Amino acid dipepetide frequency for Rhodococcus sp. MTM3W5.2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.474AlaAla: 20.474 ± 0.175
0.996AlaCys: 0.996 ± 0.03
8.333AlaAsp: 8.333 ± 0.077
8.278AlaGlu: 8.278 ± 0.094
3.437AlaPhe: 3.437 ± 0.049
12.574AlaGly: 12.574 ± 0.083
2.447AlaHis: 2.447 ± 0.039
5.02AlaIle: 5.02 ± 0.066
2.764AlaLys: 2.764 ± 0.042
13.818AlaLeu: 13.818 ± 0.112
2.836AlaMet: 2.836 ± 0.041
2.451AlaAsn: 2.451 ± 0.039
6.62AlaPro: 6.62 ± 0.085
3.744AlaGln: 3.744 ± 0.047
8.992AlaArg: 8.992 ± 0.091
6.275AlaSer: 6.275 ± 0.066
7.525AlaThr: 7.525 ± 0.079
11.916AlaVal: 11.916 ± 0.098
1.657AlaTrp: 1.657 ± 0.041
2.199AlaTyr: 2.199 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.091CysAla: 1.091 ± 0.03
0.148CysCys: 0.148 ± 0.01
0.448CysAsp: 0.448 ± 0.019
0.38CysGlu: 0.38 ± 0.016
0.218CysPhe: 0.218 ± 0.01
0.944CysGly: 0.944 ± 0.026
0.177CysHis: 0.177 ± 0.01
0.249CysIle: 0.249 ± 0.013
0.12CysLys: 0.12 ± 0.009
0.637CysLeu: 0.637 ± 0.02
0.139CysMet: 0.139 ± 0.01
0.145CysAsn: 0.145 ± 0.009
0.509CysPro: 0.509 ± 0.018
0.188CysGln: 0.188 ± 0.012
0.62CysArg: 0.62 ± 0.022
0.627CysSer: 0.627 ± 0.024
0.529CysThr: 0.529 ± 0.019
0.616CysVal: 0.616 ± 0.017
0.145CysTrp: 0.145 ± 0.01
0.142CysTyr: 0.142 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
7.582AspAla: 7.582 ± 0.081
0.414AspCys: 0.414 ± 0.019
3.433AspAsp: 3.433 ± 0.049
4.032AspGlu: 4.032 ± 0.055
1.682AspPhe: 1.682 ± 0.034
6.295AspGly: 6.295 ± 0.074
1.339AspHis: 1.339 ± 0.029
2.169AspIle: 2.169 ± 0.037
1.082AspLys: 1.082 ± 0.031
6.512AspLeu: 6.512 ± 0.071
0.874AspMet: 0.874 ± 0.022
1.013AspAsn: 1.013 ± 0.03
4.597AspPro: 4.597 ± 0.055
1.686AspGln: 1.686 ± 0.033
5.056AspArg: 5.056 ± 0.062
3.017AspSer: 3.017 ± 0.041
3.057AspThr: 3.057 ± 0.037
4.708AspVal: 4.708 ± 0.056
0.935AspTrp: 0.935 ± 0.028
1.216AspTyr: 1.216 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
6.451GluAla: 6.451 ± 0.071
0.378GluCys: 0.378 ± 0.017
2.591GluAsp: 2.591 ± 0.043
2.657GluGlu: 2.657 ± 0.051
1.96GluPhe: 1.96 ± 0.036
3.779GluGly: 3.779 ± 0.05
1.546GluHis: 1.546 ± 0.029
2.647GluIle: 2.647 ± 0.041
1.217GluLys: 1.217 ± 0.033
7.008GluLeu: 7.008 ± 0.091
1.061GluMet: 1.061 ± 0.025
1.168GluAsn: 1.168 ± 0.027
3.042GluPro: 3.042 ± 0.045
2.263GluGln: 2.263 ± 0.041
4.884GluArg: 4.884 ± 0.064
3.282GluSer: 3.282 ± 0.045
2.671GluThr: 2.671 ± 0.04
4.777GluVal: 4.777 ± 0.059
0.751GluTrp: 0.751 ± 0.021
1.145GluTyr: 1.145 ± 0.029
0.0GluXaa: 0.0 ± 0.0
Phe
4.09PheAla: 4.09 ± 0.049
0.236PheCys: 0.236 ± 0.012
2.411PheAsp: 2.411 ± 0.047
1.729PheGlu: 1.729 ± 0.037
0.909PhePhe: 0.909 ± 0.029
3.472PheGly: 3.472 ± 0.048
0.602PheHis: 0.602 ± 0.019
0.911PheIle: 0.911 ± 0.028
0.464PheLys: 0.464 ± 0.02
2.558PheLeu: 2.558 ± 0.04
0.474PheMet: 0.474 ± 0.016
0.614PheAsn: 0.614 ± 0.02
1.368PhePro: 1.368 ± 0.029
0.683PheGln: 0.683 ± 0.022
1.637PheArg: 1.637 ± 0.035
1.585PheSer: 1.585 ± 0.034
1.969PheThr: 1.969 ± 0.04
2.68PheVal: 2.68 ± 0.048
0.41PheTrp: 0.41 ± 0.015
0.576PheTyr: 0.576 ± 0.02
0.0PheXaa: 0.0 ± 0.0
Gly
11.11GlyAla: 11.11 ± 0.103
0.896GlyCys: 0.896 ± 0.027
5.021GlyAsp: 5.021 ± 0.048
4.898GlyGlu: 4.898 ± 0.076
3.154GlyPhe: 3.154 ± 0.045
8.378GlyGly: 8.378 ± 0.108
2.05GlyHis: 2.05 ± 0.036
4.164GlyIle: 4.164 ± 0.06
2.215GlyLys: 2.215 ± 0.043
9.146GlyLeu: 9.146 ± 0.087
2.255GlyMet: 2.255 ± 0.04
1.87GlyAsn: 1.87 ± 0.038
4.791GlyPro: 4.791 ± 0.054
2.622GlyGln: 2.622 ± 0.043
6.902GlyArg: 6.902 ± 0.078
6.012GlySer: 6.012 ± 0.066
5.822GlyThr: 5.822 ± 0.059
7.857GlyVal: 7.857 ± 0.071
1.726GlyTrp: 1.726 ± 0.036
2.24GlyTyr: 2.24 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.281HisAla: 2.281 ± 0.036
0.218HisCys: 0.218 ± 0.013
1.198HisAsp: 1.198 ± 0.03
1.094HisGlu: 1.094 ± 0.026
0.602HisPhe: 0.602 ± 0.019
2.047HisGly: 2.047 ± 0.033
0.648HisHis: 0.648 ± 0.024
0.683HisIle: 0.683 ± 0.022
0.324HisLys: 0.324 ± 0.012
2.142HisLeu: 2.142 ± 0.037
0.345HisMet: 0.345 ± 0.016
0.405HisAsn: 0.405 ± 0.014
1.636HisPro: 1.636 ± 0.034
0.61HisGln: 0.61 ± 0.019
1.875HisArg: 1.875 ± 0.04
1.088HisSer: 1.088 ± 0.027
1.101HisThr: 1.101 ± 0.03
1.533HisVal: 1.533 ± 0.027
0.336HisTrp: 0.336 ± 0.015
0.442HisTyr: 0.442 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.278IleAla: 6.278 ± 0.072
0.338IleCys: 0.338 ± 0.015
3.12IleAsp: 3.12 ± 0.045
2.726IleGlu: 2.726 ± 0.042
0.924IlePhe: 0.924 ± 0.026
4.575IleGly: 4.575 ± 0.066
0.661IleHis: 0.661 ± 0.019
1.239IleIle: 1.239 ± 0.036
0.759IleLys: 0.759 ± 0.023
3.087IleLeu: 3.087 ± 0.051
0.576IleMet: 0.576 ± 0.02
0.889IleAsn: 0.889 ± 0.023
2.271IlePro: 2.271 ± 0.037
0.797IleGln: 0.797 ± 0.024
2.625IleArg: 2.625 ± 0.039
2.269IleSer: 2.269 ± 0.04
2.66IleThr: 2.66 ± 0.048
3.559IleVal: 3.559 ± 0.049
0.424IleTrp: 0.424 ± 0.017
0.724IleTyr: 0.724 ± 0.02
0.0IleXaa: 0.0 ± 0.0
Lys
2.453LysAla: 2.453 ± 0.043
0.099LysCys: 0.099 ± 0.007
1.067LysAsp: 1.067 ± 0.027
0.891LysGlu: 0.891 ± 0.025
0.573LysPhe: 0.573 ± 0.021
1.493LysGly: 1.493 ± 0.035
0.408LysHis: 0.408 ± 0.018
0.96LysIle: 0.96 ± 0.026
0.612LysLys: 0.612 ± 0.032
1.886LysLeu: 1.886 ± 0.039
0.433LysMet: 0.433 ± 0.018
0.477LysAsn: 0.477 ± 0.021
1.137LysPro: 1.137 ± 0.032
0.647LysGln: 0.647 ± 0.02
1.327LysArg: 1.327 ± 0.032
1.155LysSer: 1.155 ± 0.021
1.254LysThr: 1.254 ± 0.031
1.84LysVal: 1.84 ± 0.04
0.261LysTrp: 0.261 ± 0.012
0.433LysTyr: 0.433 ± 0.016
0.0LysXaa: 0.0 ± 0.0
Leu
14.584LeuAla: 14.584 ± 0.113
0.727LeuCys: 0.727 ± 0.022
6.853LeuAsp: 6.853 ± 0.09
5.032LeuGlu: 5.032 ± 0.061
2.691LeuPhe: 2.691 ± 0.046
9.685LeuGly: 9.685 ± 0.082
1.937LeuHis: 1.937 ± 0.034
4.075LeuIle: 4.075 ± 0.064
1.533LeuLys: 1.533 ± 0.035
9.968LeuLeu: 9.968 ± 0.1
1.734LeuMet: 1.734 ± 0.038
1.722LeuAsn: 1.722 ± 0.034
5.89LeuPro: 5.89 ± 0.072
2.237LeuGln: 2.237 ± 0.04
7.789LeuArg: 7.789 ± 0.08
5.699LeuSer: 5.699 ± 0.06
6.616LeuThr: 6.616 ± 0.066
8.808LeuVal: 8.808 ± 0.083
1.199LeuTrp: 1.199 ± 0.03
1.571LeuTyr: 1.571 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.435MetAla: 2.435 ± 0.042
0.17MetCys: 0.17 ± 0.01
0.976MetAsp: 0.976 ± 0.026
0.726MetGlu: 0.726 ± 0.02
0.627MetPhe: 0.627 ± 0.022
1.481MetGly: 1.481 ± 0.03
0.423MetHis: 0.423 ± 0.016
0.919MetIle: 0.919 ± 0.021
0.402MetLys: 0.402 ± 0.015
2.101MetLeu: 2.101 ± 0.042
0.37MetMet: 0.37 ± 0.015
0.497MetAsn: 0.497 ± 0.017
1.191MetPro: 1.191 ± 0.028
0.532MetGln: 0.532 ± 0.017
1.528MetArg: 1.528 ± 0.028
1.571MetSer: 1.571 ± 0.028
1.688MetThr: 1.688 ± 0.031
1.726MetVal: 1.726 ± 0.038
0.265MetTrp: 0.265 ± 0.015
0.355MetTyr: 0.355 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.408AsnAla: 2.408 ± 0.042
0.185AsnCys: 0.185 ± 0.011
0.963AsnAsp: 0.963 ± 0.025
0.933AsnGlu: 0.933 ± 0.022
0.6AsnPhe: 0.6 ± 0.021
1.961AsnGly: 1.961 ± 0.035
0.392AsnHis: 0.392 ± 0.016
0.817AsnIle: 0.817 ± 0.024
0.455AsnLys: 0.455 ± 0.017
1.965AsnLeu: 1.965 ± 0.037
0.38AsnMet: 0.38 ± 0.016
0.471AsnAsn: 0.471 ± 0.019
1.67AsnPro: 1.67 ± 0.038
0.577AsnGln: 0.577 ± 0.021
1.387AsnArg: 1.387 ± 0.026
1.188AsnSer: 1.188 ± 0.03
1.21AsnThr: 1.21 ± 0.03
1.537AsnVal: 1.537 ± 0.03
0.329AsnTrp: 0.329 ± 0.014
0.477AsnTyr: 0.477 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
7.67ProAla: 7.67 ± 0.067
0.338ProCys: 0.338 ± 0.014
4.314ProAsp: 4.314 ± 0.058
3.894ProGlu: 3.894 ± 0.045
1.587ProPhe: 1.587 ± 0.033
5.775ProGly: 5.775 ± 0.07
1.084ProHis: 1.084 ± 0.025
2.235ProIle: 2.235 ± 0.038
1.136ProLys: 1.136 ± 0.025
4.834ProLeu: 4.834 ± 0.062
1.191ProMet: 1.191 ± 0.025
1.188ProAsn: 1.188 ± 0.025
2.952ProPro: 2.952 ± 0.063
1.59ProGln: 1.59 ± 0.034
3.973ProArg: 3.973 ± 0.065
3.404ProSer: 3.404 ± 0.046
3.62ProThr: 3.62 ± 0.055
5.195ProVal: 5.195 ± 0.071
0.823ProTrp: 0.823 ± 0.027
0.979ProTyr: 0.979 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.455GlnAla: 3.455 ± 0.05
0.18GlnCys: 0.18 ± 0.011
1.21GlnAsp: 1.21 ± 0.03
1.154GlnGlu: 1.154 ± 0.028
0.892GlnPhe: 0.892 ± 0.025
1.936GlnGly: 1.936 ± 0.044
0.602GlnHis: 0.602 ± 0.018
1.36GlnIle: 1.36 ± 0.029
0.578GlnLys: 0.578 ± 0.019
3.185GlnLeu: 3.185 ± 0.049
0.578GlnMet: 0.578 ± 0.02
0.547GlnAsn: 0.547 ± 0.02
1.553GlnPro: 1.553 ± 0.035
1.124GlnGln: 1.124 ± 0.028
2.38GlnArg: 2.38 ± 0.042
1.445GlnSer: 1.445 ± 0.031
1.383GlnThr: 1.383 ± 0.032
2.638GlnVal: 2.638 ± 0.048
0.499GlnTrp: 0.499 ± 0.019
0.567GlnTyr: 0.567 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
8.831ArgAla: 8.831 ± 0.093
0.741ArgCys: 0.741 ± 0.023
4.127ArgAsp: 4.127 ± 0.049
4.258ArgGlu: 4.258 ± 0.059
2.366ArgPhe: 2.366 ± 0.037
5.776ArgGly: 5.776 ± 0.069
1.685ArgHis: 1.685 ± 0.032
3.465ArgIle: 3.465 ± 0.055
1.478ArgLys: 1.478 ± 0.03
7.381ArgLeu: 7.381 ± 0.07
1.933ArgMet: 1.933 ± 0.036
1.451ArgAsn: 1.451 ± 0.032
4.368ArgPro: 4.368 ± 0.058
2.025ArgGln: 2.025 ± 0.039
6.873ArgArg: 6.873 ± 0.095
4.79ArgSer: 4.79 ± 0.057
4.758ArgThr: 4.758 ± 0.054
5.662ArgVal: 5.662 ± 0.066
1.452ArgTrp: 1.452 ± 0.028
1.685ArgTyr: 1.685 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
7.48SerAla: 7.48 ± 0.071
0.502SerCys: 0.502 ± 0.019
3.14SerAsp: 3.14 ± 0.044
2.795SerGlu: 2.795 ± 0.037
1.678SerPhe: 1.678 ± 0.03
6.312SerGly: 6.312 ± 0.067
1.01SerHis: 1.01 ± 0.025
2.371SerIle: 2.371 ± 0.042
1.085SerLys: 1.085 ± 0.03
5.05SerLeu: 5.05 ± 0.059
1.444SerMet: 1.444 ± 0.031
1.137SerAsn: 1.137 ± 0.026
3.41SerPro: 3.41 ± 0.049
1.382SerGln: 1.382 ± 0.029
4.111SerArg: 4.111 ± 0.053
3.545SerSer: 3.545 ± 0.055
3.855SerThr: 3.855 ± 0.05
4.974SerVal: 4.974 ± 0.063
1.019SerTrp: 1.019 ± 0.027
1.144SerTyr: 1.144 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
8.268ThrAla: 8.268 ± 0.085
0.467ThrCys: 0.467 ± 0.018
3.759ThrAsp: 3.759 ± 0.047
3.448ThrGlu: 3.448 ± 0.05
1.731ThrPhe: 1.731 ± 0.038
6.242ThrGly: 6.242 ± 0.058
1.129ThrHis: 1.129 ± 0.028
2.355ThrIle: 2.355 ± 0.041
1.14ThrLys: 1.14 ± 0.028
5.778ThrLeu: 5.778 ± 0.064
1.185ThrMet: 1.185 ± 0.025
1.144ThrAsn: 1.144 ± 0.025
3.808ThrPro: 3.808 ± 0.046
1.362ThrGln: 1.362 ± 0.029
3.923ThrArg: 3.923 ± 0.049
3.465ThrSer: 3.465 ± 0.045
4.044ThrThr: 4.044 ± 0.077
6.151ThrVal: 6.151 ± 0.069
0.841ThrTrp: 0.841 ± 0.022
1.197ThrTyr: 1.197 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
11.577ValAla: 11.577 ± 0.104
0.695ValCys: 0.695 ± 0.021
5.805ValAsp: 5.805 ± 0.058
4.683ValGlu: 4.683 ± 0.055
2.596ValPhe: 2.596 ± 0.04
7.429ValGly: 7.429 ± 0.062
1.786ValHis: 1.786 ± 0.035
3.604ValIle: 3.604 ± 0.045
1.451ValLys: 1.451 ± 0.035
9.479ValLeu: 9.479 ± 0.086
1.528ValMet: 1.528 ± 0.034
1.904ValAsn: 1.904 ± 0.038
4.999ValPro: 4.999 ± 0.061
2.06ValGln: 2.06 ± 0.044
6.24ValArg: 6.24 ± 0.07
4.887ValSer: 4.887 ± 0.058
5.595ValThr: 5.595 ± 0.059
8.299ValVal: 8.299 ± 0.084
1.057ValTrp: 1.057 ± 0.026
1.477ValTyr: 1.477 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.589TrpAla: 1.589 ± 0.029
0.174TrpCys: 0.174 ± 0.01
0.777TrpAsp: 0.777 ± 0.026
0.658TrpGlu: 0.658 ± 0.018
0.486TrpPhe: 0.486 ± 0.02
1.058TrpGly: 1.058 ± 0.025
0.314TrpHis: 0.314 ± 0.014
0.677TrpIle: 0.677 ± 0.022
0.29TrpLys: 0.29 ± 0.014
1.612TrpLeu: 1.612 ± 0.033
0.358TrpMet: 0.358 ± 0.016
0.38TrpAsn: 0.38 ± 0.017
0.82TrpPro: 0.82 ± 0.024
0.561TrpGln: 0.561 ± 0.02
1.261TrpArg: 1.261 ± 0.027
1.048TrpSer: 1.048 ± 0.022
0.991TrpThr: 0.991 ± 0.026
1.143TrpVal: 1.143 ± 0.025
0.342TrpTrp: 0.342 ± 0.015
0.314TrpTyr: 0.314 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.249TyrAla: 2.249 ± 0.033
0.173TyrCys: 0.173 ± 0.011
1.151TyrAsp: 1.151 ± 0.029
1.013TyrGlu: 1.013 ± 0.026
0.667TyrPhe: 0.667 ± 0.021
1.918TyrGly: 1.918 ± 0.038
0.364TyrHis: 0.364 ± 0.016
0.579TyrIle: 0.579 ± 0.022
0.302TyrLys: 0.302 ± 0.014
2.205TyrLeu: 2.205 ± 0.041
0.289TyrMet: 0.289 ± 0.014
0.432TyrAsn: 0.432 ± 0.016
1.149TyrPro: 1.149 ± 0.027
0.573TyrGln: 0.573 ± 0.02
1.72TyrArg: 1.72 ± 0.037
1.093TyrSer: 1.093 ± 0.026
1.092TyrThr: 1.092 ± 0.026
1.532TyrVal: 1.532 ± 0.035
0.382TyrTrp: 0.382 ± 0.014
0.418TyrTyr: 0.418 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5842 proteins (1684694 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski