Amino acid dipepetide frequency for Staphylococcus virus 37

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.212AlaAla: 2.212 ± 0.373
0.346AlaCys: 0.346 ± 0.155
2.765AlaAsp: 2.765 ± 0.362
3.249AlaGlu: 3.249 ± 0.61
1.935AlaPhe: 1.935 ± 0.523
3.18AlaGly: 3.18 ± 0.61
0.968AlaHis: 0.968 ± 0.252
5.322AlaIle: 5.322 ± 0.807
4.7AlaLys: 4.7 ± 0.794
4.908AlaLeu: 4.908 ± 0.686
1.659AlaMet: 1.659 ± 0.38
3.041AlaAsn: 3.041 ± 0.375
1.728AlaPro: 1.728 ± 0.32
2.627AlaGln: 2.627 ± 0.428
2.074AlaArg: 2.074 ± 0.327
3.249AlaSer: 3.249 ± 0.556
3.664AlaThr: 3.664 ± 0.674
4.424AlaVal: 4.424 ± 0.643
0.76AlaTrp: 0.76 ± 0.27
2.627AlaTyr: 2.627 ± 0.466
0.0AlaXaa: 0.0 ± 0.0
Cys
0.484CysAla: 0.484 ± 0.164
0.069CysCys: 0.069 ± 0.073
0.276CysAsp: 0.276 ± 0.142
0.415CysGlu: 0.415 ± 0.175
0.415CysPhe: 0.415 ± 0.195
0.346CysGly: 0.346 ± 0.139
0.207CysHis: 0.207 ± 0.133
0.553CysIle: 0.553 ± 0.211
0.553CysLys: 0.553 ± 0.203
0.346CysLeu: 0.346 ± 0.175
0.0CysMet: 0.0 ± 0.0
0.276CysAsn: 0.276 ± 0.163
0.276CysPro: 0.276 ± 0.17
0.276CysGln: 0.276 ± 0.148
0.484CysArg: 0.484 ± 0.159
0.484CysSer: 0.484 ± 0.175
0.346CysThr: 0.346 ± 0.145
0.553CysVal: 0.553 ± 0.201
0.138CysTrp: 0.138 ± 0.088
0.276CysTyr: 0.276 ± 0.156
0.0CysXaa: 0.0 ± 0.0
Asp
3.525AspAla: 3.525 ± 0.496
0.553AspCys: 0.553 ± 0.206
5.046AspAsp: 5.046 ± 0.614
5.115AspGlu: 5.115 ± 0.681
2.558AspPhe: 2.558 ± 0.381
4.7AspGly: 4.7 ± 0.562
0.622AspHis: 0.622 ± 0.19
4.147AspIle: 4.147 ± 0.505
4.7AspLys: 4.7 ± 0.538
5.599AspLeu: 5.599 ± 0.61
2.005AspMet: 2.005 ± 0.431
3.456AspAsn: 3.456 ± 0.562
1.382AspPro: 1.382 ± 0.313
1.521AspGln: 1.521 ± 0.277
2.005AspArg: 2.005 ± 0.402
3.249AspSer: 3.249 ± 0.496
2.627AspThr: 2.627 ± 0.383
4.009AspVal: 4.009 ± 0.486
0.968AspTrp: 0.968 ± 0.209
3.041AspTyr: 3.041 ± 0.528
0.0AspXaa: 0.0 ± 0.0
Glu
3.525GluAla: 3.525 ± 0.568
0.484GluCys: 0.484 ± 0.144
4.286GluAsp: 4.286 ± 0.646
4.839GluGlu: 4.839 ± 0.694
3.733GluPhe: 3.733 ± 0.523
2.765GluGly: 2.765 ± 0.383
1.866GluHis: 1.866 ± 0.482
4.562GluIle: 4.562 ± 0.709
5.115GluLys: 5.115 ± 0.579
6.083GluLeu: 6.083 ± 0.888
2.281GluMet: 2.281 ± 0.48
3.94GluAsn: 3.94 ± 0.563
1.935GluPro: 1.935 ± 0.356
4.078GluGln: 4.078 ± 0.624
3.802GluArg: 3.802 ± 0.549
3.594GluSer: 3.594 ± 0.449
3.041GluThr: 3.041 ± 0.438
5.599GluVal: 5.599 ± 0.653
0.899GluTrp: 0.899 ± 0.233
3.456GluTyr: 3.456 ± 0.432
0.0GluXaa: 0.0 ± 0.0
Phe
2.212PheAla: 2.212 ± 0.437
0.276PheCys: 0.276 ± 0.164
3.456PheAsp: 3.456 ± 0.437
2.419PheGlu: 2.419 ± 0.395
1.728PhePhe: 1.728 ± 0.368
2.696PheGly: 2.696 ± 0.568
0.76PheHis: 0.76 ± 0.235
3.456PheIle: 3.456 ± 0.503
4.286PheLys: 4.286 ± 0.485
3.041PheLeu: 3.041 ± 0.488
1.521PheMet: 1.521 ± 0.349
3.733PheAsn: 3.733 ± 0.454
0.899PhePro: 0.899 ± 0.244
1.382PheGln: 1.382 ± 0.334
1.452PheArg: 1.452 ± 0.304
2.696PheSer: 2.696 ± 0.579
3.249PheThr: 3.249 ± 0.479
2.765PheVal: 2.765 ± 0.413
0.622PheTrp: 0.622 ± 0.221
1.866PheTyr: 1.866 ± 0.338
0.0PheXaa: 0.0 ± 0.0
Gly
3.664GlyAla: 3.664 ± 0.713
0.484GlyCys: 0.484 ± 0.216
3.802GlyAsp: 3.802 ± 0.563
4.009GlyGlu: 4.009 ± 0.712
2.834GlyPhe: 2.834 ± 0.539
3.802GlyGly: 3.802 ± 0.798
0.76GlyHis: 0.76 ± 0.273
5.046GlyIle: 5.046 ± 0.917
4.424GlyLys: 4.424 ± 0.6
4.562GlyLeu: 4.562 ± 0.548
1.175GlyMet: 1.175 ± 0.248
4.147GlyAsn: 4.147 ± 0.724
1.106GlyPro: 1.106 ± 0.369
2.903GlyGln: 2.903 ± 0.592
2.627GlyArg: 2.627 ± 0.422
3.387GlySer: 3.387 ± 0.603
3.456GlyThr: 3.456 ± 0.46
4.493GlyVal: 4.493 ± 0.645
0.691GlyTrp: 0.691 ± 0.458
4.216GlyTyr: 4.216 ± 0.556
0.0GlyXaa: 0.0 ± 0.0
His
1.313HisAla: 1.313 ± 0.296
0.207HisCys: 0.207 ± 0.121
0.76HisAsp: 0.76 ± 0.235
1.244HisGlu: 1.244 ± 0.262
0.76HisPhe: 0.76 ± 0.203
1.175HisGly: 1.175 ± 0.283
0.553HisHis: 0.553 ± 0.213
0.76HisIle: 0.76 ± 0.295
1.521HisLys: 1.521 ± 0.353
1.728HisLeu: 1.728 ± 0.364
0.484HisMet: 0.484 ± 0.183
1.382HisAsn: 1.382 ± 0.303
0.484HisPro: 0.484 ± 0.164
0.899HisGln: 0.899 ± 0.261
0.622HisArg: 0.622 ± 0.19
1.175HisSer: 1.175 ± 0.306
1.382HisThr: 1.382 ± 0.292
1.106HisVal: 1.106 ± 0.283
0.207HisTrp: 0.207 ± 0.102
1.037HisTyr: 1.037 ± 0.265
0.0HisXaa: 0.0 ± 0.0
Ile
4.286IleAla: 4.286 ± 0.494
0.415IleCys: 0.415 ± 0.158
5.53IleAsp: 5.53 ± 0.636
6.705IleGlu: 6.705 ± 0.913
3.249IlePhe: 3.249 ± 0.675
4.631IleGly: 4.631 ± 0.764
1.313IleHis: 1.313 ± 0.287
5.184IleIle: 5.184 ± 0.832
6.912IleLys: 6.912 ± 0.679
3.871IleLeu: 3.871 ± 0.55
1.382IleMet: 1.382 ± 0.32
4.631IleAsn: 4.631 ± 0.596
2.765IlePro: 2.765 ± 0.395
2.765IleGln: 2.765 ± 0.512
2.834IleArg: 2.834 ± 0.393
3.94IleSer: 3.94 ± 0.598
5.322IleThr: 5.322 ± 0.606
4.908IleVal: 4.908 ± 0.569
0.622IleTrp: 0.622 ± 0.273
3.18IleTyr: 3.18 ± 0.593
0.0IleXaa: 0.0 ± 0.0
Lys
4.631LysAla: 4.631 ± 0.56
0.553LysCys: 0.553 ± 0.203
5.53LysAsp: 5.53 ± 0.567
5.737LysGlu: 5.737 ± 0.861
3.802LysPhe: 3.802 ± 0.515
6.567LysGly: 6.567 ± 0.724
2.074LysHis: 2.074 ± 0.327
5.737LysIle: 5.737 ± 0.706
6.014LysLys: 6.014 ± 0.777
5.53LysLeu: 5.53 ± 0.626
2.281LysMet: 2.281 ± 0.364
4.769LysAsn: 4.769 ± 0.544
2.488LysPro: 2.488 ± 0.467
4.009LysGln: 4.009 ± 0.611
3.871LysArg: 3.871 ± 0.673
4.562LysSer: 4.562 ± 0.482
4.908LysThr: 4.908 ± 0.505
4.977LysVal: 4.977 ± 0.565
1.175LysTrp: 1.175 ± 0.33
4.216LysTyr: 4.216 ± 0.684
0.0LysXaa: 0.0 ± 0.0
Leu
3.664LeuAla: 3.664 ± 0.522
0.346LeuCys: 0.346 ± 0.166
3.802LeuAsp: 3.802 ± 0.538
6.014LeuGlu: 6.014 ± 0.55
3.456LeuPhe: 3.456 ± 0.595
4.286LeuGly: 4.286 ± 0.521
1.106LeuHis: 1.106 ± 0.283
4.977LeuIle: 4.977 ± 0.498
9.055LeuLys: 9.055 ± 0.621
6.843LeuLeu: 6.843 ± 0.876
1.728LeuMet: 1.728 ± 0.4
5.115LeuAsn: 5.115 ± 0.473
2.627LeuPro: 2.627 ± 0.39
3.249LeuGln: 3.249 ± 0.553
3.041LeuArg: 3.041 ± 0.46
4.355LeuSer: 4.355 ± 0.579
4.769LeuThr: 4.769 ± 0.485
3.456LeuVal: 3.456 ± 0.443
0.899LeuTrp: 0.899 ± 0.256
3.318LeuTyr: 3.318 ± 0.574
0.0LeuXaa: 0.0 ± 0.0
Met
1.106MetAla: 1.106 ± 0.352
0.0MetCys: 0.0 ± 0.0
1.521MetAsp: 1.521 ± 0.36
2.281MetGlu: 2.281 ± 0.457
0.76MetPhe: 0.76 ± 0.227
1.106MetGly: 1.106 ± 0.261
0.276MetHis: 0.276 ± 0.136
1.659MetIle: 1.659 ± 0.344
2.281MetLys: 2.281 ± 0.444
1.521MetLeu: 1.521 ± 0.334
1.037MetMet: 1.037 ± 0.26
1.521MetAsn: 1.521 ± 0.349
0.691MetPro: 0.691 ± 0.207
1.452MetGln: 1.452 ± 0.313
1.521MetArg: 1.521 ± 0.411
1.59MetSer: 1.59 ± 0.274
1.659MetThr: 1.659 ± 0.4
1.106MetVal: 1.106 ± 0.26
0.346MetTrp: 0.346 ± 0.142
1.037MetTyr: 1.037 ± 0.36
0.0MetXaa: 0.0 ± 0.0
Asn
4.839AsnAla: 4.839 ± 0.741
0.622AsnCys: 0.622 ± 0.2
3.594AsnAsp: 3.594 ± 0.609
4.839AsnGlu: 4.839 ± 0.647
2.074AsnPhe: 2.074 ± 0.331
5.322AsnGly: 5.322 ± 0.823
1.037AsnHis: 1.037 ± 0.284
4.7AsnIle: 4.7 ± 0.718
5.322AsnLys: 5.322 ± 0.717
6.014AsnLeu: 6.014 ± 0.659
0.899AsnMet: 0.899 ± 0.279
5.53AsnAsn: 5.53 ± 0.918
2.005AsnPro: 2.005 ± 0.463
2.558AsnGln: 2.558 ± 0.561
2.903AsnArg: 2.903 ± 0.444
3.525AsnSer: 3.525 ± 0.421
3.94AsnThr: 3.94 ± 0.725
4.147AsnVal: 4.147 ± 0.704
0.829AsnTrp: 0.829 ± 0.252
2.35AsnTyr: 2.35 ± 0.462
0.0AsnXaa: 0.0 ± 0.0
Pro
1.037ProAla: 1.037 ± 0.307
0.138ProCys: 0.138 ± 0.096
1.382ProAsp: 1.382 ± 0.32
1.866ProGlu: 1.866 ± 0.389
2.143ProPhe: 2.143 ± 0.462
1.175ProGly: 1.175 ± 0.338
0.484ProHis: 0.484 ± 0.208
3.041ProIle: 3.041 ± 0.571
3.041ProLys: 3.041 ± 0.564
1.244ProLeu: 1.244 ± 0.204
0.691ProMet: 0.691 ± 0.214
1.866ProAsn: 1.866 ± 0.324
0.899ProPro: 0.899 ± 0.298
1.244ProGln: 1.244 ± 0.332
1.452ProArg: 1.452 ± 0.357
1.59ProSer: 1.59 ± 0.288
2.212ProThr: 2.212 ± 0.406
2.558ProVal: 2.558 ± 0.4
0.207ProTrp: 0.207 ± 0.122
1.521ProTyr: 1.521 ± 0.309
0.0ProXaa: 0.0 ± 0.0
Gln
3.111GlnAla: 3.111 ± 0.582
0.553GlnCys: 0.553 ± 0.181
1.59GlnAsp: 1.59 ± 0.283
3.041GlnGlu: 3.041 ± 0.464
2.005GlnPhe: 2.005 ± 0.367
3.18GlnGly: 3.18 ± 0.502
1.106GlnHis: 1.106 ± 0.259
2.903GlnIle: 2.903 ± 0.461
2.627GlnLys: 2.627 ± 0.456
2.488GlnLeu: 2.488 ± 0.415
0.76GlnMet: 0.76 ± 0.231
3.387GlnAsn: 3.387 ± 0.427
1.659GlnPro: 1.659 ± 0.331
2.005GlnGln: 2.005 ± 0.372
1.797GlnArg: 1.797 ± 0.428
3.041GlnSer: 3.041 ± 0.461
2.696GlnThr: 2.696 ± 0.439
2.281GlnVal: 2.281 ± 0.384
0.829GlnTrp: 0.829 ± 0.262
2.558GlnTyr: 2.558 ± 0.417
0.0GlnXaa: 0.0 ± 0.0
Arg
1.521ArgAla: 1.521 ± 0.446
0.069ArgCys: 0.069 ± 0.062
2.419ArgAsp: 2.419 ± 0.385
3.18ArgGlu: 3.18 ± 0.435
1.797ArgPhe: 1.797 ± 0.303
2.074ArgGly: 2.074 ± 0.38
0.829ArgHis: 0.829 ± 0.22
3.664ArgIle: 3.664 ± 0.489
3.871ArgLys: 3.871 ± 0.585
3.94ArgLeu: 3.94 ± 0.659
0.76ArgMet: 0.76 ± 0.207
2.972ArgAsn: 2.972 ± 0.46
1.313ArgPro: 1.313 ± 0.255
1.935ArgGln: 1.935 ± 0.409
1.452ArgArg: 1.452 ± 0.307
2.834ArgSer: 2.834 ± 0.341
2.419ArgThr: 2.419 ± 0.402
1.935ArgVal: 1.935 ± 0.458
0.553ArgTrp: 0.553 ± 0.185
2.005ArgTyr: 2.005 ± 0.392
0.0ArgXaa: 0.0 ± 0.0
Ser
3.111SerAla: 3.111 ± 0.531
0.691SerCys: 0.691 ± 0.235
3.733SerAsp: 3.733 ± 0.687
3.387SerGlu: 3.387 ± 0.505
2.903SerPhe: 2.903 ± 0.485
4.424SerGly: 4.424 ± 0.624
1.037SerHis: 1.037 ± 0.245
4.493SerIle: 4.493 ± 0.762
4.493SerLys: 4.493 ± 0.626
3.94SerLeu: 3.94 ± 0.45
1.244SerMet: 1.244 ± 0.226
5.115SerAsn: 5.115 ± 0.711
1.59SerPro: 1.59 ± 0.324
2.627SerGln: 2.627 ± 0.397
2.35SerArg: 2.35 ± 0.447
3.456SerSer: 3.456 ± 0.551
3.664SerThr: 3.664 ± 0.523
3.456SerVal: 3.456 ± 0.492
0.899SerTrp: 0.899 ± 0.229
2.074SerTyr: 2.074 ± 0.379
0.0SerXaa: 0.0 ± 0.0
Thr
4.424ThrAla: 4.424 ± 0.584
0.138ThrCys: 0.138 ± 0.095
3.94ThrAsp: 3.94 ± 0.491
3.387ThrGlu: 3.387 ± 0.537
3.802ThrPhe: 3.802 ± 0.572
3.318ThrGly: 3.318 ± 0.546
1.175ThrHis: 1.175 ± 0.301
4.562ThrIle: 4.562 ± 0.578
4.424ThrLys: 4.424 ± 0.616
5.115ThrLeu: 5.115 ± 0.423
1.106ThrMet: 1.106 ± 0.281
3.802ThrAsn: 3.802 ± 0.464
2.074ThrPro: 2.074 ± 0.369
2.488ThrGln: 2.488 ± 0.426
2.212ThrArg: 2.212 ± 0.366
3.871ThrSer: 3.871 ± 0.532
3.594ThrThr: 3.594 ± 0.438
3.664ThrVal: 3.664 ± 0.44
0.622ThrTrp: 0.622 ± 0.156
3.525ThrTyr: 3.525 ± 0.551
0.0ThrXaa: 0.0 ± 0.0
Val
3.525ValAla: 3.525 ± 0.556
0.415ValCys: 0.415 ± 0.182
4.216ValAsp: 4.216 ± 0.657
4.147ValGlu: 4.147 ± 0.592
2.074ValPhe: 2.074 ± 0.351
3.18ValGly: 3.18 ± 0.594
1.106ValHis: 1.106 ± 0.269
4.424ValIle: 4.424 ± 0.476
5.737ValLys: 5.737 ± 0.564
4.839ValLeu: 4.839 ± 0.54
2.005ValMet: 2.005 ± 0.286
4.147ValAsn: 4.147 ± 0.707
2.281ValPro: 2.281 ± 0.359
3.111ValGln: 3.111 ± 0.45
2.696ValArg: 2.696 ± 0.407
4.562ValSer: 4.562 ± 0.599
4.009ValThr: 4.009 ± 0.553
3.733ValVal: 3.733 ± 0.579
0.691ValTrp: 0.691 ± 0.246
1.728ValTyr: 1.728 ± 0.354
0.0ValXaa: 0.0 ± 0.0
Trp
0.691TrpAla: 0.691 ± 0.299
0.138TrpCys: 0.138 ± 0.102
0.622TrpAsp: 0.622 ± 0.21
0.484TrpGlu: 0.484 ± 0.179
0.346TrpPhe: 0.346 ± 0.143
0.76TrpGly: 0.76 ± 0.382
0.484TrpHis: 0.484 ± 0.174
1.452TrpIle: 1.452 ± 0.264
0.484TrpLys: 0.484 ± 0.163
1.037TrpLeu: 1.037 ± 0.323
0.138TrpMet: 0.138 ± 0.104
1.037TrpAsn: 1.037 ± 0.244
0.069TrpPro: 0.069 ± 0.072
0.691TrpGln: 0.691 ± 0.207
0.276TrpArg: 0.276 ± 0.122
1.382TrpSer: 1.382 ± 0.39
0.76TrpThr: 0.76 ± 0.222
1.037TrpVal: 1.037 ± 0.217
0.0TrpTrp: 0.0 ± 0.0
0.484TrpTyr: 0.484 ± 0.171
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.558TyrAla: 2.558 ± 0.42
0.276TyrCys: 0.276 ± 0.148
2.558TyrAsp: 2.558 ± 0.478
3.525TyrGlu: 3.525 ± 0.596
2.143TyrPhe: 2.143 ± 0.387
2.903TyrGly: 2.903 ± 0.514
1.037TyrHis: 1.037 ± 0.258
3.871TyrIle: 3.871 ± 0.531
3.871TyrLys: 3.871 ± 0.571
3.456TyrLeu: 3.456 ± 0.525
1.244TyrMet: 1.244 ± 0.321
3.18TyrAsn: 3.18 ± 0.519
1.521TyrPro: 1.521 ± 0.382
1.797TyrGln: 1.797 ± 0.288
2.074TyrArg: 2.074 ± 0.465
2.143TyrSer: 2.143 ± 0.354
3.525TyrThr: 3.525 ± 0.439
2.419TyrVal: 2.419 ± 0.386
0.415TyrTrp: 0.415 ± 0.187
2.281TyrTyr: 2.281 ± 0.441
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (14468 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski