Amino acid dipepetide frequency for Chlorobium sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.123AlaAla: 8.123 ± 0.153	1.043AlaCys: 1.043 ± 0.04	4.302AlaAsp: 4.302 ± 0.112	5.54AlaGlu: 5.54 ± 0.091	3.56AlaPhe: 3.56 ± 0.075	7.244AlaGly: 7.244 ± 0.124	1.445AlaHis: 1.445 ± 0.047	5.363AlaIle: 5.363 ± 0.092	3.928AlaLys: 3.928 ± 0.084	8.405AlaLeu: 8.405 ± 0.121	2.219AlaMet: 2.219 ± 0.054	2.427AlaAsn: 2.427 ± 0.08	2.731AlaPro: 2.731 ± 0.083	2.061AlaGln: 2.061 ± 0.052	4.092AlaArg: 4.092 ± 0.086	5.273AlaSer: 5.273 ± 0.091	3.286AlaThr: 3.286 ± 0.07	6.367AlaVal: 6.367 ± 0.096	0.885AlaTrp: 0.885 ± 0.038	2.208AlaTyr: 2.208 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.778CysAla: 0.778 ± 0.033	0.225CysCys: 0.225 ± 0.021	0.63CysAsp: 0.63 ± 0.031	0.575CysGlu: 0.575 ± 0.026	0.56CysPhe: 0.56 ± 0.03	1.097CysGly: 1.097 ± 0.042	0.328CysHis: 0.328 ± 0.034	0.804CysIle: 0.804 ± 0.032	0.417CysLys: 0.417 ± 0.022	0.956CysLeu: 0.956 ± 0.041	0.341CysMet: 0.341 ± 0.022	0.481CysAsn: 0.481 ± 0.026	0.603CysPro: 0.603 ± 0.035	0.295CysGln: 0.295 ± 0.019	0.855CysArg: 0.855 ± 0.036	1.035CysSer: 1.035 ± 0.045	0.544CysThr: 0.544 ± 0.032	0.627CysVal: 0.627 ± 0.029	0.117CysTrp: 0.117 ± 0.011	0.404CysTyr: 0.404 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.276AspAla: 4.276 ± 0.078	0.622AspCys: 0.622 ± 0.031	2.518AspAsp: 2.518 ± 0.07	3.534AspGlu: 3.534 ± 0.067	2.653AspPhe: 2.653 ± 0.065	3.477AspGly: 3.477 ± 0.129	1.101AspHis: 1.101 ± 0.044	4.477AspIle: 4.477 ± 0.104	2.592AspLys: 2.592 ± 0.065	5.042AspLeu: 5.042 ± 0.085	1.327AspMet: 1.327 ± 0.042	2.059AspAsn: 2.059 ± 0.05	2.545AspPro: 2.545 ± 0.057	1.412AspGln: 1.412 ± 0.041	3.305AspArg: 3.305 ± 0.072	3.018AspSer: 3.018 ± 0.077	2.765AspThr: 2.765 ± 0.076	3.411AspVal: 3.411 ± 0.076	0.627AspTrp: 0.627 ± 0.033	1.949AspTyr: 1.949 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.11GluAla: 5.11 ± 0.093	0.627GluCys: 0.627 ± 0.032	2.685GluAsp: 2.685 ± 0.069	4.883GluGlu: 4.883 ± 0.098	2.445GluPhe: 2.445 ± 0.064	4.03GluGly: 4.03 ± 0.081	1.578GluHis: 1.578 ± 0.046	4.874GluIle: 4.874 ± 0.085	5.754GluLys: 5.754 ± 0.101	6.835GluLeu: 6.835 ± 0.098	1.763GluMet: 1.763 ± 0.047	3.171GluAsn: 3.171 ± 0.073	2.232GluPro: 2.232 ± 0.056	2.511GluGln: 2.511 ± 0.061	3.761GluArg: 3.761 ± 0.085	3.757GluSer: 3.757 ± 0.074	3.651GluThr: 3.651 ± 0.08	3.875GluVal: 3.875 ± 0.083	0.684GluTrp: 0.684 ± 0.032	1.927GluTyr: 1.927 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.576PheAla: 3.576 ± 0.079	0.595PheCys: 0.595 ± 0.028	2.762PheAsp: 2.762 ± 0.059	2.558PheGlu: 2.558 ± 0.06	2.408PhePhe: 2.408 ± 0.071	3.432PheGly: 3.432 ± 0.078	0.98PheHis: 0.98 ± 0.037	3.088PheIle: 3.088 ± 0.079	1.689PheLys: 1.689 ± 0.049	4.52PheLeu: 4.52 ± 0.104	1.124PheMet: 1.124 ± 0.042	1.862PheAsn: 1.862 ± 0.052	1.893PhePro: 1.893 ± 0.046	1.188PheGln: 1.188 ± 0.038	2.734PheArg: 2.734 ± 0.065	3.979PheSer: 3.979 ± 0.085	2.483PheThr: 2.483 ± 0.064	2.767PheVal: 2.767 ± 0.06	0.54PheTrp: 0.54 ± 0.028	1.479PheTyr: 1.479 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	5.203GlyAla: 5.203 ± 0.101	1.011GlyCys: 1.011 ± 0.04	3.505GlyAsp: 3.505 ± 0.12	4.099GlyGlu: 4.099 ± 0.082	3.696GlyPhe: 3.696 ± 0.073	5.272GlyGly: 5.272 ± 0.151	1.545GlyHis: 1.545 ± 0.052	6.244GlyIle: 6.244 ± 0.103	5.193GlyLys: 5.193 ± 0.09	6.469GlyLeu: 6.469 ± 0.104	2.338GlyMet: 2.338 ± 0.062	3.117GlyAsn: 3.117 ± 0.102	2.025GlyPro: 2.025 ± 0.054	2.018GlyGln: 2.018 ± 0.055	3.914GlyArg: 3.914 ± 0.086	5.124GlySer: 5.124 ± 0.111	4.249GlyThr: 4.249 ± 0.103	4.705GlyVal: 4.705 ± 0.09	0.858GlyTrp: 0.858 ± 0.035	2.736GlyTyr: 2.736 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.74HisAla: 1.74 ± 0.053	0.306HisCys: 0.306 ± 0.023	1.24HisAsp: 1.24 ± 0.043	1.541HisGlu: 1.541 ± 0.052	1.035HisPhe: 1.035 ± 0.035	1.55HisGly: 1.55 ± 0.052	0.601HisHis: 0.601 ± 0.036	1.362HisIle: 1.362 ± 0.038	0.862HisLys: 0.862 ± 0.037	2.033HisLeu: 2.033 ± 0.055	0.477HisMet: 0.477 ± 0.023	0.826HisAsn: 0.826 ± 0.034	1.204HisPro: 1.204 ± 0.044	0.636HisGln: 0.636 ± 0.029	1.215HisArg: 1.215 ± 0.042	1.364HisSer: 1.364 ± 0.041	0.992HisThr: 0.992 ± 0.042	1.276HisVal: 1.276 ± 0.048	0.235HisTrp: 0.235 ± 0.02	0.76HisTyr: 0.76 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.503IleAla: 6.503 ± 0.109	0.874IleCys: 0.874 ± 0.033	4.498IleAsp: 4.498 ± 0.083	5.044IleGlu: 5.044 ± 0.09	2.931IlePhe: 2.931 ± 0.077	5.358IleGly: 5.358 ± 0.104	1.325IleHis: 1.325 ± 0.045	4.805IleIle: 4.805 ± 0.108	3.007IleLys: 3.007 ± 0.076	6.192IleLeu: 6.192 ± 0.108	1.575IleMet: 1.575 ± 0.046	2.617IleAsn: 2.617 ± 0.069	3.294IlePro: 3.294 ± 0.072	1.831IleGln: 1.831 ± 0.053	4.241IleArg: 4.241 ± 0.079	5.097IleSer: 5.097 ± 0.086	4.006IleThr: 4.006 ± 0.091	4.941IleVal: 4.941 ± 0.103	0.618IleTrp: 0.618 ± 0.032	1.921IleTyr: 1.921 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.691LysAla: 4.691 ± 0.102	0.39LysCys: 0.39 ± 0.027	2.436LysAsp: 2.436 ± 0.064	4.005LysGlu: 4.005 ± 0.069	1.755LysPhe: 1.755 ± 0.047	3.997LysGly: 3.997 ± 0.083	1.114LysHis: 1.114 ± 0.039	4.227LysIle: 4.227 ± 0.092	4.721LysLys: 4.721 ± 0.103	5.069LysLeu: 5.069 ± 0.086	1.452LysMet: 1.452 ± 0.047	2.846LysAsn: 2.846 ± 0.067	2.648LysPro: 2.648 ± 0.081	1.947LysGln: 1.947 ± 0.066	2.896LysArg: 2.896 ± 0.061	3.565LysSer: 3.565 ± 0.075	3.435LysThr: 3.435 ± 0.079	3.745LysVal: 3.745 ± 0.082	0.505LysTrp: 0.505 ± 0.032	1.613LysTyr: 1.613 ± 0.049	0.0LysXaa: 0.0 ± 0.0
Leu	8.188LeuAla: 8.188 ± 0.122	1.148LeuCys: 1.148 ± 0.035	5.643LeuAsp: 5.643 ± 0.088	6.512LeuGlu: 6.512 ± 0.105	4.845LeuPhe: 4.845 ± 0.106	6.642LeuGly: 6.642 ± 0.112	2.144LeuHis: 2.144 ± 0.054	5.657LeuIle: 5.657 ± 0.111	6.016LeuLys: 6.016 ± 0.097	10.49LeuLeu: 10.49 ± 0.169	2.382LeuMet: 2.382 ± 0.055	3.641LeuAsn: 3.641 ± 0.073	4.499LeuPro: 4.499 ± 0.086	3.658LeuGln: 3.658 ± 0.078	5.183LeuArg: 5.183 ± 0.093	7.146LeuSer: 7.146 ± 0.092	4.605LeuThr: 4.605 ± 0.092	6.619LeuVal: 6.619 ± 0.106	0.921LeuTrp: 0.921 ± 0.04	2.876LeuTyr: 2.876 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.049MetAla: 2.049 ± 0.051	0.172MetCys: 0.172 ± 0.014	1.121MetAsp: 1.121 ± 0.041	1.514MetGlu: 1.514 ± 0.045	0.939MetPhe: 0.939 ± 0.041	1.549MetGly: 1.549 ± 0.049	0.653MetHis: 0.653 ± 0.032	1.831MetIle: 1.831 ± 0.043	2.124MetLys: 2.124 ± 0.057	2.872MetLeu: 2.872 ± 0.063	0.749MetMet: 0.749 ± 0.032	1.35MetAsn: 1.35 ± 0.046	1.319MetPro: 1.319 ± 0.038	1.095MetGln: 1.095 ± 0.034	1.321MetArg: 1.321 ± 0.043	1.664MetSer: 1.664 ± 0.044	1.518MetThr: 1.518 ± 0.044	1.754MetVal: 1.754 ± 0.047	0.154MetTrp: 0.154 ± 0.016	0.485MetTyr: 0.485 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.164AsnAla: 3.164 ± 0.071	0.477AsnCys: 0.477 ± 0.031	2.058AsnAsp: 2.058 ± 0.073	2.281AsnGlu: 2.281 ± 0.055	1.614AsnPhe: 1.614 ± 0.046	3.027AsnGly: 3.027 ± 0.123	0.822AsnHis: 0.822 ± 0.034	3.258AsnIle: 3.258 ± 0.068	1.72AsnLys: 1.72 ± 0.055	3.943AsnLeu: 3.943 ± 0.075	0.945AsnMet: 0.945 ± 0.033	1.7AsnAsn: 1.7 ± 0.061	2.448AsnPro: 2.448 ± 0.059	1.058AsnGln: 1.058 ± 0.039	2.47AsnArg: 2.47 ± 0.061	2.34AsnSer: 2.34 ± 0.061	2.053AsnThr: 2.053 ± 0.054	2.531AsnVal: 2.531 ± 0.064	0.444AsnTrp: 0.444 ± 0.028	1.323AsnTyr: 1.323 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.706ProAla: 3.706 ± 0.092	0.433ProCys: 0.433 ± 0.024	3.144ProAsp: 3.144 ± 0.067	4.167ProGlu: 4.167 ± 0.071	2.165ProPhe: 2.165 ± 0.06	3.442ProGly: 3.442 ± 0.076	0.807ProHis: 0.807 ± 0.037	1.838ProIle: 1.838 ± 0.049	1.881ProLys: 1.881 ± 0.06	4.111ProLeu: 4.111 ± 0.07	0.943ProMet: 0.943 ± 0.038	1.2ProAsn: 1.2 ± 0.043	1.535ProPro: 1.535 ± 0.054	1.152ProGln: 1.152 ± 0.039	1.51ProArg: 1.51 ± 0.043	2.735ProSer: 2.735 ± 0.066	1.457ProThr: 1.457 ± 0.047	4.178ProVal: 4.178 ± 0.083	0.491ProTrp: 0.491 ± 0.027	1.365ProTyr: 1.365 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.585GlnAla: 2.585 ± 0.063	0.288GlnCys: 0.288 ± 0.02	1.436GlnAsp: 1.436 ± 0.047	2.264GlnGlu: 2.264 ± 0.053	1.13GlnPhe: 1.13 ± 0.037	1.966GlnGly: 1.966 ± 0.044	0.717GlnHis: 0.717 ± 0.032	2.062GlnIle: 2.062 ± 0.053	2.191GlnLys: 2.191 ± 0.062	3.006GlnLeu: 3.006 ± 0.075	0.796GlnMet: 0.796 ± 0.03	1.33GlnAsn: 1.33 ± 0.048	1.201GlnPro: 1.201 ± 0.042	1.398GlnGln: 1.398 ± 0.045	1.575GlnArg: 1.575 ± 0.048	2.022GlnSer: 2.022 ± 0.058	1.457GlnThr: 1.457 ± 0.04	1.994GlnVal: 1.994 ± 0.054	0.394GlnTrp: 0.394 ± 0.027	0.949GlnTyr: 0.949 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.267ArgAla: 3.267 ± 0.076	0.585ArgCys: 0.585 ± 0.031	2.769ArgAsp: 2.769 ± 0.063	4.439ArgGlu: 4.439 ± 0.081	2.777ArgPhe: 2.777 ± 0.064	2.791ArgGly: 2.791 ± 0.066	1.349ArgHis: 1.349 ± 0.05	4.215ArgIle: 4.215 ± 0.084	4.148ArgLys: 4.148 ± 0.083	5.229ArgLeu: 5.229 ± 0.097	1.677ArgMet: 1.677 ± 0.055	2.698ArgAsn: 2.698 ± 0.062	1.952ArgPro: 1.952 ± 0.059	2.18ArgGln: 2.18 ± 0.054	2.948ArgArg: 2.948 ± 0.071	3.442ArgSer: 3.442 ± 0.076	2.592ArgThr: 2.592 ± 0.055	3.11ArgVal: 3.11 ± 0.074	0.597ArgTrp: 0.597 ± 0.03	2.223ArgTyr: 2.223 ± 0.066	0.0ArgXaa: 0.0 ± 0.0
Ser	5.293SerAla: 5.293 ± 0.094	0.947SerCys: 0.947 ± 0.038	3.565SerAsp: 3.565 ± 0.092	3.915SerGlu: 3.915 ± 0.07	3.32SerPhe: 3.32 ± 0.068	6.336SerGly: 6.336 ± 0.118	1.335SerHis: 1.335 ± 0.045	4.92SerIle: 4.92 ± 0.086	3.065SerLys: 3.065 ± 0.068	6.862SerLeu: 6.862 ± 0.121	1.935SerMet: 1.935 ± 0.047	2.254SerAsn: 2.254 ± 0.062	2.82SerPro: 2.82 ± 0.062	1.767SerGln: 1.767 ± 0.051	3.99SerArg: 3.99 ± 0.069	4.848SerSer: 4.848 ± 0.095	3.147SerThr: 3.147 ± 0.069	4.75SerVal: 4.75 ± 0.118	0.822SerTrp: 0.822 ± 0.031	1.955SerTyr: 1.955 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.497ThrAla: 4.497 ± 0.107	0.574ThrCys: 0.574 ± 0.026	2.604ThrAsp: 2.604 ± 0.072	3.01ThrGlu: 3.01 ± 0.075	2.282ThrPhe: 2.282 ± 0.086	5.257ThrGly: 5.257 ± 0.11	0.948ThrHis: 0.948 ± 0.033	3.692ThrIle: 3.692 ± 0.066	2.01ThrLys: 2.01 ± 0.054	5.219ThrLeu: 5.219 ± 0.101	1.255ThrMet: 1.255 ± 0.042	1.545ThrAsn: 1.545 ± 0.046	2.475ThrPro: 2.475 ± 0.063	1.173ThrGln: 1.173 ± 0.041	2.458ThrArg: 2.458 ± 0.06	3.301ThrSer: 3.301 ± 0.075	2.444ThrThr: 2.444 ± 0.054	4.187ThrVal: 4.187 ± 0.086	0.492ThrTrp: 0.492 ± 0.027	1.479ThrTyr: 1.479 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.849ValAla: 4.849 ± 0.085	0.81ValCys: 0.81 ± 0.036	3.536ValAsp: 3.536 ± 0.074	3.863ValGlu: 3.863 ± 0.083	3.447ValPhe: 3.447 ± 0.086	3.731ValGly: 3.731 ± 0.093	1.433ValHis: 1.433 ± 0.047	5.232ValIle: 5.232 ± 0.086	3.595ValLys: 3.595 ± 0.081	7.096ValLeu: 7.096 ± 0.104	1.929ValMet: 1.929 ± 0.051	2.679ValAsn: 2.679 ± 0.069	2.986ValPro: 2.986 ± 0.076	2.003ValGln: 2.003 ± 0.052	3.717ValArg: 3.717 ± 0.083	5.352ValSer: 5.352 ± 0.109	4.044ValThr: 4.044 ± 0.103	4.636ValVal: 4.636 ± 0.091	0.65ValTrp: 0.65 ± 0.033	2.096ValTyr: 2.096 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.699TrpAla: 0.699 ± 0.032	0.118TrpCys: 0.118 ± 0.012	0.493TrpAsp: 0.493 ± 0.028	0.59TrpGlu: 0.59 ± 0.03	0.548TrpPhe: 0.548 ± 0.028	0.633TrpGly: 0.633 ± 0.025	0.276TrpHis: 0.276 ± 0.02	0.771TrpIle: 0.771 ± 0.028	0.747TrpLys: 0.747 ± 0.032	1.191TrpLeu: 1.191 ± 0.052	0.32TrpMet: 0.32 ± 0.022	0.558TrpAsn: 0.558 ± 0.024	0.381TrpPro: 0.381 ± 0.023	0.44TrpGln: 0.44 ± 0.022	0.504TrpArg: 0.504 ± 0.029	0.619TrpSer: 0.619 ± 0.03	0.508TrpThr: 0.508 ± 0.027	0.582TrpVal: 0.582 ± 0.029	0.153TrpTrp: 0.153 ± 0.017	0.383TrpTyr: 0.383 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.207TyrAla: 2.207 ± 0.051	0.429TyrCys: 0.429 ± 0.025	1.764TyrAsp: 1.764 ± 0.051	1.821TyrGlu: 1.821 ± 0.049	1.546TyrPhe: 1.546 ± 0.051	2.491TyrGly: 2.491 ± 0.065	0.752TyrHis: 0.752 ± 0.033	1.957TyrIle: 1.957 ± 0.045	1.398TyrLys: 1.398 ± 0.043	3.277TyrLeu: 3.277 ± 0.076	0.681TyrMet: 0.681 ± 0.034	1.315TyrAsn: 1.315 ± 0.043	1.467TyrPro: 1.467 ± 0.044	0.941TyrGln: 0.941 ± 0.041	2.301TyrArg: 2.301 ± 0.067	2.164TyrSer: 2.164 ± 0.06	1.665TyrThr: 1.665 ± 0.046	1.628TyrVal: 1.628 ± 0.048	0.327TyrTrp: 0.327 ± 0.021	1.188TyrTyr: 1.188 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2365 proteins (745862 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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