Amino acid dipepetide frequency for Acer yangbiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.653AlaAla: 5.653 ± 0.037
1.259AlaCys: 1.259 ± 0.013
2.949AlaAsp: 2.949 ± 0.018
3.812AlaGlu: 3.812 ± 0.022
2.72AlaPhe: 2.72 ± 0.016
3.713AlaGly: 3.713 ± 0.019
1.222AlaHis: 1.222 ± 0.01
3.765AlaIle: 3.765 ± 0.018
3.76AlaLys: 3.76 ± 0.018
6.244AlaLeu: 6.244 ± 0.029
1.773AlaMet: 1.773 ± 0.015
2.547AlaAsn: 2.547 ± 0.016
2.408AlaPro: 2.408 ± 0.018
1.953AlaGln: 1.953 ± 0.012
3.065AlaArg: 3.065 ± 0.017
5.505AlaSer: 5.505 ± 0.023
3.415AlaThr: 3.415 ± 0.019
4.553AlaVal: 4.553 ± 0.025
0.777AlaTrp: 0.777 ± 0.009
1.783AlaTyr: 1.783 ± 0.012
0.0AlaXaa: 0.0 ± 0.0
Cys
0.951CysAla: 0.951 ± 0.009
0.541CysCys: 0.541 ± 0.008
0.906CysAsp: 0.906 ± 0.01
0.917CysGlu: 0.917 ± 0.01
0.991CysPhe: 0.991 ± 0.009
1.444CysGly: 1.444 ± 0.012
0.488CysHis: 0.488 ± 0.006
1.055CysIle: 1.055 ± 0.01
1.298CysLys: 1.298 ± 0.012
2.014CysLeu: 2.014 ± 0.014
0.481CysMet: 0.481 ± 0.006
0.983CysAsn: 0.983 ± 0.012
0.988CysPro: 0.988 ± 0.011
0.608CysGln: 0.608 ± 0.009
1.038CysArg: 1.038 ± 0.011
1.895CysSer: 1.895 ± 0.014
0.885CysThr: 0.885 ± 0.009
1.119CysVal: 1.119 ± 0.01
0.271CysTrp: 0.271 ± 0.005
0.605CysTyr: 0.605 ± 0.007
0.0CysXaa: 0.0 ± 0.0
Asp
3.163AspAla: 3.163 ± 0.018
1.079AspCys: 1.079 ± 0.01
3.71AspAsp: 3.71 ± 0.022
3.9AspGlu: 3.9 ± 0.022
2.39AspPhe: 2.39 ± 0.015
3.819AspGly: 3.819 ± 0.021
1.418AspHis: 1.418 ± 0.013
3.205AspIle: 3.205 ± 0.018
2.818AspLys: 2.818 ± 0.016
5.112AspLeu: 5.112 ± 0.023
1.416AspMet: 1.416 ± 0.01
2.306AspAsn: 2.306 ± 0.015
2.463AspPro: 2.463 ± 0.016
1.927AspGln: 1.927 ± 0.014
2.406AspArg: 2.406 ± 0.016
4.265AspSer: 4.265 ± 0.02
2.226AspThr: 2.226 ± 0.015
3.691AspVal: 3.691 ± 0.019
0.703AspTrp: 0.703 ± 0.007
1.601AspTyr: 1.601 ± 0.013
0.0AspXaa: 0.0 ± 0.0
Glu
4.526GluAla: 4.526 ± 0.022
0.978GluCys: 0.978 ± 0.011
3.943GluAsp: 3.943 ± 0.023
6.169GluGlu: 6.169 ± 0.04
2.459GluPhe: 2.459 ± 0.015
3.611GluGly: 3.611 ± 0.019
1.195GluHis: 1.195 ± 0.01
4.03GluIle: 4.03 ± 0.022
4.82GluLys: 4.82 ± 0.024
6.0GluLeu: 6.0 ± 0.028
1.867GluMet: 1.867 ± 0.016
3.246GluAsn: 3.246 ± 0.017
1.985GluPro: 1.985 ± 0.014
2.09GluGln: 2.09 ± 0.017
3.166GluArg: 3.166 ± 0.022
4.659GluSer: 4.659 ± 0.024
3.103GluThr: 3.103 ± 0.02
4.168GluVal: 4.168 ± 0.022
0.754GluTrp: 0.754 ± 0.008
1.61GluTyr: 1.61 ± 0.011
0.0GluXaa: 0.0 ± 0.0
Phe
2.438PheAla: 2.438 ± 0.016
0.974PheCys: 0.974 ± 0.01
2.546PheAsp: 2.546 ± 0.013
2.447PheGlu: 2.447 ± 0.017
2.107PhePhe: 2.107 ± 0.015
3.021PheGly: 3.021 ± 0.018
1.165PheHis: 1.165 ± 0.01
2.208PheIle: 2.208 ± 0.015
2.337PheLys: 2.337 ± 0.016
4.386PheLeu: 4.386 ± 0.024
1.026PheMet: 1.026 ± 0.008
2.008PheAsn: 2.008 ± 0.013
2.109PhePro: 2.109 ± 0.015
1.583PheGln: 1.583 ± 0.012
2.048PheArg: 2.048 ± 0.014
4.115PheSer: 4.115 ± 0.02
2.103PheThr: 2.103 ± 0.014
2.951PheVal: 2.951 ± 0.019
0.623PheTrp: 0.623 ± 0.008
1.352PheTyr: 1.352 ± 0.012
0.0PheXaa: 0.0 ± 0.0
Gly
3.438GlyAla: 3.438 ± 0.02
1.392GlyCys: 1.392 ± 0.012
3.404GlyAsp: 3.404 ± 0.019
3.514GlyGlu: 3.514 ± 0.018
3.257GlyPhe: 3.257 ± 0.02
5.128GlyGly: 5.128 ± 0.037
1.527GlyHis: 1.527 ± 0.013
3.648GlyIle: 3.648 ± 0.02
4.165GlyLys: 4.165 ± 0.02
5.898GlyLeu: 5.898 ± 0.023
1.514GlyMet: 1.514 ± 0.012
3.222GlyAsn: 3.222 ± 0.02
2.307GlyPro: 2.307 ± 0.016
2.007GlyGln: 2.007 ± 0.015
3.379GlyArg: 3.379 ± 0.02
5.724GlySer: 5.724 ± 0.03
3.086GlyThr: 3.086 ± 0.018
4.207GlyVal: 4.207 ± 0.018
0.882GlyTrp: 0.882 ± 0.009
2.038GlyTyr: 2.038 ± 0.017
0.0GlyXaa: 0.0 ± 0.0
His
1.319HisAla: 1.319 ± 0.011
0.531HisCys: 0.531 ± 0.007
1.195HisAsp: 1.195 ± 0.011
1.303HisGlu: 1.303 ± 0.011
1.117HisPhe: 1.117 ± 0.01
1.679HisGly: 1.679 ± 0.013
1.007HisHis: 1.007 ± 0.012
1.271HisIle: 1.271 ± 0.011
1.192HisLys: 1.192 ± 0.011
2.433HisLeu: 2.433 ± 0.016
0.572HisMet: 0.572 ± 0.007
1.089HisAsn: 1.089 ± 0.01
1.214HisPro: 1.214 ± 0.011
1.029HisGln: 1.029 ± 0.01
1.261HisArg: 1.261 ± 0.01
1.878HisSer: 1.878 ± 0.013
0.967HisThr: 0.967 ± 0.009
1.573HisVal: 1.573 ± 0.011
0.307HisTrp: 0.307 ± 0.005
0.707HisTyr: 0.707 ± 0.009
0.0HisXaa: 0.0 ± 0.0
Ile
3.559IleAla: 3.559 ± 0.019
1.163IleCys: 1.163 ± 0.011
3.153IleAsp: 3.153 ± 0.016
3.482IleGlu: 3.482 ± 0.02
2.444IlePhe: 2.444 ± 0.015
3.596IleGly: 3.596 ± 0.02
1.358IleHis: 1.358 ± 0.014
3.031IleIle: 3.031 ± 0.018
3.185IleLys: 3.185 ± 0.017
5.327IleLeu: 5.327 ± 0.026
1.212IleMet: 1.212 ± 0.01
2.509IleAsn: 2.509 ± 0.016
3.037IlePro: 3.037 ± 0.024
2.04IleGln: 2.04 ± 0.015
2.714IleArg: 2.714 ± 0.016
5.139IleSer: 5.139 ± 0.021
2.776IleThr: 2.776 ± 0.016
3.673IleVal: 3.673 ± 0.022
0.81IleTrp: 0.81 ± 0.009
1.636IleTyr: 1.636 ± 0.013
0.0IleXaa: 0.0 ± 0.0
Lys
3.914LysAla: 3.914 ± 0.021
1.071LysCys: 1.071 ± 0.009
3.349LysAsp: 3.349 ± 0.018
4.717LysGlu: 4.717 ± 0.025
2.43LysPhe: 2.43 ± 0.014
3.618LysGly: 3.618 ± 0.019
1.325LysHis: 1.325 ± 0.012
3.487LysIle: 3.487 ± 0.019
4.937LysLys: 4.937 ± 0.03
6.496LysLeu: 6.496 ± 0.029
1.652LysMet: 1.652 ± 0.012
2.941LysAsn: 2.941 ± 0.018
2.706LysPro: 2.706 ± 0.018
2.353LysGln: 2.353 ± 0.016
3.572LysArg: 3.572 ± 0.018
4.826LysSer: 4.826 ± 0.024
3.037LysThr: 3.037 ± 0.018
3.928LysVal: 3.928 ± 0.019
0.845LysTrp: 0.845 ± 0.008
1.738LysTyr: 1.738 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
6.137LeuAla: 6.137 ± 0.026
1.979LeuCys: 1.979 ± 0.015
5.128LeuAsp: 5.128 ± 0.022
6.518LeuGlu: 6.518 ± 0.034
4.046LeuPhe: 4.046 ± 0.021
5.646LeuGly: 5.646 ± 0.026
2.591LeuHis: 2.591 ± 0.017
4.953LeuIle: 4.953 ± 0.022
6.656LeuLys: 6.656 ± 0.031
9.841LeuLeu: 9.841 ± 0.043
2.238LeuMet: 2.238 ± 0.016
4.22LeuAsn: 4.22 ± 0.019
5.077LeuPro: 5.077 ± 0.024
4.286LeuGln: 4.286 ± 0.024
5.221LeuArg: 5.221 ± 0.022
8.709LeuSer: 8.709 ± 0.036
4.577LeuThr: 4.577 ± 0.024
6.493LeuVal: 6.493 ± 0.023
1.204LeuTrp: 1.204 ± 0.011
2.635LeuTyr: 2.635 ± 0.017
0.0LeuXaa: 0.0 ± 0.0
Met
2.0MetAla: 2.0 ± 0.013
0.341MetCys: 0.341 ± 0.005
1.458MetAsp: 1.458 ± 0.012
2.067MetGlu: 2.067 ± 0.014
0.914MetPhe: 0.914 ± 0.01
1.592MetGly: 1.592 ± 0.012
0.546MetHis: 0.546 ± 0.007
1.401MetIle: 1.401 ± 0.013
1.789MetLys: 1.789 ± 0.014
2.25MetLeu: 2.25 ± 0.015
0.717MetMet: 0.717 ± 0.01
1.11MetAsn: 1.11 ± 0.01
1.025MetPro: 1.025 ± 0.011
0.939MetGln: 0.939 ± 0.009
1.178MetArg: 1.178 ± 0.01
1.874MetSer: 1.874 ± 0.013
1.108MetThr: 1.108 ± 0.011
1.774MetVal: 1.774 ± 0.012
0.283MetTrp: 0.283 ± 0.005
0.648MetTyr: 0.648 ± 0.008
0.0MetXaa: 0.0 ± 0.0
Asn
2.61AsnAla: 2.61 ± 0.017
0.995AsnCys: 0.995 ± 0.011
2.206AsnAsp: 2.206 ± 0.015
2.619AsnGlu: 2.619 ± 0.016
2.129AsnPhe: 2.129 ± 0.014
3.325AsnGly: 3.325 ± 0.02
1.149AsnHis: 1.149 ± 0.01
2.718AsnIle: 2.718 ± 0.015
2.649AsnLys: 2.649 ± 0.016
5.087AsnLeu: 5.087 ± 0.03
1.205AsnMet: 1.205 ± 0.01
2.868AsnAsn: 2.868 ± 0.024
2.389AsnPro: 2.389 ± 0.016
1.824AsnGln: 1.824 ± 0.014
2.135AsnArg: 2.135 ± 0.013
4.243AsnSer: 4.243 ± 0.021
2.117AsnThr: 2.117 ± 0.015
3.054AsnVal: 3.054 ± 0.017
0.623AsnTrp: 0.623 ± 0.009
1.422AsnTyr: 1.422 ± 0.01
0.0AsnXaa: 0.0 ± 0.0
Pro
2.607ProAla: 2.607 ± 0.021
0.765ProCys: 0.765 ± 0.009
2.492ProAsp: 2.492 ± 0.015
3.015ProGlu: 3.015 ± 0.017
1.925ProPhe: 1.925 ± 0.014
2.517ProGly: 2.517 ± 0.015
1.039ProHis: 1.039 ± 0.011
2.386ProIle: 2.386 ± 0.015
2.7ProLys: 2.7 ± 0.02
4.074ProLeu: 4.074 ± 0.022
0.962ProMet: 0.962 ± 0.01
2.326ProAsn: 2.326 ± 0.016
3.605ProPro: 3.605 ± 0.067
1.67ProGln: 1.67 ± 0.014
2.094ProArg: 2.094 ± 0.015
4.797ProSer: 4.797 ± 0.025
2.542ProThr: 2.542 ± 0.018
2.972ProVal: 2.972 ± 0.019
0.603ProTrp: 0.603 ± 0.006
1.276ProTyr: 1.276 ± 0.013
0.0ProXaa: 0.0 ± 0.0
Gln
2.282GlnAla: 2.282 ± 0.016
0.596GlnCys: 0.596 ± 0.007
1.656GlnAsp: 1.656 ± 0.012
2.358GlnGlu: 2.358 ± 0.015
1.39GlnPhe: 1.39 ± 0.011
2.017GlnGly: 2.017 ± 0.015
0.923GlnHis: 0.923 ± 0.01
2.109GlnIle: 2.109 ± 0.014
2.299GlnLys: 2.299 ± 0.017
3.768GlnLeu: 3.768 ± 0.024
0.972GlnMet: 0.972 ± 0.009
1.863GlnAsn: 1.863 ± 0.015
1.692GlnPro: 1.692 ± 0.013
2.096GlnGln: 2.096 ± 0.03
1.961GlnArg: 1.961 ± 0.015
2.836GlnSer: 2.836 ± 0.018
1.722GlnThr: 1.722 ± 0.013
2.427GlnVal: 2.427 ± 0.014
0.442GlnTrp: 0.442 ± 0.005
0.925GlnTyr: 0.925 ± 0.01
0.0GlnXaa: 0.0 ± 0.0
Arg
2.915ArgAla: 2.915 ± 0.018
0.933ArgCys: 0.933 ± 0.01
2.624ArgAsp: 2.624 ± 0.017
3.233ArgGlu: 3.233 ± 0.021
2.282ArgPhe: 2.282 ± 0.015
2.933ArgGly: 2.933 ± 0.021
1.156ArgHis: 1.156 ± 0.01
2.883ArgIle: 2.883 ± 0.016
3.663ArgLys: 3.663 ± 0.02
4.946ArgLeu: 4.946 ± 0.023
1.294ArgMet: 1.294 ± 0.01
2.466ArgAsn: 2.466 ± 0.014
2.096ArgPro: 2.096 ± 0.016
1.739ArgGln: 1.739 ± 0.014
3.507ArgArg: 3.507 ± 0.023
4.06ArgSer: 4.06 ± 0.021
2.318ArgThr: 2.318 ± 0.016
3.302ArgVal: 3.302 ± 0.019
0.738ArgTrp: 0.738 ± 0.009
1.435ArgTyr: 1.435 ± 0.011
0.0ArgXaa: 0.0 ± 0.0
Ser
4.949SerAla: 4.949 ± 0.024
1.788SerCys: 1.788 ± 0.013
4.431SerAsp: 4.431 ± 0.022
4.697SerGlu: 4.697 ± 0.023
4.042SerPhe: 4.042 ± 0.021
5.732SerGly: 5.732 ± 0.025
1.944SerHis: 1.944 ± 0.013
4.905SerIle: 4.905 ± 0.026
5.143SerLys: 5.143 ± 0.025
9.049SerLeu: 9.049 ± 0.04
2.176SerMet: 2.176 ± 0.013
4.313SerAsn: 4.313 ± 0.022
4.125SerPro: 4.125 ± 0.03
2.944SerGln: 2.944 ± 0.02
4.222SerArg: 4.222 ± 0.02
10.823SerSer: 10.823 ± 0.045
4.737SerThr: 4.737 ± 0.024
5.263SerVal: 5.263 ± 0.02
1.244SerTrp: 1.244 ± 0.012
2.328SerTyr: 2.328 ± 0.016
0.0SerXaa: 0.0 ± 0.0
Thr
3.286ThrAla: 3.286 ± 0.018
0.981ThrCys: 0.981 ± 0.011
2.344ThrAsp: 2.344 ± 0.015
2.745ThrGlu: 2.745 ± 0.018
2.109ThrPhe: 2.109 ± 0.015
3.216ThrGly: 3.216 ± 0.019
1.053ThrHis: 1.053 ± 0.01
2.904ThrIle: 2.904 ± 0.015
2.815ThrLys: 2.815 ± 0.018
4.71ThrLeu: 4.71 ± 0.022
1.192ThrMet: 1.192 ± 0.011
2.262ThrAsn: 2.262 ± 0.014
2.424ThrPro: 2.424 ± 0.02
1.558ThrGln: 1.558 ± 0.012
2.309ThrArg: 2.309 ± 0.015
4.632ThrSer: 4.632 ± 0.022
3.299ThrThr: 3.299 ± 0.024
3.382ThrVal: 3.382 ± 0.019
0.662ThrTrp: 0.662 ± 0.007
1.419ThrTyr: 1.419 ± 0.012
0.0ThrXaa: 0.0 ± 0.0
Val
4.629ValAla: 4.629 ± 0.021
1.182ValCys: 1.182 ± 0.011
3.899ValAsp: 3.899 ± 0.02
4.552ValGlu: 4.552 ± 0.021
2.881ValPhe: 2.881 ± 0.017
4.235ValGly: 4.235 ± 0.021
1.517ValHis: 1.517 ± 0.011
3.565ValIle: 3.565 ± 0.017
4.042ValLys: 4.042 ± 0.017
6.395ValLeu: 6.395 ± 0.023
1.612ValMet: 1.612 ± 0.012
2.844ValAsn: 2.844 ± 0.015
3.025ValPro: 3.025 ± 0.019
2.291ValGln: 2.291 ± 0.015
3.006ValArg: 3.006 ± 0.016
5.559ValSer: 5.559 ± 0.022
3.28ValThr: 3.28 ± 0.018
5.113ValVal: 5.113 ± 0.022
0.816ValTrp: 0.816 ± 0.009
1.912ValTyr: 1.912 ± 0.012
0.0ValXaa: 0.0 ± 0.0
Trp
0.736TrpAla: 0.736 ± 0.009
0.246TrpCys: 0.246 ± 0.004
0.702TrpAsp: 0.702 ± 0.008
0.752TrpGlu: 0.752 ± 0.009
0.582TrpPhe: 0.582 ± 0.008
0.759TrpGly: 0.759 ± 0.009
0.339TrpHis: 0.339 ± 0.007
0.778TrpIle: 0.778 ± 0.009
1.022TrpLys: 1.022 ± 0.011
1.312TrpLeu: 1.312 ± 0.011
0.336TrpMet: 0.336 ± 0.005
0.771TrpAsn: 0.771 ± 0.009
0.497TrpPro: 0.497 ± 0.007
0.457TrpGln: 0.457 ± 0.006
0.806TrpArg: 0.806 ± 0.009
1.021TrpSer: 1.021 ± 0.01
0.649TrpThr: 0.649 ± 0.009
0.871TrpVal: 0.871 ± 0.008
0.246TrpTrp: 0.246 ± 0.005
0.368TrpTyr: 0.368 ± 0.006
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.763TyrAla: 1.763 ± 0.013
0.681TyrCys: 0.681 ± 0.009
1.522TyrAsp: 1.522 ± 0.012
1.563TyrGlu: 1.563 ± 0.012
1.331TyrPhe: 1.331 ± 0.013
2.133TyrGly: 2.133 ± 0.013
0.685TyrHis: 0.685 ± 0.008
1.54TyrIle: 1.54 ± 0.012
1.652TyrLys: 1.652 ± 0.013
2.812TyrLeu: 2.812 ± 0.016
0.798TyrMet: 0.798 ± 0.009
1.473TyrAsn: 1.473 ± 0.014
1.195TyrPro: 1.195 ± 0.011
0.939TyrGln: 0.939 ± 0.008
1.435TyrArg: 1.435 ± 0.012
2.297TyrSer: 2.297 ± 0.013
1.356TyrThr: 1.356 ± 0.011
1.843TyrVal: 1.843 ± 0.012
0.418TyrTrp: 0.418 ± 0.006
0.976TyrTyr: 0.976 ± 0.011
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 28112 proteins (12256278 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski