Amino acid dipepetide frequency for Dokdonia sinensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.491AlaAla: 4.491 ± 0.096
0.587AlaCys: 0.587 ± 0.026
3.835AlaAsp: 3.835 ± 0.087
4.084AlaGlu: 4.084 ± 0.074
3.841AlaPhe: 3.841 ± 0.061
5.006AlaGly: 5.006 ± 0.086
1.262AlaHis: 1.262 ± 0.035
5.676AlaIle: 5.676 ± 0.076
4.556AlaLys: 4.556 ± 0.082
6.898AlaLeu: 6.898 ± 0.079
1.75AlaMet: 1.75 ± 0.044
3.186AlaAsn: 3.186 ± 0.068
2.333AlaPro: 2.333 ± 0.051
3.482AlaGln: 3.482 ± 0.052
2.619AlaArg: 2.619 ± 0.054
4.634AlaSer: 4.634 ± 0.073
4.871AlaThr: 4.871 ± 0.101
4.753AlaVal: 4.753 ± 0.075
0.629AlaTrp: 0.629 ± 0.026
2.559AlaTyr: 2.559 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.548CysAla: 0.548 ± 0.024
0.095CysCys: 0.095 ± 0.01
0.614CysAsp: 0.614 ± 0.078
0.445CysGlu: 0.445 ± 0.026
0.321CysPhe: 0.321 ± 0.017
0.636CysGly: 0.636 ± 0.029
0.158CysHis: 0.158 ± 0.014
0.491CysIle: 0.491 ± 0.024
0.408CysLys: 0.408 ± 0.02
0.594CysLeu: 0.594 ± 0.025
0.126CysMet: 0.126 ± 0.013
0.371CysAsn: 0.371 ± 0.018
0.321CysPro: 0.321 ± 0.018
0.207CysGln: 0.207 ± 0.018
0.18CysArg: 0.18 ± 0.014
0.514CysSer: 0.514 ± 0.026
0.43CysThr: 0.43 ± 0.025
0.452CysVal: 0.452 ± 0.02
0.063CysTrp: 0.063 ± 0.008
0.262CysTyr: 0.262 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
4.679AspAla: 4.679 ± 0.11
0.596AspCys: 0.596 ± 0.082
3.898AspAsp: 3.898 ± 0.098
4.037AspGlu: 4.037 ± 0.066
3.826AspPhe: 3.826 ± 0.07
4.955AspGly: 4.955 ± 0.144
0.981AspHis: 0.981 ± 0.033
4.612AspIle: 4.612 ± 0.074
3.677AspLys: 3.677 ± 0.062
5.388AspLeu: 5.388 ± 0.092
1.21AspMet: 1.21 ± 0.031
3.551AspAsn: 3.551 ± 0.102
2.146AspPro: 2.146 ± 0.073
1.638AspGln: 1.638 ± 0.04
2.259AspArg: 2.259 ± 0.052
3.232AspSer: 3.232 ± 0.067
3.517AspThr: 3.517 ± 0.089
4.098AspVal: 4.098 ± 0.084
0.787AspTrp: 0.787 ± 0.029
2.881AspTyr: 2.881 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
4.672GluAla: 4.672 ± 0.079
0.318GluCys: 0.318 ± 0.018
4.201GluAsp: 4.201 ± 0.082
4.875GluGlu: 4.875 ± 0.102
2.682GluPhe: 2.682 ± 0.048
4.029GluGly: 4.029 ± 0.061
1.216GluHis: 1.216 ± 0.04
5.159GluIle: 5.159 ± 0.065
5.038GluLys: 5.038 ± 0.093
5.683GluLeu: 5.683 ± 0.089
1.668GluMet: 1.668 ± 0.035
4.339GluAsn: 4.339 ± 0.074
1.724GluPro: 1.724 ± 0.04
2.409GluGln: 2.409 ± 0.05
2.976GluArg: 2.976 ± 0.064
3.431GluSer: 3.431 ± 0.06
3.942GluThr: 3.942 ± 0.069
4.612GluVal: 4.612 ± 0.074
0.605GluTrp: 0.605 ± 0.024
2.324GluTyr: 2.324 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.485PheAla: 3.485 ± 0.06
0.389PheCys: 0.389 ± 0.017
3.339PheAsp: 3.339 ± 0.065
3.432PheGlu: 3.432 ± 0.051
2.615PhePhe: 2.615 ± 0.056
3.587PheGly: 3.587 ± 0.074
0.749PheHis: 0.749 ± 0.026
3.535PheIle: 3.535 ± 0.069
3.373PheLys: 3.373 ± 0.067
4.507PheLeu: 4.507 ± 0.074
1.141PheMet: 1.141 ± 0.034
2.854PheAsn: 2.854 ± 0.066
1.813PhePro: 1.813 ± 0.04
1.618PheGln: 1.618 ± 0.04
1.736PheArg: 1.736 ± 0.037
3.425PheSer: 3.425 ± 0.066
3.381PheThr: 3.381 ± 0.062
3.014PheVal: 3.014 ± 0.059
0.597PheTrp: 0.597 ± 0.024
2.116PheTyr: 2.116 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
4.993GlyAla: 4.993 ± 0.088
0.575GlyCys: 0.575 ± 0.025
4.177GlyAsp: 4.177 ± 0.084
3.836GlyGlu: 3.836 ± 0.059
3.635GlyPhe: 3.635 ± 0.064
4.878GlyGly: 4.878 ± 0.096
1.161GlyHis: 1.161 ± 0.035
5.283GlyIle: 5.283 ± 0.081
4.542GlyLys: 4.542 ± 0.073
6.001GlyLeu: 6.001 ± 0.087
1.806GlyMet: 1.806 ± 0.047
3.906GlyAsn: 3.906 ± 0.077
1.478GlyPro: 1.478 ± 0.04
2.119GlyGln: 2.119 ± 0.049
2.459GlyArg: 2.459 ± 0.061
4.1GlySer: 4.1 ± 0.086
4.762GlyThr: 4.762 ± 0.113
4.769GlyVal: 4.769 ± 0.08
0.781GlyTrp: 0.781 ± 0.022
2.753GlyTyr: 2.753 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
0.89HisAla: 0.89 ± 0.028
0.183HisCys: 0.183 ± 0.013
0.789HisAsp: 0.789 ± 0.034
0.859HisGlu: 0.859 ± 0.029
1.11HisPhe: 1.11 ± 0.032
0.995HisGly: 0.995 ± 0.037
0.457HisHis: 0.457 ± 0.021
1.49HisIle: 1.49 ± 0.036
1.249HisLys: 1.249 ± 0.041
1.856HisLeu: 1.856 ± 0.046
0.273HisMet: 0.273 ± 0.017
0.899HisAsn: 0.899 ± 0.032
0.913HisPro: 0.913 ± 0.034
0.618HisGln: 0.618 ± 0.023
0.721HisArg: 0.721 ± 0.028
0.98HisSer: 0.98 ± 0.032
1.022HisThr: 1.022 ± 0.034
0.841HisVal: 0.841 ± 0.028
0.208HisTrp: 0.208 ± 0.015
0.814HisTyr: 0.814 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.142IleAla: 6.142 ± 0.088
0.547IleCys: 0.547 ± 0.024
4.89IleAsp: 4.89 ± 0.072
4.854IleGlu: 4.854 ± 0.08
3.503IlePhe: 3.503 ± 0.077
4.736IleGly: 4.736 ± 0.073
1.162IleHis: 1.162 ± 0.033
5.401IleIle: 5.401 ± 0.078
4.893IleLys: 4.893 ± 0.073
6.622IleLeu: 6.622 ± 0.111
1.27IleMet: 1.27 ± 0.038
3.942IleAsn: 3.942 ± 0.059
3.157IlePro: 3.157 ± 0.055
2.371IleGln: 2.371 ± 0.053
2.476IleArg: 2.476 ± 0.056
4.855IleSer: 4.855 ± 0.075
5.022IleThr: 5.022 ± 0.092
4.679IleVal: 4.679 ± 0.078
0.667IleTrp: 0.667 ± 0.027
2.581IleTyr: 2.581 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
5.072LysAla: 5.072 ± 0.09
0.28LysCys: 0.28 ± 0.017
3.932LysAsp: 3.932 ± 0.083
5.341LysGlu: 5.341 ± 0.102
2.483LysPhe: 2.483 ± 0.049
4.132LysGly: 4.132 ± 0.082
1.206LysHis: 1.206 ± 0.031
4.768LysIle: 4.768 ± 0.074
5.521LysLys: 5.521 ± 0.088
5.718LysLeu: 5.718 ± 0.087
1.912LysMet: 1.912 ± 0.051
4.034LysAsn: 4.034 ± 0.07
2.154LysPro: 2.154 ± 0.047
2.37LysGln: 2.37 ± 0.052
3.034LysArg: 3.034 ± 0.058
3.91LysSer: 3.91 ± 0.059
4.119LysThr: 4.119 ± 0.073
4.174LysVal: 4.174 ± 0.063
0.688LysTrp: 0.688 ± 0.027
2.541LysTyr: 2.541 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
6.105LeuAla: 6.105 ± 0.083
0.661LeuCys: 0.661 ± 0.028
5.564LeuAsp: 5.564 ± 0.09
6.239LeuGlu: 6.239 ± 0.087
4.567LeuPhe: 4.567 ± 0.088
6.119LeuGly: 6.119 ± 0.081
1.508LeuHis: 1.508 ± 0.041
6.412LeuIle: 6.412 ± 0.097
6.656LeuLys: 6.656 ± 0.104
8.572LeuLeu: 8.572 ± 0.127
2.042LeuMet: 2.042 ± 0.045
4.946LeuAsn: 4.946 ± 0.079
3.508LeuPro: 3.508 ± 0.055
3.147LeuGln: 3.147 ± 0.055
3.693LeuArg: 3.693 ± 0.067
6.571LeuSer: 6.571 ± 0.101
5.084LeuThr: 5.084 ± 0.067
5.443LeuVal: 5.443 ± 0.094
0.861LeuTrp: 0.861 ± 0.029
3.156LeuTyr: 3.156 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
1.65MetAla: 1.65 ± 0.041
0.152MetCys: 0.152 ± 0.012
1.311MetAsp: 1.311 ± 0.039
1.514MetGlu: 1.514 ± 0.044
0.756MetPhe: 0.756 ± 0.025
1.51MetGly: 1.51 ± 0.039
0.438MetHis: 0.438 ± 0.022
1.512MetIle: 1.512 ± 0.041
1.976MetLys: 1.976 ± 0.044
2.035MetLeu: 2.035 ± 0.05
0.639MetMet: 0.639 ± 0.023
1.147MetAsn: 1.147 ± 0.034
0.901MetPro: 0.901 ± 0.027
0.853MetGln: 0.853 ± 0.029
1.082MetArg: 1.082 ± 0.035
1.455MetSer: 1.455 ± 0.038
1.343MetThr: 1.343 ± 0.038
1.347MetVal: 1.347 ± 0.033
0.161MetTrp: 0.161 ± 0.012
0.725MetTyr: 0.725 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
4.015AsnAla: 4.015 ± 0.069
0.381AsnCys: 0.381 ± 0.026
3.651AsnAsp: 3.651 ± 0.116
3.381AsnGlu: 3.381 ± 0.058
2.683AsnPhe: 2.683 ± 0.064
4.201AsnGly: 4.201 ± 0.102
0.931AsnHis: 0.931 ± 0.03
3.974AsnIle: 3.974 ± 0.069
3.179AsnLys: 3.179 ± 0.055
4.837AsnLeu: 4.837 ± 0.078
1.116AsnMet: 1.116 ± 0.033
3.197AsnAsn: 3.197 ± 0.092
2.765AsnPro: 2.765 ± 0.061
1.817AsnGln: 1.817 ± 0.043
2.327AsnArg: 2.327 ± 0.044
3.055AsnSer: 3.055 ± 0.068
3.533AsnThr: 3.533 ± 0.064
3.56AsnVal: 3.56 ± 0.069
0.642AsnTrp: 0.642 ± 0.023
2.372AsnTyr: 2.372 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.309ProAla: 2.309 ± 0.048
0.206ProCys: 0.206 ± 0.015
2.523ProAsp: 2.523 ± 0.072
3.068ProGlu: 3.068 ± 0.066
1.989ProPhe: 1.989 ± 0.05
2.039ProGly: 2.039 ± 0.046
0.597ProHis: 0.597 ± 0.026
2.503ProIle: 2.503 ± 0.052
2.264ProLys: 2.264 ± 0.048
3.121ProLeu: 3.121 ± 0.054
0.761ProMet: 0.761 ± 0.029
2.025ProAsn: 2.025 ± 0.038
0.911ProPro: 0.911 ± 0.038
1.292ProGln: 1.292 ± 0.038
1.097ProArg: 1.097 ± 0.031
2.26ProSer: 2.26 ± 0.052
2.174ProThr: 2.174 ± 0.055
2.545ProVal: 2.545 ± 0.056
0.37ProTrp: 0.37 ± 0.018
1.398ProTyr: 1.398 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.333GlnAla: 2.333 ± 0.043
0.173GlnCys: 0.173 ± 0.012
2.069GlnAsp: 2.069 ± 0.055
2.774GlnGlu: 2.774 ± 0.061
1.693GlnPhe: 1.693 ± 0.04
2.192GlnGly: 2.192 ± 0.05
0.579GlnHis: 0.579 ± 0.021
2.392GlnIle: 2.392 ± 0.045
2.417GlnLys: 2.417 ± 0.052
3.488GlnLeu: 3.488 ± 0.066
0.912GlnMet: 0.912 ± 0.031
1.94GlnAsn: 1.94 ± 0.046
1.163GlnPro: 1.163 ± 0.034
1.367GlnGln: 1.367 ± 0.038
1.503GlnArg: 1.503 ± 0.038
2.044GlnSer: 2.044 ± 0.042
1.965GlnThr: 1.965 ± 0.042
2.162GlnVal: 2.162 ± 0.046
0.388GlnTrp: 0.388 ± 0.019
1.337GlnTyr: 1.337 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.53ArgAla: 2.53 ± 0.051
0.207ArgCys: 0.207 ± 0.012
2.357ArgAsp: 2.357 ± 0.044
2.682ArgGlu: 2.682 ± 0.058
2.236ArgPhe: 2.236 ± 0.047
2.259ArgGly: 2.259 ± 0.043
0.641ArgHis: 0.641 ± 0.023
2.967ArgIle: 2.967 ± 0.053
3.04ArgLys: 3.04 ± 0.06
3.617ArgLeu: 3.617 ± 0.061
1.012ArgMet: 1.012 ± 0.03
2.318ArgAsn: 2.318 ± 0.05
1.262ArgPro: 1.262 ± 0.039
1.249ArgGln: 1.249 ± 0.035
1.615ArgArg: 1.615 ± 0.043
2.201ArgSer: 2.201 ± 0.048
2.11ArgThr: 2.11 ± 0.042
2.456ArgVal: 2.456 ± 0.052
0.469ArgTrp: 0.469 ± 0.021
1.7ArgTyr: 1.7 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.075SerAla: 4.075 ± 0.064
0.605SerCys: 0.605 ± 0.03
3.658SerAsp: 3.658 ± 0.066
3.72SerGlu: 3.72 ± 0.076
3.464SerPhe: 3.464 ± 0.052
4.888SerGly: 4.888 ± 0.078
1.009SerHis: 1.009 ± 0.03
4.574SerIle: 4.574 ± 0.066
4.068SerLys: 4.068 ± 0.062
5.595SerLeu: 5.595 ± 0.086
1.216SerMet: 1.216 ± 0.034
3.297SerAsn: 3.297 ± 0.059
2.137SerPro: 2.137 ± 0.048
2.279SerGln: 2.279 ± 0.045
2.516SerArg: 2.516 ± 0.062
3.941SerSer: 3.941 ± 0.079
3.652SerThr: 3.652 ± 0.069
3.821SerVal: 3.821 ± 0.066
0.668SerTrp: 0.668 ± 0.03
2.582SerTyr: 2.582 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.781ThrAla: 4.781 ± 0.092
0.373ThrCys: 0.373 ± 0.029
3.871ThrAsp: 3.871 ± 0.105
3.717ThrGlu: 3.717 ± 0.064
3.298ThrPhe: 3.298 ± 0.062
4.295ThrGly: 4.295 ± 0.08
0.979ThrHis: 0.979 ± 0.03
5.04ThrIle: 5.04 ± 0.09
3.283ThrLys: 3.283 ± 0.071
5.957ThrLeu: 5.957 ± 0.076
1.166ThrMet: 1.166 ± 0.033
3.223ThrAsn: 3.223 ± 0.102
2.728ThrPro: 2.728 ± 0.071
2.075ThrGln: 2.075 ± 0.051
1.996ThrArg: 1.996 ± 0.044
3.966ThrSer: 3.966 ± 0.081
4.213ThrThr: 4.213 ± 0.09
4.487ThrVal: 4.487 ± 0.136
0.573ThrTrp: 0.573 ± 0.026
2.569ThrTyr: 2.569 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
5.024ValAla: 5.024 ± 0.076
0.498ValCys: 0.498 ± 0.023
3.989ValAsp: 3.989 ± 0.079
3.907ValGlu: 3.907 ± 0.063
3.162ValPhe: 3.162 ± 0.059
4.179ValGly: 4.179 ± 0.07
1.123ValHis: 1.123 ± 0.034
4.728ValIle: 4.728 ± 0.069
3.881ValLys: 3.881 ± 0.058
5.866ValLeu: 5.866 ± 0.084
1.465ValMet: 1.465 ± 0.035
3.41ValAsn: 3.41 ± 0.062
2.4ValPro: 2.4 ± 0.058
2.263ValGln: 2.263 ± 0.05
2.381ValArg: 2.381 ± 0.056
4.319ValSer: 4.319 ± 0.063
4.476ValThr: 4.476 ± 0.133
4.568ValVal: 4.568 ± 0.082
0.635ValTrp: 0.635 ± 0.027
2.38ValTyr: 2.38 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.6TrpAla: 0.6 ± 0.026
0.095TrpCys: 0.095 ± 0.009
0.633TrpAsp: 0.633 ± 0.025
0.688TrpGlu: 0.688 ± 0.025
0.53TrpPhe: 0.53 ± 0.019
0.696TrpGly: 0.696 ± 0.029
0.236TrpHis: 0.236 ± 0.016
0.705TrpIle: 0.705 ± 0.024
0.743TrpLys: 0.743 ± 0.03
0.991TrpLeu: 0.991 ± 0.035
0.319TrpMet: 0.319 ± 0.017
0.658TrpAsn: 0.658 ± 0.024
0.234TrpPro: 0.234 ± 0.016
0.413TrpGln: 0.413 ± 0.019
0.464TrpArg: 0.464 ± 0.022
0.627TrpSer: 0.627 ± 0.026
0.534TrpThr: 0.534 ± 0.024
0.637TrpVal: 0.637 ± 0.027
0.168TrpTrp: 0.168 ± 0.013
0.448TrpTyr: 0.448 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.659TyrAla: 2.659 ± 0.051
0.315TyrCys: 0.315 ± 0.017
2.667TyrAsp: 2.667 ± 0.052
2.449TyrGlu: 2.449 ± 0.051
2.312TyrPhe: 2.312 ± 0.055
2.684TyrGly: 2.684 ± 0.05
0.777TyrHis: 0.777 ± 0.032
2.548TyrIle: 2.548 ± 0.053
2.623TyrLys: 2.623 ± 0.056
3.509TyrLeu: 3.509 ± 0.065
0.702TyrMet: 0.702 ± 0.023
2.373TyrAsn: 2.373 ± 0.058
1.404TyrPro: 1.404 ± 0.036
1.305TyrGln: 1.305 ± 0.036
1.791TyrArg: 1.791 ± 0.044
2.245TyrSer: 2.245 ± 0.046
2.439TyrThr: 2.439 ± 0.067
2.237TyrVal: 2.237 ± 0.047
0.46TyrTrp: 0.46 ± 0.021
1.627TyrTyr: 1.627 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3191 proteins (1089628 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski