Amino acid dipepetide frequency for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.252AlaAla: 5.252 ± 0.074
0.79AlaCys: 0.79 ± 0.019
3.063AlaAsp: 3.063 ± 0.034
3.773AlaGlu: 3.773 ± 0.042
2.547AlaPhe: 2.547 ± 0.034
3.615AlaGly: 3.615 ± 0.05
1.343AlaHis: 1.343 ± 0.026
4.025AlaIle: 4.025 ± 0.044
4.205AlaLys: 4.205 ± 0.045
5.784AlaLeu: 5.784 ± 0.055
1.395AlaMet: 1.395 ± 0.02
3.059AlaAsn: 3.059 ± 0.036
3.044AlaPro: 3.044 ± 0.045
2.393AlaGln: 2.393 ± 0.034
2.95AlaArg: 2.95 ± 0.033
5.925AlaSer: 5.925 ± 0.067
3.84AlaThr: 3.84 ± 0.044
3.989AlaVal: 3.989 ± 0.045
0.6AlaTrp: 0.6 ± 0.016
1.926AlaTyr: 1.926 ± 0.029
0.0AlaXaa: 0.0 ± 0.0
Cys
0.673CysAla: 0.673 ± 0.016
0.28CysCys: 0.28 ± 0.011
0.68CysAsp: 0.68 ± 0.02
0.605CysGlu: 0.605 ± 0.017
0.67CysPhe: 0.67 ± 0.018
0.914CysGly: 0.914 ± 0.022
0.335CysHis: 0.335 ± 0.012
0.831CysIle: 0.831 ± 0.018
0.64CysLys: 0.64 ± 0.016
1.238CysLeu: 1.238 ± 0.025
0.266CysMet: 0.266 ± 0.011
0.537CysAsn: 0.537 ± 0.014
0.522CysPro: 0.522 ± 0.018
0.393CysGln: 0.393 ± 0.014
0.561CysArg: 0.561 ± 0.014
1.061CysSer: 1.061 ± 0.025
0.628CysThr: 0.628 ± 0.017
0.777CysVal: 0.777 ± 0.018
0.165CysTrp: 0.165 ± 0.008
0.462CysTyr: 0.462 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.268AspAla: 3.268 ± 0.039
0.579AspCys: 0.579 ± 0.016
4.367AspAsp: 4.367 ± 0.058
4.883AspGlu: 4.883 ± 0.063
2.696AspPhe: 2.696 ± 0.035
3.0AspGly: 3.0 ± 0.039
1.314AspHis: 1.314 ± 0.02
3.743AspIle: 3.743 ± 0.044
3.339AspLys: 3.339 ± 0.044
5.468AspLeu: 5.468 ± 0.043
1.215AspMet: 1.215 ± 0.02
2.581AspAsn: 2.581 ± 0.035
2.653AspPro: 2.653 ± 0.034
1.893AspGln: 1.893 ± 0.029
2.203AspArg: 2.203 ± 0.031
4.995AspSer: 4.995 ± 0.049
2.973AspThr: 2.973 ± 0.037
3.593AspVal: 3.593 ± 0.039
0.631AspTrp: 0.631 ± 0.016
2.115AspTyr: 2.115 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
4.041GluAla: 4.041 ± 0.048
0.631GluCys: 0.631 ± 0.018
4.076GluAsp: 4.076 ± 0.053
5.516GluGlu: 5.516 ± 0.072
2.527GluPhe: 2.527 ± 0.034
2.758GluGly: 2.758 ± 0.032
1.293GluHis: 1.293 ± 0.021
3.887GluIle: 3.887 ± 0.044
4.912GluLys: 4.912 ± 0.057
6.039GluLeu: 6.039 ± 0.054
1.377GluMet: 1.377 ± 0.021
3.567GluAsn: 3.567 ± 0.042
2.507GluPro: 2.507 ± 0.032
2.474GluGln: 2.474 ± 0.03
2.953GluArg: 2.953 ± 0.038
5.386GluSer: 5.386 ± 0.052
3.798GluThr: 3.798 ± 0.046
3.945GluVal: 3.945 ± 0.042
0.681GluTrp: 0.681 ± 0.016
2.146GluTyr: 2.146 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
2.806PheAla: 2.806 ± 0.035
0.6PheCys: 0.6 ± 0.017
2.777PheAsp: 2.777 ± 0.036
2.727PheGlu: 2.727 ± 0.036
2.127PhePhe: 2.127 ± 0.036
2.912PheGly: 2.912 ± 0.044
1.084PheHis: 1.084 ± 0.023
2.494PheIle: 2.494 ± 0.034
2.63PheLys: 2.63 ± 0.03
4.091PheLeu: 4.091 ± 0.048
0.941PheMet: 0.941 ± 0.019
2.192PheAsn: 2.192 ± 0.029
1.905PhePro: 1.905 ± 0.029
1.709PheGln: 1.709 ± 0.025
1.893PheArg: 1.893 ± 0.025
3.823PheSer: 3.823 ± 0.044
2.41PheThr: 2.41 ± 0.034
3.022PheVal: 3.022 ± 0.037
0.569PheTrp: 0.569 ± 0.018
1.498PheTyr: 1.498 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
3.66GlyAla: 3.66 ± 0.055
0.759GlyCys: 0.759 ± 0.019
2.983GlyAsp: 2.983 ± 0.035
3.018GlyGlu: 3.018 ± 0.034
2.661GlyPhe: 2.661 ± 0.036
3.728GlyGly: 3.728 ± 0.055
1.284GlyHis: 1.284 ± 0.026
3.537GlyIle: 3.537 ± 0.04
3.336GlyLys: 3.336 ± 0.039
4.93GlyLeu: 4.93 ± 0.052
1.148GlyMet: 1.148 ± 0.024
2.545GlyAsn: 2.545 ± 0.03
2.164GlyPro: 2.164 ± 0.033
1.832GlyGln: 1.832 ± 0.027
2.497GlyArg: 2.497 ± 0.038
5.336GlySer: 5.336 ± 0.067
3.325GlyThr: 3.325 ± 0.05
3.533GlyVal: 3.533 ± 0.042
0.693GlyTrp: 0.693 ± 0.015
2.062GlyTyr: 2.062 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
1.161HisAla: 1.161 ± 0.022
0.312HisCys: 0.312 ± 0.01
1.268HisAsp: 1.268 ± 0.024
1.468HisGlu: 1.468 ± 0.024
1.067HisPhe: 1.067 ± 0.021
1.345HisGly: 1.345 ± 0.027
0.823HisHis: 0.823 ± 0.022
1.434HisIle: 1.434 ± 0.022
1.367HisLys: 1.367 ± 0.023
2.266HisLeu: 2.266 ± 0.032
0.454HisMet: 0.454 ± 0.013
1.161HisAsn: 1.161 ± 0.019
1.247HisPro: 1.247 ± 0.023
1.076HisGln: 1.076 ± 0.022
1.213HisArg: 1.213 ± 0.024
1.981HisSer: 1.981 ± 0.03
1.161HisThr: 1.161 ± 0.021
1.247HisVal: 1.247 ± 0.02
0.253HisTrp: 0.253 ± 0.01
0.874HisTyr: 0.874 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
3.858IleAla: 3.858 ± 0.039
0.828IleCys: 0.828 ± 0.017
3.903IleAsp: 3.903 ± 0.043
3.759IleGlu: 3.759 ± 0.042
2.568IlePhe: 2.568 ± 0.035
3.265IleGly: 3.265 ± 0.038
1.376IleHis: 1.376 ± 0.025
3.505IleIle: 3.505 ± 0.044
3.684IleLys: 3.684 ± 0.039
5.511IleLeu: 5.511 ± 0.053
1.272IleMet: 1.272 ± 0.025
3.009IleAsn: 3.009 ± 0.04
3.009IlePro: 3.009 ± 0.036
2.096IleGln: 2.096 ± 0.029
2.759IleArg: 2.759 ± 0.033
5.324IleSer: 5.324 ± 0.054
3.402IleThr: 3.402 ± 0.037
3.873IleVal: 3.873 ± 0.043
0.682IleTrp: 0.682 ± 0.017
1.911IleTyr: 1.911 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.749LysAla: 3.749 ± 0.047
0.678LysCys: 0.678 ± 0.016
3.635LysAsp: 3.635 ± 0.041
4.398LysGlu: 4.398 ± 0.053
2.712LysPhe: 2.712 ± 0.034
2.751LysGly: 2.751 ± 0.035
1.484LysHis: 1.484 ± 0.02
3.768LysIle: 3.768 ± 0.034
5.336LysLys: 5.336 ± 0.069
6.386LysLeu: 6.386 ± 0.056
1.322LysMet: 1.322 ± 0.024
3.407LysAsn: 3.407 ± 0.037
2.901LysPro: 2.901 ± 0.037
2.567LysGln: 2.567 ± 0.033
3.58LysArg: 3.58 ± 0.039
5.629LysSer: 5.629 ± 0.053
3.501LysThr: 3.501 ± 0.036
4.121LysVal: 4.121 ± 0.043
0.724LysTrp: 0.724 ± 0.016
2.43LysTyr: 2.43 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
6.311LeuAla: 6.311 ± 0.055
1.237LeuCys: 1.237 ± 0.025
5.145LeuAsp: 5.145 ± 0.048
5.807LeuGlu: 5.807 ± 0.06
3.957LeuPhe: 3.957 ± 0.048
5.045LeuGly: 5.045 ± 0.045
2.152LeuHis: 2.152 ± 0.03
5.052LeuIle: 5.052 ± 0.054
6.119LeuLys: 6.119 ± 0.053
8.505LeuLeu: 8.505 ± 0.08
1.885LeuMet: 1.885 ± 0.031
4.598LeuAsn: 4.598 ± 0.044
4.407LeuPro: 4.407 ± 0.05
4.029LeuGln: 4.029 ± 0.047
4.739LeuArg: 4.739 ± 0.043
8.4LeuSer: 8.4 ± 0.057
5.115LeuThr: 5.115 ± 0.047
6.132LeuVal: 6.132 ± 0.054
0.965LeuTrp: 0.965 ± 0.023
2.962LeuTyr: 2.962 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
1.625MetAla: 1.625 ± 0.026
0.272MetCys: 0.272 ± 0.011
1.199MetAsp: 1.199 ± 0.024
1.242MetGlu: 1.242 ± 0.023
0.898MetPhe: 0.898 ± 0.017
1.227MetGly: 1.227 ± 0.022
0.382MetHis: 0.382 ± 0.012
1.2MetIle: 1.2 ± 0.021
1.357MetLys: 1.357 ± 0.023
1.754MetLeu: 1.754 ± 0.026
0.536MetMet: 0.536 ± 0.017
1.141MetAsn: 1.141 ± 0.025
0.888MetPro: 0.888 ± 0.018
0.67MetGln: 0.67 ± 0.018
0.936MetArg: 0.936 ± 0.018
2.177MetSer: 2.177 ± 0.032
1.159MetThr: 1.159 ± 0.019
1.439MetVal: 1.439 ± 0.024
0.222MetTrp: 0.222 ± 0.01
0.658MetTyr: 0.658 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.851AsnAla: 2.851 ± 0.032
0.615AsnCys: 0.615 ± 0.015
3.129AsnAsp: 3.129 ± 0.038
3.395AsnGlu: 3.395 ± 0.043
2.236AsnPhe: 2.236 ± 0.027
3.104AsnGly: 3.104 ± 0.035
1.256AsnHis: 1.256 ± 0.023
2.905AsnIle: 2.905 ± 0.033
2.899AsnLys: 2.899 ± 0.031
4.599AsnLeu: 4.599 ± 0.045
1.055AsnMet: 1.055 ± 0.019
2.548AsnAsn: 2.548 ± 0.041
2.37AsnPro: 2.37 ± 0.032
1.98AsnGln: 1.98 ± 0.038
2.097AsnArg: 2.097 ± 0.026
4.594AsnSer: 4.594 ± 0.049
2.602AsnThr: 2.602 ± 0.037
3.002AsnVal: 3.002 ± 0.032
0.605AsnTrp: 0.605 ± 0.018
1.96AsnTyr: 1.96 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
2.881ProAla: 2.881 ± 0.034
0.381ProCys: 0.381 ± 0.012
2.388ProAsp: 2.388 ± 0.03
3.346ProGlu: 3.346 ± 0.043
1.93ProPhe: 1.93 ± 0.029
2.392ProGly: 2.392 ± 0.034
1.109ProHis: 1.109 ± 0.022
2.7ProIle: 2.7 ± 0.033
2.969ProLys: 2.969 ± 0.037
3.86ProLeu: 3.86 ± 0.042
0.875ProMet: 0.875 ± 0.02
2.191ProAsn: 2.191 ± 0.033
2.946ProPro: 2.946 ± 0.059
2.327ProGln: 2.327 ± 0.045
2.096ProArg: 2.096 ± 0.031
4.672ProSer: 4.672 ± 0.06
2.977ProThr: 2.977 ± 0.052
3.044ProVal: 3.044 ± 0.037
0.462ProTrp: 0.462 ± 0.014
1.507ProTyr: 1.507 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
2.401GlnAla: 2.401 ± 0.038
0.418GlnCys: 0.418 ± 0.012
1.939GlnAsp: 1.939 ± 0.028
2.551GlnGlu: 2.551 ± 0.034
1.794GlnPhe: 1.794 ± 0.029
1.746GlnGly: 1.746 ± 0.031
0.902GlnHis: 0.902 ± 0.019
2.276GlnIle: 2.276 ± 0.03
2.613GlnLys: 2.613 ± 0.035
4.147GlnLeu: 4.147 ± 0.046
0.898GlnMet: 0.898 ± 0.024
2.005GlnAsn: 2.005 ± 0.042
1.88GlnPro: 1.88 ± 0.042
2.305GlnGln: 2.305 ± 0.07
1.954GlnArg: 1.954 ± 0.029
3.175GlnSer: 3.175 ± 0.043
2.057GlnThr: 2.057 ± 0.029
2.425GlnVal: 2.425 ± 0.031
0.446GlnTrp: 0.446 ± 0.013
1.313GlnTyr: 1.313 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
2.899ArgAla: 2.899 ± 0.033
0.598ArgCys: 0.598 ± 0.016
2.463ArgAsp: 2.463 ± 0.032
2.872ArgGlu: 2.872 ± 0.036
2.168ArgPhe: 2.168 ± 0.03
2.31ArgGly: 2.31 ± 0.034
1.166ArgHis: 1.166 ± 0.022
2.869ArgIle: 2.869 ± 0.034
3.479ArgLys: 3.479 ± 0.038
4.49ArgLeu: 4.49 ± 0.043
0.975ArgMet: 0.975 ± 0.018
2.414ArgAsn: 2.414 ± 0.03
1.959ArgPro: 1.959 ± 0.024
2.041ArgGln: 2.041 ± 0.03
3.094ArgArg: 3.094 ± 0.036
4.109ArgSer: 4.109 ± 0.052
2.473ArgThr: 2.473 ± 0.031
2.589ArgVal: 2.589 ± 0.032
0.542ArgTrp: 0.542 ± 0.014
1.657ArgTyr: 1.657 ± 0.025
0.0ArgXaa: 0.0 ± 0.0
Ser
5.587SerAla: 5.587 ± 0.059
0.965SerCys: 0.965 ± 0.023
5.04SerAsp: 5.04 ± 0.056
5.341SerGlu: 5.341 ± 0.053
3.978SerPhe: 3.978 ± 0.045
5.271SerGly: 5.271 ± 0.069
2.158SerHis: 2.158 ± 0.032
5.477SerIle: 5.477 ± 0.054
5.769SerLys: 5.769 ± 0.049
8.336SerLeu: 8.336 ± 0.066
1.915SerMet: 1.915 ± 0.025
4.45SerAsn: 4.45 ± 0.047
4.42SerPro: 4.42 ± 0.055
3.626SerGln: 3.626 ± 0.046
4.33SerArg: 4.33 ± 0.044
10.75SerSer: 10.75 ± 0.182
5.859SerThr: 5.859 ± 0.069
5.623SerVal: 5.623 ± 0.056
0.979SerTrp: 0.979 ± 0.021
2.821SerTyr: 2.821 ± 0.037
0.0SerXaa: 0.0 ± 0.0
Thr
3.593ThrAla: 3.593 ± 0.037
0.666ThrCys: 0.666 ± 0.018
2.741ThrAsp: 2.741 ± 0.034
3.136ThrGlu: 3.136 ± 0.04
2.549ThrPhe: 2.549 ± 0.03
3.333ThrGly: 3.333 ± 0.057
1.216ThrHis: 1.216 ± 0.026
3.718ThrIle: 3.718 ± 0.044
3.778ThrLys: 3.778 ± 0.039
4.999ThrLeu: 4.999 ± 0.045
1.172ThrMet: 1.172 ± 0.022
2.941ThrAsn: 2.941 ± 0.035
3.168ThrPro: 3.168 ± 0.046
1.926ThrGln: 1.926 ± 0.029
2.438ThrArg: 2.438 ± 0.031
5.712ThrSer: 5.712 ± 0.064
3.983ThrThr: 3.983 ± 0.094
3.612ThrVal: 3.612 ± 0.055
0.614ThrTrp: 0.614 ± 0.023
1.834ThrTyr: 1.834 ± 0.025
0.0ThrXaa: 0.0 ± 0.0
Val
4.387ValAla: 4.387 ± 0.046
0.88ValCys: 0.88 ± 0.021
3.911ValAsp: 3.911 ± 0.046
4.059ValGlu: 4.059 ± 0.044
2.852ValPhe: 2.852 ± 0.034
3.54ValGly: 3.54 ± 0.038
1.385ValHis: 1.385 ± 0.022
3.521ValIle: 3.521 ± 0.041
3.835ValLys: 3.835 ± 0.04
5.773ValLeu: 5.773 ± 0.051
1.269ValMet: 1.269 ± 0.019
2.975ValAsn: 2.975 ± 0.033
3.336ValPro: 3.336 ± 0.046
2.214ValGln: 2.214 ± 0.031
2.722ValArg: 2.722 ± 0.039
5.827ValSer: 5.827 ± 0.048
3.473ValThr: 3.473 ± 0.04
4.643ValVal: 4.643 ± 0.049
0.694ValTrp: 0.694 ± 0.017
2.044ValTyr: 2.044 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
0.606TrpAla: 0.606 ± 0.016
0.239TrpCys: 0.239 ± 0.009
0.658TrpAsp: 0.658 ± 0.017
0.571TrpGlu: 0.571 ± 0.015
0.589TrpPhe: 0.589 ± 0.016
0.636TrpGly: 0.636 ± 0.02
0.248TrpHis: 0.248 ± 0.009
0.682TrpIle: 0.682 ± 0.019
0.788TrpLys: 0.788 ± 0.015
1.04TrpLeu: 1.04 ± 0.021
0.259TrpMet: 0.259 ± 0.011
0.638TrpAsn: 0.638 ± 0.017
0.34TrpPro: 0.34 ± 0.011
0.348TrpGln: 0.348 ± 0.011
0.591TrpArg: 0.591 ± 0.017
0.977TrpSer: 0.977 ± 0.02
0.641TrpThr: 0.641 ± 0.018
0.666TrpVal: 0.666 ± 0.017
0.19TrpTrp: 0.19 ± 0.008
0.429TrpTyr: 0.429 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.913TyrAla: 1.913 ± 0.028
0.511TyrCys: 0.511 ± 0.014
2.145TyrAsp: 2.145 ± 0.031
2.047TyrGlu: 2.047 ± 0.032
1.685TyrPhe: 1.685 ± 0.026
2.138TyrGly: 2.138 ± 0.034
0.869TyrHis: 0.869 ± 0.016
1.971TyrIle: 1.971 ± 0.028
2.024TyrLys: 2.024 ± 0.029
3.346TyrLeu: 3.346 ± 0.04
0.749TyrMet: 0.749 ± 0.016
1.843TyrAsn: 1.843 ± 0.028
1.386TyrPro: 1.386 ± 0.025
1.346TyrGln: 1.346 ± 0.024
1.561TyrArg: 1.561 ± 0.028
2.841TyrSer: 2.841 ± 0.036
1.749TyrThr: 1.749 ± 0.025
2.067TyrVal: 2.067 ± 0.03
0.418TyrTrp: 0.418 ± 0.012
1.406TyrTyr: 1.406 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5919 proteins (2761741 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski