Amino acid dipepetide frequency for Amycolatopsis suaedae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.497AlaAla: 21.497 ± 0.166	1.052AlaCys: 1.052 ± 0.025	8.654AlaAsp: 8.654 ± 0.076	9.332AlaGlu: 9.332 ± 0.085	3.399AlaPhe: 3.399 ± 0.039	14.83AlaGly: 14.83 ± 0.113	2.417AlaHis: 2.417 ± 0.033	3.799AlaIle: 3.799 ± 0.046	2.746AlaLys: 2.746 ± 0.046	13.996AlaLeu: 13.996 ± 0.107	2.502AlaMet: 2.502 ± 0.036	2.142AlaAsn: 2.142 ± 0.031	6.15AlaPro: 6.15 ± 0.064	3.465AlaGln: 3.465 ± 0.039	9.916AlaArg: 9.916 ± 0.084	5.318AlaSer: 5.318 ± 0.048	7.457AlaThr: 7.457 ± 0.065	12.893AlaVal: 12.893 ± 0.094	1.845AlaTrp: 1.845 ± 0.033	2.282AlaTyr: 2.282 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.036CysAla: 1.036 ± 0.021	0.105CysCys: 0.105 ± 0.007	0.432CysAsp: 0.432 ± 0.013	0.393CysGlu: 0.393 ± 0.015	0.21CysPhe: 0.21 ± 0.01	0.919CysGly: 0.919 ± 0.021	0.18CysHis: 0.18 ± 0.009	0.126CysIle: 0.126 ± 0.007	0.108CysLys: 0.108 ± 0.007	0.707CysLeu: 0.707 ± 0.02	0.089CysMet: 0.089 ± 0.006	0.122CysAsn: 0.122 ± 0.008	0.479CysPro: 0.479 ± 0.016	0.184CysGln: 0.184 ± 0.009	0.58CysArg: 0.58 ± 0.014	0.438CysSer: 0.438 ± 0.014	0.451CysThr: 0.451 ± 0.016	0.69CysVal: 0.69 ± 0.017	0.143CysTrp: 0.143 ± 0.009	0.164CysTyr: 0.164 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.303AspAla: 7.303 ± 0.066	0.394AspCys: 0.394 ± 0.014	3.558AspAsp: 3.558 ± 0.044	3.929AspGlu: 3.929 ± 0.047	1.552AspPhe: 1.552 ± 0.031	6.337AspGly: 6.337 ± 0.057	1.319AspHis: 1.319 ± 0.024	1.851AspIle: 1.851 ± 0.032	1.044AspLys: 1.044 ± 0.027	6.337AspLeu: 6.337 ± 0.059	0.723AspMet: 0.723 ± 0.019	1.087AspAsn: 1.087 ± 0.023	4.586AspPro: 4.586 ± 0.056	1.63AspGln: 1.63 ± 0.03	5.13AspArg: 5.13 ± 0.053	2.411AspSer: 2.411 ± 0.032	3.126AspThr: 3.126 ± 0.035	5.299AspVal: 5.299 ± 0.05	1.017AspTrp: 1.017 ± 0.023	1.206AspTyr: 1.206 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.573GluAla: 6.573 ± 0.067	0.356GluCys: 0.356 ± 0.014	2.406GluAsp: 2.406 ± 0.039	2.695GluGlu: 2.695 ± 0.046	1.826GluPhe: 1.826 ± 0.03	3.575GluGly: 3.575 ± 0.034	1.64GluHis: 1.64 ± 0.03	2.212GluIle: 2.212 ± 0.034	1.163GluLys: 1.163 ± 0.024	7.676GluLeu: 7.676 ± 0.071	0.811GluMet: 0.811 ± 0.021	1.008GluAsn: 1.008 ± 0.022	3.814GluPro: 3.814 ± 0.05	2.409GluGln: 2.409 ± 0.036	5.386GluArg: 5.386 ± 0.057	2.45GluSer: 2.45 ± 0.039	2.666GluThr: 2.666 ± 0.03	5.005GluVal: 5.005 ± 0.051	0.822GluTrp: 0.822 ± 0.021	1.072GluTyr: 1.072 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.077PheAla: 4.077 ± 0.048	0.255PheCys: 0.255 ± 0.011	2.245PheAsp: 2.245 ± 0.034	1.382PheGlu: 1.382 ± 0.028	0.837PhePhe: 0.837 ± 0.023	3.399PheGly: 3.399 ± 0.039	0.619PheHis: 0.619 ± 0.018	0.629PheIle: 0.629 ± 0.019	0.377PheLys: 0.377 ± 0.016	2.679PheLeu: 2.679 ± 0.04	0.338PheMet: 0.338 ± 0.013	0.558PheAsn: 0.558 ± 0.016	1.392PhePro: 1.392 ± 0.024	0.636PheGln: 0.636 ± 0.016	1.862PheArg: 1.862 ± 0.026	1.389PheSer: 1.389 ± 0.024	2.187PheThr: 2.187 ± 0.036	2.456PheVal: 2.456 ± 0.037	0.455PheTrp: 0.455 ± 0.017	0.625PheTyr: 0.625 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.578GlyAla: 10.578 ± 0.075	0.824GlyCys: 0.824 ± 0.022	5.167GlyAsp: 5.167 ± 0.065	5.473GlyGlu: 5.473 ± 0.055	3.118GlyPhe: 3.118 ± 0.042	8.785GlyGly: 8.785 ± 0.096	2.13GlyHis: 2.13 ± 0.038	3.496GlyIle: 3.496 ± 0.043	2.426GlyLys: 2.426 ± 0.039	9.856GlyLeu: 9.856 ± 0.075	2.119GlyMet: 2.119 ± 0.032	1.926GlyAsn: 1.926 ± 0.033	5.058GlyPro: 5.058 ± 0.061	2.928GlyGln: 2.928 ± 0.032	7.595GlyArg: 7.595 ± 0.065	5.017GlySer: 5.017 ± 0.054	6.188GlyThr: 6.188 ± 0.062	8.407GlyVal: 8.407 ± 0.076	1.847GlyTrp: 1.847 ± 0.031	2.452GlyTyr: 2.452 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.583HisAla: 2.583 ± 0.039	0.21HisCys: 0.21 ± 0.01	1.297HisAsp: 1.297 ± 0.025	1.094HisGlu: 1.094 ± 0.023	0.59HisPhe: 0.59 ± 0.015	2.308HisGly: 2.308 ± 0.032	0.603HisHis: 0.603 ± 0.021	0.559HisIle: 0.559 ± 0.017	0.294HisLys: 0.294 ± 0.012	2.261HisLeu: 2.261 ± 0.035	0.273HisMet: 0.273 ± 0.01	0.397HisAsn: 0.397 ± 0.012	1.591HisPro: 1.591 ± 0.03	0.599HisGln: 0.599 ± 0.019	1.966HisArg: 1.966 ± 0.028	0.961HisSer: 0.961 ± 0.02	1.176HisThr: 1.176 ± 0.027	1.729HisVal: 1.729 ± 0.026	0.339HisTrp: 0.339 ± 0.012	0.505HisTyr: 0.505 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.88IleAla: 4.88 ± 0.052	0.278IleCys: 0.278 ± 0.013	2.237IleAsp: 2.237 ± 0.034	2.005IleGlu: 2.005 ± 0.036	0.7IlePhe: 0.7 ± 0.022	3.685IleGly: 3.685 ± 0.045	0.542IleHis: 0.542 ± 0.017	0.904IleIle: 0.904 ± 0.023	0.647IleLys: 0.647 ± 0.019	2.407IleLeu: 2.407 ± 0.04	0.415IleMet: 0.415 ± 0.017	0.703IleAsn: 0.703 ± 0.021	1.819IlePro: 1.819 ± 0.028	0.695IleGln: 0.695 ± 0.017	2.24IleArg: 2.24 ± 0.03	1.658IleSer: 1.658 ± 0.03	2.275IleThr: 2.275 ± 0.034	2.855IleVal: 2.855 ± 0.046	0.375IleTrp: 0.375 ± 0.014	0.565IleTyr: 0.565 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.545LysAla: 2.545 ± 0.044	0.094LysCys: 0.094 ± 0.005	0.954LysAsp: 0.954 ± 0.022	0.91LysGlu: 0.91 ± 0.024	0.487LysPhe: 0.487 ± 0.014	1.406LysGly: 1.406 ± 0.03	0.43LysHis: 0.43 ± 0.015	0.786LysIle: 0.786 ± 0.02	0.571LysLys: 0.571 ± 0.024	2.17LysLeu: 2.17 ± 0.033	0.337LysMet: 0.337 ± 0.014	0.396LysAsn: 0.396 ± 0.014	1.471LysPro: 1.471 ± 0.032	0.695LysGln: 0.695 ± 0.02	1.385LysArg: 1.385 ± 0.028	0.941LysSer: 0.941 ± 0.023	1.123LysThr: 1.123 ± 0.024	1.814LysVal: 1.814 ± 0.036	0.266LysTrp: 0.266 ± 0.01	0.401LysTyr: 0.401 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	16.717LeuAla: 16.717 ± 0.124	0.804LeuCys: 0.804 ± 0.022	7.1LeuAsp: 7.1 ± 0.057	4.488LeuGlu: 4.488 ± 0.051	2.768LeuPhe: 2.768 ± 0.038	9.855LeuGly: 9.855 ± 0.073	2.216LeuHis: 2.216 ± 0.035	3.192LeuIle: 3.192 ± 0.046	1.57LeuLys: 1.57 ± 0.031	11.639LeuLeu: 11.639 ± 0.116	1.376LeuMet: 1.376 ± 0.026	1.72LeuAsn: 1.72 ± 0.025	6.669LeuPro: 6.669 ± 0.069	1.815LeuGln: 1.815 ± 0.033	9.516LeuArg: 9.516 ± 0.086	5.443LeuSer: 5.443 ± 0.048	6.943LeuThr: 6.943 ± 0.056	9.776LeuVal: 9.776 ± 0.079	1.337LeuTrp: 1.337 ± 0.029	1.725LeuTyr: 1.725 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.095MetAla: 2.095 ± 0.033	0.103MetCys: 0.103 ± 0.008	0.795MetAsp: 0.795 ± 0.019	0.64MetGlu: 0.64 ± 0.018	0.495MetPhe: 0.495 ± 0.015	1.186MetGly: 1.186 ± 0.024	0.303MetHis: 0.303 ± 0.012	0.679MetIle: 0.679 ± 0.019	0.337MetLys: 0.337 ± 0.013	1.799MetLeu: 1.799 ± 0.029	0.257MetMet: 0.257 ± 0.012	0.385MetAsn: 0.385 ± 0.015	1.088MetPro: 1.088 ± 0.022	0.379MetGln: 0.379 ± 0.013	1.468MetArg: 1.468 ± 0.024	1.243MetSer: 1.243 ± 0.022	1.467MetThr: 1.467 ± 0.027	1.383MetVal: 1.383 ± 0.028	0.197MetTrp: 0.197 ± 0.01	0.262MetTyr: 0.262 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.225AsnAla: 2.225 ± 0.039	0.165AsnCys: 0.165 ± 0.009	0.971AsnAsp: 0.971 ± 0.021	0.849AsnGlu: 0.849 ± 0.018	0.5AsnPhe: 0.5 ± 0.016	1.924AsnGly: 1.924 ± 0.036	0.405AsnHis: 0.405 ± 0.013	0.634AsnIle: 0.634 ± 0.017	0.376AsnLys: 0.376 ± 0.014	1.878AsnLeu: 1.878 ± 0.033	0.283AsnMet: 0.283 ± 0.011	0.479AsnAsn: 0.479 ± 0.017	1.461AsnPro: 1.461 ± 0.029	0.558AsnGln: 0.558 ± 0.017	1.378AsnArg: 1.378 ± 0.024	0.923AsnSer: 0.923 ± 0.019	1.13AsnThr: 1.13 ± 0.027	1.488AsnVal: 1.488 ± 0.027	0.315AsnTrp: 0.315 ± 0.013	0.454AsnTyr: 0.454 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.973ProAla: 8.973 ± 0.078	0.336ProCys: 0.336 ± 0.014	4.514ProAsp: 4.514 ± 0.051	4.188ProGlu: 4.188 ± 0.053	1.539ProPhe: 1.539 ± 0.024	6.788ProGly: 6.788 ± 0.072	1.201ProHis: 1.201 ± 0.025	1.49ProIle: 1.49 ± 0.025	1.183ProLys: 1.183 ± 0.028	5.189ProLeu: 5.189 ± 0.053	1.009ProMet: 1.009 ± 0.02	1.063ProAsn: 1.063 ± 0.024	3.96ProPro: 3.96 ± 0.068	1.441ProGln: 1.441 ± 0.029	3.97ProArg: 3.97 ± 0.041	2.897ProSer: 2.897 ± 0.038	2.763ProThr: 2.763 ± 0.039	5.761ProVal: 5.761 ± 0.052	0.912ProTrp: 0.912 ± 0.02	1.121ProTyr: 1.121 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.764GlnAla: 3.764 ± 0.044	0.166GlnCys: 0.166 ± 0.009	1.124GlnAsp: 1.124 ± 0.022	1.141GlnGlu: 1.141 ± 0.023	0.747GlnPhe: 0.747 ± 0.019	1.976GlnGly: 1.976 ± 0.03	0.598GlnHis: 0.598 ± 0.016	1.007GlnIle: 1.007 ± 0.022	0.495GlnLys: 0.495 ± 0.018	3.292GlnLeu: 3.292 ± 0.039	0.371GlnMet: 0.371 ± 0.012	0.496GlnAsn: 0.496 ± 0.016	1.88GlnPro: 1.88 ± 0.036	1.176GlnGln: 1.176 ± 0.028	2.723GlnArg: 2.723 ± 0.039	1.085GlnSer: 1.085 ± 0.021	1.22GlnThr: 1.22 ± 0.023	2.525GlnVal: 2.525 ± 0.033	0.466GlnTrp: 0.466 ± 0.015	0.536GlnTyr: 0.536 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.849ArgAla: 9.849 ± 0.076	0.58ArgCys: 0.58 ± 0.018	4.521ArgAsp: 4.521 ± 0.043	4.727ArgGlu: 4.727 ± 0.049	2.658ArgPhe: 2.658 ± 0.032	5.933ArgGly: 5.933 ± 0.053	2.022ArgHis: 2.022 ± 0.032	3.155ArgIle: 3.155 ± 0.044	1.714ArgLys: 1.714 ± 0.033	9.129ArgLeu: 9.129 ± 0.08	1.887ArgMet: 1.887 ± 0.03	1.46ArgAsn: 1.46 ± 0.025	4.739ArgPro: 4.739 ± 0.051	2.539ArgGln: 2.539 ± 0.035	8.016ArgArg: 8.016 ± 0.076	3.917ArgSer: 3.917 ± 0.047	4.913ArgThr: 4.913 ± 0.044	6.403ArgVal: 6.403 ± 0.058	1.518ArgTrp: 1.518 ± 0.028	1.935ArgTyr: 1.935 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.248SerAla: 6.248 ± 0.054	0.403SerCys: 0.403 ± 0.014	2.472SerAsp: 2.472 ± 0.034	2.329SerGlu: 2.329 ± 0.033	1.458SerPhe: 1.458 ± 0.027	5.625SerGly: 5.625 ± 0.056	0.849SerHis: 0.849 ± 0.019	1.513SerIle: 1.513 ± 0.026	0.95SerLys: 0.95 ± 0.025	4.604SerLeu: 4.604 ± 0.052	1.074SerMet: 1.074 ± 0.023	0.87SerAsn: 0.87 ± 0.022	2.914SerPro: 2.914 ± 0.038	1.162SerGln: 1.162 ± 0.025	3.53SerArg: 3.53 ± 0.042	2.531SerSer: 2.531 ± 0.042	3.06SerThr: 3.06 ± 0.037	4.316SerVal: 4.316 ± 0.043	0.934SerTrp: 0.934 ± 0.019	1.089SerTyr: 1.089 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.225ThrAla: 8.225 ± 0.068	0.434ThrCys: 0.434 ± 0.015	3.411ThrAsp: 3.411 ± 0.041	3.423ThrGlu: 3.423 ± 0.038	1.707ThrPhe: 1.707 ± 0.033	6.773ThrGly: 6.773 ± 0.062	1.059ThrHis: 1.059 ± 0.022	1.916ThrIle: 1.916 ± 0.031	1.107ThrLys: 1.107 ± 0.027	5.883ThrLeu: 5.883 ± 0.053	1.05ThrMet: 1.05 ± 0.021	1.011ThrAsn: 1.011 ± 0.023	3.717ThrPro: 3.717 ± 0.041	1.327ThrGln: 1.327 ± 0.025	4.001ThrArg: 4.001 ± 0.048	2.956ThrSer: 2.956 ± 0.04	3.743ThrThr: 3.743 ± 0.047	6.481ThrVal: 6.481 ± 0.063	0.903ThrTrp: 0.903 ± 0.02	1.148ThrTyr: 1.148 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	12.421ValAla: 12.421 ± 0.096	0.655ValCys: 0.655 ± 0.017	5.855ValAsp: 5.855 ± 0.059	4.914ValGlu: 4.914 ± 0.049	2.592ValPhe: 2.592 ± 0.037	7.025ValGly: 7.025 ± 0.056	1.972ValHis: 1.972 ± 0.029	2.954ValIle: 2.954 ± 0.04	1.492ValLys: 1.492 ± 0.033	10.836ValLeu: 10.836 ± 0.088	1.198ValMet: 1.198 ± 0.028	1.795ValAsn: 1.795 ± 0.03	5.454ValPro: 5.454 ± 0.059	1.905ValGln: 1.905 ± 0.032	7.569ValArg: 7.569 ± 0.064	4.511ValSer: 4.511 ± 0.055	6.175ValThr: 6.175 ± 0.054	9.267ValVal: 9.267 ± 0.082	1.116ValTrp: 1.116 ± 0.02	1.555ValTyr: 1.555 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.669TrpAla: 1.669 ± 0.028	0.172TrpCys: 0.172 ± 0.009	0.816TrpAsp: 0.816 ± 0.018	0.698TrpGlu: 0.698 ± 0.019	0.543TrpPhe: 0.543 ± 0.015	1.043TrpGly: 1.043 ± 0.025	0.378TrpHis: 0.378 ± 0.015	0.554TrpIle: 0.554 ± 0.014	0.281TrpLys: 0.281 ± 0.011	2.031TrpLeu: 2.031 ± 0.034	0.272TrpMet: 0.272 ± 0.012	0.384TrpAsn: 0.384 ± 0.015	0.898TrpPro: 0.898 ± 0.022	0.62TrpGln: 0.62 ± 0.015	1.481TrpArg: 1.481 ± 0.03	0.886TrpSer: 0.886 ± 0.024	1.035TrpThr: 1.035 ± 0.026	1.092TrpVal: 1.092 ± 0.023	0.354TrpTrp: 0.354 ± 0.013	0.319TrpTyr: 0.319 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.438TyrAla: 2.438 ± 0.033	0.166TyrCys: 0.166 ± 0.009	1.31TyrAsp: 1.31 ± 0.027	0.957TyrGlu: 0.957 ± 0.021	0.669TyrPhe: 0.669 ± 0.019	2.018TyrGly: 2.018 ± 0.032	0.451TyrHis: 0.451 ± 0.015	0.43TyrIle: 0.43 ± 0.015	0.299TyrLys: 0.299 ± 0.012	2.299TyrLeu: 2.299 ± 0.033	0.178TyrMet: 0.178 ± 0.01	0.394TyrAsn: 0.394 ± 0.013	1.157TyrPro: 1.157 ± 0.025	0.627TyrGln: 0.627 ± 0.018	1.902TyrArg: 1.902 ± 0.032	0.957TyrSer: 0.957 ± 0.022	1.177TyrThr: 1.177 ± 0.025	1.622TyrVal: 1.622 ± 0.032	0.363TyrTrp: 0.363 ± 0.015	0.437TyrTyr: 0.437 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6878 proteins (2267144 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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