Amino acid dipepetide frequency for Aphanothece hegewaldii CCALA 016

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.41AlaAla: 5.41 ± 0.068	0.696AlaCys: 0.696 ± 0.022	3.291AlaAsp: 3.291 ± 0.054	4.205AlaGlu: 4.205 ± 0.056	2.743AlaPhe: 2.743 ± 0.048	4.583AlaGly: 4.583 ± 0.076	1.143AlaHis: 1.143 ± 0.033	6.46AlaIle: 6.46 ± 0.07	4.018AlaLys: 4.018 ± 0.063	7.634AlaLeu: 7.634 ± 0.079	1.445AlaMet: 1.445 ± 0.037	3.212AlaAsn: 3.212 ± 0.068	2.337AlaPro: 2.337 ± 0.044	3.76AlaGln: 3.76 ± 0.062	2.943AlaArg: 2.943 ± 0.046	4.331AlaSer: 4.331 ± 0.055	4.262AlaThr: 4.262 ± 0.056	4.417AlaVal: 4.417 ± 0.064	0.937AlaTrp: 0.937 ± 0.028	2.279AlaTyr: 2.279 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.54CysAla: 0.54 ± 0.021	0.153CysCys: 0.153 ± 0.012	0.519CysAsp: 0.519 ± 0.016	0.498CysGlu: 0.498 ± 0.022	0.428CysPhe: 0.428 ± 0.015	0.687CysGly: 0.687 ± 0.022	0.272CysHis: 0.272 ± 0.015	0.551CysIle: 0.551 ± 0.018	0.364CysLys: 0.364 ± 0.016	1.141CysLeu: 1.141 ± 0.029	0.125CysMet: 0.125 ± 0.01	0.363CysAsn: 0.363 ± 0.015	0.509CysPro: 0.509 ± 0.021	0.59CysGln: 0.59 ± 0.019	0.537CysArg: 0.537 ± 0.02	0.644CysSer: 0.644 ± 0.02	0.446CysThr: 0.446 ± 0.018	0.531CysVal: 0.531 ± 0.02	0.142CysTrp: 0.142 ± 0.01	0.385CysTyr: 0.385 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.256AspAla: 3.256 ± 0.048	0.477AspCys: 0.477 ± 0.016	2.534AspAsp: 2.534 ± 0.061	3.365AspGlu: 3.365 ± 0.058	2.362AspPhe: 2.362 ± 0.048	3.477AspGly: 3.477 ± 0.074	0.896AspHis: 0.896 ± 0.024	3.467AspIle: 3.467 ± 0.056	2.188AspLys: 2.188 ± 0.042	6.182AspLeu: 6.182 ± 0.074	0.692AspMet: 0.692 ± 0.022	2.049AspAsn: 2.049 ± 0.039	2.486AspPro: 2.486 ± 0.052	2.083AspGln: 2.083 ± 0.042	2.75AspArg: 2.75 ± 0.047	2.937AspSer: 2.937 ± 0.055	2.75AspThr: 2.75 ± 0.074	2.907AspVal: 2.907 ± 0.046	0.875AspTrp: 0.875 ± 0.028	2.199AspTyr: 2.199 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.808GluAla: 4.808 ± 0.063	0.461GluCys: 0.461 ± 0.018	2.828GluAsp: 2.828 ± 0.045	4.179GluGlu: 4.179 ± 0.063	2.272GluPhe: 2.272 ± 0.038	3.295GluGly: 3.295 ± 0.051	0.99GluHis: 0.99 ± 0.024	5.652GluIle: 5.652 ± 0.063	4.442GluLys: 4.442 ± 0.064	6.821GluLeu: 6.821 ± 0.078	1.329GluMet: 1.329 ± 0.033	3.114GluAsn: 3.114 ± 0.048	2.429GluPro: 2.429 ± 0.055	4.178GluGln: 4.178 ± 0.063	3.291GluArg: 3.291 ± 0.051	3.462GluSer: 3.462 ± 0.056	3.855GluThr: 3.855 ± 0.056	3.788GluVal: 3.788 ± 0.058	0.804GluTrp: 0.804 ± 0.023	1.962GluTyr: 1.962 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	2.785PheAla: 2.785 ± 0.049	0.542PheCys: 0.542 ± 0.02	2.357PheAsp: 2.357 ± 0.047	2.31PheGlu: 2.31 ± 0.04	1.91PhePhe: 1.91 ± 0.046	2.869PheGly: 2.869 ± 0.051	0.674PheHis: 0.674 ± 0.026	2.775PheIle: 2.775 ± 0.055	1.957PheLys: 1.957 ± 0.042	4.372PheLeu: 4.372 ± 0.066	0.659PheMet: 0.659 ± 0.021	2.124PheAsn: 2.124 ± 0.04	1.858PhePro: 1.858 ± 0.038	1.662PheGln: 1.662 ± 0.038	1.801PheArg: 1.801 ± 0.035	3.208PheSer: 3.208 ± 0.046	2.392PheThr: 2.392 ± 0.043	2.296PheVal: 2.296 ± 0.041	0.723PheTrp: 0.723 ± 0.026	1.598PheTyr: 1.598 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	4.114GlyAla: 4.114 ± 0.067	0.68GlyCys: 0.68 ± 0.023	3.237GlyAsp: 3.237 ± 0.068	3.806GlyGlu: 3.806 ± 0.054	2.841GlyPhe: 2.841 ± 0.05	4.772GlyGly: 4.772 ± 0.107	1.129GlyHis: 1.129 ± 0.032	5.323GlyIle: 5.323 ± 0.061	3.914GlyLys: 3.914 ± 0.057	6.811GlyLeu: 6.811 ± 0.084	1.387GlyMet: 1.387 ± 0.034	3.338GlyAsn: 3.338 ± 0.115	1.126GlyPro: 1.126 ± 0.03	3.005GlyGln: 3.005 ± 0.05	2.781GlyArg: 2.781 ± 0.048	3.893GlySer: 3.893 ± 0.058	4.143GlyThr: 4.143 ± 0.099	4.248GlyVal: 4.248 ± 0.062	1.027GlyTrp: 1.027 ± 0.026	2.442GlyTyr: 2.442 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	0.9HisAla: 0.9 ± 0.027	0.256HisCys: 0.256 ± 0.015	0.758HisAsp: 0.758 ± 0.022	0.836HisGlu: 0.836 ± 0.027	0.852HisPhe: 0.852 ± 0.025	0.965HisGly: 0.965 ± 0.026	0.646HisHis: 0.646 ± 0.025	1.008HisIle: 1.008 ± 0.029	0.729HisLys: 0.729 ± 0.025	2.326HisLeu: 2.326 ± 0.044	0.238HisMet: 0.238 ± 0.012	0.701HisAsn: 0.701 ± 0.023	1.282HisPro: 1.282 ± 0.026	1.302HisGln: 1.302 ± 0.034	0.998HisArg: 0.998 ± 0.029	1.139HisSer: 1.139 ± 0.028	0.849HisThr: 0.849 ± 0.026	0.7HisVal: 0.7 ± 0.02	0.323HisTrp: 0.323 ± 0.015	0.729HisTyr: 0.729 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.604IleAla: 6.604 ± 0.072	0.759IleCys: 0.759 ± 0.025	4.196IleAsp: 4.196 ± 0.055	5.184IleGlu: 5.184 ± 0.06	2.874IlePhe: 2.874 ± 0.044	4.645IleGly: 4.645 ± 0.076	1.247IleHis: 1.247 ± 0.028	5.464IleIle: 5.464 ± 0.077	3.832IleLys: 3.832 ± 0.055	7.941IleLeu: 7.941 ± 0.071	0.993IleMet: 0.993 ± 0.027	3.933IleAsn: 3.933 ± 0.068	3.885IlePro: 3.885 ± 0.051	3.476IleGln: 3.476 ± 0.054	3.22IleArg: 3.22 ± 0.051	5.102IleSer: 5.102 ± 0.066	4.607IleThr: 4.607 ± 0.068	4.359IleVal: 4.359 ± 0.058	0.954IleTrp: 0.954 ± 0.028	2.492IleTyr: 2.492 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.996LysAla: 3.996 ± 0.062	0.383LysCys: 0.383 ± 0.016	2.612LysAsp: 2.612 ± 0.04	3.592LysGlu: 3.592 ± 0.055	1.717LysPhe: 1.717 ± 0.038	2.963LysGly: 2.963 ± 0.043	0.807LysHis: 0.807 ± 0.026	4.58LysIle: 4.58 ± 0.064	3.085LysLys: 3.085 ± 0.059	5.49LysLeu: 5.49 ± 0.063	1.11LysMet: 1.11 ± 0.029	2.795LysAsn: 2.795 ± 0.048	2.483LysPro: 2.483 ± 0.044	2.822LysGln: 2.822 ± 0.054	2.567LysArg: 2.567 ± 0.045	3.091LysSer: 3.091 ± 0.05	3.57LysThr: 3.57 ± 0.05	3.289LysVal: 3.289 ± 0.05	0.584LysTrp: 0.584 ± 0.02	1.601LysTyr: 1.601 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	8.767LeuAla: 8.767 ± 0.087	0.99LeuCys: 0.99 ± 0.028	5.58LeuAsp: 5.58 ± 0.059	7.972LeuGlu: 7.972 ± 0.088	4.138LeuPhe: 4.138 ± 0.068	7.363LeuGly: 7.363 ± 0.081	1.633LeuHis: 1.633 ± 0.032	8.028LeuIle: 8.028 ± 0.092	6.783LeuLys: 6.783 ± 0.077	11.361LeuLeu: 11.361 ± 0.125	2.138LeuMet: 2.138 ± 0.037	5.319LeuAsn: 5.319 ± 0.066	5.284LeuPro: 5.284 ± 0.068	5.219LeuGln: 5.219 ± 0.071	4.762LeuArg: 4.762 ± 0.062	8.275LeuSer: 8.275 ± 0.08	6.864LeuThr: 6.864 ± 0.073	6.559LeuVal: 6.559 ± 0.077	1.306LeuTrp: 1.306 ± 0.037	3.069LeuTyr: 3.069 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.498MetAla: 1.498 ± 0.035	0.116MetCys: 0.116 ± 0.009	0.714MetAsp: 0.714 ± 0.02	0.92MetGlu: 0.92 ± 0.028	0.573MetPhe: 0.573 ± 0.022	1.364MetGly: 1.364 ± 0.037	0.197MetHis: 0.197 ± 0.012	1.407MetIle: 1.407 ± 0.037	1.027MetLys: 1.027 ± 0.027	1.779MetLeu: 1.779 ± 0.038	0.491MetMet: 0.491 ± 0.019	0.923MetAsn: 0.923 ± 0.023	0.804MetPro: 0.804 ± 0.028	0.741MetGln: 0.741 ± 0.021	0.876MetArg: 0.876 ± 0.026	1.447MetSer: 1.447 ± 0.03	1.408MetThr: 1.408 ± 0.03	1.119MetVal: 1.119 ± 0.033	0.136MetTrp: 0.136 ± 0.01	0.378MetTyr: 0.378 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.997AsnAla: 2.997 ± 0.056	0.523AsnCys: 0.523 ± 0.02	2.35AsnAsp: 2.35 ± 0.083	2.315AsnGlu: 2.315 ± 0.041	2.085AsnPhe: 2.085 ± 0.043	3.071AsnGly: 3.071 ± 0.077	1.009AsnHis: 1.009 ± 0.03	3.338AsnIle: 3.338 ± 0.069	2.06AsnLys: 2.06 ± 0.041	6.124AsnLeu: 6.124 ± 0.089	0.643AsnMet: 0.643 ± 0.023	2.682AsnAsn: 2.682 ± 0.067	2.948AsnPro: 2.948 ± 0.047	3.038AsnGln: 3.038 ± 0.059	2.313AsnArg: 2.313 ± 0.043	3.312AsnSer: 3.312 ± 0.063	2.707AsnThr: 2.707 ± 0.058	2.32AsnVal: 2.32 ± 0.042	0.823AsnTrp: 0.823 ± 0.024	1.856AsnTyr: 1.856 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.305ProAla: 2.305 ± 0.044	0.345ProCys: 0.345 ± 0.014	2.883ProAsp: 2.883 ± 0.046	3.569ProGlu: 3.569 ± 0.051	1.891ProPhe: 1.891 ± 0.037	2.125ProGly: 2.125 ± 0.044	0.861ProHis: 0.861 ± 0.024	3.524ProIle: 3.524 ± 0.051	2.342ProLys: 2.342 ± 0.043	4.695ProLeu: 4.695 ± 0.065	0.73ProMet: 0.73 ± 0.022	2.52ProAsn: 2.52 ± 0.043	2.025ProPro: 2.025 ± 0.047	2.355ProGln: 2.355 ± 0.043	1.605ProArg: 1.605 ± 0.035	3.191ProSer: 3.191 ± 0.053	2.817ProThr: 2.817 ± 0.052	2.952ProVal: 2.952 ± 0.051	0.527ProTrp: 0.527 ± 0.02	1.415ProTyr: 1.415 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.094GlnAla: 4.094 ± 0.067	0.34GlnCys: 0.34 ± 0.016	2.303GlnAsp: 2.303 ± 0.039	3.682GlnGlu: 3.682 ± 0.057	2.012GlnPhe: 2.012 ± 0.034	3.143GlnGly: 3.143 ± 0.05	0.786GlnHis: 0.786 ± 0.023	4.053GlnIle: 4.053 ± 0.055	3.336GlnLys: 3.336 ± 0.057	5.9GlnLeu: 5.9 ± 0.076	1.028GlnMet: 1.028 ± 0.028	2.509GlnAsn: 2.509 ± 0.043	2.212GlnPro: 2.212 ± 0.046	3.543GlnGln: 3.543 ± 0.067	2.468GlnArg: 2.468 ± 0.045	3.093GlnSer: 3.093 ± 0.049	3.21GlnThr: 3.21 ± 0.052	3.358GlnVal: 3.358 ± 0.046	0.765GlnTrp: 0.765 ± 0.024	1.535GlnTyr: 1.535 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	2.55ArgAla: 2.55 ± 0.046	0.473ArgCys: 0.473 ± 0.019	2.113ArgAsp: 2.113 ± 0.042	2.965ArgGlu: 2.965 ± 0.052	2.23ArgPhe: 2.23 ± 0.037	2.567ArgGly: 2.567 ± 0.051	0.985ArgHis: 0.985 ± 0.025	3.308ArgIle: 3.308 ± 0.05	2.303ArgLys: 2.303 ± 0.046	5.638ArgLeu: 5.638 ± 0.06	0.937ArgMet: 0.937 ± 0.026	2.042ArgAsn: 2.042 ± 0.036	1.843ArgPro: 1.843 ± 0.036	2.936ArgGln: 2.936 ± 0.049	2.613ArgArg: 2.613 ± 0.045	3.099ArgSer: 3.099 ± 0.045	2.34ArgThr: 2.34 ± 0.037	2.794ArgVal: 2.794 ± 0.049	0.811ArgTrp: 0.811 ± 0.024	1.842ArgTyr: 1.842 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	3.812SerAla: 3.812 ± 0.051	0.624SerCys: 0.624 ± 0.022	3.43SerAsp: 3.43 ± 0.055	4.029SerGlu: 4.029 ± 0.054	2.878SerPhe: 2.878 ± 0.046	4.448SerGly: 4.448 ± 0.06	1.24SerHis: 1.24 ± 0.028	4.561SerIle: 4.561 ± 0.065	2.917SerLys: 2.917 ± 0.047	8.011SerLeu: 8.011 ± 0.09	1.196SerMet: 1.196 ± 0.026	3.21SerAsn: 3.21 ± 0.059	3.324SerPro: 3.324 ± 0.06	3.647SerGln: 3.647 ± 0.056	3.002SerArg: 3.002 ± 0.044	4.826SerSer: 4.826 ± 0.064	3.451SerThr: 3.451 ± 0.048	4.034SerVal: 4.034 ± 0.056	0.904SerTrp: 0.904 ± 0.031	2.223SerTyr: 2.223 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.381ThrAla: 4.381 ± 0.065	0.449ThrCys: 0.449 ± 0.019	2.8ThrAsp: 2.8 ± 0.048	3.8ThrGlu: 3.8 ± 0.056	2.391ThrPhe: 2.391 ± 0.046	4.421ThrGly: 4.421 ± 0.101	1.082ThrHis: 1.082 ± 0.027	4.589ThrIle: 4.589 ± 0.079	2.48ThrLys: 2.48 ± 0.043	7.082ThrLeu: 7.082 ± 0.083	0.804ThrMet: 0.804 ± 0.026	2.604ThrAsn: 2.604 ± 0.052	3.35ThrPro: 3.35 ± 0.066	3.161ThrGln: 3.161 ± 0.05	2.331ThrArg: 2.331 ± 0.039	3.627ThrSer: 3.627 ± 0.058	3.72ThrThr: 3.72 ± 0.075	4.047ThrVal: 4.047 ± 0.058	0.776ThrTrp: 0.776 ± 0.023	1.835ThrTyr: 1.835 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.616ValAla: 4.616 ± 0.066	0.608ValCys: 0.608 ± 0.021	3.102ValAsp: 3.102 ± 0.047	4.016ValGlu: 4.016 ± 0.058	2.437ValPhe: 2.437 ± 0.042	4.148ValGly: 4.148 ± 0.056	0.861ValHis: 0.861 ± 0.026	4.774ValIle: 4.774 ± 0.06	3.219ValLys: 3.219 ± 0.048	5.916ValLeu: 5.916 ± 0.061	1.245ValMet: 1.245 ± 0.03	2.898ValAsn: 2.898 ± 0.05	2.494ValPro: 2.494 ± 0.052	2.532ValGln: 2.532 ± 0.04	2.74ValArg: 2.74 ± 0.043	4.02ValSer: 4.02 ± 0.056	3.819ValThr: 3.819 ± 0.063	3.826ValVal: 3.826 ± 0.062	0.765ValTrp: 0.765 ± 0.025	1.892ValTyr: 1.892 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.75TrpAla: 0.75 ± 0.025	0.146TrpCys: 0.146 ± 0.011	0.629TrpAsp: 0.629 ± 0.023	0.842TrpGlu: 0.842 ± 0.023	0.652TrpPhe: 0.652 ± 0.021	0.935TrpGly: 0.935 ± 0.027	0.31TrpHis: 0.31 ± 0.015	0.904TrpIle: 0.904 ± 0.027	0.722TrpLys: 0.722 ± 0.024	1.981TrpLeu: 1.981 ± 0.045	0.312TrpMet: 0.312 ± 0.013	0.661TrpAsn: 0.661 ± 0.023	0.286TrpPro: 0.286 ± 0.015	1.046TrpGln: 1.046 ± 0.026	0.72TrpArg: 0.72 ± 0.021	0.865TrpSer: 0.865 ± 0.026	0.715TrpThr: 0.715 ± 0.024	0.858TrpVal: 0.858 ± 0.025	0.223TrpTrp: 0.223 ± 0.011	0.45TrpTyr: 0.45 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.924TyrAla: 1.924 ± 0.036	0.404TyrCys: 0.404 ± 0.019	1.697TyrAsp: 1.697 ± 0.049	1.877TyrGlu: 1.877 ± 0.038	1.586TyrPhe: 1.586 ± 0.04	2.175TyrGly: 2.175 ± 0.045	0.77TyrHis: 0.77 ± 0.024	2.002TyrIle: 2.002 ± 0.042	1.42TyrLys: 1.42 ± 0.035	4.206TyrLeu: 4.206 ± 0.062	0.416TyrMet: 0.416 ± 0.016	1.516TyrAsn: 1.516 ± 0.04	1.714TyrPro: 1.714 ± 0.033	2.272TyrGln: 2.272 ± 0.042	2.074TyrArg: 2.074 ± 0.041	2.205TyrSer: 2.205 ± 0.039	1.804TyrThr: 1.804 ± 0.044	1.523TyrVal: 1.523 ± 0.038	0.601TyrTrp: 0.601 ± 0.021	1.354TyrTyr: 1.354 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4827 proteins (1539476 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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