Amino acid dipepetide frequency for Halarchaeum acidiphilum MH1-52-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.61AlaAla: 15.61 ± 0.229	0.981AlaCys: 0.981 ± 0.045	11.181AlaAsp: 11.181 ± 0.173	8.787AlaGlu: 8.787 ± 0.152	4.435AlaPhe: 4.435 ± 0.086	10.161AlaGly: 10.161 ± 0.13	2.188AlaHis: 2.188 ± 0.057	4.483AlaIle: 4.483 ± 0.095	2.001AlaLys: 2.001 ± 0.057	12.468AlaLeu: 12.468 ± 0.204	2.207AlaMet: 2.207 ± 0.055	2.687AlaAsn: 2.687 ± 0.068	4.405AlaPro: 4.405 ± 0.085	2.008AlaGln: 2.008 ± 0.059	7.972AlaArg: 7.972 ± 0.15	6.622AlaSer: 6.622 ± 0.128	7.39AlaThr: 7.39 ± 0.137	11.443AlaVal: 11.443 ± 0.179	1.176AlaTrp: 1.176 ± 0.049	3.084AlaTyr: 3.084 ± 0.08	0.0AlaXaa: 0.0 ± 0.0
Cys	0.832CysAla: 0.832 ± 0.031	0.092CysCys: 0.092 ± 0.01	0.587CysAsp: 0.587 ± 0.031	0.661CysGlu: 0.661 ± 0.029	0.205CysPhe: 0.205 ± 0.019	0.953CysGly: 0.953 ± 0.041	0.176CysHis: 0.176 ± 0.018	0.268CysIle: 0.268 ± 0.019	0.106CysLys: 0.106 ± 0.012	0.595CysLeu: 0.595 ± 0.028	0.1CysMet: 0.1 ± 0.014	0.166CysAsn: 0.166 ± 0.016	0.532CysPro: 0.532 ± 0.031	0.139CysGln: 0.139 ± 0.016	0.525CysArg: 0.525 ± 0.025	0.419CysSer: 0.419 ± 0.024	0.47CysThr: 0.47 ± 0.027	0.611CysVal: 0.611 ± 0.03	0.1CysTrp: 0.1 ± 0.012	0.242CysTyr: 0.242 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	13.299AspAla: 13.299 ± 0.222	0.585AspCys: 0.585 ± 0.035	8.004AspAsp: 8.004 ± 0.143	7.852AspGlu: 7.852 ± 0.133	2.214AspPhe: 2.214 ± 0.065	7.795AspGly: 7.795 ± 0.148	1.677AspHis: 1.677 ± 0.049	2.666AspIle: 2.666 ± 0.073	0.716AspLys: 0.716 ± 0.034	7.828AspLeu: 7.828 ± 0.123	1.114AspMet: 1.114 ± 0.04	1.015AspAsn: 1.015 ± 0.041	4.412AspPro: 4.412 ± 0.082	1.288AspGln: 1.288 ± 0.043	5.492AspArg: 5.492 ± 0.087	2.809AspSer: 2.809 ± 0.072	3.923AspThr: 3.923 ± 0.077	9.942AspVal: 9.942 ± 0.131	0.905AspTrp: 0.905 ± 0.038	2.319AspTyr: 2.319 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	8.61GluAla: 8.61 ± 0.136	0.552GluCys: 0.552 ± 0.032	5.438GluAsp: 5.438 ± 0.117	6.516GluGlu: 6.516 ± 0.154	2.488GluPhe: 2.488 ± 0.072	5.378GluGly: 5.378 ± 0.098	2.264GluHis: 2.264 ± 0.063	3.379GluIle: 3.379 ± 0.082	1.761GluLys: 1.761 ± 0.055	6.321GluLeu: 6.321 ± 0.102	1.816GluMet: 1.816 ± 0.055	2.132GluAsn: 2.132 ± 0.054	3.174GluPro: 3.174 ± 0.074	1.997GluGln: 1.997 ± 0.063	9.503GluArg: 9.503 ± 0.134	4.7GluSer: 4.7 ± 0.085	6.603GluThr: 6.603 ± 0.116	5.089GluVal: 5.089 ± 0.097	0.992GluTrp: 0.992 ± 0.035	2.338GluTyr: 2.338 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.886PheAla: 3.886 ± 0.081	0.321PheCys: 0.321 ± 0.02	3.192PheAsp: 3.192 ± 0.072	2.802PheGlu: 2.802 ± 0.067	1.015PhePhe: 1.015 ± 0.041	3.103PheGly: 3.103 ± 0.068	0.626PheHis: 0.626 ± 0.03	0.795PheIle: 0.795 ± 0.037	0.445PheLys: 0.445 ± 0.027	2.76PheLeu: 2.76 ± 0.064	0.449PheMet: 0.449 ± 0.028	0.588PheAsn: 0.588 ± 0.035	1.275PhePro: 1.275 ± 0.048	0.595PheGln: 0.595 ± 0.028	1.787PheArg: 1.787 ± 0.055	1.589PheSer: 1.589 ± 0.048	1.68PheThr: 1.68 ± 0.049	3.319PheVal: 3.319 ± 0.079	0.345PheTrp: 0.345 ± 0.023	0.841PheTyr: 0.841 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.11GlyAla: 9.11 ± 0.148	0.661GlyCys: 0.661 ± 0.031	7.14GlyAsp: 7.14 ± 0.116	6.961GlyGlu: 6.961 ± 0.12	3.049GlyPhe: 3.049 ± 0.07	7.624GlyGly: 7.624 ± 0.145	1.874GlyHis: 1.874 ± 0.056	3.721GlyIle: 3.721 ± 0.086	1.806GlyLys: 1.806 ± 0.054	7.183GlyLeu: 7.183 ± 0.123	1.622GlyMet: 1.622 ± 0.049	1.834GlyAsn: 1.834 ± 0.06	3.335GlyPro: 3.335 ± 0.073	1.662GlyGln: 1.662 ± 0.053	5.731GlyArg: 5.731 ± 0.108	4.799GlySer: 4.799 ± 0.098	5.485GlyThr: 5.485 ± 0.104	8.42GlyVal: 8.42 ± 0.133	1.044GlyTrp: 1.044 ± 0.038	2.727GlyTyr: 2.727 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.547HisAla: 2.547 ± 0.071	0.185HisCys: 0.185 ± 0.015	1.959HisAsp: 1.959 ± 0.051	1.794HisGlu: 1.794 ± 0.051	0.582HisPhe: 0.582 ± 0.031	2.06HisGly: 2.06 ± 0.057	0.544HisHis: 0.544 ± 0.028	0.537HisIle: 0.537 ± 0.029	0.273HisLys: 0.273 ± 0.022	1.847HisLeu: 1.847 ± 0.056	0.284HisMet: 0.284 ± 0.02	0.42HisAsn: 0.42 ± 0.025	1.271HisPro: 1.271 ± 0.043	0.409HisGln: 0.409 ± 0.025	1.525HisArg: 1.525 ± 0.056	0.812HisSer: 0.812 ± 0.035	1.051HisThr: 1.051 ± 0.038	2.161HisVal: 2.161 ± 0.055	0.223HisTrp: 0.223 ± 0.017	0.624HisTyr: 0.624 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	4.525IleAla: 4.525 ± 0.103	0.203IleCys: 0.203 ± 0.016	3.604IleAsp: 3.604 ± 0.08	3.793IleGlu: 3.793 ± 0.095	0.644IlePhe: 0.644 ± 0.034	3.492IleGly: 3.492 ± 0.09	0.713IleHis: 0.713 ± 0.034	0.996IleIle: 0.996 ± 0.05	0.581IleLys: 0.581 ± 0.031	2.316IleLeu: 2.316 ± 0.07	0.415IleMet: 0.415 ± 0.028	0.717IleAsn: 0.717 ± 0.037	1.816IlePro: 1.816 ± 0.056	0.802IleGln: 0.802 ± 0.034	2.385IleArg: 2.385 ± 0.059	1.676IleSer: 1.676 ± 0.051	2.018IleThr: 2.018 ± 0.057	3.335IleVal: 3.335 ± 0.078	0.269IleTrp: 0.269 ± 0.019	0.727IleTyr: 0.727 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	1.691LysAla: 1.691 ± 0.055	0.144LysCys: 0.144 ± 0.014	0.996LysAsp: 0.996 ± 0.046	1.161LysGlu: 1.161 ± 0.048	0.505LysPhe: 0.505 ± 0.026	1.365LysGly: 1.365 ± 0.051	0.501LysHis: 0.501 ± 0.026	0.72LysIle: 0.72 ± 0.038	0.457LysLys: 0.457 ± 0.029	1.415LysLeu: 1.415 ± 0.049	0.332LysMet: 0.332 ± 0.022	0.511LysAsn: 0.511 ± 0.03	0.901LysPro: 0.901 ± 0.036	0.639LysGln: 0.639 ± 0.032	1.695LysArg: 1.695 ± 0.053	0.981LysSer: 0.981 ± 0.037	1.301LysThr: 1.301 ± 0.049	1.152LysVal: 1.152 ± 0.043	0.213LysTrp: 0.213 ± 0.016	0.584LysTyr: 0.584 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.231LeuAla: 12.231 ± 0.198	0.81LeuCys: 0.81 ± 0.032	8.729LeuAsp: 8.729 ± 0.147	5.725LeuGlu: 5.725 ± 0.115	2.692LeuPhe: 2.692 ± 0.08	7.869LeuGly: 7.869 ± 0.133	1.702LeuHis: 1.702 ± 0.052	2.426LeuIle: 2.426 ± 0.062	1.474LeuLys: 1.474 ± 0.045	8.239LeuLeu: 8.239 ± 0.172	1.203LeuMet: 1.203 ± 0.042	1.817LeuAsn: 1.817 ± 0.056	4.206LeuPro: 4.206 ± 0.075	1.732LeuGln: 1.732 ± 0.058	6.107LeuArg: 6.107 ± 0.11	4.673LeuSer: 4.673 ± 0.09	5.133LeuThr: 5.133 ± 0.082	8.935LeuVal: 8.935 ± 0.151	0.764LeuTrp: 0.764 ± 0.038	2.074LeuTyr: 2.074 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	1.904MetAla: 1.904 ± 0.051	0.14MetCys: 0.14 ± 0.014	1.236MetAsp: 1.236 ± 0.038	1.059MetGlu: 1.059 ± 0.041	0.453MetPhe: 0.453 ± 0.026	1.435MetGly: 1.435 ± 0.043	0.35MetHis: 0.35 ± 0.021	0.512MetIle: 0.512 ± 0.028	0.397MetLys: 0.397 ± 0.023	1.39MetLeu: 1.39 ± 0.049	0.294MetMet: 0.294 ± 0.022	0.512MetAsn: 0.512 ± 0.026	0.871MetPro: 0.871 ± 0.034	0.452MetGln: 0.452 ± 0.026	1.266MetArg: 1.266 ± 0.043	1.448MetSer: 1.448 ± 0.044	1.389MetThr: 1.389 ± 0.044	1.144MetVal: 1.144 ± 0.043	0.161MetTrp: 0.161 ± 0.014	0.383MetTyr: 0.383 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.097AsnAla: 3.097 ± 0.087	0.199AsnCys: 0.199 ± 0.016	1.679AsnAsp: 1.679 ± 0.053	1.608AsnGlu: 1.608 ± 0.053	0.576AsnPhe: 0.576 ± 0.031	1.886AsnGly: 1.886 ± 0.062	0.473AsnHis: 0.473 ± 0.024	0.669AsnIle: 0.669 ± 0.03	0.385AsnLys: 0.385 ± 0.026	1.701AsnLeu: 1.701 ± 0.053	0.363AsnMet: 0.363 ± 0.021	0.444AsnAsn: 0.444 ± 0.025	1.356AsnPro: 1.356 ± 0.041	0.478AsnGln: 0.478 ± 0.028	1.492AsnArg: 1.492 ± 0.051	0.848AsnSer: 0.848 ± 0.037	1.21AsnThr: 1.21 ± 0.043	2.269AsnVal: 2.269 ± 0.055	0.269AsnTrp: 0.269 ± 0.023	0.596AsnTyr: 0.596 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	5.049ProAla: 5.049 ± 0.096	0.264ProCys: 0.264 ± 0.019	4.63ProAsp: 4.63 ± 0.09	4.173ProGlu: 4.173 ± 0.078	1.571ProPhe: 1.571 ± 0.053	3.597ProGly: 3.597 ± 0.073	0.979ProHis: 0.979 ± 0.035	1.863ProIle: 1.863 ± 0.055	0.786ProLys: 0.786 ± 0.034	3.787ProLeu: 3.787 ± 0.086	0.812ProMet: 0.812 ± 0.032	1.084ProAsn: 1.084 ± 0.042	2.047ProPro: 2.047 ± 0.062	0.772ProGln: 0.772 ± 0.036	2.871ProArg: 2.871 ± 0.081	2.685ProSer: 2.685 ± 0.066	3.074ProThr: 3.074 ± 0.066	4.157ProVal: 4.157 ± 0.081	0.508ProTrp: 0.508 ± 0.027	1.125ProTyr: 1.125 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	1.97GlnAla: 1.97 ± 0.058	0.144GlnCys: 0.144 ± 0.014	1.15GlnAsp: 1.15 ± 0.041	1.315GlnGlu: 1.315 ± 0.051	0.795GlnPhe: 0.795 ± 0.036	1.349GlnGly: 1.349 ± 0.048	0.507GlnHis: 0.507 ± 0.026	0.871GlnIle: 0.871 ± 0.04	0.547GlnLys: 0.547 ± 0.034	1.867GlnLeu: 1.867 ± 0.056	0.434GlnMet: 0.434 ± 0.024	0.635GlnAsn: 0.635 ± 0.029	0.926GlnPro: 0.926 ± 0.032	0.779GlnGln: 0.779 ± 0.041	1.685GlnArg: 1.685 ± 0.052	1.309GlnSer: 1.309 ± 0.052	1.363GlnThr: 1.363 ± 0.046	1.515GlnVal: 1.515 ± 0.054	0.304GlnTrp: 0.304 ± 0.021	0.794GlnTyr: 0.794 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	8.145ArgAla: 8.145 ± 0.136	0.624ArgCys: 0.624 ± 0.036	6.619ArgAsp: 6.619 ± 0.106	7.335ArgGlu: 7.335 ± 0.133	2.233ArgPhe: 2.233 ± 0.051	5.585ArgGly: 5.585 ± 0.11	1.463ArgHis: 1.463 ± 0.046	2.625ArgIle: 2.625 ± 0.067	1.264ArgLys: 1.264 ± 0.048	6.323ArgLeu: 6.323 ± 0.106	1.33ArgMet: 1.33 ± 0.04	1.489ArgAsn: 1.489 ± 0.05	3.047ArgPro: 3.047 ± 0.08	1.444ArgGln: 1.444 ± 0.045	6.154ArgArg: 6.154 ± 0.188	3.802ArgSer: 3.802 ± 0.093	4.284ArgThr: 4.284 ± 0.073	6.457ArgVal: 6.457 ± 0.108	0.813ArgTrp: 0.813 ± 0.037	2.136ArgTyr: 2.136 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	5.629SerAla: 5.629 ± 0.097	0.317SerCys: 0.317 ± 0.023	4.051SerAsp: 4.051 ± 0.075	3.916SerGlu: 3.916 ± 0.078	1.783SerPhe: 1.783 ± 0.05	5.191SerGly: 5.191 ± 0.093	1.015SerHis: 1.015 ± 0.039	2.041SerIle: 2.041 ± 0.061	1.108SerLys: 1.108 ± 0.042	4.603SerLeu: 4.603 ± 0.102	1.07SerMet: 1.07 ± 0.038	1.225SerAsn: 1.225 ± 0.046	2.471SerPro: 2.471 ± 0.062	1.122SerGln: 1.122 ± 0.05	3.497SerArg: 3.497 ± 0.071	3.023SerSer: 3.023 ± 0.085	3.402SerThr: 3.402 ± 0.089	4.802SerVal: 4.802 ± 0.084	0.543SerTrp: 0.543 ± 0.031	1.315SerTyr: 1.315 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	6.834ThrAla: 6.834 ± 0.101	0.408ThrCys: 0.408 ± 0.025	5.074ThrAsp: 5.074 ± 0.098	4.305ThrGlu: 4.305 ± 0.075	2.037ThrPhe: 2.037 ± 0.056	5.724ThrGly: 5.724 ± 0.09	1.317ThrHis: 1.317 ± 0.043	2.496ThrIle: 2.496 ± 0.065	1.06ThrLys: 1.06 ± 0.042	5.795ThrLeu: 5.795 ± 0.099	1.054ThrMet: 1.054 ± 0.039	1.468ThrAsn: 1.468 ± 0.06	3.536ThrPro: 3.536 ± 0.075	1.17ThrGln: 1.17 ± 0.041	3.935ThrArg: 3.935 ± 0.075	3.25ThrSer: 3.25 ± 0.075	4.235ThrThr: 4.235 ± 0.092	6.603ThrVal: 6.603 ± 0.104	0.651ThrTrp: 0.651 ± 0.035	1.827ThrTyr: 1.827 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	12.074ValAla: 12.074 ± 0.188	0.808ValCys: 0.808 ± 0.036	7.148ValAsp: 7.148 ± 0.106	8.24ValGlu: 8.24 ± 0.125	2.96ValPhe: 2.96 ± 0.079	7.977ValGly: 7.977 ± 0.135	1.902ValHis: 1.902 ± 0.054	2.9ValIle: 2.9 ± 0.075	1.42ValLys: 1.42 ± 0.046	8.516ValLeu: 8.516 ± 0.131	1.33ValMet: 1.33 ± 0.048	1.945ValAsn: 1.945 ± 0.055	4.604ValPro: 4.604 ± 0.088	1.736ValGln: 1.736 ± 0.052	6.542ValArg: 6.542 ± 0.123	5.047ValSer: 5.047 ± 0.089	6.439ValThr: 6.439 ± 0.099	10.115ValVal: 10.115 ± 0.162	0.731ValTrp: 0.731 ± 0.033	2.249ValTyr: 2.249 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.953TrpAla: 0.953 ± 0.04	0.088TrpCys: 0.088 ± 0.01	0.736TrpAsp: 0.736 ± 0.036	0.728TrpGlu: 0.728 ± 0.036	0.431TrpPhe: 0.431 ± 0.025	0.772TrpGly: 0.772 ± 0.035	0.201TrpHis: 0.201 ± 0.015	0.413TrpIle: 0.413 ± 0.026	0.287TrpLys: 0.287 ± 0.025	1.095TrpLeu: 1.095 ± 0.044	0.194TrpMet: 0.194 ± 0.016	0.317TrpAsn: 0.317 ± 0.024	0.402TrpPro: 0.402 ± 0.024	0.312TrpGln: 0.312 ± 0.019	0.902TrpArg: 0.902 ± 0.04	0.537TrpSer: 0.537 ± 0.028	0.81TrpThr: 0.81 ± 0.038	0.736TrpVal: 0.736 ± 0.03	0.191TrpTrp: 0.191 ± 0.019	0.359TrpTyr: 0.359 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.295TyrAla: 3.295 ± 0.073	0.25TyrCys: 0.25 ± 0.02	2.702TyrAsp: 2.702 ± 0.071	2.32TyrGlu: 2.32 ± 0.062	0.742TyrPhe: 0.742 ± 0.032	2.471TyrGly: 2.471 ± 0.057	0.636TyrHis: 0.636 ± 0.029	0.644TyrIle: 0.644 ± 0.029	0.39TyrLys: 0.39 ± 0.022	2.494TyrLeu: 2.494 ± 0.061	0.374TyrMet: 0.374 ± 0.023	0.589TyrAsn: 0.589 ± 0.03	1.249TyrPro: 1.249 ± 0.047	0.72TyrGln: 0.72 ± 0.034	2.107TyrArg: 2.107 ± 0.058	1.096TyrSer: 1.096 ± 0.039	1.519TyrThr: 1.519 ± 0.049	2.477TyrVal: 2.477 ± 0.06	0.265TyrTrp: 0.265 ± 0.02	0.834TyrTyr: 0.834 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2706 proteins (728013 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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