Amino acid dipepetide frequency for Sutterella megalosphaeroides

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.379AlaAla: 16.379 ± 0.22	1.362AlaCys: 1.362 ± 0.052	6.448AlaAsp: 6.448 ± 0.091	8.315AlaGlu: 8.315 ± 0.146	4.51AlaPhe: 4.51 ± 0.086	9.903AlaGly: 9.903 ± 0.134	2.101AlaHis: 2.101 ± 0.06	4.438AlaIle: 4.438 ± 0.087	4.854AlaLys: 4.854 ± 0.108	13.132AlaLeu: 13.132 ± 0.193	2.868AlaMet: 2.868 ± 0.067	2.863AlaAsn: 2.863 ± 0.069	5.265AlaPro: 5.265 ± 0.115	3.18AlaGln: 3.18 ± 0.075	8.677AlaArg: 8.677 ± 0.16	6.82AlaSer: 6.82 ± 0.123	5.588AlaThr: 5.588 ± 0.099	9.318AlaVal: 9.318 ± 0.119	1.519AlaTrp: 1.519 ± 0.049	2.523AlaTyr: 2.523 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.318CysAla: 1.318 ± 0.047	0.176CysCys: 0.176 ± 0.017	0.622CysAsp: 0.622 ± 0.032	0.655CysGlu: 0.655 ± 0.026	0.38CysPhe: 0.38 ± 0.024	1.176CysGly: 1.176 ± 0.043	0.333CysHis: 0.333 ± 0.032	0.346CysIle: 0.346 ± 0.025	0.253CysLys: 0.253 ± 0.019	0.863CysLeu: 0.863 ± 0.04	0.238CysMet: 0.238 ± 0.019	0.279CysAsn: 0.279 ± 0.02	0.656CysPro: 0.656 ± 0.039	0.183CysGln: 0.183 ± 0.015	0.875CysArg: 0.875 ± 0.037	0.585CysSer: 0.585 ± 0.029	0.571CysThr: 0.571 ± 0.029	0.9CysVal: 0.9 ± 0.037	0.131CysTrp: 0.131 ± 0.013	0.261CysTyr: 0.261 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	7.163AspAla: 7.163 ± 0.11	0.555AspCys: 0.555 ± 0.03	3.095AspAsp: 3.095 ± 0.085	4.493AspGlu: 4.493 ± 0.094	2.555AspPhe: 2.555 ± 0.06	4.05AspGly: 4.05 ± 0.09	0.809AspHis: 0.809 ± 0.03	2.346AspIle: 2.346 ± 0.06	1.738AspLys: 1.738 ± 0.057	5.315AspLeu: 5.315 ± 0.089	1.269AspMet: 1.269 ± 0.042	1.234AspAsn: 1.234 ± 0.049	3.454AspPro: 3.454 ± 0.071	1.022AspGln: 1.022 ± 0.044	4.132AspArg: 4.132 ± 0.083	2.183AspSer: 2.183 ± 0.059	2.734AspThr: 2.734 ± 0.064	4.569AspVal: 4.569 ± 0.093	0.919AspTrp: 0.919 ± 0.033	1.515AspTyr: 1.515 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	9.71GluAla: 9.71 ± 0.178	0.584GluCys: 0.584 ± 0.027	3.219GluAsp: 3.219 ± 0.069	4.702GluGlu: 4.702 ± 0.114	1.979GluPhe: 1.979 ± 0.05	5.571GluGly: 5.571 ± 0.092	1.445GluHis: 1.445 ± 0.04	3.144GluIle: 3.144 ± 0.068	3.973GluLys: 3.973 ± 0.078	6.635GluLeu: 6.635 ± 0.114	1.436GluMet: 1.436 ± 0.043	2.24GluAsn: 2.24 ± 0.058	2.926GluPro: 2.926 ± 0.069	1.479GluGln: 1.479 ± 0.043	6.096GluArg: 6.096 ± 0.115	3.636GluSer: 3.636 ± 0.074	4.462GluThr: 4.462 ± 0.075	4.41GluVal: 4.41 ± 0.084	0.739GluTrp: 0.739 ± 0.033	1.222GluTyr: 1.222 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.538PheAla: 4.538 ± 0.089	0.456PheCys: 0.456 ± 0.028	2.622PheAsp: 2.622 ± 0.065	2.842PheGlu: 2.842 ± 0.059	1.682PhePhe: 1.682 ± 0.054	3.764PheGly: 3.764 ± 0.079	0.617PheHis: 0.617 ± 0.029	1.436PheIle: 1.436 ± 0.047	1.146PheLys: 1.146 ± 0.045	3.594PheLeu: 3.594 ± 0.089	0.916PheMet: 0.916 ± 0.036	1.085PheAsn: 1.085 ± 0.045	1.644PhePro: 1.644 ± 0.05	0.747PheGln: 0.747 ± 0.031	2.27PheArg: 2.27 ± 0.059	2.383PheSer: 2.383 ± 0.057	2.173PheThr: 2.173 ± 0.051	3.202PheVal: 3.202 ± 0.076	0.572PheTrp: 0.572 ± 0.028	0.981PheTyr: 0.981 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	8.659GlyAla: 8.659 ± 0.132	1.124GlyCys: 1.124 ± 0.041	4.06GlyAsp: 4.06 ± 0.096	5.077GlyGlu: 5.077 ± 0.101	3.513GlyPhe: 3.513 ± 0.068	5.872GlyGly: 5.872 ± 0.125	1.468GlyHis: 1.468 ± 0.054	4.322GlyIle: 4.322 ± 0.086	3.53GlyLys: 3.53 ± 0.068	8.442GlyLeu: 8.442 ± 0.119	2.063GlyMet: 2.063 ± 0.055	2.41GlyAsn: 2.41 ± 0.074	2.569GlyPro: 2.569 ± 0.071	1.581GlyGln: 1.581 ± 0.048	5.915GlyArg: 5.915 ± 0.106	4.571GlySer: 4.571 ± 0.128	5.159GlyThr: 5.159 ± 0.139	6.398GlyVal: 6.398 ± 0.106	1.206GlyTrp: 1.206 ± 0.046	2.206GlyTyr: 2.206 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.035HisAla: 2.035 ± 0.058	0.24HisCys: 0.24 ± 0.019	0.999HisAsp: 0.999 ± 0.038	1.158HisGlu: 1.158 ± 0.041	0.796HisPhe: 0.796 ± 0.029	1.525HisGly: 1.525 ± 0.048	0.423HisHis: 0.423 ± 0.022	0.749HisIle: 0.749 ± 0.032	0.547HisLys: 0.547 ± 0.033	1.763HisLeu: 1.763 ± 0.05	0.397HisMet: 0.397 ± 0.022	0.472HisAsn: 0.472 ± 0.027	1.21HisPro: 1.21 ± 0.049	0.399HisGln: 0.399 ± 0.024	1.189HisArg: 1.189 ± 0.043	0.811HisSer: 0.811 ± 0.039	0.938HisThr: 0.938 ± 0.038	1.446HisVal: 1.446 ± 0.051	0.254HisTrp: 0.254 ± 0.019	0.554HisTyr: 0.554 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.29IleAla: 5.29 ± 0.098	0.472IleCys: 0.472 ± 0.026	3.35IleAsp: 3.35 ± 0.07	3.646IleGlu: 3.646 ± 0.075	1.515IlePhe: 1.515 ± 0.044	3.662IleGly: 3.662 ± 0.072	0.707IleHis: 0.707 ± 0.033	1.502IleIle: 1.502 ± 0.051	1.223IleLys: 1.223 ± 0.047	4.393IleLeu: 4.393 ± 0.073	0.724IleMet: 0.724 ± 0.033	1.178IleAsn: 1.178 ± 0.045	2.326IlePro: 2.326 ± 0.053	0.902IleGln: 0.902 ± 0.036	3.183IleArg: 3.183 ± 0.07	2.104IleSer: 2.104 ± 0.063	2.068IleThr: 2.068 ± 0.057	3.95IleVal: 3.95 ± 0.092	0.39IleTrp: 0.39 ± 0.023	1.052IleTyr: 1.052 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.212LysAla: 5.212 ± 0.123	0.359LysCys: 0.359 ± 0.025	2.283LysAsp: 2.283 ± 0.056	2.466LysGlu: 2.466 ± 0.069	1.201LysPhe: 1.201 ± 0.044	3.197LysGly: 3.197 ± 0.081	0.701LysHis: 0.701 ± 0.033	1.785LysIle: 1.785 ± 0.049	2.291LysLys: 2.291 ± 0.069	3.758LysLeu: 3.758 ± 0.069	1.003LysMet: 1.003 ± 0.044	1.488LysAsn: 1.488 ± 0.046	2.237LysPro: 2.237 ± 0.055	0.887LysGln: 0.887 ± 0.036	2.95LysArg: 2.95 ± 0.077	2.403LysSer: 2.403 ± 0.063	3.056LysThr: 3.056 ± 0.062	2.558LysVal: 2.558 ± 0.071	0.364LysTrp: 0.364 ± 0.02	0.798LysTyr: 0.798 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	11.978LeuAla: 11.978 ± 0.162	1.153LeuCys: 1.153 ± 0.043	5.263LeuAsp: 5.263 ± 0.092	7.141LeuGlu: 7.141 ± 0.131	3.975LeuPhe: 3.975 ± 0.099	7.804LeuGly: 7.804 ± 0.107	1.637LeuHis: 1.637 ± 0.045	3.624LeuIle: 3.624 ± 0.081	4.466LeuLys: 4.466 ± 0.073	9.561LeuLeu: 9.561 ± 0.135	2.335LeuMet: 2.335 ± 0.058	2.554LeuAsn: 2.554 ± 0.06	5.316LeuPro: 5.316 ± 0.082	2.445LeuGln: 2.445 ± 0.063	6.942LeuArg: 6.942 ± 0.124	6.46LeuSer: 6.46 ± 0.107	6.18LeuThr: 6.18 ± 0.106	7.619LeuVal: 7.619 ± 0.119	1.246LeuTrp: 1.246 ± 0.045	2.211LeuTyr: 2.211 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.373MetAla: 2.373 ± 0.066	0.202MetCys: 0.202 ± 0.017	0.954MetAsp: 0.954 ± 0.033	1.065MetGlu: 1.065 ± 0.039	0.672MetPhe: 0.672 ± 0.034	1.754MetGly: 1.754 ± 0.054	0.477MetHis: 0.477 ± 0.027	1.067MetIle: 1.067 ± 0.043	1.27MetLys: 1.27 ± 0.046	2.507MetLeu: 2.507 ± 0.051	0.588MetMet: 0.588 ± 0.035	0.82MetAsn: 0.82 ± 0.035	1.392MetPro: 1.392 ± 0.042	0.811MetGln: 0.811 ± 0.032	1.734MetArg: 1.734 ± 0.054	1.591MetSer: 1.591 ± 0.044	2.143MetThr: 2.143 ± 0.053	1.412MetVal: 1.412 ± 0.057	0.157MetTrp: 0.157 ± 0.015	0.355MetTyr: 0.355 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.551AsnAla: 3.551 ± 0.085	0.257AsnCys: 0.257 ± 0.02	1.587AsnAsp: 1.587 ± 0.048	1.665AsnGlu: 1.665 ± 0.046	1.102AsnPhe: 1.102 ± 0.036	2.453AsnGly: 2.453 ± 0.066	0.532AsnHis: 0.532 ± 0.026	1.214AsnIle: 1.214 ± 0.048	0.758AsnLys: 0.758 ± 0.039	2.862AsnLeu: 2.862 ± 0.07	0.571AsnMet: 0.571 ± 0.031	0.68AsnAsn: 0.68 ± 0.041	1.988AsnPro: 1.988 ± 0.047	0.603AsnGln: 0.603 ± 0.032	1.999AsnArg: 1.999 ± 0.057	1.26AsnSer: 1.26 ± 0.047	1.447AsnThr: 1.447 ± 0.053	2.232AsnVal: 2.232 ± 0.062	0.359AsnTrp: 0.359 ± 0.024	0.77AsnTyr: 0.77 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.65ProAla: 5.65 ± 0.111	0.42ProCys: 0.42 ± 0.023	3.048ProAsp: 3.048 ± 0.073	5.182ProGlu: 5.182 ± 0.102	1.938ProPhe: 1.938 ± 0.051	3.66ProGly: 3.66 ± 0.071	0.853ProHis: 0.853 ± 0.036	1.97ProIle: 1.97 ± 0.053	2.356ProLys: 2.356 ± 0.066	4.22ProLeu: 4.22 ± 0.085	1.17ProMet: 1.17 ± 0.04	1.358ProAsn: 1.358 ± 0.043	1.483ProPro: 1.483 ± 0.05	1.21ProGln: 1.21 ± 0.046	2.435ProArg: 2.435 ± 0.066	2.723ProSer: 2.723 ± 0.071	2.418ProThr: 2.418 ± 0.047	4.519ProVal: 4.519 ± 0.079	0.652ProTrp: 0.652 ± 0.035	1.328ProTyr: 1.328 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.629GlnAla: 2.629 ± 0.062	0.258GlnCys: 0.258 ± 0.02	0.899GlnAsp: 0.899 ± 0.037	1.234GlnGlu: 1.234 ± 0.044	0.819GlnPhe: 0.819 ± 0.034	1.766GlnGly: 1.766 ± 0.051	0.461GlnHis: 0.461 ± 0.027	1.247GlnIle: 1.247 ± 0.04	1.335GlnLys: 1.335 ± 0.048	2.244GlnLeu: 2.244 ± 0.06	0.631GlnMet: 0.631 ± 0.032	0.791GlnAsn: 0.791 ± 0.038	1.079GlnPro: 1.079 ± 0.038	0.701GlnGln: 0.701 ± 0.03	1.531GlnArg: 1.531 ± 0.053	1.31GlnSer: 1.31 ± 0.05	1.523GlnThr: 1.523 ± 0.045	1.548GlnVal: 1.548 ± 0.053	0.283GlnTrp: 0.283 ± 0.019	0.621GlnTyr: 0.621 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	8.108ArgAla: 8.108 ± 0.144	0.659ArgCys: 0.659 ± 0.03	3.485ArgAsp: 3.485 ± 0.074	5.192ArgGlu: 5.192 ± 0.105	3.115ArgPhe: 3.115 ± 0.07	4.354ArgGly: 4.354 ± 0.071	1.35ArgHis: 1.35 ± 0.043	4.008ArgIle: 4.008 ± 0.082	2.348ArgLys: 2.348 ± 0.069	7.483ArgLeu: 7.483 ± 0.136	1.91ArgMet: 1.91 ± 0.048	1.916ArgAsn: 1.916 ± 0.049	3.327ArgPro: 3.327 ± 0.084	1.648ArgGln: 1.648 ± 0.053	5.986ArgArg: 5.986 ± 0.14	3.914ArgSer: 3.914 ± 0.081	4.472ArgThr: 4.472 ± 0.096	5.142ArgVal: 5.142 ± 0.086	1.007ArgTrp: 1.007 ± 0.038	1.88ArgTyr: 1.88 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.563SerAla: 6.563 ± 0.112	0.546SerCys: 0.546 ± 0.031	3.238SerAsp: 3.238 ± 0.069	3.483SerGlu: 3.483 ± 0.08	2.105SerPhe: 2.105 ± 0.049	5.611SerGly: 5.611 ± 0.118	0.933SerHis: 0.933 ± 0.039	2.774SerIle: 2.774 ± 0.056	1.976SerLys: 1.976 ± 0.067	5.003SerLeu: 5.003 ± 0.095	1.286SerMet: 1.286 ± 0.041	1.624SerAsn: 1.624 ± 0.053	2.795SerPro: 2.795 ± 0.065	1.184SerGln: 1.184 ± 0.039	3.513SerArg: 3.513 ± 0.067	3.522SerSer: 3.522 ± 0.084	3.318SerThr: 3.318 ± 0.086	4.371SerVal: 4.371 ± 0.086	0.643SerTrp: 0.643 ± 0.027	1.27SerTyr: 1.27 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	6.474ThrAla: 6.474 ± 0.108	0.553ThrCys: 0.553 ± 0.033	3.357ThrAsp: 3.357 ± 0.077	3.543ThrGlu: 3.543 ± 0.073	2.114ThrPhe: 2.114 ± 0.06	5.618ThrGly: 5.618 ± 0.125	1.065ThrHis: 1.065 ± 0.039	2.844ThrIle: 2.844 ± 0.063	2.181ThrLys: 2.181 ± 0.05	6.313ThrLeu: 6.313 ± 0.143	1.274ThrMet: 1.274 ± 0.043	1.649ThrAsn: 1.649 ± 0.047	3.525ThrPro: 3.525 ± 0.076	1.319ThrGln: 1.319 ± 0.047	3.035ThrArg: 3.035 ± 0.07	3.195ThrSer: 3.195 ± 0.066	3.488ThrThr: 3.488 ± 0.097	5.213ThrVal: 5.213 ± 0.1	0.616ThrTrp: 0.616 ± 0.027	1.441ThrTyr: 1.441 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	8.531ValAla: 8.531 ± 0.123	0.929ValCys: 0.929 ± 0.032	4.586ValAsp: 4.586 ± 0.072	5.489ValGlu: 5.489 ± 0.081	3.174ValPhe: 3.174 ± 0.071	5.125ValGly: 5.125 ± 0.096	1.34ValHis: 1.34 ± 0.052	3.424ValIle: 3.424 ± 0.079	3.422ValLys: 3.422 ± 0.075	8.227ValLeu: 8.227 ± 0.123	1.822ValMet: 1.822 ± 0.057	2.19ValAsn: 2.19 ± 0.061	3.805ValPro: 3.805 ± 0.069	1.607ValGln: 1.607 ± 0.048	6.075ValArg: 6.075 ± 0.12	4.417ValSer: 4.417 ± 0.094	5.07ValThr: 5.07 ± 0.095	6.672ValVal: 6.672 ± 0.115	0.938ValTrp: 0.938 ± 0.033	1.619ValTyr: 1.619 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.184TrpAla: 1.184 ± 0.042	0.202TrpCys: 0.202 ± 0.016	0.566TrpAsp: 0.566 ± 0.03	0.651TrpGlu: 0.651 ± 0.034	0.513TrpPhe: 0.513 ± 0.028	0.974TrpGly: 0.974 ± 0.038	0.284TrpHis: 0.284 ± 0.019	0.625TrpIle: 0.625 ± 0.029	0.595TrpLys: 0.595 ± 0.026	1.39TrpLeu: 1.39 ± 0.048	0.371TrpMet: 0.371 ± 0.02	0.414TrpAsn: 0.414 ± 0.024	0.494TrpPro: 0.494 ± 0.028	0.394TrpGln: 0.394 ± 0.025	0.908TrpArg: 0.908 ± 0.039	0.719TrpSer: 0.719 ± 0.031	0.788TrpThr: 0.788 ± 0.037	0.969TrpVal: 0.969 ± 0.036	0.173TrpTrp: 0.173 ± 0.015	0.322TrpTyr: 0.322 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.718TyrAla: 2.718 ± 0.065	0.296TyrCys: 0.296 ± 0.023	1.47TyrAsp: 1.47 ± 0.048	1.608TyrGlu: 1.608 ± 0.056	1.011TyrPhe: 1.011 ± 0.037	2.307TyrGly: 2.307 ± 0.068	0.371TyrHis: 0.371 ± 0.022	0.775TyrIle: 0.775 ± 0.029	0.732TyrLys: 0.732 ± 0.036	2.206TyrLeu: 2.206 ± 0.052	0.47TyrMet: 0.47 ± 0.026	0.646TyrAsn: 0.646 ± 0.032	1.102TyrPro: 1.102 ± 0.037	0.606TyrGln: 0.606 ± 0.028	1.859TyrArg: 1.859 ± 0.048	1.153TyrSer: 1.153 ± 0.043	1.219TyrThr: 1.219 ± 0.045	2.013TyrVal: 2.013 ± 0.053	0.367TyrTrp: 0.367 ± 0.022	0.574TyrTyr: 0.574 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2112 proteins (763480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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