Amino acid dipepetide frequency for Choanephora cucurbitarum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.23AlaAla: 5.23 ± 0.05	1.01AlaCys: 1.01 ± 0.016	3.153AlaAsp: 3.153 ± 0.028	3.859AlaGlu: 3.859 ± 0.037	2.81AlaPhe: 2.81 ± 0.028	3.171AlaGly: 3.171 ± 0.035	1.533AlaHis: 1.533 ± 0.019	4.374AlaIle: 4.374 ± 0.034	4.029AlaLys: 4.029 ± 0.033	6.492AlaLeu: 6.492 ± 0.039	1.703AlaMet: 1.703 ± 0.019	3.013AlaAsn: 3.013 ± 0.026	2.763AlaPro: 2.763 ± 0.03	2.758AlaGln: 2.758 ± 0.027	3.06AlaArg: 3.06 ± 0.027	5.642AlaSer: 5.642 ± 0.042	4.138AlaThr: 4.138 ± 0.03	3.965AlaVal: 3.965 ± 0.033	0.696AlaTrp: 0.696 ± 0.012	2.245AlaTyr: 2.245 ± 0.024	0.01AlaXaa: 0.01 ± 0.001
Cys	0.77CysAla: 0.77 ± 0.015	0.305CysCys: 0.305 ± 0.008	0.682CysAsp: 0.682 ± 0.012	0.631CysGlu: 0.631 ± 0.012	0.717CysPhe: 0.717 ± 0.013	0.813CysGly: 0.813 ± 0.016	0.458CysHis: 0.458 ± 0.011	0.962CysIle: 0.962 ± 0.014	0.737CysLys: 0.737 ± 0.011	1.547CysLeu: 1.547 ± 0.02	0.336CysMet: 0.336 ± 0.008	0.595CysAsn: 0.595 ± 0.013	0.675CysPro: 0.675 ± 0.014	0.679CysGln: 0.679 ± 0.012	0.701CysArg: 0.701 ± 0.012	1.124CysSer: 1.124 ± 0.018	0.748CysThr: 0.748 ± 0.012	0.828CysVal: 0.828 ± 0.014	0.187CysTrp: 0.187 ± 0.006	0.518CysTyr: 0.518 ± 0.013	0.004CysXaa: 0.004 ± 0.001
Asp	3.545AspAla: 3.545 ± 0.03	0.725AspCys: 0.725 ± 0.014	4.095AspAsp: 4.095 ± 0.044	4.51AspGlu: 4.51 ± 0.04	2.352AspPhe: 2.352 ± 0.02	2.563AspGly: 2.563 ± 0.025	1.552AspHis: 1.552 ± 0.021	3.768AspIle: 3.768 ± 0.032	3.125AspLys: 3.125 ± 0.028	5.291AspLeu: 5.291 ± 0.039	1.531AspMet: 1.531 ± 0.016	2.583AspAsn: 2.583 ± 0.028	2.567AspPro: 2.567 ± 0.026	2.658AspGln: 2.658 ± 0.026	2.663AspArg: 2.663 ± 0.029	3.895AspSer: 3.895 ± 0.034	3.294AspThr: 3.294 ± 0.029	3.268AspVal: 3.268 ± 0.026	0.731AspTrp: 0.731 ± 0.014	2.135AspTyr: 2.135 ± 0.021	0.011AspXaa: 0.011 ± 0.001
Glu	4.567GluAla: 4.567 ± 0.039	0.742GluCys: 0.742 ± 0.014	4.564GluAsp: 4.564 ± 0.042	6.976GluGlu: 6.976 ± 0.076	2.259GluPhe: 2.259 ± 0.021	2.84GluGly: 2.84 ± 0.03	1.592GluHis: 1.592 ± 0.022	3.575GluIle: 3.575 ± 0.031	4.884GluLys: 4.884 ± 0.041	5.743GluLeu: 5.743 ± 0.045	1.546GluMet: 1.546 ± 0.019	2.995GluAsn: 2.995 ± 0.027	2.32GluPro: 2.32 ± 0.03	3.461GluGln: 3.461 ± 0.037	3.458GluArg: 3.458 ± 0.035	4.477GluSer: 4.477 ± 0.041	3.569GluThr: 3.569 ± 0.032	3.236GluVal: 3.236 ± 0.03	0.743GluTrp: 0.743 ± 0.012	2.013GluTyr: 2.013 ± 0.019	0.011GluXaa: 0.011 ± 0.002
Phe	2.55PheAla: 2.55 ± 0.027	0.686PheCys: 0.686 ± 0.013	2.629PheAsp: 2.629 ± 0.027	2.648PheGlu: 2.648 ± 0.024	1.851PhePhe: 1.851 ± 0.024	2.531PheGly: 2.531 ± 0.034	0.982PheHis: 0.982 ± 0.014	2.329PheIle: 2.329 ± 0.026	2.231PheLys: 2.231 ± 0.024	3.647PheLeu: 3.647 ± 0.032	1.033PheMet: 1.033 ± 0.015	1.857PheAsn: 1.857 ± 0.019	1.64PhePro: 1.64 ± 0.021	1.607PheGln: 1.607 ± 0.02	1.816PheArg: 1.816 ± 0.022	3.336PheSer: 3.336 ± 0.033	2.093PheThr: 2.093 ± 0.024	2.774PheVal: 2.774 ± 0.027	0.517PheTrp: 0.517 ± 0.01	1.489PheTyr: 1.489 ± 0.02	0.009PheXaa: 0.009 ± 0.002
Gly	2.926GlyAla: 2.926 ± 0.034	0.773GlyCys: 0.773 ± 0.014	2.425GlyAsp: 2.425 ± 0.027	2.401GlyGlu: 2.401 ± 0.025	2.339GlyPhe: 2.339 ± 0.028	3.033GlyGly: 3.033 ± 0.041	1.426GlyHis: 1.426 ± 0.019	3.093GlyIle: 3.093 ± 0.03	2.966GlyLys: 2.966 ± 0.029	4.635GlyLeu: 4.635 ± 0.039	1.129GlyMet: 1.129 ± 0.019	2.142GlyAsn: 2.142 ± 0.024	1.733GlyPro: 1.733 ± 0.02	2.052GlyGln: 2.052 ± 0.025	2.383GlyArg: 2.383 ± 0.026	3.921GlySer: 3.921 ± 0.032	2.713GlyThr: 2.713 ± 0.029	2.978GlyVal: 2.978 ± 0.034	0.705GlyTrp: 0.705 ± 0.012	1.962GlyTyr: 1.962 ± 0.025	0.008GlyXaa: 0.008 ± 0.002
His	1.622HisAla: 1.622 ± 0.022	0.434HisCys: 0.434 ± 0.011	1.362HisAsp: 1.362 ± 0.017	1.417HisGlu: 1.417 ± 0.018	1.111HisPhe: 1.111 ± 0.017	1.271HisGly: 1.271 ± 0.019	1.263HisHis: 1.263 ± 0.021	1.616HisIle: 1.616 ± 0.019	1.33HisLys: 1.33 ± 0.016	2.709HisLeu: 2.709 ± 0.023	0.643HisMet: 0.643 ± 0.011	1.086HisAsn: 1.086 ± 0.016	1.6HisPro: 1.6 ± 0.019	1.583HisGln: 1.583 ± 0.024	1.454HisArg: 1.454 ± 0.019	2.118HisSer: 2.118 ± 0.021	1.605HisThr: 1.605 ± 0.018	1.625HisVal: 1.625 ± 0.02	0.318HisTrp: 0.318 ± 0.008	1.022HisTyr: 1.022 ± 0.016	0.005HisXaa: 0.005 ± 0.001
Ile	4.093IleAla: 4.093 ± 0.036	0.953IleCys: 0.953 ± 0.014	3.67IleAsp: 3.67 ± 0.029	4.067IleGlu: 4.067 ± 0.033	2.134IlePhe: 2.134 ± 0.026	2.979IleGly: 2.979 ± 0.031	1.714IleHis: 1.714 ± 0.02	3.135IleIle: 3.135 ± 0.027	3.633IleLys: 3.633 ± 0.03	5.261IleLeu: 5.261 ± 0.042	1.377IleMet: 1.377 ± 0.016	2.689IleAsn: 2.689 ± 0.027	3.075IlePro: 3.075 ± 0.026	3.081IleGln: 3.081 ± 0.029	3.057IleArg: 3.057 ± 0.027	4.516IleSer: 4.516 ± 0.032	3.269IleThr: 3.269 ± 0.025	3.737IleVal: 3.737 ± 0.031	0.674IleTrp: 0.674 ± 0.013	1.965IleTyr: 1.965 ± 0.02	0.012IleXaa: 0.012 ± 0.002
Lys	4.313LysAla: 4.313 ± 0.039	0.672LysCys: 0.672 ± 0.013	3.493LysAsp: 3.493 ± 0.03	5.026LysGlu: 5.026 ± 0.047	1.829LysPhe: 1.829 ± 0.02	2.646LysGly: 2.646 ± 0.028	1.642LysHis: 1.642 ± 0.02	3.308LysIle: 3.308 ± 0.027	5.844LysLys: 5.844 ± 0.057	5.336LysLeu: 5.336 ± 0.037	1.513LysMet: 1.513 ± 0.019	2.839LysAsn: 2.839 ± 0.025	2.95LysPro: 2.95 ± 0.029	3.409LysGln: 3.409 ± 0.031	4.159LysArg: 4.159 ± 0.035	4.678LysSer: 4.678 ± 0.041	3.815LysThr: 3.815 ± 0.033	3.267LysVal: 3.267 ± 0.031	0.629LysTrp: 0.629 ± 0.012	1.976LysTyr: 1.976 ± 0.02	0.012LysXaa: 0.012 ± 0.002
Leu	6.277LeuAla: 6.277 ± 0.042	1.446LeuCys: 1.446 ± 0.019	5.6LeuAsp: 5.6 ± 0.035	6.096LeuGlu: 6.096 ± 0.048	3.957LeuPhe: 3.957 ± 0.037	4.469LeuGly: 4.469 ± 0.037	2.23LeuHis: 2.23 ± 0.024	5.166LeuIle: 5.166 ± 0.036	6.062LeuLys: 6.062 ± 0.048	9.062LeuLeu: 9.062 ± 0.063	2.28LeuMet: 2.28 ± 0.025	4.406LeuAsn: 4.406 ± 0.035	4.883LeuPro: 4.883 ± 0.036	4.318LeuGln: 4.318 ± 0.039	4.535LeuArg: 4.535 ± 0.037	8.111LeuSer: 8.111 ± 0.046	5.196LeuThr: 5.196 ± 0.04	5.504LeuVal: 5.504 ± 0.041	1.001LeuTrp: 1.001 ± 0.014	3.013LeuTyr: 3.013 ± 0.026	0.023LeuXaa: 0.023 ± 0.002
Met	1.823MetAla: 1.823 ± 0.021	0.282MetCys: 0.282 ± 0.007	1.546MetAsp: 1.546 ± 0.017	1.483MetGlu: 1.483 ± 0.021	0.913MetPhe: 0.913 ± 0.012	1.125MetGly: 1.125 ± 0.017	0.571MetHis: 0.571 ± 0.011	1.518MetIle: 1.518 ± 0.018	1.498MetLys: 1.498 ± 0.017	2.182MetLeu: 2.182 ± 0.022	0.827MetMet: 0.827 ± 0.015	1.245MetAsn: 1.245 ± 0.015	1.213MetPro: 1.213 ± 0.018	1.001MetGln: 1.001 ± 0.016	1.129MetArg: 1.129 ± 0.016	2.214MetSer: 2.214 ± 0.022	1.702MetThr: 1.702 ± 0.018	1.405MetVal: 1.405 ± 0.018	0.207MetTrp: 0.207 ± 0.007	0.721MetTyr: 0.721 ± 0.014	0.006MetXaa: 0.006 ± 0.001
Asn	3.062AsnAla: 3.062 ± 0.027	0.608AsnCys: 0.608 ± 0.012	2.658AsnAsp: 2.658 ± 0.028	3.012AsnGlu: 3.012 ± 0.027	1.58AsnPhe: 1.58 ± 0.02	2.325AsnGly: 2.325 ± 0.028	1.3AsnHis: 1.3 ± 0.016	2.727AsnIle: 2.727 ± 0.026	3.029AsnLys: 3.029 ± 0.025	3.922AsnLeu: 3.922 ± 0.034	1.243AsnMet: 1.243 ± 0.018	2.843AsnAsn: 2.843 ± 0.04	2.237AsnPro: 2.237 ± 0.027	2.421AsnGln: 2.421 ± 0.023	2.304AsnArg: 2.304 ± 0.024	3.613AsnSer: 3.613 ± 0.032	3.186AsnThr: 3.186 ± 0.031	2.576AsnVal: 2.576 ± 0.026	0.564AsnTrp: 0.564 ± 0.011	1.584AsnTyr: 1.584 ± 0.02	0.01AsnXaa: 0.01 ± 0.002
Pro	2.887ProAla: 2.887 ± 0.031	0.501ProCys: 0.501 ± 0.011	2.378ProAsp: 2.378 ± 0.021	3.049ProGlu: 3.049 ± 0.024	1.987ProPhe: 1.987 ± 0.021	1.93ProGly: 1.93 ± 0.023	1.211ProHis: 1.211 ± 0.018	2.907ProIle: 2.907 ± 0.025	2.804ProLys: 2.804 ± 0.024	4.255ProLeu: 4.255 ± 0.037	1.051ProMet: 1.051 ± 0.017	2.332ProAsn: 2.332 ± 0.023	3.343ProPro: 3.343 ± 0.052	2.12ProGln: 2.12 ± 0.031	1.937ProArg: 1.937 ± 0.02	5.036ProSer: 5.036 ± 0.055	3.461ProThr: 3.461 ± 0.038	3.096ProVal: 3.096 ± 0.025	0.458ProTrp: 0.458 ± 0.011	1.596ProTyr: 1.596 ± 0.02	0.01ProXaa: 0.01 ± 0.001
Gln	3.169GlnAla: 3.169 ± 0.024	0.563GlnCys: 0.563 ± 0.012	2.461GlnAsp: 2.461 ± 0.024	3.257GlnGlu: 3.257 ± 0.029	1.82GlnPhe: 1.82 ± 0.022	1.852GlnGly: 1.852 ± 0.02	1.585GlnHis: 1.585 ± 0.02	2.535GlnIle: 2.535 ± 0.02	3.192GlnLys: 3.192 ± 0.028	4.998GlnLeu: 4.998 ± 0.045	1.182GlnMet: 1.182 ± 0.017	2.025GlnAsn: 2.025 ± 0.022	2.566GlnPro: 2.566 ± 0.033	4.72GlnGln: 4.72 ± 0.092	2.474GlnArg: 2.474 ± 0.025	3.649GlnSer: 3.649 ± 0.032	2.666GlnThr: 2.666 ± 0.025	2.668GlnVal: 2.668 ± 0.024	0.54GlnTrp: 0.54 ± 0.012	1.553GlnTyr: 1.553 ± 0.022	0.007GlnXaa: 0.007 ± 0.001
Arg	2.958ArgAla: 2.958 ± 0.031	0.658ArgCys: 0.658 ± 0.013	2.496ArgAsp: 2.496 ± 0.031	2.991ArgGlu: 2.991 ± 0.038	2.128ArgPhe: 2.128 ± 0.019	2.173ArgGly: 2.173 ± 0.029	1.541ArgHis: 1.541 ± 0.017	3.007ArgIle: 3.007 ± 0.027	3.635ArgLys: 3.635 ± 0.029	5.113ArgLeu: 5.113 ± 0.038	1.265ArgMet: 1.265 ± 0.017	2.246ArgAsn: 2.246 ± 0.019	2.265ArgPro: 2.265 ± 0.027	2.659ArgGln: 2.659 ± 0.024	3.436ArgArg: 3.436 ± 0.035	3.97ArgSer: 3.97 ± 0.035	2.655ArgThr: 2.655 ± 0.024	2.774ArgVal: 2.774 ± 0.025	0.633ArgTrp: 0.633 ± 0.012	1.753ArgTyr: 1.753 ± 0.022	0.009ArgXaa: 0.009 ± 0.002
Ser	4.999SerAla: 4.999 ± 0.04	1.048SerCys: 1.048 ± 0.017	4.311SerAsp: 4.311 ± 0.032	4.317SerGlu: 4.317 ± 0.033	3.54SerPhe: 3.54 ± 0.029	3.672SerGly: 3.672 ± 0.031	2.129SerHis: 2.129 ± 0.024	5.121SerIle: 5.121 ± 0.035	4.748SerLys: 4.748 ± 0.038	7.861SerLeu: 7.861 ± 0.043	1.941SerMet: 1.941 ± 0.022	4.196SerAsn: 4.196 ± 0.036	4.365SerPro: 4.365 ± 0.04	3.628SerGln: 3.628 ± 0.028	3.957SerArg: 3.957 ± 0.034	9.394SerSer: 9.394 ± 0.089	5.741SerThr: 5.741 ± 0.053	4.703SerVal: 4.703 ± 0.03	0.854SerTrp: 0.854 ± 0.015	2.405SerTyr: 2.405 ± 0.024	0.017SerXaa: 0.017 ± 0.002
Thr	3.995ThrAla: 3.995 ± 0.031	0.842ThrCys: 0.842 ± 0.013	3.025ThrAsp: 3.025 ± 0.031	3.621ThrGlu: 3.621 ± 0.031	2.364ThrPhe: 2.364 ± 0.024	3.05ThrGly: 3.05 ± 0.033	1.534ThrHis: 1.534 ± 0.017	3.77ThrIle: 3.77 ± 0.032	3.582ThrLys: 3.582 ± 0.035	5.569ThrLeu: 5.569 ± 0.042	1.392ThrMet: 1.392 ± 0.018	2.83ThrAsn: 2.83 ± 0.024	3.394ThrPro: 3.394 ± 0.033	2.534ThrGln: 2.534 ± 0.025	2.646ThrArg: 2.646 ± 0.025	5.352ThrSer: 5.352 ± 0.037	4.585ThrThr: 4.585 ± 0.05	3.736ThrVal: 3.736 ± 0.033	0.63ThrTrp: 0.63 ± 0.012	1.794ThrTyr: 1.794 ± 0.019	0.011ThrXaa: 0.011 ± 0.002
Val	4.069ValAla: 4.069 ± 0.037	0.973ValCys: 0.973 ± 0.015	3.638ValAsp: 3.638 ± 0.029	3.725ValGlu: 3.725 ± 0.032	2.529ValPhe: 2.529 ± 0.029	2.893ValGly: 2.893 ± 0.026	1.511ValHis: 1.511 ± 0.017	3.49ValIle: 3.49 ± 0.03	3.463ValLys: 3.463 ± 0.032	5.589ValLeu: 5.589 ± 0.037	1.468ValMet: 1.468 ± 0.022	2.653ValAsn: 2.653 ± 0.025	2.838ValPro: 2.838 ± 0.025	2.565ValGln: 2.565 ± 0.023	2.732ValArg: 2.732 ± 0.024	4.538ValSer: 4.538 ± 0.035	3.243ValThr: 3.243 ± 0.027	3.933ValVal: 3.933 ± 0.036	0.692ValTrp: 0.692 ± 0.012	2.07ValTyr: 2.07 ± 0.023	0.009ValXaa: 0.009 ± 0.001
Trp	0.664TrpAla: 0.664 ± 0.011	0.185TrpCys: 0.185 ± 0.006	0.679TrpAsp: 0.679 ± 0.013	0.59TrpGlu: 0.59 ± 0.011	0.52TrpPhe: 0.52 ± 0.012	0.51TrpGly: 0.51 ± 0.012	0.312TrpHis: 0.312 ± 0.008	0.808TrpIle: 0.808 ± 0.013	0.775TrpLys: 0.775 ± 0.014	1.075TrpLeu: 1.075 ± 0.015	0.321TrpMet: 0.321 ± 0.008	0.586TrpAsn: 0.586 ± 0.013	0.394TrpPro: 0.394 ± 0.01	0.496TrpGln: 0.496 ± 0.009	0.62TrpArg: 0.62 ± 0.012	0.932TrpSer: 0.932 ± 0.015	0.717TrpThr: 0.717 ± 0.012	0.617TrpVal: 0.617 ± 0.012	0.178TrpTrp: 0.178 ± 0.006	0.396TrpTyr: 0.396 ± 0.009	0.003TrpXaa: 0.003 ± 0.001
Tyr	2.119TyrAla: 2.119 ± 0.023	0.61TyrCys: 0.61 ± 0.011	1.987TyrAsp: 1.987 ± 0.023	1.885TyrGlu: 1.885 ± 0.021	1.51TyrPhe: 1.51 ± 0.022	1.889TyrGly: 1.889 ± 0.025	1.105TyrHis: 1.105 ± 0.015	1.868TyrIle: 1.868 ± 0.02	1.77TyrLys: 1.77 ± 0.021	3.334TyrLeu: 3.334 ± 0.031	0.826TyrMet: 0.826 ± 0.014	1.632TyrAsn: 1.632 ± 0.02	1.516TyrPro: 1.516 ± 0.019	1.724TyrGln: 1.724 ± 0.021	1.834TyrArg: 1.834 ± 0.022	2.418TyrSer: 2.418 ± 0.025	1.844TyrThr: 1.844 ± 0.018	1.918TyrVal: 1.918 ± 0.022	0.422TyrTrp: 0.422 ± 0.01	1.378TyrTyr: 1.378 ± 0.019	0.008TyrXaa: 0.008 ± 0.001
Xaa	0.012XaaAla: 0.012 ± 0.002	0.002XaaCys: 0.002 ± 0.001	0.009XaaAsp: 0.009 ± 0.001	0.012XaaGlu: 0.012 ± 0.002	0.007XaaPhe: 0.007 ± 0.001	0.008XaaGly: 0.008 ± 0.001	0.005XaaHis: 0.005 ± 0.001	0.013XaaIle: 0.013 ± 0.002	0.016XaaLys: 0.016 ± 0.002	0.014XaaLeu: 0.014 ± 0.002	0.005XaaMet: 0.005 ± 0.001	0.012XaaAsn: 0.012 ± 0.002	0.008XaaPro: 0.008 ± 0.001	0.008XaaGln: 0.008 ± 0.001	0.01XaaArg: 0.01 ± 0.002	0.017XaaSer: 0.017 ± 0.002	0.015XaaThr: 0.015 ± 0.002	0.012XaaVal: 0.012 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.006XaaTyr: 0.006 ± 0.001	0.018XaaXaa: 0.018 ± 0.009

Statistics based on 11924 proteins (4748132 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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