Amino acid dipepetide frequency for Prevotella timonensis CRIS 5C-B1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.071AlaAla: 5.071 ± 0.093
0.933AlaCys: 0.933 ± 0.033
3.925AlaAsp: 3.925 ± 0.083
4.159AlaGlu: 4.159 ± 0.091
3.102AlaPhe: 3.102 ± 0.063
4.359AlaGly: 4.359 ± 0.093
1.544AlaHis: 1.544 ± 0.042
4.806AlaIle: 4.806 ± 0.098
4.801AlaLys: 4.801 ± 0.088
6.451AlaLeu: 6.451 ± 0.092
2.093AlaMet: 2.093 ± 0.054
3.557AlaAsn: 3.557 ± 0.07
2.181AlaPro: 2.181 ± 0.052
3.267AlaGln: 3.267 ± 0.072
2.794AlaArg: 2.794 ± 0.058
3.96AlaSer: 3.96 ± 0.079
4.05AlaThr: 4.05 ± 0.083
4.422AlaVal: 4.422 ± 0.085
0.776AlaTrp: 0.776 ± 0.033
3.014AlaTyr: 3.014 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.8CysAla: 0.8 ± 0.026
0.218CysCys: 0.218 ± 0.019
0.655CysAsp: 0.655 ± 0.031
0.669CysGlu: 0.669 ± 0.03
0.549CysPhe: 0.549 ± 0.026
0.975CysGly: 0.975 ± 0.038
0.336CysHis: 0.336 ± 0.024
0.819CysIle: 0.819 ± 0.033
0.749CysLys: 0.749 ± 0.033
1.102CysLeu: 1.102 ± 0.039
0.303CysMet: 0.303 ± 0.022
0.628CysAsn: 0.628 ± 0.029
0.516CysPro: 0.516 ± 0.03
0.473CysGln: 0.473 ± 0.025
0.539CysArg: 0.539 ± 0.027
0.698CysSer: 0.698 ± 0.032
0.687CysThr: 0.687 ± 0.029
0.845CysVal: 0.845 ± 0.036
0.154CysTrp: 0.154 ± 0.014
0.535CysTyr: 0.535 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.18AspAla: 4.18 ± 0.066
0.638AspCys: 0.638 ± 0.026
3.002AspAsp: 3.002 ± 0.069
4.073AspGlu: 4.073 ± 0.092
2.865AspPhe: 2.865 ± 0.058
3.794AspGly: 3.794 ± 0.068
0.964AspHis: 0.964 ± 0.034
4.129AspIle: 4.129 ± 0.072
4.137AspLys: 4.137 ± 0.077
4.717AspLeu: 4.717 ± 0.085
1.674AspMet: 1.674 ± 0.047
2.943AspAsn: 2.943 ± 0.069
1.647AspPro: 1.647 ± 0.047
1.534AspGln: 1.534 ± 0.047
2.337AspArg: 2.337 ± 0.057
3.025AspSer: 3.025 ± 0.072
2.93AspThr: 2.93 ± 0.069
3.766AspVal: 3.766 ± 0.08
0.791AspTrp: 0.791 ± 0.028
2.709AspTyr: 2.709 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.311GluAla: 4.311 ± 0.086
0.59GluCys: 0.59 ± 0.025
3.162GluAsp: 3.162 ± 0.074
4.611GluGlu: 4.611 ± 0.095
2.157GluPhe: 2.157 ± 0.058
3.702GluGly: 3.702 ± 0.064
1.321GluHis: 1.321 ± 0.042
4.317GluIle: 4.317 ± 0.071
4.922GluLys: 4.922 ± 0.104
5.607GluLeu: 5.607 ± 0.09
1.91GluMet: 1.91 ± 0.047
3.24GluAsn: 3.24 ± 0.069
1.775GluPro: 1.775 ± 0.05
3.002GluGln: 3.002 ± 0.07
3.292GluArg: 3.292 ± 0.066
2.933GluSer: 2.933 ± 0.069
3.142GluThr: 3.142 ± 0.066
3.985GluVal: 3.985 ± 0.067
0.705GluTrp: 0.705 ± 0.03
2.375GluTyr: 2.375 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.046PheAla: 3.046 ± 0.068
0.673PheCys: 0.673 ± 0.031
2.746PheAsp: 2.746 ± 0.063
2.478PheGlu: 2.478 ± 0.059
2.074PhePhe: 2.074 ± 0.055
3.151PheGly: 3.151 ± 0.074
1.018PheHis: 1.018 ± 0.042
2.855PheIle: 2.855 ± 0.066
2.651PheLys: 2.651 ± 0.059
3.66PheLeu: 3.66 ± 0.086
1.227PheMet: 1.227 ± 0.04
2.413PheAsn: 2.413 ± 0.065
1.539PhePro: 1.539 ± 0.039
1.424PheGln: 1.424 ± 0.041
1.887PheArg: 1.887 ± 0.05
3.068PheSer: 3.068 ± 0.067
2.696PheThr: 2.696 ± 0.059
3.054PheVal: 3.054 ± 0.079
0.511PheTrp: 0.511 ± 0.029
1.921PheTyr: 1.921 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.082GlyAla: 4.082 ± 0.084
0.908GlyCys: 0.908 ± 0.035
3.361GlyAsp: 3.361 ± 0.067
3.825GlyGlu: 3.825 ± 0.07
2.941GlyPhe: 2.941 ± 0.07
4.494GlyGly: 4.494 ± 0.097
1.367GlyHis: 1.367 ± 0.042
4.827GlyIle: 4.827 ± 0.079
5.398GlyLys: 5.398 ± 0.09
5.495GlyLeu: 5.495 ± 0.086
2.109GlyMet: 2.109 ± 0.055
3.493GlyAsn: 3.493 ± 0.083
1.101GlyPro: 1.101 ± 0.041
2.226GlyGln: 2.226 ± 0.059
2.93GlyArg: 2.93 ± 0.064
3.781GlySer: 3.781 ± 0.085
3.918GlyThr: 3.918 ± 0.078
4.741GlyVal: 4.741 ± 0.089
0.911GlyTrp: 0.911 ± 0.039
3.217GlyTyr: 3.217 ± 0.07
0.0GlyXaa: 0.0 ± 0.0
His
1.494HisAla: 1.494 ± 0.045
0.345HisCys: 0.345 ± 0.021
1.221HisAsp: 1.221 ± 0.038
1.242HisGlu: 1.242 ± 0.033
1.121HisPhe: 1.121 ± 0.037
1.409HisGly: 1.409 ± 0.049
0.744HisHis: 0.744 ± 0.035
1.666HisIle: 1.666 ± 0.048
1.116HisLys: 1.116 ± 0.041
2.078HisLeu: 2.078 ± 0.055
0.41HisMet: 0.41 ± 0.025
0.978HisAsn: 0.978 ± 0.034
1.157HisPro: 1.157 ± 0.043
1.105HisGln: 1.105 ± 0.042
1.139HisArg: 1.139 ± 0.039
1.199HisSer: 1.199 ± 0.036
1.279HisThr: 1.279 ± 0.042
1.357HisVal: 1.357 ± 0.049
0.292HisTrp: 0.292 ± 0.019
1.037HisTyr: 1.037 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.262IleAla: 5.262 ± 0.093
0.957IleCys: 0.957 ± 0.041
4.603IleAsp: 4.603 ± 0.077
4.39IleGlu: 4.39 ± 0.079
2.695IlePhe: 2.695 ± 0.072
4.471IleGly: 4.471 ± 0.094
1.477IleHis: 1.477 ± 0.046
4.329IleIle: 4.329 ± 0.087
4.407IleLys: 4.407 ± 0.078
5.578IleLeu: 5.578 ± 0.104
1.543IleMet: 1.543 ± 0.051
3.477IleAsn: 3.477 ± 0.069
2.952IlePro: 2.952 ± 0.065
2.56IleGln: 2.56 ± 0.06
3.079IleArg: 3.079 ± 0.053
4.259IleSer: 4.259 ± 0.079
3.908IleThr: 3.908 ± 0.089
4.392IleVal: 4.392 ± 0.083
0.613IleTrp: 0.613 ± 0.029
2.579IleTyr: 2.579 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.002LysAla: 5.002 ± 0.107
0.562LysCys: 0.562 ± 0.027
4.184LysAsp: 4.184 ± 0.088
5.166LysGlu: 5.166 ± 0.104
2.293LysPhe: 2.293 ± 0.065
4.523LysGly: 4.523 ± 0.08
1.386LysHis: 1.386 ± 0.041
4.359LysIle: 4.359 ± 0.069
5.298LysLys: 5.298 ± 0.102
5.601LysLeu: 5.601 ± 0.084
2.174LysMet: 2.174 ± 0.054
3.776LysAsn: 3.776 ± 0.069
2.405LysPro: 2.405 ± 0.063
3.192LysGln: 3.192 ± 0.069
3.471LysArg: 3.471 ± 0.07
3.783LysSer: 3.783 ± 0.067
4.02LysThr: 4.02 ± 0.074
4.443LysVal: 4.443 ± 0.076
0.877LysTrp: 0.877 ± 0.032
2.956LysTyr: 2.956 ± 0.06
0.0LysXaa: 0.0 ± 0.0
Leu
5.97LeuAla: 5.97 ± 0.091
1.319LeuCys: 1.319 ± 0.044
4.648LeuAsp: 4.648 ± 0.081
4.599LeuGlu: 4.599 ± 0.086
4.124LeuPhe: 4.124 ± 0.08
5.626LeuGly: 5.626 ± 0.088
2.134LeuHis: 2.134 ± 0.06
5.294LeuIle: 5.294 ± 0.092
6.328LeuLys: 6.328 ± 0.099
8.638LeuLeu: 8.638 ± 0.146
2.534LeuMet: 2.534 ± 0.06
4.603LeuAsn: 4.603 ± 0.092
3.897LeuPro: 3.897 ± 0.073
4.057LeuGln: 4.057 ± 0.095
4.52LeuArg: 4.52 ± 0.086
6.733LeuSer: 6.733 ± 0.103
5.402LeuThr: 5.402 ± 0.094
5.044LeuVal: 5.044 ± 0.097
1.022LeuTrp: 1.022 ± 0.038
3.576LeuTyr: 3.576 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
2.16MetAla: 2.16 ± 0.055
0.284MetCys: 0.284 ± 0.018
1.431MetAsp: 1.431 ± 0.041
1.669MetGlu: 1.669 ± 0.056
1.116MetPhe: 1.116 ± 0.043
1.855MetGly: 1.855 ± 0.048
0.505MetHis: 0.505 ± 0.025
1.677MetIle: 1.677 ± 0.051
2.51MetLys: 2.51 ± 0.057
2.576MetLeu: 2.576 ± 0.064
1.0MetMet: 1.0 ± 0.041
1.734MetAsn: 1.734 ± 0.048
1.283MetPro: 1.283 ± 0.044
1.222MetGln: 1.222 ± 0.037
1.466MetArg: 1.466 ± 0.038
1.735MetSer: 1.735 ± 0.052
1.608MetThr: 1.608 ± 0.043
1.703MetVal: 1.703 ± 0.052
0.241MetTrp: 0.241 ± 0.018
0.852MetTyr: 0.852 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.65AsnAla: 3.65 ± 0.071
0.508AsnCys: 0.508 ± 0.025
2.927AsnAsp: 2.927 ± 0.072
3.165AsnGlu: 3.165 ± 0.066
2.255AsnPhe: 2.255 ± 0.055
3.9AsnGly: 3.9 ± 0.091
1.186AsnHis: 1.186 ± 0.04
3.888AsnIle: 3.888 ± 0.075
3.437AsnLys: 3.437 ± 0.064
4.323AsnLeu: 4.323 ± 0.077
1.372AsnMet: 1.372 ± 0.041
2.794AsnAsn: 2.794 ± 0.076
2.425AsnPro: 2.425 ± 0.059
2.102AsnGln: 2.102 ± 0.055
2.611AsnArg: 2.611 ± 0.058
2.786AsnSer: 2.786 ± 0.065
2.733AsnThr: 2.733 ± 0.066
3.272AsnVal: 3.272 ± 0.068
0.659AsnTrp: 0.659 ± 0.03
2.353AsnTyr: 2.353 ± 0.059
0.0AsnXaa: 0.0 ± 0.0
Pro
2.488ProAla: 2.488 ± 0.055
0.362ProCys: 0.362 ± 0.024
2.143ProAsp: 2.143 ± 0.061
2.585ProGlu: 2.585 ± 0.06
1.865ProPhe: 1.865 ± 0.052
1.891ProGly: 1.891 ± 0.048
0.893ProHis: 0.893 ± 0.035
2.488ProIle: 2.488 ± 0.058
2.334ProLys: 2.334 ± 0.054
3.237ProLeu: 3.237 ± 0.064
1.031ProMet: 1.031 ± 0.033
1.988ProAsn: 1.988 ± 0.058
0.764ProPro: 0.764 ± 0.033
1.701ProGln: 1.701 ± 0.052
1.232ProArg: 1.232 ± 0.043
2.269ProSer: 2.269 ± 0.057
2.418ProThr: 2.418 ± 0.056
2.402ProVal: 2.402 ± 0.055
0.448ProTrp: 0.448 ± 0.027
1.765ProTyr: 1.765 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
2.858GlnAla: 2.858 ± 0.063
0.429GlnCys: 0.429 ± 0.025
1.87GlnAsp: 1.87 ± 0.046
2.551GlnGlu: 2.551 ± 0.051
1.551GlnPhe: 1.551 ± 0.041
2.486GlnGly: 2.486 ± 0.055
1.112GlnHis: 1.112 ± 0.038
2.686GlnIle: 2.686 ± 0.072
2.884GlnLys: 2.884 ± 0.061
4.452GlnLeu: 4.452 ± 0.086
1.252GlnMet: 1.252 ± 0.04
1.93GlnAsn: 1.93 ± 0.051
1.622GlnPro: 1.622 ± 0.054
2.633GlnGln: 2.633 ± 0.069
2.337GlnArg: 2.337 ± 0.062
2.302GlnSer: 2.302 ± 0.051
2.518GlnThr: 2.518 ± 0.064
2.455GlnVal: 2.455 ± 0.064
0.619GlnTrp: 0.619 ± 0.027
1.655GlnTyr: 1.655 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
2.753ArgAla: 2.753 ± 0.062
0.508ArgCys: 0.508 ± 0.025
2.188ArgAsp: 2.188 ± 0.054
2.725ArgGlu: 2.725 ± 0.061
2.114ArgPhe: 2.114 ± 0.049
2.562ArgGly: 2.562 ± 0.059
1.112ArgHis: 1.112 ± 0.041
3.477ArgIle: 3.477 ± 0.075
3.328ArgLys: 3.328 ± 0.063
4.517ArgLeu: 4.517 ± 0.083
1.616ArgMet: 1.616 ± 0.046
2.544ArgAsn: 2.544 ± 0.06
1.624ArgPro: 1.624 ± 0.042
2.297ArgGln: 2.297 ± 0.055
2.272ArgArg: 2.272 ± 0.059
2.404ArgSer: 2.404 ± 0.061
2.566ArgThr: 2.566 ± 0.057
2.519ArgVal: 2.519 ± 0.059
0.65ArgTrp: 0.65 ± 0.033
2.426ArgTyr: 2.426 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
3.899SerAla: 3.899 ± 0.081
0.757SerCys: 0.757 ± 0.028
3.157SerAsp: 3.157 ± 0.063
3.204SerGlu: 3.204 ± 0.069
3.115SerPhe: 3.115 ± 0.068
4.031SerGly: 4.031 ± 0.069
1.314SerHis: 1.314 ± 0.044
4.235SerIle: 4.235 ± 0.078
3.899SerLys: 3.899 ± 0.072
5.765SerLeu: 5.765 ± 0.091
1.691SerMet: 1.691 ± 0.051
2.92SerAsn: 2.92 ± 0.064
2.167SerPro: 2.167 ± 0.049
2.227SerGln: 2.227 ± 0.061
2.39SerArg: 2.39 ± 0.053
3.873SerSer: 3.873 ± 0.088
3.416SerThr: 3.416 ± 0.067
4.119SerVal: 4.119 ± 0.081
0.775SerTrp: 0.775 ± 0.034
2.714SerTyr: 2.714 ± 0.064
0.0SerXaa: 0.0 ± 0.0
Thr
4.068ThrAla: 4.068 ± 0.08
0.638ThrCys: 0.638 ± 0.027
3.412ThrAsp: 3.412 ± 0.066
3.192ThrGlu: 3.192 ± 0.066
2.83ThrPhe: 2.83 ± 0.063
3.976ThrGly: 3.976 ± 0.074
1.277ThrHis: 1.277 ± 0.04
3.999ThrIle: 3.999 ± 0.083
3.383ThrLys: 3.383 ± 0.071
5.561ThrLeu: 5.561 ± 0.079
1.342ThrMet: 1.342 ± 0.038
2.874ThrAsn: 2.874 ± 0.076
2.732ThrPro: 2.732 ± 0.067
2.116ThrGln: 2.116 ± 0.059
2.041ThrArg: 2.041 ± 0.056
3.435ThrSer: 3.435 ± 0.069
3.63ThrThr: 3.63 ± 0.081
3.821ThrVal: 3.821 ± 0.077
0.697ThrTrp: 0.697 ± 0.032
2.588ThrTyr: 2.588 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
4.538ValAla: 4.538 ± 0.091
0.926ValCys: 0.926 ± 0.037
3.937ValAsp: 3.937 ± 0.07
3.837ValGlu: 3.837 ± 0.075
2.761ValPhe: 2.761 ± 0.062
4.129ValGly: 4.129 ± 0.093
1.212ValHis: 1.212 ± 0.042
4.201ValIle: 4.201 ± 0.08
4.407ValLys: 4.407 ± 0.085
5.612ValLeu: 5.612 ± 0.096
1.859ValMet: 1.859 ± 0.051
3.246ValAsn: 3.246 ± 0.065
2.482ValPro: 2.482 ± 0.062
2.374ValGln: 2.374 ± 0.053
2.949ValArg: 2.949 ± 0.065
4.245ValSer: 4.245 ± 0.084
3.594ValThr: 3.594 ± 0.077
4.631ValVal: 4.631 ± 0.084
0.701ValTrp: 0.701 ± 0.028
2.611ValTyr: 2.611 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.708TrpAla: 0.708 ± 0.03
0.163TrpCys: 0.163 ± 0.014
0.67TrpAsp: 0.67 ± 0.029
0.633TrpGlu: 0.633 ± 0.028
0.543TrpPhe: 0.543 ± 0.027
0.832TrpGly: 0.832 ± 0.036
0.308TrpHis: 0.308 ± 0.024
0.775TrpIle: 0.775 ± 0.035
0.935TrpLys: 0.935 ± 0.037
1.226TrpLeu: 1.226 ± 0.04
0.423TrpMet: 0.423 ± 0.022
0.823TrpAsn: 0.823 ± 0.036
0.248TrpPro: 0.248 ± 0.018
0.599TrpGln: 0.599 ± 0.03
0.581TrpArg: 0.581 ± 0.026
0.648TrpSer: 0.648 ± 0.029
0.679TrpThr: 0.679 ± 0.032
0.689TrpVal: 0.689 ± 0.029
0.196TrpTrp: 0.196 ± 0.018
0.519TrpTyr: 0.519 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.923TyrAla: 2.923 ± 0.064
0.531TyrCys: 0.531 ± 0.027
2.617TyrAsp: 2.617 ± 0.068
2.284TyrGlu: 2.284 ± 0.062
2.022TyrPhe: 2.022 ± 0.046
2.96TyrGly: 2.96 ± 0.065
1.18TyrHis: 1.18 ± 0.043
2.702TyrIle: 2.702 ± 0.059
2.544TyrLys: 2.544 ± 0.062
3.874TyrLeu: 3.874 ± 0.079
1.064TyrMet: 1.064 ± 0.035
2.382TyrAsn: 2.382 ± 0.066
1.786TyrPro: 1.786 ± 0.046
2.093TyrGln: 2.093 ± 0.05
2.334TyrArg: 2.334 ± 0.06
2.529TyrSer: 2.529 ± 0.059
2.418TyrThr: 2.418 ± 0.063
2.593TyrVal: 2.593 ± 0.064
0.563TyrTrp: 0.563 ± 0.03
2.089TyrTyr: 2.089 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2202 proteins (784895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski