Amino acid dipepetide frequency for Lysobacter daejeonensis GH1-9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.941AlaAla: 17.941 ± 0.219	1.208AlaCys: 1.208 ± 0.043	7.184AlaAsp: 7.184 ± 0.101	7.372AlaGlu: 7.372 ± 0.11	4.19AlaPhe: 4.19 ± 0.069	10.926AlaGly: 10.926 ± 0.122	2.832AlaHis: 2.832 ± 0.066	5.523AlaIle: 5.523 ± 0.087	4.01AlaLys: 4.01 ± 0.104	15.31AlaLeu: 15.31 ± 0.215	3.664AlaMet: 3.664 ± 0.071	3.074AlaAsn: 3.074 ± 0.072	6.343AlaPro: 6.343 ± 0.106	5.106AlaGln: 5.106 ± 0.089	9.785AlaArg: 9.785 ± 0.154	6.336AlaSer: 6.336 ± 0.101	6.636AlaThr: 6.636 ± 0.107	9.329AlaVal: 9.329 ± 0.119	2.047AlaTrp: 2.047 ± 0.067	2.535AlaTyr: 2.535 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	1.028CysAla: 1.028 ± 0.039	0.1CysCys: 0.1 ± 0.011	0.448CysAsp: 0.448 ± 0.021	0.46CysGlu: 0.46 ± 0.022	0.258CysPhe: 0.258 ± 0.019	0.896CysGly: 0.896 ± 0.033	0.252CysHis: 0.252 ± 0.018	0.335CysIle: 0.335 ± 0.021	0.21CysLys: 0.21 ± 0.017	0.73CysLeu: 0.73 ± 0.031	0.151CysMet: 0.151 ± 0.015	0.217CysAsn: 0.217 ± 0.018	0.44CysPro: 0.44 ± 0.031	0.243CysGln: 0.243 ± 0.017	0.566CysArg: 0.566 ± 0.026	0.462CysSer: 0.462 ± 0.023	0.491CysThr: 0.491 ± 0.037	0.666CysVal: 0.666 ± 0.03	0.095CysTrp: 0.095 ± 0.01	0.202CysTyr: 0.202 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	8.525AspAla: 8.525 ± 0.122	0.406AspCys: 0.406 ± 0.02	3.352AspAsp: 3.352 ± 0.07	3.515AspGlu: 3.515 ± 0.072	2.048AspPhe: 2.048 ± 0.051	5.679AspGly: 5.679 ± 0.088	1.217AspHis: 1.217 ± 0.037	2.394AspIle: 2.394 ± 0.055	1.718AspLys: 1.718 ± 0.056	5.535AspLeu: 5.535 ± 0.09	1.14AspMet: 1.14 ± 0.037	1.278AspAsn: 1.278 ± 0.042	3.373AspPro: 3.373 ± 0.066	1.533AspGln: 1.533 ± 0.041	4.006AspArg: 4.006 ± 0.076	2.331AspSer: 2.331 ± 0.052	2.878AspThr: 2.878 ± 0.055	4.6AspVal: 4.6 ± 0.075	1.115AspTrp: 1.115 ± 0.043	1.65AspTyr: 1.65 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	7.485GluAla: 7.485 ± 0.113	0.374GluCys: 0.374 ± 0.024	2.559GluAsp: 2.559 ± 0.055	2.464GluGlu: 2.464 ± 0.058	1.839GluPhe: 1.839 ± 0.051	4.523GluGly: 4.523 ± 0.077	1.457GluHis: 1.457 ± 0.043	2.402GluIle: 2.402 ± 0.064	1.565GluLys: 1.565 ± 0.05	6.02GluLeu: 6.02 ± 0.099	1.164GluMet: 1.164 ± 0.038	1.123GluAsn: 1.123 ± 0.043	2.509GluPro: 2.509 ± 0.058	2.53GluGln: 2.53 ± 0.055	5.343GluArg: 5.343 ± 0.083	2.532GluSer: 2.532 ± 0.053	2.584GluThr: 2.584 ± 0.051	4.294GluVal: 4.294 ± 0.081	0.753GluTrp: 0.753 ± 0.03	1.219GluTyr: 1.219 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.224PheAla: 4.224 ± 0.077	0.317PheCys: 0.317 ± 0.021	2.648PheAsp: 2.648 ± 0.062	2.048PheGlu: 2.048 ± 0.052	1.168PhePhe: 1.168 ± 0.045	3.387PheGly: 3.387 ± 0.069	0.795PheHis: 0.795 ± 0.033	1.303PheIle: 1.303 ± 0.045	0.93PheLys: 0.93 ± 0.033	3.003PheLeu: 3.003 ± 0.066	0.648PheMet: 0.648 ± 0.03	1.119PheAsn: 1.119 ± 0.04	1.429PhePro: 1.429 ± 0.043	0.95PheGln: 0.95 ± 0.035	2.167PheArg: 2.167 ± 0.052	1.836PheSer: 1.836 ± 0.044	1.794PheThr: 1.794 ± 0.049	2.708PheVal: 2.708 ± 0.06	0.496PheTrp: 0.496 ± 0.029	0.794PheTyr: 0.794 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.448GlyAla: 9.448 ± 0.111	0.828GlyCys: 0.828 ± 0.032	4.938GlyAsp: 4.938 ± 0.083	5.0GlyGlu: 5.0 ± 0.085	3.434GlyPhe: 3.434 ± 0.072	7.32GlyGly: 7.32 ± 0.117	2.204GlyHis: 2.204 ± 0.052	3.846GlyIle: 3.846 ± 0.074	3.173GlyLys: 3.173 ± 0.07	9.013GlyLeu: 9.013 ± 0.137	2.411GlyMet: 2.411 ± 0.054	2.338GlyAsn: 2.338 ± 0.059	3.215GlyPro: 3.215 ± 0.061	3.112GlyGln: 3.112 ± 0.058	6.129GlyArg: 6.129 ± 0.097	4.354GlySer: 4.354 ± 0.076	4.582GlyThr: 4.582 ± 0.083	6.894GlyVal: 6.894 ± 0.099	1.63GlyTrp: 1.63 ± 0.044	2.411GlyTyr: 2.411 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	3.285HisAla: 3.285 ± 0.062	0.272HisCys: 0.272 ± 0.019	1.421HisAsp: 1.421 ± 0.039	1.24HisGlu: 1.24 ± 0.041	0.822HisPhe: 0.822 ± 0.032	2.431HisGly: 2.431 ± 0.054	0.66HisHis: 0.66 ± 0.034	0.788HisIle: 0.788 ± 0.03	0.509HisLys: 0.509 ± 0.022	2.317HisLeu: 2.317 ± 0.059	0.453HisMet: 0.453 ± 0.022	0.473HisAsn: 0.473 ± 0.022	1.557HisPro: 1.557 ± 0.052	0.663HisGln: 0.663 ± 0.028	1.752HisArg: 1.752 ± 0.049	0.921HisSer: 0.921 ± 0.036	1.018HisThr: 1.018 ± 0.036	1.78HisVal: 1.78 ± 0.05	0.437HisTrp: 0.437 ± 0.021	0.615HisTyr: 0.615 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.201IleAla: 6.201 ± 0.094	0.334IleCys: 0.334 ± 0.022	3.039IleAsp: 3.039 ± 0.066	2.966IleGlu: 2.966 ± 0.065	1.062IlePhe: 1.062 ± 0.036	4.204IleGly: 4.204 ± 0.076	0.851IleHis: 0.851 ± 0.037	1.325IleIle: 1.325 ± 0.05	1.266IleLys: 1.266 ± 0.047	2.962IleLeu: 2.962 ± 0.077	0.544IleMet: 0.544 ± 0.024	1.238IleAsn: 1.238 ± 0.04	2.1IlePro: 2.1 ± 0.048	1.092IleGln: 1.092 ± 0.034	2.674IleArg: 2.674 ± 0.057	1.957IleSer: 1.957 ± 0.051	2.273IleThr: 2.273 ± 0.073	3.177IleVal: 3.177 ± 0.068	0.36IleTrp: 0.36 ± 0.021	0.814IleTyr: 0.814 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.876LysAla: 3.876 ± 0.082	0.164LysCys: 0.164 ± 0.013	1.604LysAsp: 1.604 ± 0.057	1.286LysGlu: 1.286 ± 0.047	0.859LysPhe: 0.859 ± 0.034	2.236LysGly: 2.236 ± 0.058	0.654LysHis: 0.654 ± 0.028	1.164LysIle: 1.164 ± 0.047	1.034LysLys: 1.034 ± 0.064	3.24LysLeu: 3.24 ± 0.068	0.647LysMet: 0.647 ± 0.032	0.666LysAsn: 0.666 ± 0.032	1.974LysPro: 1.974 ± 0.062	1.143LysGln: 1.143 ± 0.039	2.278LysArg: 2.278 ± 0.061	1.443LysSer: 1.443 ± 0.042	1.497LysThr: 1.497 ± 0.052	2.49LysVal: 2.49 ± 0.066	0.381LysTrp: 0.381 ± 0.024	0.683LysTyr: 0.683 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	15.294LeuAla: 15.294 ± 0.211	0.884LeuCys: 0.884 ± 0.035	6.689LeuAsp: 6.689 ± 0.097	5.378LeuGlu: 5.378 ± 0.102	3.298LeuPhe: 3.298 ± 0.081	8.871LeuGly: 8.871 ± 0.119	2.552LeuHis: 2.552 ± 0.066	3.711LeuIle: 3.711 ± 0.067	3.099LeuLys: 3.099 ± 0.066	11.436LeuLeu: 11.436 ± 0.193	2.202LeuMet: 2.202 ± 0.053	2.382LeuAsn: 2.382 ± 0.064	6.324LeuPro: 6.324 ± 0.092	3.751LeuGln: 3.751 ± 0.08	8.614LeuArg: 8.614 ± 0.119	5.474LeuSer: 5.474 ± 0.091	5.109LeuThr: 5.109 ± 0.086	8.293LeuVal: 8.293 ± 0.119	1.372LeuTrp: 1.372 ± 0.051	2.151LeuTyr: 2.151 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.069MetAla: 3.069 ± 0.064	0.151MetCys: 0.151 ± 0.015	1.196MetAsp: 1.196 ± 0.041	1.003MetGlu: 1.003 ± 0.036	0.707MetPhe: 0.707 ± 0.033	1.745MetGly: 1.745 ± 0.045	0.494MetHis: 0.494 ± 0.026	0.83MetIle: 0.83 ± 0.038	0.779MetLys: 0.779 ± 0.033	2.435MetLeu: 2.435 ± 0.052	0.495MetMet: 0.495 ± 0.026	0.668MetAsn: 0.668 ± 0.028	1.45MetPro: 1.45 ± 0.041	0.898MetGln: 0.898 ± 0.031	1.736MetArg: 1.736 ± 0.045	1.418MetSer: 1.418 ± 0.041	1.405MetThr: 1.405 ± 0.049	1.57MetVal: 1.57 ± 0.044	0.23MetTrp: 0.23 ± 0.018	0.382MetTyr: 0.382 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.376AsnAla: 3.376 ± 0.06	0.213AsnCys: 0.213 ± 0.015	1.417AsnAsp: 1.417 ± 0.044	1.176AsnGlu: 1.176 ± 0.038	0.856AsnPhe: 0.856 ± 0.037	2.341AsnGly: 2.341 ± 0.058	0.521AsnHis: 0.521 ± 0.027	1.013AsnIle: 1.013 ± 0.039	0.627AsnLys: 0.627 ± 0.031	2.419AsnLeu: 2.419 ± 0.057	0.409AsnMet: 0.409 ± 0.023	0.67AsnAsn: 0.67 ± 0.037	1.782AsnPro: 1.782 ± 0.051	0.755AsnGln: 0.755 ± 0.034	1.792AsnArg: 1.792 ± 0.048	1.052AsnSer: 1.052 ± 0.042	1.31AsnThr: 1.31 ± 0.044	1.9AsnVal: 1.9 ± 0.055	0.359AsnTrp: 0.359 ± 0.023	0.582AsnTyr: 0.582 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	7.177ProAla: 7.177 ± 0.12	0.334ProCys: 0.334 ± 0.02	3.405ProAsp: 3.405 ± 0.067	3.419ProGlu: 3.419 ± 0.062	1.664ProPhe: 1.664 ± 0.046	4.78ProGly: 4.78 ± 0.076	1.117ProHis: 1.117 ± 0.037	1.909ProIle: 1.909 ± 0.055	1.479ProLys: 1.479 ± 0.045	5.349ProLeu: 5.349 ± 0.081	1.308ProMet: 1.308 ± 0.034	1.214ProAsn: 1.214 ± 0.041	2.565ProPro: 2.565 ± 0.071	1.827ProGln: 1.827 ± 0.046	3.363ProArg: 3.363 ± 0.068	2.659ProSer: 2.659 ± 0.061	2.68ProThr: 2.68 ± 0.056	4.404ProVal: 4.404 ± 0.081	0.795ProTrp: 0.795 ± 0.038	1.264ProTyr: 1.264 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	5.004GlnAla: 5.004 ± 0.08	0.256GlnCys: 0.256 ± 0.016	1.477GlnAsp: 1.477 ± 0.036	1.418GlnGlu: 1.418 ± 0.05	1.163GlnPhe: 1.163 ± 0.036	2.69GlnGly: 2.69 ± 0.059	0.88GlnHis: 0.88 ± 0.031	1.374GlnIle: 1.374 ± 0.048	0.948GlnLys: 0.948 ± 0.038	4.006GlnLeu: 4.006 ± 0.082	0.808GlnMet: 0.808 ± 0.031	0.679GlnAsn: 0.679 ± 0.029	2.093GlnPro: 2.093 ± 0.054	1.658GlnGln: 1.658 ± 0.053	3.503GlnArg: 3.503 ± 0.073	1.635GlnSer: 1.635 ± 0.042	1.477GlnThr: 1.477 ± 0.04	2.951GlnVal: 2.951 ± 0.065	0.572GlnTrp: 0.572 ± 0.026	0.838GlnTyr: 0.838 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	8.598ArgAla: 8.598 ± 0.109	0.558ArgCys: 0.558 ± 0.031	4.744ArgAsp: 4.744 ± 0.09	4.954ArgGlu: 4.954 ± 0.085	2.898ArgPhe: 2.898 ± 0.062	5.499ArgGly: 5.499 ± 0.079	2.105ArgHis: 2.105 ± 0.057	3.745ArgIle: 3.745 ± 0.067	2.14ArgLys: 2.14 ± 0.057	8.315ArgLeu: 8.315 ± 0.139	1.969ArgMet: 1.969 ± 0.054	1.901ArgAsn: 1.901 ± 0.046	3.509ArgPro: 3.509 ± 0.073	2.82ArgGln: 2.82 ± 0.061	5.75ArgArg: 5.75 ± 0.108	3.256ArgSer: 3.256 ± 0.06	3.482ArgThr: 3.482 ± 0.066	5.768ArgVal: 5.768 ± 0.087	1.321ArgTrp: 1.321 ± 0.049	2.208ArgTyr: 2.208 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.963SerAla: 5.963 ± 0.09	0.397SerCys: 0.397 ± 0.024	2.6SerAsp: 2.6 ± 0.055	2.379SerGlu: 2.379 ± 0.049	1.742SerPhe: 1.742 ± 0.048	4.794SerGly: 4.794 ± 0.089	1.096SerHis: 1.096 ± 0.034	2.009SerIle: 2.009 ± 0.056	1.477SerLys: 1.477 ± 0.05	5.245SerLeu: 5.245 ± 0.089	1.052SerMet: 1.052 ± 0.031	1.378SerAsn: 1.378 ± 0.047	2.571SerPro: 2.571 ± 0.047	1.685SerGln: 1.685 ± 0.045	3.467SerArg: 3.467 ± 0.065	2.591SerSer: 2.591 ± 0.064	2.615SerThr: 2.615 ± 0.067	3.747SerVal: 3.747 ± 0.075	0.69SerTrp: 0.69 ± 0.029	1.233SerTyr: 1.233 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.284ThrAla: 6.284 ± 0.113	0.458ThrCys: 0.458 ± 0.041	2.749ThrAsp: 2.749 ± 0.059	2.267ThrGlu: 2.267 ± 0.056	1.641ThrPhe: 1.641 ± 0.048	4.776ThrGly: 4.776 ± 0.088	1.164ThrHis: 1.164 ± 0.043	1.982ThrIle: 1.982 ± 0.051	1.167ThrLys: 1.167 ± 0.04	6.241ThrLeu: 6.241 ± 0.091	0.939ThrMet: 0.939 ± 0.031	1.105ThrAsn: 1.105 ± 0.054	3.391ThrPro: 3.391 ± 0.066	1.682ThrGln: 1.682 ± 0.047	3.649ThrArg: 3.649 ± 0.064	2.43ThrSer: 2.43 ± 0.06	2.776ThrThr: 2.776 ± 0.071	4.254ThrVal: 4.254 ± 0.1	0.722ThrTrp: 0.722 ± 0.035	1.14ThrTyr: 1.14 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	10.36ValAla: 10.36 ± 0.125	0.641ValCys: 0.641 ± 0.027	4.753ValAsp: 4.753 ± 0.081	4.644ValGlu: 4.644 ± 0.079	2.659ValPhe: 2.659 ± 0.059	6.026ValGly: 6.026 ± 0.095	1.715ValHis: 1.715 ± 0.043	3.404ValIle: 3.404 ± 0.079	2.145ValLys: 2.145 ± 0.054	8.623ValLeu: 8.623 ± 0.127	1.798ValMet: 1.798 ± 0.048	1.965ValAsn: 1.965 ± 0.056	4.076ValPro: 4.076 ± 0.076	2.464ValGln: 2.464 ± 0.061	5.563ValArg: 5.563 ± 0.08	4.062ValSer: 4.062 ± 0.067	4.196ValThr: 4.196 ± 0.103	6.781ValVal: 6.781 ± 0.123	0.957ValTrp: 0.957 ± 0.033	1.605ValTyr: 1.605 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.333TrpAla: 1.333 ± 0.047	0.137TrpCys: 0.137 ± 0.013	0.666TrpAsp: 0.666 ± 0.03	0.525TrpGlu: 0.525 ± 0.027	0.559TrpPhe: 0.559 ± 0.025	0.992TrpGly: 0.992 ± 0.039	0.388TrpHis: 0.388 ± 0.025	0.651TrpIle: 0.651 ± 0.029	0.444TrpLys: 0.444 ± 0.023	2.201TrpLeu: 2.201 ± 0.073	0.441TrpMet: 0.441 ± 0.028	0.449TrpAsn: 0.449 ± 0.026	0.783TrpPro: 0.783 ± 0.033	0.72TrpGln: 0.72 ± 0.034	1.386TrpArg: 1.386 ± 0.049	0.838TrpSer: 0.838 ± 0.032	0.789TrpThr: 0.789 ± 0.03	1.056TrpVal: 1.056 ± 0.036	0.347TrpTrp: 0.347 ± 0.024	0.344TrpTyr: 0.344 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.878TyrAla: 2.878 ± 0.054	0.218TyrCys: 0.218 ± 0.017	1.404TyrAsp: 1.404 ± 0.048	1.225TyrGlu: 1.225 ± 0.036	0.896TyrPhe: 0.896 ± 0.036	2.164TyrGly: 2.164 ± 0.057	0.461TyrHis: 0.461 ± 0.024	0.732TyrIle: 0.732 ± 0.031	0.597TyrLys: 0.597 ± 0.026	2.484TyrLeu: 2.484 ± 0.055	0.417TyrMet: 0.417 ± 0.022	0.635TyrAsn: 0.635 ± 0.03	1.227TyrPro: 1.227 ± 0.045	0.802TyrGln: 0.802 ± 0.032	2.016TyrArg: 2.016 ± 0.059	1.143TyrSer: 1.143 ± 0.043	1.225TyrThr: 1.225 ± 0.051	1.776TyrVal: 1.776 ± 0.046	0.371TyrTrp: 0.371 ± 0.021	0.647TyrTyr: 0.647 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2570 proteins (830463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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