Amino acid dipepetide frequency for Naematelia encephala

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.377AlaAla: 8.377 ± 0.072	0.968AlaCys: 0.968 ± 0.017	4.04AlaAsp: 4.04 ± 0.037	5.22AlaGlu: 5.22 ± 0.045	3.081AlaPhe: 3.081 ± 0.03	6.053AlaGly: 6.053 ± 0.048	1.748AlaHis: 1.748 ± 0.023	4.17AlaIle: 4.17 ± 0.037	4.07AlaLys: 4.07 ± 0.039	8.06AlaLeu: 8.06 ± 0.053	1.959AlaMet: 1.959 ± 0.023	2.567AlaAsn: 2.567 ± 0.027	5.029AlaPro: 5.029 ± 0.051	3.282AlaGln: 3.282 ± 0.034	5.236AlaArg: 5.236 ± 0.043	7.803AlaSer: 7.803 ± 0.059	5.096AlaThr: 5.096 ± 0.041	5.363AlaVal: 5.363 ± 0.042	1.223AlaTrp: 1.223 ± 0.02	2.094AlaTyr: 2.094 ± 0.028	0.0AlaXaa: 0.0 ± 0.0
Cys	0.786CysAla: 0.786 ± 0.016	0.205CysCys: 0.205 ± 0.009	0.518CysAsp: 0.518 ± 0.013	0.533CysGlu: 0.533 ± 0.013	0.459CysPhe: 0.459 ± 0.011	0.833CysGly: 0.833 ± 0.019	0.276CysHis: 0.276 ± 0.01	0.59CysIle: 0.59 ± 0.013	0.408CysLys: 0.408 ± 0.01	1.161CysLeu: 1.161 ± 0.02	0.241CysMet: 0.241 ± 0.007	0.316CysAsn: 0.316 ± 0.01	0.58CysPro: 0.58 ± 0.014	0.395CysGln: 0.395 ± 0.011	0.652CysArg: 0.652 ± 0.017	0.807CysSer: 0.807 ± 0.017	0.586CysThr: 0.586 ± 0.013	0.732CysVal: 0.732 ± 0.015	0.176CysTrp: 0.176 ± 0.006	0.307CysTyr: 0.307 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.336AspAla: 4.336 ± 0.034	0.523AspCys: 0.523 ± 0.012	4.27AspAsp: 4.27 ± 0.046	4.936AspGlu: 4.936 ± 0.046	1.932AspPhe: 1.932 ± 0.026	4.271AspGly: 4.271 ± 0.036	1.216AspHis: 1.216 ± 0.021	2.742AspIle: 2.742 ± 0.029	2.422AspLys: 2.422 ± 0.028	5.226AspLeu: 5.226 ± 0.042	1.231AspMet: 1.231 ± 0.017	1.497AspAsn: 1.497 ± 0.021	3.459AspPro: 3.459 ± 0.037	1.919AspGln: 1.919 ± 0.022	3.125AspArg: 3.125 ± 0.032	3.896AspSer: 3.896 ± 0.035	2.899AspThr: 2.899 ± 0.029	3.838AspVal: 3.838 ± 0.033	0.928AspTrp: 0.928 ± 0.018	1.365AspTyr: 1.365 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	5.411GluAla: 5.411 ± 0.043	0.515GluCys: 0.515 ± 0.014	4.282GluAsp: 4.282 ± 0.047	5.812GluGlu: 5.812 ± 0.064	1.602GluPhe: 1.602 ± 0.022	4.321GluGly: 4.321 ± 0.034	1.293GluHis: 1.293 ± 0.021	3.008GluIle: 3.008 ± 0.032	3.309GluLys: 3.309 ± 0.041	5.19GluLeu: 5.19 ± 0.046	1.568GluMet: 1.568 ± 0.022	1.795GluAsn: 1.795 ± 0.021	2.7GluPro: 2.7 ± 0.031	2.326GluGln: 2.326 ± 0.025	4.285GluArg: 4.285 ± 0.045	4.219GluSer: 4.219 ± 0.043	3.386GluThr: 3.386 ± 0.03	3.936GluVal: 3.936 ± 0.038	0.943GluTrp: 0.943 ± 0.017	1.469GluTyr: 1.469 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	2.988PheAla: 2.988 ± 0.033	0.475PheCys: 0.475 ± 0.011	2.133PheAsp: 2.133 ± 0.028	1.913PheGlu: 1.913 ± 0.024	1.441PhePhe: 1.441 ± 0.024	2.799PheGly: 2.799 ± 0.037	0.829PheHis: 0.829 ± 0.014	1.644PheIle: 1.644 ± 0.024	1.321PheLys: 1.321 ± 0.021	3.233PheLeu: 3.233 ± 0.036	0.674PheMet: 0.674 ± 0.015	1.138PheAsn: 1.138 ± 0.019	1.959PhePro: 1.959 ± 0.022	1.16PheGln: 1.16 ± 0.02	1.8PheArg: 1.8 ± 0.023	2.877PheSer: 2.877 ± 0.03	2.056PheThr: 2.056 ± 0.025	2.231PheVal: 2.231 ± 0.026	0.576PheTrp: 0.576 ± 0.014	0.933PheTyr: 0.933 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.194GlyAla: 5.194 ± 0.046	0.765GlyCys: 0.765 ± 0.017	3.847GlyAsp: 3.847 ± 0.035	4.329GlyGlu: 4.329 ± 0.036	2.621GlyPhe: 2.621 ± 0.032	6.811GlyGly: 6.811 ± 0.071	1.657GlyHis: 1.657 ± 0.025	3.516GlyIle: 3.516 ± 0.033	3.826GlyLys: 3.826 ± 0.042	6.393GlyLeu: 6.393 ± 0.043	1.85GlyMet: 1.85 ± 0.028	2.278GlyAsn: 2.278 ± 0.029	3.549GlyPro: 3.549 ± 0.034	2.734GlyGln: 2.734 ± 0.033	4.528GlyArg: 4.528 ± 0.034	5.975GlySer: 5.975 ± 0.044	4.034GlyThr: 4.034 ± 0.038	4.663GlyVal: 4.663 ± 0.042	1.402GlyTrp: 1.402 ± 0.022	2.01GlyTyr: 2.01 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.839HisAla: 1.839 ± 0.023	0.279HisCys: 0.279 ± 0.01	1.193HisAsp: 1.193 ± 0.018	1.208HisGlu: 1.208 ± 0.018	0.864HisPhe: 0.864 ± 0.016	1.566HisGly: 1.566 ± 0.025	0.885HisHis: 0.885 ± 0.021	1.14HisIle: 1.14 ± 0.018	0.78HisLys: 0.78 ± 0.015	2.584HisLeu: 2.584 ± 0.029	0.421HisMet: 0.421 ± 0.01	0.694HisAsn: 0.694 ± 0.014	1.933HisPro: 1.933 ± 0.024	0.914HisGln: 0.914 ± 0.017	1.525HisArg: 1.525 ± 0.023	1.936HisSer: 1.936 ± 0.024	1.364HisThr: 1.364 ± 0.02	1.429HisVal: 1.429 ± 0.019	0.311HisTrp: 0.311 ± 0.01	0.614HisTyr: 0.614 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.155IleAla: 4.155 ± 0.038	0.651IleCys: 0.651 ± 0.013	2.844IleAsp: 2.844 ± 0.026	2.781IleGlu: 2.781 ± 0.027	1.756IlePhe: 1.756 ± 0.026	3.309IleGly: 3.309 ± 0.036	1.181IleHis: 1.181 ± 0.017	2.431IleIle: 2.431 ± 0.032	2.157IleLys: 2.157 ± 0.025	4.439IleLeu: 4.439 ± 0.039	0.978IleMet: 0.978 ± 0.018	1.636IleAsn: 1.636 ± 0.022	3.36IlePro: 3.36 ± 0.031	1.72IleGln: 1.72 ± 0.022	2.84IleArg: 2.84 ± 0.028	4.008IleSer: 4.008 ± 0.034	2.746IleThr: 2.746 ± 0.027	3.128IleVal: 3.128 ± 0.04	0.708IleTrp: 0.708 ± 0.014	1.235IleTyr: 1.235 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	4.26LysAla: 4.26 ± 0.041	0.402LysCys: 0.402 ± 0.01	2.55LysAsp: 2.55 ± 0.033	3.195LysGlu: 3.195 ± 0.04	1.182LysPhe: 1.182 ± 0.018	3.283LysGly: 3.283 ± 0.033	0.99LysHis: 0.99 ± 0.017	2.044LysIle: 2.044 ± 0.025	2.88LysLys: 2.88 ± 0.041	3.686LysLeu: 3.686 ± 0.034	0.944LysMet: 0.944 ± 0.016	1.284LysAsn: 1.284 ± 0.022	2.587LysPro: 2.587 ± 0.03	1.612LysGln: 1.612 ± 0.02	3.52LysArg: 3.52 ± 0.035	3.321LysSer: 3.321 ± 0.033	2.646LysThr: 2.646 ± 0.03	2.886LysVal: 2.886 ± 0.028	0.674LysTrp: 0.674 ± 0.014	1.119LysTyr: 1.119 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	8.427LeuAla: 8.427 ± 0.055	1.076LeuCys: 1.076 ± 0.016	5.385LeuAsp: 5.385 ± 0.038	5.403LeuGlu: 5.403 ± 0.045	3.23LeuPhe: 3.23 ± 0.035	6.396LeuGly: 6.396 ± 0.052	2.313LeuHis: 2.313 ± 0.026	4.055LeuIle: 4.055 ± 0.038	3.832LeuLys: 3.832 ± 0.032	8.864LeuLeu: 8.864 ± 0.065	1.674LeuMet: 1.674 ± 0.022	2.903LeuAsn: 2.903 ± 0.03	6.696LeuPro: 6.696 ± 0.043	3.415LeuGln: 3.415 ± 0.029	5.703LeuArg: 5.703 ± 0.049	8.2LeuSer: 8.2 ± 0.059	5.0LeuThr: 5.0 ± 0.036	5.869LeuVal: 5.869 ± 0.044	1.127LeuTrp: 1.127 ± 0.019	2.223LeuTyr: 2.223 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	1.944MetAla: 1.944 ± 0.022	0.23MetCys: 0.23 ± 0.008	1.205MetAsp: 1.205 ± 0.019	1.171MetGlu: 1.171 ± 0.018	0.684MetPhe: 0.684 ± 0.014	1.528MetGly: 1.528 ± 0.024	0.381MetHis: 0.381 ± 0.01	1.021MetIle: 1.021 ± 0.018	0.824MetLys: 0.824 ± 0.014	1.84MetLeu: 1.84 ± 0.022	0.596MetMet: 0.596 ± 0.013	0.669MetAsn: 0.669 ± 0.013	1.315MetPro: 1.315 ± 0.019	0.74MetGln: 0.74 ± 0.014	1.339MetArg: 1.339 ± 0.018	2.248MetSer: 2.248 ± 0.023	1.398MetThr: 1.398 ± 0.02	1.255MetVal: 1.255 ± 0.018	0.256MetTrp: 0.256 ± 0.008	0.503MetTyr: 0.503 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.744AsnAla: 2.744 ± 0.027	0.304AsnCys: 0.304 ± 0.009	1.746AsnAsp: 1.746 ± 0.023	1.76AsnGlu: 1.76 ± 0.021	1.035AsnPhe: 1.035 ± 0.015	2.823AsnGly: 2.823 ± 0.032	0.734AsnHis: 0.734 ± 0.014	1.604AsnIle: 1.604 ± 0.022	1.269AsnLys: 1.269 ± 0.021	2.937AsnLeu: 2.937 ± 0.03	0.644AsnMet: 0.644 ± 0.012	1.102AsnAsn: 1.102 ± 0.023	2.256AsnPro: 2.256 ± 0.026	1.135AsnGln: 1.135 ± 0.02	1.685AsnArg: 1.685 ± 0.023	2.393AsnSer: 2.393 ± 0.028	1.921AsnThr: 1.921 ± 0.026	2.063AsnVal: 2.063 ± 0.024	0.446AsnTrp: 0.446 ± 0.012	0.803AsnTyr: 0.803 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	5.473ProAla: 5.473 ± 0.055	0.441ProCys: 0.441 ± 0.014	3.232ProAsp: 3.232 ± 0.035	3.565ProGlu: 3.565 ± 0.034	2.133ProPhe: 2.133 ± 0.022	3.943ProGly: 3.943 ± 0.035	1.554ProHis: 1.554 ± 0.019	3.07ProIle: 3.07 ± 0.035	2.546ProLys: 2.546 ± 0.028	5.693ProLeu: 5.693 ± 0.046	1.086ProMet: 1.086 ± 0.015	2.187ProAsn: 2.187 ± 0.028	6.719ProPro: 6.719 ± 0.099	2.359ProGln: 2.359 ± 0.034	3.686ProArg: 3.686 ± 0.038	7.883ProSer: 7.883 ± 0.066	4.88ProThr: 4.88 ± 0.039	3.783ProVal: 3.783 ± 0.035	0.697ProTrp: 0.697 ± 0.015	1.513ProTyr: 1.513 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.59GlnAla: 3.59 ± 0.035	0.372GlnCys: 0.372 ± 0.01	1.86GlnAsp: 1.86 ± 0.026	2.055GlnGlu: 2.055 ± 0.024	1.045GlnPhe: 1.045 ± 0.016	2.483GlnGly: 2.483 ± 0.027	0.963GlnHis: 0.963 ± 0.018	1.809GlnIle: 1.809 ± 0.023	1.439GlnLys: 1.439 ± 0.022	3.369GlnLeu: 3.369 ± 0.036	0.827GlnMet: 0.827 ± 0.016	1.177GlnAsn: 1.177 ± 0.021	2.54GlnPro: 2.54 ± 0.035	2.134GlnGln: 2.134 ± 0.071	2.477GlnArg: 2.477 ± 0.025	3.134GlnSer: 3.134 ± 0.033	2.256GlnThr: 2.256 ± 0.025	2.338GlnVal: 2.338 ± 0.024	0.512GlnTrp: 0.512 ± 0.012	1.002GlnTyr: 1.002 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	5.03ArgAla: 5.03 ± 0.043	0.635ArgCys: 0.635 ± 0.013	3.389ArgAsp: 3.389 ± 0.037	3.896ArgGlu: 3.896 ± 0.043	2.039ArgPhe: 2.039 ± 0.021	4.115ArgGly: 4.115 ± 0.042	1.556ArgHis: 1.556 ± 0.024	2.96ArgIle: 2.96 ± 0.029	3.329ArgLys: 3.329 ± 0.037	5.782ArgLeu: 5.782 ± 0.05	1.373ArgMet: 1.373 ± 0.02	1.901ArgAsn: 1.901 ± 0.021	4.053ArgPro: 4.053 ± 0.042	2.613ArgGln: 2.613 ± 0.031	5.523ArgArg: 5.523 ± 0.058	5.183ArgSer: 5.183 ± 0.047	3.446ArgThr: 3.446 ± 0.031	3.561ArgVal: 3.561 ± 0.035	0.94ArgTrp: 0.94 ± 0.014	1.582ArgTyr: 1.582 ± 0.023	0.0ArgXaa: 0.0 ± 0.0
Ser	7.335SerAla: 7.335 ± 0.052	0.788SerCys: 0.788 ± 0.016	4.369SerAsp: 4.369 ± 0.037	4.186SerGlu: 4.186 ± 0.031	3.048SerPhe: 3.048 ± 0.032	6.017SerGly: 6.017 ± 0.042	2.102SerHis: 2.102 ± 0.027	4.155SerIle: 4.155 ± 0.036	3.525SerLys: 3.525 ± 0.037	7.953SerLeu: 7.953 ± 0.05	1.724SerMet: 1.724 ± 0.02	2.868SerAsn: 2.868 ± 0.032	6.671SerPro: 6.671 ± 0.07	3.19SerGln: 3.19 ± 0.036	5.412SerArg: 5.412 ± 0.054	11.525SerSer: 11.525 ± 0.115	6.964SerThr: 6.964 ± 0.064	4.861SerVal: 4.861 ± 0.035	1.111SerTrp: 1.111 ± 0.018	1.957SerTyr: 1.957 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	5.227ThrAla: 5.227 ± 0.038	0.664ThrCys: 0.664 ± 0.014	2.824ThrAsp: 2.824 ± 0.029	2.901ThrGlu: 2.901 ± 0.028	2.224ThrPhe: 2.224 ± 0.025	4.221ThrGly: 4.221 ± 0.038	1.392ThrHis: 1.392 ± 0.022	3.089ThrIle: 3.089 ± 0.03	2.384ThrLys: 2.384 ± 0.027	5.65ThrLeu: 5.65 ± 0.043	1.154ThrMet: 1.154 ± 0.019	1.916ThrAsn: 1.916 ± 0.025	5.069ThrPro: 5.069 ± 0.046	1.947ThrGln: 1.947 ± 0.024	3.359ThrArg: 3.359 ± 0.033	6.585ThrSer: 6.585 ± 0.059	4.558ThrThr: 4.558 ± 0.05	3.603ThrVal: 3.603 ± 0.034	0.812ThrTrp: 0.812 ± 0.018	1.559ThrTyr: 1.559 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	5.092ValAla: 5.092 ± 0.041	0.749ValCys: 0.749 ± 0.014	3.9ValAsp: 3.9 ± 0.032	4.207ValGlu: 4.207 ± 0.045	2.287ValPhe: 2.287 ± 0.027	4.316ValGly: 4.316 ± 0.038	1.381ValHis: 1.381 ± 0.022	3.084ValIle: 3.084 ± 0.032	3.037ValLys: 3.037 ± 0.031	5.871ValLeu: 5.871 ± 0.043	1.306ValMet: 1.306 ± 0.019	2.031ValAsn: 2.031 ± 0.022	3.894ValPro: 3.894 ± 0.033	2.341ValGln: 2.341 ± 0.024	3.663ValArg: 3.663 ± 0.034	4.811ValSer: 4.811 ± 0.039	3.4ValThr: 3.4 ± 0.032	4.459ValVal: 4.459 ± 0.039	0.941ValTrp: 0.941 ± 0.015	1.593ValTyr: 1.593 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.159TrpAla: 1.159 ± 0.019	0.197TrpCys: 0.197 ± 0.008	0.904TrpAsp: 0.904 ± 0.018	0.901TrpGlu: 0.901 ± 0.015	0.513TrpPhe: 0.513 ± 0.012	0.999TrpGly: 0.999 ± 0.017	0.317TrpHis: 0.317 ± 0.009	0.711TrpIle: 0.711 ± 0.014	0.759TrpLys: 0.759 ± 0.015	1.297TrpLeu: 1.297 ± 0.022	0.376TrpMet: 0.376 ± 0.009	0.548TrpAsn: 0.548 ± 0.014	0.585TrpPro: 0.585 ± 0.014	0.524TrpGln: 0.524 ± 0.012	1.034TrpArg: 1.034 ± 0.017	1.101TrpSer: 1.101 ± 0.017	0.954TrpThr: 0.954 ± 0.015	0.882TrpVal: 0.882 ± 0.018	0.325TrpTrp: 0.325 ± 0.011	0.398TrpTyr: 0.398 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.073TyrAla: 2.073 ± 0.027	0.323TyrCys: 0.323 ± 0.009	1.537TyrAsp: 1.537 ± 0.024	1.398TyrGlu: 1.398 ± 0.023	1.006TyrPhe: 1.006 ± 0.019	1.897TyrGly: 1.897 ± 0.028	0.711TyrHis: 0.711 ± 0.014	1.223TyrIle: 1.223 ± 0.018	0.944TyrLys: 0.944 ± 0.016	2.563TyrLeu: 2.563 ± 0.028	0.52TyrMet: 0.52 ± 0.013	0.894TyrAsn: 0.894 ± 0.017	1.489TyrPro: 1.489 ± 0.025	0.921TyrGln: 0.921 ± 0.016	1.517TyrArg: 1.517 ± 0.021	1.857TyrSer: 1.857 ± 0.024	1.545TyrThr: 1.545 ± 0.021	1.484TyrVal: 1.484 ± 0.021	0.374TyrTrp: 0.374 ± 0.012	0.734TyrTyr: 0.734 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7963 proteins (3808585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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