Amino acid dipepetide frequency for Planococcus halotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.906AlaAla: 7.906 ± 0.117
0.517AlaCys: 0.517 ± 0.023
4.409AlaAsp: 4.409 ± 0.073
6.544AlaGlu: 6.544 ± 0.094
3.743AlaPhe: 3.743 ± 0.066
6.54AlaGly: 6.54 ± 0.095
1.326AlaHis: 1.326 ± 0.035
6.083AlaIle: 6.083 ± 0.087
4.589AlaLys: 4.589 ± 0.076
7.742AlaLeu: 7.742 ± 0.091
2.372AlaMet: 2.372 ± 0.056
2.73AlaAsn: 2.73 ± 0.054
2.418AlaPro: 2.418 ± 0.062
2.413AlaGln: 2.413 ± 0.05
2.879AlaArg: 2.879 ± 0.059
4.458AlaSer: 4.458 ± 0.064
3.721AlaThr: 3.721 ± 0.067
6.406AlaVal: 6.406 ± 0.091
0.704AlaTrp: 0.704 ± 0.024
2.579AlaTyr: 2.579 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.41CysAla: 0.41 ± 0.027
0.063CysCys: 0.063 ± 0.009
0.293CysAsp: 0.293 ± 0.019
0.387CysGlu: 0.387 ± 0.02
0.232CysPhe: 0.232 ± 0.015
0.589CysGly: 0.589 ± 0.028
0.147CysHis: 0.147 ± 0.013
0.337CysIle: 0.337 ± 0.018
0.248CysLys: 0.248 ± 0.016
0.517CysLeu: 0.517 ± 0.025
0.144CysMet: 0.144 ± 0.011
0.216CysAsn: 0.216 ± 0.014
0.287CysPro: 0.287 ± 0.017
0.168CysGln: 0.168 ± 0.012
0.292CysArg: 0.292 ± 0.017
0.388CysSer: 0.388 ± 0.02
0.322CysThr: 0.322 ± 0.019
0.32CysVal: 0.32 ± 0.016
0.063CysTrp: 0.063 ± 0.007
0.177CysTyr: 0.177 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.098AspAla: 4.098 ± 0.073
0.302AspCys: 0.302 ± 0.02
2.633AspAsp: 2.633 ± 0.057
4.77AspGlu: 4.77 ± 0.083
2.871AspPhe: 2.871 ± 0.059
3.845AspGly: 3.845 ± 0.071
1.143AspHis: 1.143 ± 0.035
3.997AspIle: 3.997 ± 0.067
2.944AspLys: 2.944 ± 0.064
5.013AspLeu: 5.013 ± 0.077
1.575AspMet: 1.575 ± 0.041
1.917AspAsn: 1.917 ± 0.047
2.2AspPro: 2.2 ± 0.049
1.801AspGln: 1.801 ± 0.049
2.522AspArg: 2.522 ± 0.053
3.024AspSer: 3.024 ± 0.061
2.602AspThr: 2.602 ± 0.047
3.761AspVal: 3.761 ± 0.063
0.687AspTrp: 0.687 ± 0.027
2.248AspTyr: 2.248 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
6.322GluAla: 6.322 ± 0.093
0.33GluCys: 0.33 ± 0.022
4.365GluAsp: 4.365 ± 0.07
7.997GluGlu: 7.997 ± 0.111
3.073GluPhe: 3.073 ± 0.059
4.955GluGly: 4.955 ± 0.079
1.453GluHis: 1.453 ± 0.035
5.574GluIle: 5.574 ± 0.081
6.119GluLys: 6.119 ± 0.094
7.747GluLeu: 7.747 ± 0.104
2.649GluMet: 2.649 ± 0.052
3.649GluAsn: 3.649 ± 0.069
2.287GluPro: 2.287 ± 0.051
3.627GluGln: 3.627 ± 0.071
3.831GluArg: 3.831 ± 0.067
3.965GluSer: 3.965 ± 0.062
4.499GluThr: 4.499 ± 0.067
5.267GluVal: 5.267 ± 0.08
0.939GluTrp: 0.939 ± 0.033
2.225GluTyr: 2.225 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.45PheAla: 3.45 ± 0.064
0.266PheCys: 0.266 ± 0.017
2.599PheAsp: 2.599 ± 0.054
3.197PheGlu: 3.197 ± 0.062
2.366PhePhe: 2.366 ± 0.058
3.594PheGly: 3.594 ± 0.061
0.978PheHis: 0.978 ± 0.038
3.67PheIle: 3.67 ± 0.069
2.244PheLys: 2.244 ± 0.052
4.485PheLeu: 4.485 ± 0.079
1.255PheMet: 1.255 ± 0.034
1.864PheAsn: 1.864 ± 0.044
1.651PhePro: 1.651 ± 0.038
1.471PheGln: 1.471 ± 0.038
1.697PheArg: 1.697 ± 0.037
3.268PheSer: 3.268 ± 0.054
2.697PheThr: 2.697 ± 0.054
3.044PheVal: 3.044 ± 0.062
0.505PheTrp: 0.505 ± 0.026
1.722PheTyr: 1.722 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
5.371GlyAla: 5.371 ± 0.079
0.477GlyCys: 0.477 ± 0.021
3.602GlyAsp: 3.602 ± 0.066
5.037GlyGlu: 5.037 ± 0.07
3.555GlyPhe: 3.555 ± 0.061
5.153GlyGly: 5.153 ± 0.103
1.431GlyHis: 1.431 ± 0.039
5.941GlyIle: 5.941 ± 0.092
4.807GlyLys: 4.807 ± 0.08
6.621GlyLeu: 6.621 ± 0.113
2.31GlyMet: 2.31 ± 0.049
2.803GlyAsn: 2.803 ± 0.062
1.833GlyPro: 1.833 ± 0.038
2.353GlyGln: 2.353 ± 0.052
2.907GlyArg: 2.907 ± 0.06
4.289GlySer: 4.289 ± 0.07
4.303GlyThr: 4.303 ± 0.079
5.027GlyVal: 5.027 ± 0.073
0.857GlyTrp: 0.857 ± 0.031
2.71GlyTyr: 2.71 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.405HisAla: 1.405 ± 0.04
0.17HisCys: 0.17 ± 0.014
1.012HisAsp: 1.012 ± 0.032
1.409HisGlu: 1.409 ± 0.036
1.047HisPhe: 1.047 ± 0.031
1.396HisGly: 1.396 ± 0.04
0.54HisHis: 0.54 ± 0.028
1.374HisIle: 1.374 ± 0.04
0.962HisLys: 0.962 ± 0.035
1.949HisLeu: 1.949 ± 0.049
0.537HisMet: 0.537 ± 0.023
0.676HisAsn: 0.676 ± 0.026
1.185HisPro: 1.185 ± 0.039
0.762HisGln: 0.762 ± 0.028
0.865HisArg: 0.865 ± 0.029
1.194HisSer: 1.194 ± 0.038
0.993HisThr: 0.993 ± 0.03
1.221HisVal: 1.221 ± 0.032
0.229HisTrp: 0.229 ± 0.015
0.786HisTyr: 0.786 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.443IleAla: 6.443 ± 0.087
0.492IleCys: 0.492 ± 0.02
4.327IleAsp: 4.327 ± 0.075
5.677IleGlu: 5.677 ± 0.073
3.17IlePhe: 3.17 ± 0.07
5.94IleGly: 5.94 ± 0.096
1.515IleHis: 1.515 ± 0.04
5.185IleIle: 5.185 ± 0.088
3.479IleLys: 3.479 ± 0.062
6.796IleLeu: 6.796 ± 0.101
1.7IleMet: 1.7 ± 0.048
2.69IleAsn: 2.69 ± 0.047
3.07IlePro: 3.07 ± 0.06
2.514IleGln: 2.514 ± 0.046
3.331IleArg: 3.331 ± 0.069
4.742IleSer: 4.742 ± 0.073
3.9IleThr: 3.9 ± 0.061
5.137IleVal: 5.137 ± 0.081
0.662IleTrp: 0.662 ± 0.026
2.286IleTyr: 2.286 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.617LysAla: 4.617 ± 0.07
0.235LysCys: 0.235 ± 0.014
3.347LysAsp: 3.347 ± 0.065
6.0LysGlu: 6.0 ± 0.085
1.981LysPhe: 1.981 ± 0.046
3.991LysGly: 3.991 ± 0.063
1.099LysHis: 1.099 ± 0.035
4.097LysIle: 4.097 ± 0.065
4.963LysLys: 4.963 ± 0.084
5.278LysLeu: 5.278 ± 0.088
2.147LysMet: 2.147 ± 0.047
2.855LysAsn: 2.855 ± 0.057
2.154LysPro: 2.154 ± 0.05
2.375LysGln: 2.375 ± 0.046
3.013LysArg: 3.013 ± 0.06
3.307LysSer: 3.307 ± 0.063
3.42LysThr: 3.42 ± 0.061
4.108LysVal: 4.108 ± 0.064
0.713LysTrp: 0.713 ± 0.028
1.806LysTyr: 1.806 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
8.301LeuAla: 8.301 ± 0.116
0.485LeuCys: 0.485 ± 0.021
4.926LeuAsp: 4.926 ± 0.078
7.168LeuGlu: 7.168 ± 0.103
4.708LeuPhe: 4.708 ± 0.091
6.236LeuGly: 6.236 ± 0.099
1.822LeuHis: 1.822 ± 0.044
6.775LeuIle: 6.775 ± 0.103
6.038LeuLys: 6.038 ± 0.091
10.267LeuLeu: 10.267 ± 0.152
2.741LeuMet: 2.741 ± 0.054
3.857LeuAsn: 3.857 ± 0.059
4.05LeuPro: 4.05 ± 0.065
3.488LeuGln: 3.488 ± 0.063
3.721LeuArg: 3.721 ± 0.061
6.411LeuSer: 6.411 ± 0.084
5.55LeuThr: 5.55 ± 0.069
6.301LeuVal: 6.301 ± 0.089
0.89LeuTrp: 0.89 ± 0.031
3.058LeuTyr: 3.058 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.569MetAla: 2.569 ± 0.053
0.108MetCys: 0.108 ± 0.01
1.776MetAsp: 1.776 ± 0.045
2.445MetGlu: 2.445 ± 0.047
1.031MetPhe: 1.031 ± 0.035
1.828MetGly: 1.828 ± 0.046
0.478MetHis: 0.478 ± 0.023
2.026MetIle: 2.026 ± 0.052
2.552MetLys: 2.552 ± 0.051
2.599MetLeu: 2.599 ± 0.059
0.931MetMet: 0.931 ± 0.033
1.471MetAsn: 1.471 ± 0.033
1.143MetPro: 1.143 ± 0.035
1.034MetGln: 1.034 ± 0.031
1.191MetArg: 1.191 ± 0.033
1.582MetSer: 1.582 ± 0.043
1.84MetThr: 1.84 ± 0.042
1.846MetVal: 1.846 ± 0.041
0.191MetTrp: 0.191 ± 0.013
0.717MetTyr: 0.717 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.854AsnAla: 2.854 ± 0.055
0.261AsnCys: 0.261 ± 0.018
2.105AsnAsp: 2.105 ± 0.045
3.283AsnGlu: 3.283 ± 0.051
1.68AsnPhe: 1.68 ± 0.034
3.141AsnGly: 3.141 ± 0.071
0.859AsnHis: 0.859 ± 0.028
2.812AsnIle: 2.812 ± 0.051
2.335AsnLys: 2.335 ± 0.051
3.579AsnLeu: 3.579 ± 0.064
1.15AsnMet: 1.15 ± 0.042
1.592AsnAsn: 1.592 ± 0.043
2.086AsnPro: 2.086 ± 0.049
1.44AsnGln: 1.44 ± 0.042
1.994AsnArg: 1.994 ± 0.049
2.329AsnSer: 2.329 ± 0.057
1.92AsnThr: 1.92 ± 0.043
2.716AsnVal: 2.716 ± 0.053
0.505AsnTrp: 0.505 ± 0.025
1.444AsnTyr: 1.444 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
3.083ProAla: 3.083 ± 0.065
0.156ProCys: 0.156 ± 0.013
2.226ProAsp: 2.226 ± 0.048
3.76ProGlu: 3.76 ± 0.065
1.907ProPhe: 1.907 ± 0.039
2.426ProGly: 2.426 ± 0.053
0.848ProHis: 0.848 ± 0.033
2.435ProIle: 2.435 ± 0.049
1.968ProLys: 1.968 ± 0.048
3.503ProLeu: 3.503 ± 0.059
0.91ProMet: 0.91 ± 0.033
1.437ProAsn: 1.437 ± 0.039
0.997ProPro: 0.997 ± 0.035
1.152ProGln: 1.152 ± 0.031
1.129ProArg: 1.129 ± 0.033
2.204ProSer: 2.204 ± 0.046
1.738ProThr: 1.738 ± 0.045
3.272ProVal: 3.272 ± 0.054
0.356ProTrp: 0.356 ± 0.019
1.344ProTyr: 1.344 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.891GlnAla: 2.891 ± 0.054
0.148GlnCys: 0.148 ± 0.011
1.669GlnAsp: 1.669 ± 0.043
2.902GlnGlu: 2.902 ± 0.054
1.537GlnPhe: 1.537 ± 0.036
2.105GlnGly: 2.105 ± 0.044
0.73GlnHis: 0.73 ± 0.026
2.288GlnIle: 2.288 ± 0.045
2.401GlnLys: 2.401 ± 0.047
3.863GlnLeu: 3.863 ± 0.07
1.18GlnMet: 1.18 ± 0.031
1.504GlnAsn: 1.504 ± 0.04
1.247GlnPro: 1.247 ± 0.036
1.84GlnGln: 1.84 ± 0.052
1.454GlnArg: 1.454 ± 0.041
1.999GlnSer: 1.999 ± 0.047
1.881GlnThr: 1.881 ± 0.046
2.263GlnVal: 2.263 ± 0.046
0.401GlnTrp: 0.401 ± 0.023
1.202GlnTyr: 1.202 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.627ArgAla: 2.627 ± 0.054
0.21ArgCys: 0.21 ± 0.016
2.252ArgAsp: 2.252 ± 0.051
3.437ArgGlu: 3.437 ± 0.055
2.012ArgPhe: 2.012 ± 0.044
2.468ArgGly: 2.468 ± 0.058
0.83ArgHis: 0.83 ± 0.031
3.215ArgIle: 3.215 ± 0.056
3.202ArgLys: 3.202 ± 0.056
4.255ArgLeu: 4.255 ± 0.07
1.375ArgMet: 1.375 ± 0.037
1.906ArgAsn: 1.906 ± 0.046
1.415ArgPro: 1.415 ± 0.039
1.652ArgGln: 1.652 ± 0.042
1.928ArgArg: 1.928 ± 0.05
2.412ArgSer: 2.412 ± 0.049
2.157ArgThr: 2.157 ± 0.043
2.717ArgVal: 2.717 ± 0.054
0.418ArgTrp: 0.418 ± 0.02
1.552ArgTyr: 1.552 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.519SerAla: 4.519 ± 0.064
0.323SerCys: 0.323 ± 0.017
3.051SerAsp: 3.051 ± 0.052
4.25SerGlu: 4.25 ± 0.075
3.142SerPhe: 3.142 ± 0.056
4.871SerGly: 4.871 ± 0.069
1.237SerHis: 1.237 ± 0.035
4.573SerIle: 4.573 ± 0.069
3.338SerLys: 3.338 ± 0.054
5.904SerLeu: 5.904 ± 0.085
1.791SerMet: 1.791 ± 0.039
2.233SerAsn: 2.233 ± 0.055
2.14SerPro: 2.14 ± 0.046
1.944SerGln: 1.944 ± 0.045
2.588SerArg: 2.588 ± 0.049
3.91SerSer: 3.91 ± 0.075
2.972SerThr: 2.972 ± 0.051
4.204SerVal: 4.204 ± 0.058
0.656SerTrp: 0.656 ± 0.026
2.213SerTyr: 2.213 ± 0.05
0.0SerXaa: 0.0 ± 0.0
Thr
4.928ThrAla: 4.928 ± 0.066
0.294ThrCys: 0.294 ± 0.02
3.133ThrAsp: 3.133 ± 0.057
4.115ThrGlu: 4.115 ± 0.071
2.423ThrPhe: 2.423 ± 0.052
4.688ThrGly: 4.688 ± 0.079
1.033ThrHis: 1.033 ± 0.029
4.201ThrIle: 4.201 ± 0.07
2.807ThrLys: 2.807 ± 0.059
4.987ThrLeu: 4.987 ± 0.081
1.323ThrMet: 1.323 ± 0.033
1.963ThrAsn: 1.963 ± 0.05
2.218ThrPro: 2.218 ± 0.048
1.49ThrGln: 1.49 ± 0.037
1.846ThrArg: 1.846 ± 0.04
3.006ThrSer: 3.006 ± 0.064
2.772ThrThr: 2.772 ± 0.07
4.316ThrVal: 4.316 ± 0.075
0.51ThrTrp: 0.51 ± 0.023
1.806ThrTyr: 1.806 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
5.207ValAla: 5.207 ± 0.084
0.434ValCys: 0.434 ± 0.018
3.703ValAsp: 3.703 ± 0.06
5.209ValGlu: 5.209 ± 0.082
3.253ValPhe: 3.253 ± 0.058
4.464ValGly: 4.464 ± 0.073
1.343ValHis: 1.343 ± 0.035
5.242ValIle: 5.242 ± 0.085
4.122ValLys: 4.122 ± 0.076
7.19ValLeu: 7.19 ± 0.087
2.017ValMet: 2.017 ± 0.044
2.822ValAsn: 2.822 ± 0.05
2.756ValPro: 2.756 ± 0.053
2.249ValGln: 2.249 ± 0.044
2.77ValArg: 2.77 ± 0.056
4.635ValSer: 4.635 ± 0.065
4.175ValThr: 4.175 ± 0.071
4.647ValVal: 4.647 ± 0.082
0.676ValTrp: 0.676 ± 0.027
2.306ValTyr: 2.306 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
0.663TrpAla: 0.663 ± 0.028
0.058TrpCys: 0.058 ± 0.008
0.511TrpAsp: 0.511 ± 0.026
0.688TrpGlu: 0.688 ± 0.029
0.516TrpPhe: 0.516 ± 0.024
0.679TrpGly: 0.679 ± 0.027
0.2TrpHis: 0.2 ± 0.015
0.849TrpIle: 0.849 ± 0.031
0.68TrpLys: 0.68 ± 0.027
1.23TrpLeu: 1.23 ± 0.038
0.363TrpMet: 0.363 ± 0.021
0.585TrpAsn: 0.585 ± 0.022
0.317TrpPro: 0.317 ± 0.02
0.468TrpGln: 0.468 ± 0.025
0.426TrpArg: 0.426 ± 0.021
0.617TrpSer: 0.617 ± 0.031
0.555TrpThr: 0.555 ± 0.027
0.634TrpVal: 0.634 ± 0.026
0.147TrpTrp: 0.147 ± 0.011
0.316TrpTyr: 0.316 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.414TyrAla: 2.414 ± 0.057
0.271TyrCys: 0.271 ± 0.019
2.016TyrAsp: 2.016 ± 0.055
2.599TyrGlu: 2.599 ± 0.056
1.776TyrPhe: 1.776 ± 0.05
2.479TyrGly: 2.479 ± 0.052
0.702TyrHis: 0.702 ± 0.025
2.378TyrIle: 2.378 ± 0.05
1.712TyrLys: 1.712 ± 0.044
3.268TyrLeu: 3.268 ± 0.05
0.886TyrMet: 0.886 ± 0.032
1.315TyrAsn: 1.315 ± 0.038
1.396TyrPro: 1.396 ± 0.037
1.263TyrGln: 1.263 ± 0.034
1.658TyrArg: 1.658 ± 0.048
2.118TyrSer: 2.118 ± 0.047
1.843TyrThr: 1.843 ± 0.055
2.01TyrVal: 2.01 ± 0.046
0.392TyrTrp: 0.392 ± 0.02
1.248TyrTyr: 1.248 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3547 proteins (1025973 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski