.689 ± 0.094
10.494LeuAsn: 10.494 ± 0.346
2.876LeuPro: 2.876 ± 0.113
2.695LeuGln: 2.695 ± 0.129
2.627LeuArg: 2.627 ± 0.105
6.981LeuSer: 6.981 ± 0.192
5.705LeuThr: 5.705 ± 0.242
5.584LeuVal: 5.584 ± 0.179
0.838LeuTrp: 0.838 ± 0.05
2.975LeuTyr: 2.975 ± 0.154
0.0LeuXaa: 0.0 ± 0.0
Met
1.118MetAla: 1.118 ± 0.073
0.056MetCys: 0.056 ± 0.016
0.705MetAsp: 0.705 ± 0.061
0.937MetGlu: 0.937 ± 0.078
0.911MetPhe: 0.911 ± 0.072
0.748MetGly: 0.748 ± 0.052
0.365MetHis: 0.365 ± 0.036
1.505MetIle: 1.505 ± 0.099
1.81MetLys: 1.81 ± 0.103
1.664MetLeu: 1.664 ± 0.112
0.314MetMet: 0.314 ± 0.05
1.29MetAsn: 1.29 ± 0.084
0.782MetPro: 0.782 ± 0.071
0.722MetGln: 0.722 ± 0.056
0.486MetArg: 0.486 ± 0.051
1.221MetSer: 1.221 ± 0.088
0.86MetThr: 0.86 ± 0.072
0.731MetVal: 0.731 ± 0.065
0.133MetTrp: 0.133 ± 0.026
0.486MetTyr: 0.486 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
4.114AsnAla: 4.114 ± 0.312
0.301AsnCys: 0.301 ± 0.045
4.935AsnAsp: 4.935 ± 0.261
7.05AsnGlu: 7.05 ± 0.217
5.24AsnPhe: 5.24 ± 0.21
3.663AsnGly: 3.663 ± 0.139
1.169AsnHis: 1.169 ± 0.078
6.818AsnIle: 6.818 ± 0.227
8.912AsnLys: 8.912 ± 0.247
10.61AsnLeu: 10.61 ± 0.337
1.229AsnMet: 1.229 ± 0.087
8.43AsnAsn: 8.43 ± 0.426
2.915AsnPro: 2.915 ± 0.116
4.419AsnGln: 4.419 ± 0.261
2.111AsnArg: 2.111 ± 0.094
5.709AsnSer: 5.709 ± 0.256
3.525AsnThr: 3.525 ± 0.206
4.114AsnVal: 4.114 ± 0.151
1.122AsnTrp: 1.122 ± 0.08
4.118AsnTyr: 4.118 ± 0.15
0.0AsnXaa: 0.0 ± 0.0
Pro
1.32ProAla: 1.32 ± 0.088
0.095ProCys: 0.095 ± 0.021
1.328ProAsp: 1.328 ± 0.075
2.038ProGlu: 2.038 ± 0.116
1.363ProPhe: 1.363 ± 0.099
1.208ProGly: 1.208 ± 0.08
0.473ProHis: 0.473 ± 0.047
2.627ProIle: 2.627 ± 0.131
2.39ProLys: 2.39 ± 0.111
2.433ProLeu: 2.433 ± 0.117
0.451ProMet: 0.451 ± 0.048
2.425ProAsn: 2.425 ± 0.104
0.451ProPro: 0.451 ± 0.039
0.795ProGln: 0.795 ± 0.058
0.675ProArg: 0.675 ± 0.059
1.775ProSer: 1.775 ± 0.099
1.591ProThr: 1.591 ± 0.102
1.603ProVal: 1.603 ± 0.098
0.245ProTrp: 0.245 ± 0.033
1.204ProTyr: 1.204 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
2.137GlnAla: 2.137 ± 0.166
0.086GlnCys: 0.086 ± 0.02
1.483GlnAsp: 1.483 ± 0.115
2.579GlnGlu: 2.579 ± 0.116
1.767GlnPhe: 1.767 ± 0.08
1.182GlnGly: 1.182 ± 0.069
0.383GlnHis: 0.383 ± 0.04
4.062GlnIle: 4.062 ± 0.148
4.093GlnLys: 4.093 ± 0.148
3.19GlnLeu: 3.19 ± 0.129
0.679GlnMet: 0.679 ± 0.053
4.015GlnAsn: 4.015 ± 0.229
0.812GlnPro: 0.812 ± 0.072
1.101GlnGln: 1.101 ± 0.074
1.165GlnArg: 1.165 ± 0.092
1.853GlnSer: 1.853 ± 0.12
1.909GlnThr: 1.909 ± 0.1
1.642GlnVal: 1.642 ± 0.098
0.318GlnTrp: 0.318 ± 0.032
1.5GlnTyr: 1.5 ± 0.088
0.0GlnXaa: 0.0 ± 0.0
Arg
1.526ArgAla: 1.526 ± 0.08
0.107ArgCys: 0.107 ± 0.024
1.651ArgAsp: 1.651 ± 0.08
2.081ArgGlu: 2.081 ± 0.103
1.251ArgPhe: 1.251 ± 0.079
1.268ArgGly: 1.268 ± 0.083
0.378ArgHis: 0.378 ± 0.042
2.536ArgIle: 2.536 ± 0.133
2.661ArgLys: 2.661 ± 0.138
2.842ArgLeu: 2.842 ± 0.153
0.585ArgMet: 0.585 ± 0.057
2.218ArgAsn: 2.218 ± 0.099
0.795ArgPro: 0.795 ± 0.068
1.015ArgGln: 1.015 ± 0.071
0.972ArgArg: 0.972 ± 0.081
1.444ArgSer: 1.444 ± 0.092
1.29ArgThr: 1.29 ± 0.078
1.565ArgVal: 1.565 ± 0.091
0.245ArgTrp: 0.245 ± 0.035
1.139ArgTyr: 1.139 ± 0.078
0.0ArgXaa: 0.0 ± 0.0
Ser
3.104SerAla: 3.104 ± 0.176
0.267SerCys: 0.267 ± 0.038
3.254SerAsp: 3.254 ± 0.187
4.166SerGlu: 4.166 ± 0.148
3.59SerPhe: 3.59 ± 0.149
3.065SerGly: 3.065 ± 0.127
0.83SerHis: 0.83 ± 0.064
5.666SerIle: 5.666 ± 0.182
5.778SerLys: 5.778 ± 0.157
6.702SerLeu: 6.702 ± 0.187
0.83SerMet: 0.83 ± 0.064
5.0SerAsn: 5.0 ± 0.186
1.552SerPro: 1.552 ± 0.08
2.674SerGln: 2.674 ± 0.161
1.651SerArg: 1.651 ± 0.083
3.998SerSer: 3.998 ± 0.173
3.486SerThr: 3.486 ± 0.22
3.048SerVal: 3.048 ± 0.126
0.684SerTrp: 0.684 ± 0.06
2.64SerTyr: 2.64 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
2.511ThrAla: 2.511 ± 0.144
0.172ThrCys: 0.172 ± 0.033
2.597ThrAsp: 2.597 ± 0.153
3.293ThrGlu: 3.293 ± 0.151
2.923ThrPhe: 2.923 ± 0.108
2.661ThrGly: 2.661 ± 0.126
0.645ThrHis: 0.645 ± 0.056
4.957ThrIle: 4.957 ± 0.164
5.498ThrLys: 5.498 ± 0.192
5.262ThrLeu: 5.262 ± 0.203
0.662ThrMet: 0.662 ± 0.059
4.841ThrAsn: 4.841 ± 0.322
1.397ThrPro: 1.397 ± 0.082
1.642ThrGln: 1.642 ± 0.13
1.462ThrArg: 1.462 ± 0.074
3.216ThrSer: 3.216 ± 0.206
2.906ThrThr: 2.906 ± 0.212
2.463ThrVal: 2.463 ± 0.108
0.469ThrTrp: 0.469 ± 0.045
2.214ThrTyr: 2.214 ± 0.108
0.0ThrXaa: 0.0 ± 0.0
Val
3.688ValAla: 3.688 ± 0.133
0.215ValCys: 0.215 ± 0.034
3.091ValAsp: 3.091 ± 0.12
3.542ValGlu: 3.542 ± 0.149
2.566ValPhe: 2.566 ± 0.129
2.347ValGly: 2.347 ± 0.135
0.662ValHis: 0.662 ± 0.057
4.767ValIle: 4.767 ± 0.178
4.514ValLys: 4.514 ± 0.144
4.931ValLeu: 4.931 ± 0.18
0.825ValMet: 0.825 ± 0.063
4.179ValAsn: 4.179 ± 0.158
1.397ValPro: 1.397 ± 0.097
1.694ValGln: 1.694 ± 0.089
1.324ValArg: 1.324 ± 0.084
3.375ValSer: 3.375 ± 0.129
2.45ValThr: 2.45 ± 0.15
3.138ValVal: 3.138 ± 0.121
0.447ValTrp: 0.447 ± 0.046
1.93ValTyr: 1.93 ± 0.092
0.0ValXaa: 0.0 ± 0.0
Trp
0.486TrpAla: 0.486 ± 0.044
0.026TrpCys: 0.026 ± 0.009
0.524TrpAsp: 0.524 ± 0.054
0.606TrpGlu: 0.606 ± 0.064
0.576TrpPhe: 0.576 ± 0.058
0.408TrpGly: 0.408 ± 0.044
0.095TrpHis: 0.095 ± 0.021
1.139TrpIle: 1.139 ± 0.075
0.92TrpLys: 0.92 ± 0.077
0.929TrpLeu: 0.929 ± 0.06
0.193TrpMet: 0.193 ± 0.031
0.963TrpAsn: 0.963 ± 0.061
0.215TrpPro: 0.215 ± 0.036
0.292TrpGln: 0.292 ± 0.032
0.331TrpArg: 0.331 ± 0.035
0.537TrpSer: 0.537 ± 0.053
0.628TrpThr: 0.628 ± 0.058
0.456TrpVal: 0.456 ± 0.048
0.116TrpTrp: 0.116 ± 0.022
0.464TrpTyr: 0.464 ± 0.053
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.416TyrAla: 2.416 ± 0.11
0.206TyrCys: 0.206 ± 0.028
2.738TyrAsp: 2.738 ± 0.129
3.138TyrGlu: 3.138 ± 0.126
2.558TyrPhe: 2.558 ± 0.136
2.038TyrGly: 2.038 ± 0.112
0.585TyrHis: 0.585 ± 0.048
3.061TyrIle: 3.061 ± 0.125
3.89TyrLys: 3.89 ± 0.149
4.742TyrLeu: 4.742 ± 0.177
0.503TyrMet: 0.503 ± 0.053
2.962TyrAsn: 2.962 ± 0.141
1.174TyrPro: 1.174 ± 0.075
1.973TyrGln: 1.973 ± 0.095
1.242TyrArg: 1.242 ± 0.068
2.756TyrSer: 2.756 ± 0.127
1.763TyrThr: 1.763 ± 0.107
2.081TyrVal: 2.081 ± 0.095
0.567TyrTrp: 0.567 ± 0.051
1.793TyrTyr: 1.793 ± 0.109
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 601 proteins (232620 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski