Amino acid dipepetide frequency for Pseudolabrys sp. GY_H

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.279AlaAla: 18.279 ± 0.175	1.018AlaCys: 1.018 ± 0.033	6.904AlaAsp: 6.904 ± 0.09	7.06AlaGlu: 7.06 ± 0.093	4.574AlaPhe: 4.574 ± 0.061	10.726AlaGly: 10.726 ± 0.129	2.095AlaHis: 2.095 ± 0.043	6.729AlaIle: 6.729 ± 0.084	5.167AlaLys: 5.167 ± 0.079	13.227AlaLeu: 13.227 ± 0.127	3.739AlaMet: 3.739 ± 0.059	3.098AlaAsn: 3.098 ± 0.059	5.963AlaPro: 5.963 ± 0.079	4.242AlaGln: 4.242 ± 0.067	8.544AlaArg: 8.544 ± 0.095	6.294AlaSer: 6.294 ± 0.079	6.355AlaThr: 6.355 ± 0.086	9.378AlaVal: 9.378 ± 0.104	1.394AlaTrp: 1.394 ± 0.032	2.608AlaTyr: 2.608 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.027	0.101CysCys: 0.101 ± 0.009	0.504CysAsp: 0.504 ± 0.023	0.415CysGlu: 0.415 ± 0.018	0.303CysPhe: 0.303 ± 0.018	0.92CysGly: 0.92 ± 0.03	0.23CysHis: 0.23 ± 0.014	0.435CysIle: 0.435 ± 0.02	0.239CysLys: 0.239 ± 0.014	0.693CysLeu: 0.693 ± 0.024	0.155CysMet: 0.155 ± 0.011	0.205CysAsn: 0.205 ± 0.012	0.448CysPro: 0.448 ± 0.021	0.197CysGln: 0.197 ± 0.013	0.569CysArg: 0.569 ± 0.02	0.425CysSer: 0.425 ± 0.018	0.386CysThr: 0.386 ± 0.02	0.648CysVal: 0.648 ± 0.026	0.106CysTrp: 0.106 ± 0.009	0.202CysTyr: 0.202 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.701AspAla: 6.701 ± 0.08	0.465AspCys: 0.465 ± 0.019	3.047AspAsp: 3.047 ± 0.058	3.287AspGlu: 3.287 ± 0.062	2.138AspPhe: 2.138 ± 0.051	4.722AspGly: 4.722 ± 0.071	1.127AspHis: 1.127 ± 0.032	3.348AspIle: 3.348 ± 0.057	2.503AspLys: 2.503 ± 0.056	5.524AspLeu: 5.524 ± 0.075	1.336AspMet: 1.336 ± 0.036	1.472AspAsn: 1.472 ± 0.035	2.973AspPro: 2.973 ± 0.052	1.514AspGln: 1.514 ± 0.04	4.023AspArg: 4.023 ± 0.07	1.97AspSer: 1.97 ± 0.041	2.589AspThr: 2.589 ± 0.053	4.356AspVal: 4.356 ± 0.064	0.814AspTrp: 0.814 ± 0.027	1.472AspTyr: 1.472 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.97GluAla: 6.97 ± 0.092	0.352GluCys: 0.352 ± 0.019	2.289GluAsp: 2.289 ± 0.048	2.618GluGlu: 2.618 ± 0.053	1.81GluPhe: 1.81 ± 0.04	3.663GluGly: 3.663 ± 0.069	1.134GluHis: 1.134 ± 0.035	3.21GluIle: 3.21 ± 0.051	2.493GluLys: 2.493 ± 0.054	4.885GluLeu: 4.885 ± 0.071	1.404GluMet: 1.404 ± 0.034	1.484GluAsn: 1.484 ± 0.035	2.698GluPro: 2.698 ± 0.059	2.028GluGln: 2.028 ± 0.045	4.656GluArg: 4.656 ± 0.076	2.179GluSer: 2.179 ± 0.04	3.113GluThr: 3.113 ± 0.053	3.679GluVal: 3.679 ± 0.056	0.597GluTrp: 0.597 ± 0.025	0.992GluTyr: 0.992 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.945PheAla: 4.945 ± 0.064	0.366PheCys: 0.366 ± 0.015	2.635PheAsp: 2.635 ± 0.042	1.915PheGlu: 1.915 ± 0.04	1.485PhePhe: 1.485 ± 0.038	3.909PheGly: 3.909 ± 0.06	0.667PheHis: 0.667 ± 0.025	1.859PheIle: 1.859 ± 0.041	1.332PheLys: 1.332 ± 0.037	3.212PheLeu: 3.212 ± 0.055	0.877PheMet: 0.877 ± 0.03	1.165PheAsn: 1.165 ± 0.029	1.633PhePro: 1.633 ± 0.035	0.872PheGln: 0.872 ± 0.026	2.142PheArg: 2.142 ± 0.042	2.088PheSer: 2.088 ± 0.042	2.051PheThr: 2.051 ± 0.042	3.077PheVal: 3.077 ± 0.055	0.524PheTrp: 0.524 ± 0.023	0.945PheTyr: 0.945 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.61GlyAla: 9.61 ± 0.147	0.82GlyCys: 0.82 ± 0.028	4.283GlyAsp: 4.283 ± 0.058	4.339GlyGlu: 4.339 ± 0.072	3.627GlyPhe: 3.627 ± 0.059	7.349GlyGly: 7.349 ± 0.135	1.873GlyHis: 1.873 ± 0.037	4.882GlyIle: 4.882 ± 0.072	3.817GlyLys: 3.817 ± 0.061	8.446GlyLeu: 8.446 ± 0.076	2.254GlyMet: 2.254 ± 0.041	2.327GlyAsn: 2.327 ± 0.049	3.553GlyPro: 3.553 ± 0.053	2.74GlyGln: 2.74 ± 0.046	5.709GlyArg: 5.709 ± 0.066	4.522GlySer: 4.522 ± 0.09	4.521GlyThr: 4.521 ± 0.093	6.3GlyVal: 6.3 ± 0.082	1.261GlyTrp: 1.261 ± 0.038	2.418GlyTyr: 2.418 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.221HisAla: 2.221 ± 0.051	0.221HisCys: 0.221 ± 0.013	1.151HisAsp: 1.151 ± 0.034	0.989HisGlu: 0.989 ± 0.033	0.817HisPhe: 0.817 ± 0.03	1.791HisGly: 1.791 ± 0.044	0.539HisHis: 0.539 ± 0.024	1.006HisIle: 1.006 ± 0.03	0.578HisLys: 0.578 ± 0.023	1.842HisLeu: 1.842 ± 0.043	0.477HisMet: 0.477 ± 0.021	0.501HisAsn: 0.501 ± 0.021	1.192HisPro: 1.192 ± 0.029	0.527HisGln: 0.527 ± 0.022	1.305HisArg: 1.305 ± 0.037	0.886HisSer: 0.886 ± 0.025	0.857HisThr: 0.857 ± 0.024	1.48HisVal: 1.48 ± 0.037	0.291HisTrp: 0.291 ± 0.015	0.546HisTyr: 0.546 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	8.133IleAla: 8.133 ± 0.089	0.478IleCys: 0.478 ± 0.022	3.871IleAsp: 3.871 ± 0.053	3.716IleGlu: 3.716 ± 0.058	1.723IlePhe: 1.723 ± 0.04	5.477IleGly: 5.477 ± 0.071	0.891IleHis: 0.891 ± 0.028	2.444IleIle: 2.444 ± 0.05	2.077IleLys: 2.077 ± 0.038	4.273IleLeu: 4.273 ± 0.072	1.087IleMet: 1.087 ± 0.033	1.586IleAsn: 1.586 ± 0.038	2.374IlePro: 2.374 ± 0.048	1.084IleGln: 1.084 ± 0.031	2.952IleArg: 2.952 ± 0.044	2.717IleSer: 2.717 ± 0.044	2.759IleThr: 2.759 ± 0.054	5.075IleVal: 5.075 ± 0.068	0.565IleTrp: 0.565 ± 0.021	1.235IleTyr: 1.235 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.175LysAla: 5.175 ± 0.083	0.199LysCys: 0.199 ± 0.013	2.226LysAsp: 2.226 ± 0.045	1.84LysGlu: 1.84 ± 0.049	1.205LysPhe: 1.205 ± 0.035	3.007LysGly: 3.007 ± 0.048	0.736LysHis: 0.736 ± 0.027	2.173LysIle: 2.173 ± 0.046	2.006LysLys: 2.006 ± 0.05	4.12LysLeu: 4.12 ± 0.063	1.055LysMet: 1.055 ± 0.032	1.141LysAsn: 1.141 ± 0.036	2.755LysPro: 2.755 ± 0.053	1.219LysGln: 1.219 ± 0.03	2.836LysArg: 2.836 ± 0.046	2.29LysSer: 2.29 ± 0.041	2.334LysThr: 2.334 ± 0.047	3.125LysVal: 3.125 ± 0.059	0.407LysTrp: 0.407 ± 0.018	0.803LysTyr: 0.803 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	13.097LeuAla: 13.097 ± 0.14	0.823LeuCys: 0.823 ± 0.027	5.648LeuAsp: 5.648 ± 0.073	4.504LeuGlu: 4.504 ± 0.066	3.526LeuPhe: 3.526 ± 0.059	8.104LeuGly: 8.104 ± 0.095	1.679LeuHis: 1.679 ± 0.043	5.422LeuIle: 5.422 ± 0.079	4.244LeuLys: 4.244 ± 0.065	8.855LeuLeu: 8.855 ± 0.123	2.441LeuMet: 2.441 ± 0.048	2.714LeuAsn: 2.714 ± 0.051	5.356LeuPro: 5.356 ± 0.077	2.408LeuGln: 2.408 ± 0.045	6.263LeuArg: 6.263 ± 0.085	5.96LeuSer: 5.96 ± 0.079	5.724LeuThr: 5.724 ± 0.073	7.234LeuVal: 7.234 ± 0.095	1.11LeuTrp: 1.11 ± 0.032	2.05LeuTyr: 2.05 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.212MetAla: 3.212 ± 0.056	0.174MetCys: 0.174 ± 0.012	1.078MetAsp: 1.078 ± 0.031	0.993MetGlu: 0.993 ± 0.03	0.81MetPhe: 0.81 ± 0.026	1.751MetGly: 1.751 ± 0.038	0.459MetHis: 0.459 ± 0.021	1.443MetIle: 1.443 ± 0.036	1.186MetLys: 1.186 ± 0.035	2.642MetLeu: 2.642 ± 0.056	0.731MetMet: 0.731 ± 0.027	0.753MetAsn: 0.753 ± 0.024	1.694MetPro: 1.694 ± 0.043	0.856MetGln: 0.856 ± 0.028	1.927MetArg: 1.927 ± 0.042	1.763MetSer: 1.763 ± 0.037	1.969MetThr: 1.969 ± 0.039	1.755MetVal: 1.755 ± 0.039	0.237MetTrp: 0.237 ± 0.015	0.366MetTyr: 0.366 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.565AsnAla: 3.565 ± 0.065	0.224AsnCys: 0.224 ± 0.014	1.549AsnAsp: 1.549 ± 0.036	1.328AsnGlu: 1.328 ± 0.031	1.07AsnPhe: 1.07 ± 0.034	2.596AsnGly: 2.596 ± 0.059	0.49AsnHis: 0.49 ± 0.021	1.519AsnIle: 1.519 ± 0.036	0.972AsnLys: 0.972 ± 0.029	2.61AsnLeu: 2.61 ± 0.044	0.68AsnMet: 0.68 ± 0.026	0.821AsnAsn: 0.821 ± 0.038	1.753AsnPro: 1.753 ± 0.036	0.686AsnGln: 0.686 ± 0.027	1.836AsnArg: 1.836 ± 0.044	1.306AsnSer: 1.306 ± 0.039	1.391AsnThr: 1.391 ± 0.045	2.259AsnVal: 2.259 ± 0.047	0.421AsnTrp: 0.421 ± 0.018	0.785AsnTyr: 0.785 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.531ProAla: 6.531 ± 0.095	0.303ProCys: 0.303 ± 0.016	3.449ProAsp: 3.449 ± 0.055	3.097ProGlu: 3.097 ± 0.051	2.038ProPhe: 2.038 ± 0.044	4.375ProGly: 4.375 ± 0.063	1.083ProHis: 1.083 ± 0.032	2.51ProIle: 2.51 ± 0.041	2.256ProLys: 2.256 ± 0.054	4.703ProLeu: 4.703 ± 0.061	1.318ProMet: 1.318 ± 0.034	1.552ProAsn: 1.552 ± 0.036	2.909ProPro: 2.909 ± 0.088	1.793ProGln: 1.793 ± 0.042	3.042ProArg: 3.042 ± 0.054	2.767ProSer: 2.767 ± 0.047	2.543ProThr: 2.543 ± 0.044	4.332ProVal: 4.332 ± 0.062	0.677ProTrp: 0.677 ± 0.028	1.21ProTyr: 1.21 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.865GlnAla: 3.865 ± 0.055	0.217GlnCys: 0.217 ± 0.014	1.272GlnAsp: 1.272 ± 0.03	1.256GlnGlu: 1.256 ± 0.034	1.117GlnPhe: 1.117 ± 0.033	2.227GlnGly: 2.227 ± 0.049	0.592GlnHis: 0.592 ± 0.021	1.706GlnIle: 1.706 ± 0.041	1.208GlnLys: 1.208 ± 0.033	2.727GlnLeu: 2.727 ± 0.057	0.904GlnMet: 0.904 ± 0.028	0.913GlnAsn: 0.913 ± 0.032	1.745GlnPro: 1.745 ± 0.043	1.26GlnGln: 1.26 ± 0.045	2.382GlnArg: 2.382 ± 0.051	1.708GlnSer: 1.708 ± 0.042	1.699GlnThr: 1.699 ± 0.043	2.294GlnVal: 2.294 ± 0.042	0.426GlnTrp: 0.426 ± 0.018	0.643GlnTyr: 0.643 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.904ArgAla: 7.904 ± 0.1	0.51ArgCys: 0.51 ± 0.023	3.887ArgAsp: 3.887 ± 0.066	3.819ArgGlu: 3.819 ± 0.063	2.744ArgPhe: 2.744 ± 0.053	4.887ArgGly: 4.887 ± 0.076	1.538ArgHis: 1.538 ± 0.035	3.828ArgIle: 3.828 ± 0.065	2.661ArgLys: 2.661 ± 0.052	7.17ArgLeu: 7.17 ± 0.079	1.825ArgMet: 1.825 ± 0.037	1.967ArgAsn: 1.967 ± 0.037	3.426ArgPro: 3.426 ± 0.056	2.271ArgGln: 2.271 ± 0.048	5.166ArgArg: 5.166 ± 0.091	3.343ArgSer: 3.343 ± 0.06	3.325ArgThr: 3.325 ± 0.054	4.86ArgVal: 4.86 ± 0.069	0.867ArgTrp: 0.867 ± 0.026	1.704ArgTyr: 1.704 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.988SerAla: 5.988 ± 0.087	0.404SerCys: 0.404 ± 0.019	2.792SerAsp: 2.792 ± 0.051	2.574SerGlu: 2.574 ± 0.053	2.26SerPhe: 2.26 ± 0.039	5.431SerGly: 5.431 ± 0.094	1.029SerHis: 1.029 ± 0.029	2.895SerIle: 2.895 ± 0.056	1.845SerLys: 1.845 ± 0.044	5.098SerLeu: 5.098 ± 0.076	1.289SerMet: 1.289 ± 0.032	1.435SerAsn: 1.435 ± 0.04	2.719SerPro: 2.719 ± 0.049	1.568SerGln: 1.568 ± 0.04	3.381SerArg: 3.381 ± 0.054	2.86SerSer: 2.86 ± 0.064	2.677SerThr: 2.677 ± 0.067	3.984SerVal: 3.984 ± 0.061	0.64SerTrp: 0.64 ± 0.022	1.275SerTyr: 1.275 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.553ThrAla: 6.553 ± 0.095	0.44ThrCys: 0.44 ± 0.021	2.667ThrAsp: 2.667 ± 0.044	2.562ThrGlu: 2.562 ± 0.052	2.085ThrPhe: 2.085 ± 0.044	4.913ThrGly: 4.913 ± 0.101	1.019ThrHis: 1.019 ± 0.033	3.088ThrIle: 3.088 ± 0.064	1.738ThrLys: 1.738 ± 0.044	5.747ThrLeu: 5.747 ± 0.077	1.305ThrMet: 1.305 ± 0.032	1.364ThrAsn: 1.364 ± 0.04	3.434ThrPro: 3.434 ± 0.057	1.588ThrGln: 1.588 ± 0.042	3.323ThrArg: 3.323 ± 0.055	2.727ThrSer: 2.727 ± 0.068	2.891ThrThr: 2.891 ± 0.067	4.547ThrVal: 4.547 ± 0.082	0.695ThrTrp: 0.695 ± 0.027	1.229ThrTyr: 1.229 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.974ValAla: 9.974 ± 0.097	0.631ValCys: 0.631 ± 0.023	4.12ValAsp: 4.12 ± 0.059	4.268ValGlu: 4.268 ± 0.062	2.877ValPhe: 2.877 ± 0.051	5.78ValGly: 5.78 ± 0.078	1.339ValHis: 1.339 ± 0.038	4.382ValIle: 4.382 ± 0.07	3.024ValLys: 3.024 ± 0.057	7.607ValLeu: 7.607 ± 0.101	2.116ValMet: 2.116 ± 0.038	2.27ValAsn: 2.27 ± 0.05	3.962ValPro: 3.962 ± 0.057	2.066ValGln: 2.066 ± 0.044	4.85ValArg: 4.85 ± 0.072	4.363ValSer: 4.363 ± 0.074	4.835ValThr: 4.835 ± 0.083	6.503ValVal: 6.503 ± 0.092	0.89ValTrp: 0.89 ± 0.029	1.584ValTyr: 1.584 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.136TrpAla: 1.136 ± 0.033	0.126TrpCys: 0.126 ± 0.011	0.555TrpAsp: 0.555 ± 0.024	0.454TrpGlu: 0.454 ± 0.021	0.488TrpPhe: 0.488 ± 0.019	0.834TrpGly: 0.834 ± 0.026	0.298TrpHis: 0.298 ± 0.015	0.642TrpIle: 0.642 ± 0.026	0.489TrpLys: 0.489 ± 0.021	1.539TrpLeu: 1.539 ± 0.042	0.34TrpMet: 0.34 ± 0.016	0.418TrpAsn: 0.418 ± 0.017	0.715TrpPro: 0.715 ± 0.023	0.547TrpGln: 0.547 ± 0.021	1.089TrpArg: 1.089 ± 0.028	0.787TrpSer: 0.787 ± 0.028	0.756TrpThr: 0.756 ± 0.027	0.761TrpVal: 0.761 ± 0.022	0.217TrpTrp: 0.217 ± 0.014	0.28TrpTyr: 0.28 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.61TyrAla: 2.61 ± 0.049	0.234TyrCys: 0.234 ± 0.015	1.455TyrAsp: 1.455 ± 0.042	1.22TyrGlu: 1.22 ± 0.035	1.003TyrPhe: 1.003 ± 0.028	2.191TyrGly: 2.191 ± 0.042	0.394TyrHis: 0.394 ± 0.018	0.995TyrIle: 0.995 ± 0.033	0.818TyrLys: 0.818 ± 0.029	2.244TyrLeu: 2.244 ± 0.046	0.465TyrMet: 0.465 ± 0.02	0.675TyrAsn: 0.675 ± 0.032	1.183TyrPro: 1.183 ± 0.033	0.693TyrGln: 0.693 ± 0.025	1.707TyrArg: 1.707 ± 0.042	1.191TyrSer: 1.191 ± 0.035	1.138TyrThr: 1.138 ± 0.034	1.798TyrVal: 1.798 ± 0.044	0.333TyrTrp: 0.333 ± 0.017	0.648TyrTyr: 0.648 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3838 proteins (1211684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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