Amino acid dipepetide frequency for Hafnia alvei FB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.547AlaAla: 9.547 ± 0.112
1.133AlaCys: 1.133 ± 0.035
4.872AlaAsp: 4.872 ± 0.061
5.773AlaGlu: 5.773 ± 0.074
3.491AlaPhe: 3.491 ± 0.057
7.202AlaGly: 7.202 ± 0.081
1.833AlaHis: 1.833 ± 0.043
5.86AlaIle: 5.86 ± 0.078
4.238AlaLys: 4.238 ± 0.058
11.37AlaLeu: 11.37 ± 0.096
2.904AlaMet: 2.904 ± 0.054
3.337AlaAsn: 3.337 ± 0.052
3.439AlaPro: 3.439 ± 0.057
4.573AlaGln: 4.573 ± 0.065
4.626AlaArg: 4.626 ± 0.072
5.323AlaSer: 5.323 ± 0.069
4.612AlaThr: 4.612 ± 0.07
6.552AlaVal: 6.552 ± 0.077
1.217AlaTrp: 1.217 ± 0.034
2.308AlaTyr: 2.308 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.009CysAla: 1.009 ± 0.03
0.191CysCys: 0.191 ± 0.012
0.6CysAsp: 0.6 ± 0.022
0.606CysGlu: 0.606 ± 0.022
0.473CysPhe: 0.473 ± 0.018
1.085CysGly: 1.085 ± 0.027
0.352CysHis: 0.352 ± 0.018
0.626CysIle: 0.626 ± 0.021
0.378CysLys: 0.378 ± 0.017
1.045CysLeu: 1.045 ± 0.028
0.254CysMet: 0.254 ± 0.016
0.347CysAsn: 0.347 ± 0.016
0.499CysPro: 0.499 ± 0.021
0.481CysGln: 0.481 ± 0.02
0.591CysArg: 0.591 ± 0.021
0.738CysSer: 0.738 ± 0.023
0.514CysThr: 0.514 ± 0.02
0.803CysVal: 0.803 ± 0.022
0.165CysTrp: 0.165 ± 0.013
0.374CysTyr: 0.374 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.996AspAla: 4.996 ± 0.069
0.534AspCys: 0.534 ± 0.02
2.836AspAsp: 2.836 ± 0.056
3.513AspGlu: 3.513 ± 0.061
2.143AspPhe: 2.143 ± 0.041
3.801AspGly: 3.801 ± 0.077
1.028AspHis: 1.028 ± 0.032
3.571AspIle: 3.571 ± 0.052
2.548AspLys: 2.548 ± 0.053
4.962AspLeu: 4.962 ± 0.067
1.38AspMet: 1.38 ± 0.036
2.096AspAsn: 2.096 ± 0.039
2.184AspPro: 2.184 ± 0.049
1.732AspGln: 1.732 ± 0.041
2.645AspArg: 2.645 ± 0.057
2.921AspSer: 2.921 ± 0.053
2.446AspThr: 2.446 ± 0.052
3.89AspVal: 3.89 ± 0.058
0.82AspTrp: 0.82 ± 0.024
1.772AspTyr: 1.772 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.83GluAla: 4.83 ± 0.064
0.548GluCys: 0.548 ± 0.02
2.376GluAsp: 2.376 ± 0.048
3.236GluGlu: 3.236 ± 0.066
1.96GluPhe: 1.96 ± 0.037
3.438GluGly: 3.438 ± 0.052
1.531GluHis: 1.531 ± 0.032
3.448GluIle: 3.448 ± 0.061
3.12GluLys: 3.12 ± 0.058
6.178GluLeu: 6.178 ± 0.088
1.78GluMet: 1.78 ± 0.038
2.473GluAsn: 2.473 ± 0.048
2.078GluPro: 2.078 ± 0.04
3.63GluGln: 3.63 ± 0.058
3.69GluArg: 3.69 ± 0.065
3.187GluSer: 3.187 ± 0.054
2.773GluThr: 2.773 ± 0.048
3.689GluVal: 3.689 ± 0.058
0.791GluTrp: 0.791 ± 0.026
1.506GluTyr: 1.506 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.624PheAla: 3.624 ± 0.061
0.552PheCys: 0.552 ± 0.021
2.269PheAsp: 2.269 ± 0.05
1.789PheGlu: 1.789 ± 0.044
1.659PhePhe: 1.659 ± 0.048
3.382PheGly: 3.382 ± 0.048
0.833PheHis: 0.833 ± 0.025
2.669PheIle: 2.669 ± 0.053
1.417PheLys: 1.417 ± 0.032
3.343PheLeu: 3.343 ± 0.058
1.033PheMet: 1.033 ± 0.031
1.795PheAsn: 1.795 ± 0.034
1.53PhePro: 1.53 ± 0.04
1.179PheGln: 1.179 ± 0.027
1.753PheArg: 1.753 ± 0.035
3.214PheSer: 3.214 ± 0.056
2.357PheThr: 2.357 ± 0.046
2.595PheVal: 2.595 ± 0.05
0.583PheTrp: 0.583 ± 0.024
1.272PheTyr: 1.272 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
6.131GlyAla: 6.131 ± 0.079
1.026GlyCys: 1.026 ± 0.032
3.669GlyAsp: 3.669 ± 0.066
4.277GlyGlu: 4.277 ± 0.07
3.311GlyPhe: 3.311 ± 0.055
5.325GlyGly: 5.325 ± 0.079
1.6GlyHis: 1.6 ± 0.033
5.192GlyIle: 5.192 ± 0.075
4.028GlyLys: 4.028 ± 0.061
7.478GlyLeu: 7.478 ± 0.093
2.435GlyMet: 2.435 ± 0.048
2.817GlyAsn: 2.817 ± 0.074
1.877GlyPro: 1.877 ± 0.036
2.858GlyGln: 2.858 ± 0.055
3.512GlyArg: 3.512 ± 0.057
4.372GlySer: 4.372 ± 0.071
3.657GlyThr: 3.657 ± 0.069
5.822GlyVal: 5.822 ± 0.074
1.216GlyTrp: 1.216 ± 0.033
2.659GlyTyr: 2.659 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
1.951HisAla: 1.951 ± 0.04
0.332HisCys: 0.332 ± 0.016
1.16HisAsp: 1.16 ± 0.031
1.135HisGlu: 1.135 ± 0.03
1.039HisPhe: 1.039 ± 0.03
1.762HisGly: 1.762 ± 0.039
0.781HisHis: 0.781 ± 0.032
1.377HisIle: 1.377 ± 0.037
0.817HisLys: 0.817 ± 0.028
2.301HisLeu: 2.301 ± 0.048
0.604HisMet: 0.604 ± 0.021
0.872HisAsn: 0.872 ± 0.026
1.315HisPro: 1.315 ± 0.032
1.308HisGln: 1.308 ± 0.036
1.217HisArg: 1.217 ± 0.03
1.383HisSer: 1.383 ± 0.034
1.064HisThr: 1.064 ± 0.026
1.293HisVal: 1.293 ± 0.027
0.438HisTrp: 0.438 ± 0.018
0.831HisTyr: 0.831 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.55IleAla: 6.55 ± 0.081
0.745IleCys: 0.745 ± 0.025
3.623IleAsp: 3.623 ± 0.051
3.596IleGlu: 3.596 ± 0.056
2.186IlePhe: 2.186 ± 0.049
4.871IleGly: 4.871 ± 0.076
1.253IleHis: 1.253 ± 0.028
3.554IleIle: 3.554 ± 0.067
2.657IleLys: 2.657 ± 0.052
5.254IleLeu: 5.254 ± 0.089
1.435IleMet: 1.435 ± 0.035
2.691IleAsn: 2.691 ± 0.047
2.869IlePro: 2.869 ± 0.054
2.071IleGln: 2.071 ± 0.043
2.959IleArg: 2.959 ± 0.048
4.237IleSer: 4.237 ± 0.056
3.681IleThr: 3.681 ± 0.052
4.165IleVal: 4.165 ± 0.064
0.688IleTrp: 0.688 ± 0.025
1.659IleTyr: 1.659 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.271LysAla: 4.271 ± 0.07
0.275LysCys: 0.275 ± 0.017
2.206LysAsp: 2.206 ± 0.045
2.451LysGlu: 2.451 ± 0.047
1.294LysPhe: 1.294 ± 0.035
2.906LysGly: 2.906 ± 0.051
0.999LysHis: 0.999 ± 0.03
2.704LysIle: 2.704 ± 0.05
2.285LysLys: 2.285 ± 0.047
4.563LysLeu: 4.563 ± 0.074
1.353LysMet: 1.353 ± 0.035
1.952LysAsn: 1.952 ± 0.039
2.256LysPro: 2.256 ± 0.051
2.24LysGln: 2.24 ± 0.05
2.582LysArg: 2.582 ± 0.046
2.556LysSer: 2.556 ± 0.044
2.557LysThr: 2.557 ± 0.043
3.142LysVal: 3.142 ± 0.05
0.448LysTrp: 0.448 ± 0.018
1.138LysTyr: 1.138 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
10.942LeuAla: 10.942 ± 0.106
1.306LeuCys: 1.306 ± 0.033
5.543LeuAsp: 5.543 ± 0.071
5.454LeuGlu: 5.454 ± 0.07
4.183LeuPhe: 4.183 ± 0.07
7.523LeuGly: 7.523 ± 0.107
2.319LeuHis: 2.319 ± 0.05
6.165LeuIle: 6.165 ± 0.085
4.799LeuLys: 4.799 ± 0.062
11.776LeuLeu: 11.776 ± 0.145
3.163LeuMet: 3.163 ± 0.056
4.413LeuAsn: 4.413 ± 0.072
5.556LeuPro: 5.556 ± 0.07
4.195LeuGln: 4.195 ± 0.072
5.764LeuArg: 5.764 ± 0.081
7.671LeuSer: 7.671 ± 0.091
6.202LeuThr: 6.202 ± 0.078
7.073LeuVal: 7.073 ± 0.088
1.294LeuTrp: 1.294 ± 0.035
2.64LeuTyr: 2.64 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.924MetAla: 2.924 ± 0.051
0.218MetCys: 0.218 ± 0.012
1.273MetAsp: 1.273 ± 0.033
1.231MetGlu: 1.231 ± 0.032
1.004MetPhe: 1.004 ± 0.025
1.979MetGly: 1.979 ± 0.044
0.565MetHis: 0.565 ± 0.02
1.54MetIle: 1.54 ± 0.038
1.434MetLys: 1.434 ± 0.035
3.249MetLeu: 3.249 ± 0.052
0.969MetMet: 0.969 ± 0.029
1.196MetAsn: 1.196 ± 0.033
1.416MetPro: 1.416 ± 0.036
1.346MetGln: 1.346 ± 0.034
1.483MetArg: 1.483 ± 0.033
2.026MetSer: 2.026 ± 0.043
1.807MetThr: 1.807 ± 0.039
2.021MetVal: 2.021 ± 0.042
0.284MetTrp: 0.284 ± 0.016
0.604MetTyr: 0.604 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.664AsnAla: 3.664 ± 0.057
0.362AsnCys: 0.362 ± 0.015
2.088AsnAsp: 2.088 ± 0.048
2.02AsnGlu: 2.02 ± 0.04
1.395AsnPhe: 1.395 ± 0.03
3.205AsnGly: 3.205 ± 0.077
0.935AsnHis: 0.935 ± 0.027
2.528AsnIle: 2.528 ± 0.056
1.736AsnLys: 1.736 ± 0.046
3.649AsnLeu: 3.649 ± 0.055
1.052AsnMet: 1.052 ± 0.025
1.734AsnAsn: 1.734 ± 0.042
2.174AsnPro: 2.174 ± 0.048
1.849AsnGln: 1.849 ± 0.041
1.96AsnArg: 1.96 ± 0.04
2.288AsnSer: 2.288 ± 0.052
2.105AsnThr: 2.105 ± 0.042
2.652AsnVal: 2.652 ± 0.053
0.513AsnTrp: 0.513 ± 0.018
1.22AsnTyr: 1.22 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
4.183ProAla: 4.183 ± 0.062
0.37ProCys: 0.37 ± 0.018
2.575ProAsp: 2.575 ± 0.044
3.423ProGlu: 3.423 ± 0.058
1.824ProPhe: 1.824 ± 0.033
2.665ProGly: 2.665 ± 0.049
1.05ProHis: 1.05 ± 0.028
2.295ProIle: 2.295 ± 0.041
1.72ProLys: 1.72 ± 0.039
4.966ProLeu: 4.966 ± 0.067
1.146ProMet: 1.146 ± 0.034
1.566ProAsn: 1.566 ± 0.038
1.47ProPro: 1.47 ± 0.036
2.247ProGln: 2.247 ± 0.044
1.832ProArg: 1.832 ± 0.035
2.454ProSer: 2.454 ± 0.045
2.253ProThr: 2.253 ± 0.055
3.575ProVal: 3.575 ± 0.062
0.604ProTrp: 0.604 ± 0.023
1.312ProTyr: 1.312 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.642GlnAla: 4.642 ± 0.07
0.393GlnCys: 0.393 ± 0.018
2.056GlnAsp: 2.056 ± 0.042
2.315GlnGlu: 2.315 ± 0.043
1.524GlnPhe: 1.524 ± 0.035
3.193GlnGly: 3.193 ± 0.047
1.329GlnHis: 1.329 ± 0.033
2.549GlnIle: 2.549 ± 0.051
2.036GlnLys: 2.036 ± 0.038
5.118GlnLeu: 5.118 ± 0.079
1.29GlnMet: 1.29 ± 0.034
1.597GlnAsn: 1.597 ± 0.042
2.2GlnPro: 2.2 ± 0.044
3.494GlnGln: 3.494 ± 0.079
3.115GlnArg: 3.115 ± 0.059
2.532GlnSer: 2.532 ± 0.043
2.286GlnThr: 2.286 ± 0.052
3.045GlnVal: 3.045 ± 0.052
0.695GlnTrp: 0.695 ± 0.023
1.193GlnTyr: 1.193 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
4.122ArgAla: 4.122 ± 0.051
0.59ArgCys: 0.59 ± 0.022
2.842ArgAsp: 2.842 ± 0.046
3.521ArgGlu: 3.521 ± 0.061
2.415ArgPhe: 2.415 ± 0.044
3.178ArgGly: 3.178 ± 0.056
1.391ArgHis: 1.391 ± 0.037
3.239ArgIle: 3.239 ± 0.051
2.291ArgLys: 2.291 ± 0.051
5.952ArgLeu: 5.952 ± 0.084
1.554ArgMet: 1.554 ± 0.033
1.945ArgAsn: 1.945 ± 0.039
1.992ArgPro: 1.992 ± 0.044
2.817ArgGln: 2.817 ± 0.061
3.139ArgArg: 3.139 ± 0.061
2.886ArgSer: 2.886 ± 0.053
2.406ArgThr: 2.406 ± 0.043
3.601ArgVal: 3.601 ± 0.052
0.9ArgTrp: 0.9 ± 0.028
2.057ArgTyr: 2.057 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.939SerAla: 5.939 ± 0.071
0.631SerCys: 0.631 ± 0.024
3.327SerAsp: 3.327 ± 0.058
3.35SerGlu: 3.35 ± 0.054
2.381SerPhe: 2.381 ± 0.045
5.3SerGly: 5.3 ± 0.084
1.53SerHis: 1.53 ± 0.032
3.485SerIle: 3.485 ± 0.058
2.266SerLys: 2.266 ± 0.05
7.011SerLeu: 7.011 ± 0.086
1.69SerMet: 1.69 ± 0.038
2.195SerAsn: 2.195 ± 0.046
2.655SerPro: 2.655 ± 0.048
2.877SerGln: 2.877 ± 0.058
3.199SerArg: 3.199 ± 0.05
3.945SerSer: 3.945 ± 0.068
3.178SerThr: 3.178 ± 0.069
4.46SerVal: 4.46 ± 0.064
0.895SerTrp: 0.895 ± 0.027
1.841SerTyr: 1.841 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
4.856ThrAla: 4.856 ± 0.074
0.504ThrCys: 0.504 ± 0.02
2.635ThrAsp: 2.635 ± 0.057
2.723ThrGlu: 2.723 ± 0.045
2.008ThrPhe: 2.008 ± 0.043
4.278ThrGly: 4.278 ± 0.071
1.237ThrHis: 1.237 ± 0.034
2.993ThrIle: 2.993 ± 0.063
1.771ThrLys: 1.771 ± 0.038
7.039ThrLeu: 7.039 ± 0.094
1.165ThrMet: 1.165 ± 0.031
1.718ThrAsn: 1.718 ± 0.052
3.114ThrPro: 3.114 ± 0.047
2.425ThrGln: 2.425 ± 0.043
2.601ThrArg: 2.601 ± 0.045
3.11ThrSer: 3.11 ± 0.056
2.899ThrThr: 2.899 ± 0.07
3.718ThrVal: 3.718 ± 0.075
0.663ThrTrp: 0.663 ± 0.023
1.36ThrTyr: 1.36 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
6.625ValAla: 6.625 ± 0.076
0.858ValCys: 0.858 ± 0.027
3.752ValAsp: 3.752 ± 0.066
4.022ValGlu: 4.022 ± 0.068
2.656ValPhe: 2.656 ± 0.051
5.051ValGly: 5.051 ± 0.076
1.237ValHis: 1.237 ± 0.029
4.719ValIle: 4.719 ± 0.074
3.139ValLys: 3.139 ± 0.052
7.33ValLeu: 7.33 ± 0.087
2.274ValMet: 2.274 ± 0.047
2.859ValAsn: 2.859 ± 0.062
2.941ValPro: 2.941 ± 0.05
2.403ValGln: 2.403 ± 0.047
3.465ValArg: 3.465 ± 0.06
4.658ValSer: 4.658 ± 0.056
4.059ValThr: 4.059 ± 0.07
5.475ValVal: 5.475 ± 0.078
0.881ValTrp: 0.881 ± 0.03
1.829ValTyr: 1.829 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.934TrpAla: 0.934 ± 0.027
0.171TrpCys: 0.171 ± 0.011
0.592TrpAsp: 0.592 ± 0.02
0.57TrpGlu: 0.57 ± 0.024
0.642TrpPhe: 0.642 ± 0.025
0.861TrpGly: 0.861 ± 0.028
0.407TrpHis: 0.407 ± 0.018
0.73TrpIle: 0.73 ± 0.024
0.548TrpLys: 0.548 ± 0.022
2.082TrpLeu: 2.082 ± 0.045
0.423TrpMet: 0.423 ± 0.019
0.477TrpAsn: 0.477 ± 0.019
0.571TrpPro: 0.571 ± 0.023
1.036TrpGln: 1.036 ± 0.034
0.872TrpArg: 0.872 ± 0.035
0.789TrpSer: 0.789 ± 0.03
0.534TrpThr: 0.534 ± 0.021
0.95TrpVal: 0.95 ± 0.031
0.235TrpTrp: 0.235 ± 0.013
0.366TrpTyr: 0.366 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.47TyrAla: 2.47 ± 0.041
0.394TyrCys: 0.394 ± 0.018
1.524TyrAsp: 1.524 ± 0.038
1.259TyrGlu: 1.259 ± 0.03
1.26TyrPhe: 1.26 ± 0.033
2.257TyrGly: 2.257 ± 0.036
0.769TyrHis: 0.769 ± 0.023
1.5TyrIle: 1.5 ± 0.04
0.95TyrLys: 0.95 ± 0.029
3.315TyrLeu: 3.315 ± 0.06
0.665TyrMet: 0.665 ± 0.021
1.046TyrAsn: 1.046 ± 0.03
1.397TyrPro: 1.397 ± 0.037
1.842TyrGln: 1.842 ± 0.038
1.83TyrArg: 1.83 ± 0.033
1.865TyrSer: 1.865 ± 0.041
1.425TyrThr: 1.425 ± 0.034
1.713TyrVal: 1.713 ± 0.036
0.46TyrTrp: 0.46 ± 0.02
0.98TyrTyr: 0.98 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4059 proteins (1290908 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski