Amino acid dipepetide frequency for Microbacterium oleivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.071AlaAla: 21.071 ± 0.244	0.601AlaCys: 0.601 ± 0.028	8.845AlaAsp: 8.845 ± 0.11	8.193AlaGlu: 8.193 ± 0.129	4.093AlaPhe: 4.093 ± 0.075	11.992AlaGly: 11.992 ± 0.139	2.478AlaHis: 2.478 ± 0.057	5.842AlaIle: 5.842 ± 0.087	2.729AlaLys: 2.729 ± 0.074	13.924AlaLeu: 13.924 ± 0.151	2.604AlaMet: 2.604 ± 0.053	2.168AlaAsn: 2.168 ± 0.048	6.65AlaPro: 6.65 ± 0.107	3.543AlaGln: 3.543 ± 0.058	9.319AlaArg: 9.319 ± 0.134	7.788AlaSer: 7.788 ± 0.115	7.602AlaThr: 7.602 ± 0.098	11.913AlaVal: 11.913 ± 0.137	2.037AlaTrp: 2.037 ± 0.045	2.406AlaTyr: 2.406 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.659CysAla: 0.659 ± 0.029	0.04CysCys: 0.04 ± 0.008	0.292CysAsp: 0.292 ± 0.019	0.241CysGlu: 0.241 ± 0.018	0.145CysPhe: 0.145 ± 0.013	0.491CysGly: 0.491 ± 0.025	0.119CysHis: 0.119 ± 0.012	0.168CysIle: 0.168 ± 0.013	0.052CysLys: 0.052 ± 0.007	0.425CysLeu: 0.425 ± 0.021	0.057CysMet: 0.057 ± 0.007	0.087CysAsn: 0.087 ± 0.01	0.248CysPro: 0.248 ± 0.016	0.104CysGln: 0.104 ± 0.012	0.306CysArg: 0.306 ± 0.02	0.254CysSer: 0.254 ± 0.015	0.256CysThr: 0.256 ± 0.019	0.368CysVal: 0.368 ± 0.021	0.06CysTrp: 0.06 ± 0.008	0.078CysTyr: 0.078 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	10.203AspAla: 10.203 ± 0.124	0.217AspCys: 0.217 ± 0.015	4.716AspAsp: 4.716 ± 0.088	4.526AspGlu: 4.526 ± 0.068	1.724AspPhe: 1.724 ± 0.041	6.407AspGly: 6.407 ± 0.113	1.203AspHis: 1.203 ± 0.036	2.552AspIle: 2.552 ± 0.057	1.06AspLys: 1.06 ± 0.041	6.589AspLeu: 6.589 ± 0.089	0.882AspMet: 0.882 ± 0.031	0.917AspAsn: 0.917 ± 0.036	4.213AspPro: 4.213 ± 0.08	1.518AspGln: 1.518 ± 0.041	4.714AspArg: 4.714 ± 0.084	2.665AspSer: 2.665 ± 0.059	3.089AspThr: 3.089 ± 0.065	6.082AspVal: 6.082 ± 0.085	0.929AspTrp: 0.929 ± 0.033	1.235AspTyr: 1.235 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	6.905GluAla: 6.905 ± 0.111	0.226GluCys: 0.226 ± 0.015	2.92GluAsp: 2.92 ± 0.061	2.902GluGlu: 2.902 ± 0.074	1.63GluPhe: 1.63 ± 0.043	4.134GluGly: 4.134 ± 0.07	1.299GluHis: 1.299 ± 0.036	2.845GluIle: 2.845 ± 0.071	1.513GluLys: 1.513 ± 0.053	6.142GluLeu: 6.142 ± 0.092	0.888GluMet: 0.888 ± 0.032	1.265GluAsn: 1.265 ± 0.038	2.98GluPro: 2.98 ± 0.061	1.972GluGln: 1.972 ± 0.051	5.287GluArg: 5.287 ± 0.096	2.791GluSer: 2.791 ± 0.063	3.177GluThr: 3.177 ± 0.061	4.743GluVal: 4.743 ± 0.076	0.914GluTrp: 0.914 ± 0.034	1.131GluTyr: 1.131 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.468PheAla: 4.468 ± 0.069	0.128PheCys: 0.128 ± 0.012	2.505PheAsp: 2.505 ± 0.059	1.768PheGlu: 1.768 ± 0.049	1.149PhePhe: 1.149 ± 0.039	3.356PheGly: 3.356 ± 0.076	0.545PheHis: 0.545 ± 0.024	1.174PheIle: 1.174 ± 0.036	0.412PheLys: 0.412 ± 0.02	2.831PheLeu: 2.831 ± 0.058	0.471PheMet: 0.471 ± 0.024	0.563PheAsn: 0.563 ± 0.024	1.413PhePro: 1.413 ± 0.035	0.748PheGln: 0.748 ± 0.031	1.904PheArg: 1.904 ± 0.05	1.792PheSer: 1.792 ± 0.043	2.142PheThr: 2.142 ± 0.053	2.931PheVal: 2.931 ± 0.062	0.517PheTrp: 0.517 ± 0.029	0.636PheTyr: 0.636 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.852GlyAla: 10.852 ± 0.135	0.547GlyCys: 0.547 ± 0.021	5.43GlyAsp: 5.43 ± 0.081	5.02GlyGlu: 5.02 ± 0.075	3.268GlyPhe: 3.268 ± 0.062	7.612GlyGly: 7.612 ± 0.108	1.779GlyHis: 1.779 ± 0.054	4.977GlyIle: 4.977 ± 0.081	2.174GlyLys: 2.174 ± 0.06	8.358GlyLeu: 8.358 ± 0.11	2.021GlyMet: 2.021 ± 0.058	1.553GlyAsn: 1.553 ± 0.05	3.754GlyPro: 3.754 ± 0.074	2.359GlyGln: 2.359 ± 0.054	6.505GlyArg: 6.505 ± 0.085	5.25GlySer: 5.25 ± 0.09	5.496GlyThr: 5.496 ± 0.084	8.163GlyVal: 8.163 ± 0.113	1.64GlyTrp: 1.64 ± 0.05	2.11GlyTyr: 2.11 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.381HisAla: 2.381 ± 0.056	0.095HisCys: 0.095 ± 0.011	1.27HisAsp: 1.27 ± 0.042	1.135HisGlu: 1.135 ± 0.035	0.53HisPhe: 0.53 ± 0.026	1.89HisGly: 1.89 ± 0.048	0.535HisHis: 0.535 ± 0.028	0.724HisIle: 0.724 ± 0.029	0.259HisLys: 0.259 ± 0.018	2.054HisLeu: 2.054 ± 0.049	0.286HisMet: 0.286 ± 0.019	0.32HisAsn: 0.32 ± 0.022	1.513HisPro: 1.513 ± 0.045	0.441HisGln: 0.441 ± 0.024	1.567HisArg: 1.567 ± 0.048	0.994HisSer: 0.994 ± 0.033	0.958HisThr: 0.958 ± 0.031	1.752HisVal: 1.752 ± 0.044	0.295HisTrp: 0.295 ± 0.016	0.396HisTyr: 0.396 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.033IleAla: 7.033 ± 0.095	0.22IleCys: 0.22 ± 0.016	3.589IleAsp: 3.589 ± 0.06	2.728IleGlu: 2.728 ± 0.063	1.12IlePhe: 1.12 ± 0.039	4.629IleGly: 4.629 ± 0.085	0.733IleHis: 0.733 ± 0.03	1.708IleIle: 1.708 ± 0.048	0.731IleLys: 0.731 ± 0.034	3.981IleLeu: 3.981 ± 0.077	0.574IleMet: 0.574 ± 0.024	0.842IleAsn: 0.842 ± 0.035	2.582IlePro: 2.582 ± 0.057	0.91IleGln: 0.91 ± 0.037	3.015IleArg: 3.015 ± 0.059	2.252IleSer: 2.252 ± 0.052	2.642IleThr: 2.642 ± 0.061	4.966IleVal: 4.966 ± 0.083	0.51IleTrp: 0.51 ± 0.027	0.714IleTyr: 0.714 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.48LysAla: 2.48 ± 0.066	0.048LysCys: 0.048 ± 0.007	1.248LysAsp: 1.248 ± 0.047	0.939LysGlu: 0.939 ± 0.036	0.455LysPhe: 0.455 ± 0.023	1.654LysGly: 1.654 ± 0.06	0.364LysHis: 0.364 ± 0.02	0.952LysIle: 0.952 ± 0.038	0.866LysLys: 0.866 ± 0.041	1.866LysLeu: 1.866 ± 0.055	0.389LysMet: 0.389 ± 0.023	0.535LysAsn: 0.535 ± 0.026	1.191LysPro: 1.191 ± 0.043	0.602LysGln: 0.602 ± 0.025	1.437LysArg: 1.437 ± 0.048	1.086LysSer: 1.086 ± 0.045	1.364LysThr: 1.364 ± 0.046	1.754LysVal: 1.754 ± 0.057	0.23LysTrp: 0.23 ± 0.015	0.408LysTyr: 0.408 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.263LeuAla: 14.263 ± 0.159	0.451LeuCys: 0.451 ± 0.02	6.76LeuAsp: 6.76 ± 0.095	4.985LeuGlu: 4.985 ± 0.087	2.942LeuPhe: 2.942 ± 0.072	8.844LeuGly: 8.844 ± 0.101	1.765LeuHis: 1.765 ± 0.048	4.336LeuIle: 4.336 ± 0.08	1.695LeuLys: 1.695 ± 0.049	9.78LeuLeu: 9.78 ± 0.147	1.569LeuMet: 1.569 ± 0.045	1.691LeuAsn: 1.691 ± 0.053	5.489LeuPro: 5.489 ± 0.084	2.442LeuGln: 2.442 ± 0.052	7.598LeuArg: 7.598 ± 0.113	5.883LeuSer: 5.883 ± 0.078	6.364LeuThr: 6.364 ± 0.093	9.315LeuVal: 9.315 ± 0.117	1.311LeuTrp: 1.311 ± 0.044	1.607LeuTyr: 1.607 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.035MetAla: 2.035 ± 0.059	0.086MetCys: 0.086 ± 0.01	0.777MetAsp: 0.777 ± 0.033	0.581MetGlu: 0.581 ± 0.022	0.507MetPhe: 0.507 ± 0.026	1.313MetGly: 1.313 ± 0.041	0.318MetHis: 0.318 ± 0.017	0.861MetIle: 0.861 ± 0.035	0.386MetLys: 0.386 ± 0.022	1.807MetLeu: 1.807 ± 0.045	0.304MetMet: 0.304 ± 0.016	0.428MetAsn: 0.428 ± 0.023	1.258MetPro: 1.258 ± 0.036	0.54MetGln: 0.54 ± 0.023	1.394MetArg: 1.394 ± 0.042	1.531MetSer: 1.531 ± 0.038	1.733MetThr: 1.733 ± 0.047	1.264MetVal: 1.264 ± 0.039	0.225MetTrp: 0.225 ± 0.015	0.271MetTyr: 0.271 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.331AsnAla: 2.331 ± 0.058	0.092AsnCys: 0.092 ± 0.01	1.231AsnAsp: 1.231 ± 0.039	0.969AsnGlu: 0.969 ± 0.033	0.588AsnPhe: 0.588 ± 0.031	1.778AsnGly: 1.778 ± 0.055	0.332AsnHis: 0.332 ± 0.022	0.747AsnIle: 0.747 ± 0.033	0.391AsnLys: 0.391 ± 0.022	1.825AsnLeu: 1.825 ± 0.045	0.304AsnMet: 0.304 ± 0.017	0.408AsnAsn: 0.408 ± 0.023	1.449AsnPro: 1.449 ± 0.042	0.475AsnGln: 0.475 ± 0.025	1.249AsnArg: 1.249 ± 0.04	0.878AsnSer: 0.878 ± 0.038	0.979AsnThr: 0.979 ± 0.039	1.674AsnVal: 1.674 ± 0.051	0.272AsnTrp: 0.272 ± 0.016	0.433AsnTyr: 0.433 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.279ProAla: 7.279 ± 0.108	0.173ProCys: 0.173 ± 0.013	4.019ProAsp: 4.019 ± 0.075	3.712ProGlu: 3.712 ± 0.074	1.806ProPhe: 1.806 ± 0.042	4.845ProGly: 4.845 ± 0.085	1.155ProHis: 1.155 ± 0.034	2.143ProIle: 2.143 ± 0.043	1.086ProLys: 1.086 ± 0.038	4.995ProLeu: 4.995 ± 0.075	0.804ProMet: 0.804 ± 0.028	0.981ProAsn: 0.981 ± 0.036	2.28ProPro: 2.28 ± 0.068	1.506ProGln: 1.506 ± 0.034	3.59ProArg: 3.59 ± 0.065	3.041ProSer: 3.041 ± 0.06	3.495ProThr: 3.495 ± 0.065	4.986ProVal: 4.986 ± 0.09	0.9ProTrp: 0.9 ± 0.031	1.008ProTyr: 1.008 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.199GlnAla: 3.199 ± 0.065	0.085GlnCys: 0.085 ± 0.009	1.238GlnAsp: 1.238 ± 0.04	1.166GlnGlu: 1.166 ± 0.038	0.83GlnPhe: 0.83 ± 0.034	1.967GlnGly: 1.967 ± 0.046	0.586GlnHis: 0.586 ± 0.025	1.333GlnIle: 1.333 ± 0.04	0.699GlnLys: 0.699 ± 0.033	2.836GlnLeu: 2.836 ± 0.06	0.468GlnMet: 0.468 ± 0.025	0.646GlnAsn: 0.646 ± 0.028	1.397GlnPro: 1.397 ± 0.043	1.023GlnGln: 1.023 ± 0.042	2.367GlnArg: 2.367 ± 0.055	1.437GlnSer: 1.437 ± 0.042	1.572GlnThr: 1.572 ± 0.046	2.293GlnVal: 2.293 ± 0.05	0.416GlnTrp: 0.416 ± 0.023	0.565GlnTyr: 0.565 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.977ArgAla: 8.977 ± 0.126	0.323ArgCys: 0.323 ± 0.023	4.56ArgAsp: 4.56 ± 0.078	4.482ArgGlu: 4.482 ± 0.088	2.45ArgPhe: 2.45 ± 0.048	5.867ArgGly: 5.867 ± 0.075	1.655ArgHis: 1.655 ± 0.046	3.683ArgIle: 3.683 ± 0.06	1.279ArgLys: 1.279 ± 0.04	7.272ArgLeu: 7.272 ± 0.119	1.818ArgMet: 1.818 ± 0.044	1.316ArgAsn: 1.316 ± 0.043	3.757ArgPro: 3.757 ± 0.071	1.939ArgGln: 1.939 ± 0.051	6.902ArgArg: 6.902 ± 0.114	4.355ArgSer: 4.355 ± 0.077	4.54ArgThr: 4.54 ± 0.069	6.516ArgVal: 6.516 ± 0.09	1.219ArgTrp: 1.219 ± 0.039	1.599ArgTyr: 1.599 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.293SerAla: 7.293 ± 0.097	0.245SerCys: 0.245 ± 0.019	3.453SerAsp: 3.453 ± 0.068	2.73SerGlu: 2.73 ± 0.056	1.97SerPhe: 1.97 ± 0.052	5.772SerGly: 5.772 ± 0.095	1.012SerHis: 1.012 ± 0.034	2.634SerIle: 2.634 ± 0.06	1.023SerLys: 1.023 ± 0.031	5.459SerLeu: 5.459 ± 0.078	1.174SerMet: 1.174 ± 0.035	1.036SerAsn: 1.036 ± 0.043	3.151SerPro: 3.151 ± 0.063	1.31SerGln: 1.31 ± 0.041	3.961SerArg: 3.961 ± 0.07	3.452SerSer: 3.452 ± 0.082	3.639SerThr: 3.639 ± 0.068	4.865SerVal: 4.865 ± 0.079	0.946SerTrp: 0.946 ± 0.035	1.144SerTyr: 1.144 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.948ThrAla: 7.948 ± 0.096	0.233ThrCys: 0.233 ± 0.02	4.036ThrAsp: 4.036 ± 0.074	2.904ThrGlu: 2.904 ± 0.062	1.888ThrPhe: 1.888 ± 0.049	5.852ThrGly: 5.852 ± 0.083	1.163ThrHis: 1.163 ± 0.035	2.871ThrIle: 2.871 ± 0.058	1.225ThrLys: 1.225 ± 0.04	5.956ThrLeu: 5.956 ± 0.088	0.925ThrMet: 0.925 ± 0.032	1.104ThrAsn: 1.104 ± 0.033	4.015ThrPro: 4.015 ± 0.081	1.416ThrGln: 1.416 ± 0.043	3.946ThrArg: 3.946 ± 0.062	3.405ThrSer: 3.405 ± 0.067	3.916ThrThr: 3.916 ± 0.081	6.116ThrVal: 6.116 ± 0.09	0.943ThrTrp: 0.943 ± 0.035	1.241ThrTyr: 1.241 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	12.343ValAla: 12.343 ± 0.147	0.469ValCys: 0.469 ± 0.025	6.384ValAsp: 6.384 ± 0.089	4.887ValGlu: 4.887 ± 0.078	3.113ValPhe: 3.113 ± 0.065	7.454ValGly: 7.454 ± 0.108	1.73ValHis: 1.73 ± 0.051	4.523ValIle: 4.523 ± 0.08	1.65ValLys: 1.65 ± 0.048	9.219ValLeu: 9.219 ± 0.129	1.495ValMet: 1.495 ± 0.039	1.646ValAsn: 1.646 ± 0.051	4.731ValPro: 4.731 ± 0.073	2.223ValGln: 2.223 ± 0.049	6.406ValArg: 6.406 ± 0.1	5.373ValSer: 5.373 ± 0.089	6.024ValThr: 6.024 ± 0.082	9.472ValVal: 9.472 ± 0.124	1.27ValTrp: 1.27 ± 0.042	1.589ValTyr: 1.589 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.628TrpAla: 1.628 ± 0.054	0.085TrpCys: 0.085 ± 0.01	0.835TrpAsp: 0.835 ± 0.033	0.68TrpGlu: 0.68 ± 0.026	0.585TrpPhe: 0.585 ± 0.026	1.166TrpGly: 1.166 ± 0.042	0.328TrpHis: 0.328 ± 0.018	0.734TrpIle: 0.734 ± 0.033	0.294TrpLys: 0.294 ± 0.02	1.714TrpLeu: 1.714 ± 0.047	0.34TrpMet: 0.34 ± 0.019	0.43TrpAsn: 0.43 ± 0.024	0.741TrpPro: 0.741 ± 0.031	0.558TrpGln: 0.558 ± 0.022	1.356TrpArg: 1.356 ± 0.039	0.95TrpSer: 0.95 ± 0.031	0.974TrpThr: 0.974 ± 0.036	1.262TrpVal: 1.262 ± 0.041	0.358TrpTrp: 0.358 ± 0.02	0.308TrpTyr: 0.308 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.448TyrAla: 2.448 ± 0.055	0.087TyrCys: 0.087 ± 0.01	1.335TyrAsp: 1.335 ± 0.039	1.118TyrGlu: 1.118 ± 0.036	0.661TyrPhe: 0.661 ± 0.03	1.849TyrGly: 1.849 ± 0.052	0.294TyrHis: 0.294 ± 0.017	0.673TyrIle: 0.673 ± 0.031	0.344TyrLys: 0.344 ± 0.02	2.058TyrLeu: 2.058 ± 0.046	0.24TyrMet: 0.24 ± 0.016	0.47TyrAsn: 0.47 ± 0.024	0.995TyrPro: 0.995 ± 0.037	0.491TyrGln: 0.491 ± 0.023	1.683TyrArg: 1.683 ± 0.04	1.092TyrSer: 1.092 ± 0.037	1.142TyrThr: 1.142 ± 0.038	1.568TyrVal: 1.568 ± 0.039	0.332TyrTrp: 0.332 ± 0.022	0.459TyrTyr: 0.459 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2781 proteins (897455 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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