Amino acid dipepetide frequency for Streptomyces kaniharaensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.714AlaAla: 23.714 ± 0.167	1.119AlaCys: 1.119 ± 0.022	8.854AlaAsp: 8.854 ± 0.066	9.411AlaGlu: 9.411 ± 0.09	3.51AlaPhe: 3.51 ± 0.045	13.619AlaGly: 13.619 ± 0.089	2.92AlaHis: 2.92 ± 0.04	3.66AlaIle: 3.66 ± 0.041	2.763AlaLys: 2.763 ± 0.048	14.957AlaLeu: 14.957 ± 0.106	2.526AlaMet: 2.526 ± 0.035	2.052AlaAsn: 2.052 ± 0.031	7.894AlaPro: 7.894 ± 0.094	4.161AlaGln: 4.161 ± 0.055	10.6AlaArg: 10.6 ± 0.09	5.745AlaSer: 5.745 ± 0.056	7.467AlaThr: 7.467 ± 0.071	12.675AlaVal: 12.675 ± 0.084	1.992AlaTrp: 1.992 ± 0.032	2.596AlaTyr: 2.596 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.098CysAla: 1.098 ± 0.02	0.121CysCys: 0.121 ± 0.008	0.467CysAsp: 0.467 ± 0.015	0.398CysGlu: 0.398 ± 0.014	0.215CysPhe: 0.215 ± 0.01	0.986CysGly: 0.986 ± 0.023	0.214CysHis: 0.214 ± 0.01	0.202CysIle: 0.202 ± 0.01	0.111CysLys: 0.111 ± 0.007	0.803CysLeu: 0.803 ± 0.02	0.121CysMet: 0.121 ± 0.008	0.141CysAsn: 0.141 ± 0.008	0.594CysPro: 0.594 ± 0.017	0.201CysGln: 0.201 ± 0.01	0.674CysArg: 0.674 ± 0.019	0.466CysSer: 0.466 ± 0.016	0.544CysThr: 0.544 ± 0.016	0.556CysVal: 0.556 ± 0.016	0.135CysTrp: 0.135 ± 0.007	0.16CysTyr: 0.16 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.472AspAla: 7.472 ± 0.065	0.443AspCys: 0.443 ± 0.016	3.244AspAsp: 3.244 ± 0.041	3.697AspGlu: 3.697 ± 0.046	1.602AspPhe: 1.602 ± 0.028	6.323AspGly: 6.323 ± 0.059	1.488AspHis: 1.488 ± 0.027	1.597AspIle: 1.597 ± 0.029	1.037AspLys: 1.037 ± 0.025	6.541AspLeu: 6.541 ± 0.064	0.646AspMet: 0.646 ± 0.017	0.955AspAsn: 0.955 ± 0.025	4.63AspPro: 4.63 ± 0.056	1.75AspGln: 1.75 ± 0.031	5.045AspArg: 5.045 ± 0.055	2.269AspSer: 2.269 ± 0.031	3.057AspThr: 3.057 ± 0.038	4.307AspVal: 4.307 ± 0.044	1.002AspTrp: 1.002 ± 0.021	1.134AspTyr: 1.134 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.478GluAla: 7.478 ± 0.071	0.366GluCys: 0.366 ± 0.014	2.687GluAsp: 2.687 ± 0.037	3.282GluGlu: 3.282 ± 0.05	1.455GluPhe: 1.455 ± 0.026	3.842GluGly: 3.842 ± 0.044	1.673GluHis: 1.673 ± 0.028	2.151GluIle: 2.151 ± 0.035	1.19GluLys: 1.19 ± 0.028	7.277GluLeu: 7.277 ± 0.075	0.789GluMet: 0.789 ± 0.019	0.907GluAsn: 0.907 ± 0.019	3.459GluPro: 3.459 ± 0.041	2.52GluGln: 2.52 ± 0.04	5.359GluArg: 5.359 ± 0.059	2.319GluSer: 2.319 ± 0.034	2.632GluThr: 2.632 ± 0.034	4.251GluVal: 4.251 ± 0.048	0.764GluTrp: 0.764 ± 0.018	1.067GluTyr: 1.067 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.603PheAla: 3.603 ± 0.04	0.273PheCys: 0.273 ± 0.011	1.896PheAsp: 1.896 ± 0.033	1.372PheGlu: 1.372 ± 0.023	0.792PhePhe: 0.792 ± 0.02	2.862PheGly: 2.862 ± 0.035	0.625PheHis: 0.625 ± 0.018	0.681PheIle: 0.681 ± 0.019	0.446PheLys: 0.446 ± 0.015	2.408PheLeu: 2.408 ± 0.032	0.355PheMet: 0.355 ± 0.011	0.547PheAsn: 0.547 ± 0.013	1.407PhePro: 1.407 ± 0.024	0.701PheGln: 0.701 ± 0.018	1.8PheArg: 1.8 ± 0.031	1.333PheSer: 1.333 ± 0.027	1.955PheThr: 1.955 ± 0.032	1.999PheVal: 1.999 ± 0.034	0.401PheTrp: 0.401 ± 0.014	0.51PheTyr: 0.51 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.915GlyAla: 10.915 ± 0.074	0.904GlyCys: 0.904 ± 0.021	4.797GlyAsp: 4.797 ± 0.053	4.963GlyGlu: 4.963 ± 0.05	2.704GlyPhe: 2.704 ± 0.039	8.581GlyGly: 8.581 ± 0.085	2.367GlyHis: 2.367 ± 0.031	3.22GlyIle: 3.22 ± 0.042	2.252GlyLys: 2.252 ± 0.038	9.712GlyLeu: 9.712 ± 0.073	1.89GlyMet: 1.89 ± 0.027	1.711GlyAsn: 1.711 ± 0.036	5.565GlyPro: 5.565 ± 0.055	2.854GlyGln: 2.854 ± 0.044	8.017GlyArg: 8.017 ± 0.071	5.18GlySer: 5.18 ± 0.058	6.156GlyThr: 6.156 ± 0.066	7.076GlyVal: 7.076 ± 0.06	1.817GlyTrp: 1.817 ± 0.031	2.294GlyTyr: 2.294 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.8HisAla: 2.8 ± 0.039	0.232HisCys: 0.232 ± 0.011	1.315HisAsp: 1.315 ± 0.029	1.166HisGlu: 1.166 ± 0.022	0.653HisPhe: 0.653 ± 0.017	2.421HisGly: 2.421 ± 0.029	0.795HisHis: 0.795 ± 0.022	0.631HisIle: 0.631 ± 0.017	0.339HisLys: 0.339 ± 0.014	2.721HisLeu: 2.721 ± 0.033	0.305HisMet: 0.305 ± 0.013	0.401HisAsn: 0.401 ± 0.013	2.002HisPro: 2.002 ± 0.033	0.795HisGln: 0.795 ± 0.018	2.309HisArg: 2.309 ± 0.032	1.011HisSer: 1.011 ± 0.022	1.31HisThr: 1.31 ± 0.026	1.579HisVal: 1.579 ± 0.026	0.427HisTrp: 0.427 ± 0.014	0.479HisTyr: 0.479 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.892IleAla: 4.892 ± 0.055	0.311IleCys: 0.311 ± 0.012	2.107IleAsp: 2.107 ± 0.028	1.879IleGlu: 1.879 ± 0.031	0.638IlePhe: 0.638 ± 0.018	3.536IleGly: 3.536 ± 0.048	0.638IleHis: 0.638 ± 0.016	0.81IleIle: 0.81 ± 0.02	0.68IleLys: 0.68 ± 0.021	2.312IleLeu: 2.312 ± 0.034	0.389IleMet: 0.389 ± 0.012	0.688IleAsn: 0.688 ± 0.019	1.823IlePro: 1.823 ± 0.029	0.737IleGln: 0.737 ± 0.019	2.334IleArg: 2.334 ± 0.033	1.628IleSer: 1.628 ± 0.03	2.22IleThr: 2.22 ± 0.033	2.492IleVal: 2.492 ± 0.038	0.381IleTrp: 0.381 ± 0.013	0.494IleTyr: 0.494 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.877LysAla: 2.877 ± 0.047	0.103LysCys: 0.103 ± 0.006	1.137LysAsp: 1.137 ± 0.028	1.017LysGlu: 1.017 ± 0.025	0.419LysPhe: 0.419 ± 0.014	1.563LysGly: 1.563 ± 0.032	0.447LysHis: 0.447 ± 0.016	0.777LysIle: 0.777 ± 0.022	0.66LysLys: 0.66 ± 0.021	1.957LysLeu: 1.957 ± 0.034	0.325LysMet: 0.325 ± 0.012	0.461LysAsn: 0.461 ± 0.015	1.322LysPro: 1.322 ± 0.026	0.672LysGln: 0.672 ± 0.019	1.313LysArg: 1.313 ± 0.024	1.019LysSer: 1.019 ± 0.022	1.133LysThr: 1.133 ± 0.025	1.712LysVal: 1.712 ± 0.032	0.238LysTrp: 0.238 ± 0.012	0.416LysTyr: 0.416 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.786LeuAla: 16.786 ± 0.115	0.857LeuCys: 0.857 ± 0.02	6.876LeuAsp: 6.876 ± 0.063	4.655LeuGlu: 4.655 ± 0.049	2.508LeuPhe: 2.508 ± 0.034	9.548LeuGly: 9.548 ± 0.065	2.491LeuHis: 2.491 ± 0.033	3.257LeuIle: 3.257 ± 0.046	1.811LeuLys: 1.811 ± 0.036	11.928LeuLeu: 11.928 ± 0.103	1.555LeuMet: 1.555 ± 0.025	1.705LeuAsn: 1.705 ± 0.025	7.063LeuPro: 7.063 ± 0.06	2.35LeuGln: 2.35 ± 0.032	8.923LeuArg: 8.923 ± 0.078	5.024LeuSer: 5.024 ± 0.049	7.02LeuThr: 7.02 ± 0.06	8.883LeuVal: 8.883 ± 0.077	1.305LeuTrp: 1.305 ± 0.024	1.771LeuTyr: 1.771 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.188MetAla: 2.188 ± 0.03	0.108MetCys: 0.108 ± 0.007	0.821MetAsp: 0.821 ± 0.02	0.657MetGlu: 0.657 ± 0.018	0.421MetPhe: 0.421 ± 0.013	1.169MetGly: 1.169 ± 0.024	0.341MetHis: 0.341 ± 0.013	0.638MetIle: 0.638 ± 0.017	0.369MetLys: 0.369 ± 0.012	1.624MetLeu: 1.624 ± 0.03	0.281MetMet: 0.281 ± 0.012	0.405MetAsn: 0.405 ± 0.014	1.15MetPro: 1.15 ± 0.023	0.41MetGln: 0.41 ± 0.014	1.339MetArg: 1.339 ± 0.026	1.189MetSer: 1.189 ± 0.019	1.478MetThr: 1.478 ± 0.024	1.22MetVal: 1.22 ± 0.023	0.195MetTrp: 0.195 ± 0.009	0.285MetTyr: 0.285 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.229AsnAla: 2.229 ± 0.032	0.158AsnCys: 0.158 ± 0.007	0.934AsnAsp: 0.934 ± 0.024	0.754AsnGlu: 0.754 ± 0.018	0.431AsnPhe: 0.431 ± 0.014	1.96AsnGly: 1.96 ± 0.035	0.406AsnHis: 0.406 ± 0.014	0.567AsnIle: 0.567 ± 0.016	0.355AsnLys: 0.355 ± 0.012	1.714AsnLeu: 1.714 ± 0.03	0.271AsnMet: 0.271 ± 0.011	0.406AsnAsn: 0.406 ± 0.015	1.433AsnPro: 1.433 ± 0.028	0.548AsnGln: 0.548 ± 0.016	1.327AsnArg: 1.327 ± 0.026	0.916AsnSer: 0.916 ± 0.021	1.111AsnThr: 1.111 ± 0.026	1.31AsnVal: 1.31 ± 0.025	0.288AsnTrp: 0.288 ± 0.012	0.391AsnTyr: 0.391 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	10.369ProAla: 10.369 ± 0.093	0.374ProCys: 0.374 ± 0.013	4.635ProAsp: 4.635 ± 0.052	4.38ProGlu: 4.38 ± 0.044	1.512ProPhe: 1.512 ± 0.026	7.102ProGly: 7.102 ± 0.07	1.422ProHis: 1.422 ± 0.024	1.438ProIle: 1.438 ± 0.026	1.184ProLys: 1.184 ± 0.023	5.483ProLeu: 5.483 ± 0.06	0.967ProMet: 0.967 ± 0.019	1.014ProAsn: 1.014 ± 0.023	3.71ProPro: 3.71 ± 0.054	2.022ProGln: 2.022 ± 0.039	3.974ProArg: 3.974 ± 0.044	3.326ProSer: 3.326 ± 0.049	3.621ProThr: 3.621 ± 0.058	5.797ProVal: 5.797 ± 0.055	0.944ProTrp: 0.944 ± 0.021	1.32ProTyr: 1.32 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.399GlnAla: 4.399 ± 0.061	0.19GlnCys: 0.19 ± 0.009	1.478GlnAsp: 1.478 ± 0.028	1.467GlnGlu: 1.467 ± 0.026	0.674GlnPhe: 0.674 ± 0.018	2.28GlnGly: 2.28 ± 0.037	0.757GlnHis: 0.757 ± 0.021	1.117GlnIle: 1.117 ± 0.024	0.584GlnLys: 0.584 ± 0.018	3.539GlnLeu: 3.539 ± 0.038	0.466GlnMet: 0.466 ± 0.015	0.513GlnAsn: 0.513 ± 0.015	2.057GlnPro: 2.057 ± 0.041	1.474GlnGln: 1.474 ± 0.036	2.544GlnArg: 2.544 ± 0.036	1.284GlnSer: 1.284 ± 0.025	1.421GlnThr: 1.421 ± 0.024	2.494GlnVal: 2.494 ± 0.028	0.505GlnTrp: 0.505 ± 0.018	0.61GlnTyr: 0.61 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.18ArgAla: 10.18 ± 0.081	0.645ArgCys: 0.645 ± 0.02	4.056ArgAsp: 4.056 ± 0.047	4.66ArgGlu: 4.66 ± 0.047	2.243ArgPhe: 2.243 ± 0.032	5.553ArgGly: 5.553 ± 0.048	2.193ArgHis: 2.193 ± 0.037	3.356ArgIle: 3.356 ± 0.039	1.516ArgLys: 1.516 ± 0.029	9.32ArgLeu: 9.32 ± 0.081	1.717ArgMet: 1.717 ± 0.029	1.329ArgAsn: 1.329 ± 0.023	5.552ArgPro: 5.552 ± 0.075	2.513ArgGln: 2.513 ± 0.035	8.185ArgArg: 8.185 ± 0.083	4.11ArgSer: 4.11 ± 0.04	5.343ArgThr: 5.343 ± 0.051	5.443ArgVal: 5.443 ± 0.063	1.491ArgTrp: 1.491 ± 0.027	1.829ArgTyr: 1.829 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.718SerAla: 6.718 ± 0.065	0.455SerCys: 0.455 ± 0.015	2.432SerAsp: 2.432 ± 0.036	2.171SerGlu: 2.171 ± 0.029	1.414SerPhe: 1.414 ± 0.027	5.538SerGly: 5.538 ± 0.057	1.0SerHis: 1.0 ± 0.022	1.452SerIle: 1.452 ± 0.029	0.933SerLys: 0.933 ± 0.022	4.561SerLeu: 4.561 ± 0.044	1.011SerMet: 1.011 ± 0.021	0.87SerAsn: 0.87 ± 0.02	3.241SerPro: 3.241 ± 0.041	1.252SerGln: 1.252 ± 0.028	3.518SerArg: 3.518 ± 0.039	2.761SerSer: 2.761 ± 0.041	3.06SerThr: 3.06 ± 0.036	3.918SerVal: 3.918 ± 0.043	0.925SerTrp: 0.925 ± 0.02	1.127SerTyr: 1.127 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.623ThrAla: 9.623 ± 0.083	0.442ThrCys: 0.442 ± 0.014	3.616ThrAsp: 3.616 ± 0.044	3.079ThrGlu: 3.079 ± 0.038	1.497ThrPhe: 1.497 ± 0.022	6.733ThrGly: 6.733 ± 0.059	1.151ThrHis: 1.151 ± 0.021	1.735ThrIle: 1.735 ± 0.027	1.036ThrLys: 1.036 ± 0.025	5.605ThrLeu: 5.605 ± 0.051	0.871ThrMet: 0.871 ± 0.019	1.024ThrAsn: 1.024 ± 0.023	4.403ThrPro: 4.403 ± 0.055	1.29ThrGln: 1.29 ± 0.024	3.841ThrArg: 3.841 ± 0.044	2.978ThrSer: 2.978 ± 0.047	4.091ThrThr: 4.091 ± 0.063	6.146ThrVal: 6.146 ± 0.06	0.906ThrTrp: 0.906 ± 0.02	1.146ThrTyr: 1.146 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	10.644ValAla: 10.644 ± 0.08	0.724ValCys: 0.724 ± 0.018	4.768ValAsp: 4.768 ± 0.05	4.644ValGlu: 4.644 ± 0.056	2.206ValPhe: 2.206 ± 0.033	6.227ValGly: 6.227 ± 0.045	1.948ValHis: 1.948 ± 0.032	2.744ValIle: 2.744 ± 0.035	1.616ValLys: 1.616 ± 0.03	9.78ValLeu: 9.78 ± 0.073	1.311ValMet: 1.311 ± 0.026	1.589ValAsn: 1.589 ± 0.029	5.307ValPro: 5.307 ± 0.056	2.207ValGln: 2.207 ± 0.03	6.806ValArg: 6.806 ± 0.064	3.975ValSer: 3.975 ± 0.048	5.329ValThr: 5.329 ± 0.061	7.562ValVal: 7.562 ± 0.081	1.058ValTrp: 1.058 ± 0.024	1.461ValTyr: 1.461 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.751TrpAla: 1.751 ± 0.026	0.186TrpCys: 0.186 ± 0.008	0.786TrpAsp: 0.786 ± 0.02	0.743TrpGlu: 0.743 ± 0.02	0.493TrpPhe: 0.493 ± 0.016	0.974TrpGly: 0.974 ± 0.022	0.418TrpHis: 0.418 ± 0.013	0.534TrpIle: 0.534 ± 0.015	0.348TrpLys: 0.348 ± 0.012	1.857TrpLeu: 1.857 ± 0.029	0.275TrpMet: 0.275 ± 0.012	0.398TrpAsn: 0.398 ± 0.014	0.859TrpPro: 0.859 ± 0.022	0.699TrpGln: 0.699 ± 0.02	1.379TrpArg: 1.379 ± 0.026	0.935TrpSer: 0.935 ± 0.021	1.103TrpThr: 1.103 ± 0.021	1.023TrpVal: 1.023 ± 0.023	0.393TrpTrp: 0.393 ± 0.014	0.363TrpTyr: 0.363 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.497TyrAla: 2.497 ± 0.037	0.195TyrCys: 0.195 ± 0.01	1.333TyrAsp: 1.333 ± 0.035	1.074TyrGlu: 1.074 ± 0.022	0.581TyrPhe: 0.581 ± 0.018	2.157TyrGly: 2.157 ± 0.035	0.398TyrHis: 0.398 ± 0.012	0.423TyrIle: 0.423 ± 0.014	0.34TyrLys: 0.34 ± 0.013	2.213TyrLeu: 2.213 ± 0.033	0.216TyrMet: 0.216 ± 0.01	0.393TyrAsn: 0.393 ± 0.015	1.121TyrPro: 1.121 ± 0.025	0.697TyrGln: 0.697 ± 0.018	1.945TyrArg: 1.945 ± 0.025	0.891TyrSer: 0.891 ± 0.018	1.163TyrThr: 1.163 ± 0.026	1.467TyrVal: 1.467 ± 0.028	0.348TyrTrp: 0.348 ± 0.013	0.426TyrTyr: 0.426 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7336 proteins (2347241 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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